OA09432A - N-aryl-azétidinones, leur procédé de préparation et leur utilisation comme inhibiteurs des élastases. - Google Patents

N-aryl-azétidinones, leur procédé de préparation et leur utilisation comme inhibiteurs des élastases.

Info

Publication number
OA09432A
OA09432A OA59703A OA59703A OA09432A OA 09432 A OA09432 A OA 09432A OA 59703 A OA59703 A OA 59703A OA 59703 A OA59703 A OA 59703A OA 09432 A OA09432 A OA 09432A
Authority
OA
OAPI
Prior art keywords
azetidinones
aryl
preparation process
elastase inhibitors
elastase
Prior art date
Application number
OA59703A
Other languages
English (en)
French (fr)
Inventor
Joyeau Roger
Kobaiter Randa
Wakselman Michel
Reboud Michele
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Publication of OA09432A publication Critical patent/OA09432A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
OA59703A 1988-12-19 1989-12-19 N-aryl-azétidinones, leur procédé de préparation et leur utilisation comme inhibiteurs des élastases. OA09432A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8816732A FR2640621B1 (fr) 1988-12-19 1988-12-19 N-aryl-azetidinones, leur procede de preparation et leur utilisation comme inhibiteurs des elastases

Publications (1)

Publication Number Publication Date
OA09432A true OA09432A (fr) 1992-10-15

Family

ID=9373095

Family Applications (1)

Application Number Title Priority Date Filing Date
OA59703A OA09432A (fr) 1988-12-19 1989-12-19 N-aryl-azétidinones, leur procédé de préparation et leur utilisation comme inhibiteurs des élastases.

Country Status (11)

Country Link
US (1) US5030628A (xx)
EP (1) EP0375527A1 (xx)
JP (1) JPH0334966A (xx)
AU (1) AU628445B2 (xx)
CA (1) CA2005759A1 (xx)
DK (1) DK641589A (xx)
FR (1) FR2640621B1 (xx)
NZ (1) NZ231817A (xx)
OA (1) OA09432A (xx)
PT (1) PT92612A (xx)
ZA (1) ZA899725B (xx)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688787A (en) * 1991-07-23 1997-11-18 Schering Corporation Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof
US5688785A (en) * 1991-07-23 1997-11-18 Schering Corporation Substituted azetidinone compounds useful as hypocholesterolemic agents
EP0524595A1 (en) * 1991-07-23 1993-01-27 Schering Corporation Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
FR2755015B1 (fr) * 1996-10-25 1998-12-24 Sod Conseils Rech Applic Utilisation d'un extrait flavonoidique de ginkgo biloba substantiellement depourvu de terpenes, dans le domaine buccodentaire, et composition contenant un tel extrait
JP2001524132A (ja) * 1997-05-09 2001-11-27 スミスクライン・ビーチャム・コーポレイション ＣｏＡ−ＩＴのベータ−ラクタム阻害剤
US6274597B1 (en) 1998-06-01 2001-08-14 Mount Sinai School Of Medicine Of New York University Method of enhancing lysosomal α-Galactosidase A
WO2000063703A1 (en) * 1999-04-16 2000-10-26 Schering Corporation Use of azetidinone compounds
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
MXPA03006727A (es) * 2001-01-26 2003-10-24 Schering Corp Combinaciones de acido nicotinico y derivados del mismo con inhibidor(es) de la absorcion de los esteroles, y tratamiento para indicaciones vasculares.
PT1353694E (pt) * 2001-01-26 2008-03-12 Schering Corp Combinações de ezetimiba com aspirina para o tratamento de doenças vasculares
DE60221798T2 (de) * 2001-01-26 2008-06-05 Schering Corp. Kombinationen von gallensäure sequestriermitteln und hemmern der sterol absorption zur behandlung von kardiovaskulären indikationen
DK1353696T3 (da) * 2001-01-26 2007-04-10 Schering Corp Kombinationer af peroxisomproliferatoraktiveret receptor (PPAR)-aktivator(er) og sterolabsorptionsinhibitor(er) og behandlinger til vaskulære indikationer
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
RU2756946C2 (ru) * 2001-01-26 2021-10-07 Мерк Шарп И Доум Корп. Применение замещенных азетидинонов для лечения ситостеролемии
ES2286233T3 (es) * 2001-01-26 2007-12-01 Schering Corporation Combinaciones de inhibidor(es) de la absorcion de esteroles con agente(s) cardiovascular(es) para el tratamiento de afecciones vasculares.
RS50386B (sr) 2001-03-28 2009-12-31 Schering Corporation, Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona
CA2447884A1 (en) * 2001-05-25 2002-12-05 Schering Corporation Use of azetidinone substituted derivatives in the treatment of alzheimer's disease
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
PT1427409E (pt) * 2001-09-21 2008-11-27 Schering Corp Métodos para tratar ou para impedir a inflamação vascular utilizando inibidor(es) de absorção de esteróis
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
EP1429756B1 (en) * 2001-09-21 2006-11-22 Schering Corporation Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
WO2004043456A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
EP1601668B1 (en) 2003-03-07 2008-08-27 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
ES2318274T3 (es) 2003-03-07 2009-05-01 Schering Corporation Compuestos de azetidinona sustituida, formulaciones y uso de los mismos para el tratamiento de hipercolesterolemia.
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CA2517573C (en) 2003-03-07 2011-12-06 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
CA2544309A1 (en) * 2003-11-05 2005-05-26 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
AR047658A1 (es) 2004-02-03 2006-02-01 Cargill Inc Concentrado de proteinas y corriente acuosa con carbohidratos hidrosolubles
CA2617908C (en) * 2005-08-03 2012-10-09 Cargill, Incorporated Corn protein concentrates
WO2007019178A2 (en) * 2005-08-03 2007-02-15 Cargill, Incorporated Corn protein concentrates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4680391A (en) * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US4803266A (en) * 1986-10-17 1989-02-07 Taisho Pharmaceutical Co., Ltd. 3-Oxoalkylidene-2-azetidinone derivatives

