DK563789A - Hydrater af et beta-lactam-antibiotikum og fremgangsmaade til fremstilling af saadanne hydrater - Google Patents

Hydrater af et beta-lactam-antibiotikum og fremgangsmaade til fremstilling af saadanne hydrater

Info

Publication number
DK563789A
DK563789A DK563789A DK563789A DK563789A DK 563789 A DK563789 A DK 563789A DK 563789 A DK563789 A DK 563789A DK 563789 A DK563789 A DK 563789A DK 563789 A DK563789 A DK 563789A
Authority
DK
Denmark
Prior art keywords
hydrates
beta
procedure
preparation
lactam antibiotic
Prior art date
Application number
DK563789A
Other languages
Danish (da)
English (en)
Other versions
DK563789D0 (da
Inventor
Thomas Michael Eckrich
Carol Elaine Pasini
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK563789D0 publication Critical patent/DK563789D0/da
Publication of DK563789A publication Critical patent/DK563789A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D463/00Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16Nitrogen atoms
    • C07D463/18Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
DK563789A 1988-11-14 1989-11-10 Hydrater af et beta-lactam-antibiotikum og fremgangsmaade til fremstilling af saadanne hydrater DK563789A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27179488A 1988-11-14 1988-11-14

Publications (2)

Publication Number Publication Date
DK563789D0 DK563789D0 (da) 1989-11-10
DK563789A true DK563789A (da) 1990-05-15

Family

ID=23037114

Family Applications (1)

Application Number Title Priority Date Filing Date
DK563789A DK563789A (da) 1988-11-14 1989-11-10 Hydrater af et beta-lactam-antibiotikum og fremgangsmaade til fremstilling af saadanne hydrater

Country Status (13)

Country Link
EP (1) EP0369686A1 (ja)
JP (1) JPH02178281A (ja)
KR (1) KR900007840A (ja)
CN (1) CN1042712A (ja)
AU (1) AU620659B2 (ja)
CA (1) CA2002596A1 (ja)
DK (1) DK563789A (ja)
HU (1) HU205113B (ja)
IL (1) IL92271A0 (ja)
NZ (1) NZ231368A (ja)
PT (1) PT92275A (ja)
SU (1) SU1757468A3 (ja)
ZA (1) ZA898611B (