Also Published As

Publication number Publication date
DK641589D0 (da) 1989-12-18
CA2005759A1 (en) 1990-06-19
FR2640621A1 (fr) 1990-06-22
EP0375527A1 (fr) 1990-06-27
AU628445B2 (en) 1992-09-17
ZA899725B (en) 1990-09-26
JPH0334966A (ja) 1991-02-14
AU4691789A (en) 1990-06-21
US5030628A (en) 1991-07-09
DK641589A (da) 1990-06-20
PT92612A (pt) 1990-06-29
FR2640621B1 (fr) 1992-10-30
NZ231817A (en) 1992-03-26

Similar Documents

Publication Publication Date Title
OA09432A (fr) N-aryl-azétidinones, leur procédé de préparation et leur utilisation comme inhibiteurs des élastases.
FR2620451B1 (fr) Nouveaux inhibiteurs de la renine, leur preparation et leur utilisation comme medicaments
NO873598L (no) Kirurgisk protese.
FR2711989B1 (fr) Nouvelles isoquinoléines, leur préparation et leur utilisation comme médicaments.
FR2707641B1 (fr) Composés de l'imidazol-5-carboxamide, leur procédé de préparation leurs intermédiaires et leur utilisation en thérapeutique.
NO881491D0 (no) Fremgangsmaate ved dyrking av leukocyter.
FR2715843B1 (fr) Compositions cosmétiques antisolaires, procédé de préparation et utilisation.
FR2660556B1 (fr) Microspheres, leur procede de preparation et leur utilisation.
NO913780L (no) Forbedret fremgangsmaate for fremstilling av masse.
NO880336D0 (no) Fremgangsmaate ved gruppeoverfoeringspolymerisering.
NL960005I1 (nl) Optisch zuivere verbinding, en werkwijze voor de bereiding daarvan.
ATE95847T1 (de) Koagulationsverfahren fuer filamente.
OA08389A (fr) 1-arylpyrazoles, leur procédé de production et leur utilisation comme pesticides.
NO168654C (no) Fremgangsmaate for polymerisering av 1,3-butadien.
FI920196A0 (fi) Miljoevaenligare process foer blekning av lignocellulosamaterial.
FR2710338B1 (fr) Oxydes de propylèneglycol cyclohexyle, leur procédé de préparation et leur utilisation.
FI900837A0 (fi) Dragked med tvao skruvgaengformade, av plastmonofilament framstaellda spaerrorganrader.
FI102169B (fi) 3-aminopyrrolit, menetelmä niiden valmistamiseksi ja niiden käyttö lää keaineina
FR2704773B1 (fr) Procédé de préparation de catalyseurs utilisables en déshydrogénation.
FI903088A0 (fi) Process foer framstaellning av straengsprutade skumkroppar.
FR2700336B1 (fr) Succinimides substituées, leur procédé de préparation et leur application comme inhibiteur de corrosion.
FR2612185B1 (fr) Derives oxo-isoindolinyliques optiquement actifs, leur preparation et leur utilisation comme medicaments
NO175746C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktivt 1-etyl-fenoksatiin-10,10-dioksyd
FR2700538B1 (fr) Procédé de préparation de 2-méthyl-3-aminobenzotrifluorure.
FR2657873B1 (fr) Nouvelle elfamycine, son procede de preparation et son utilisation.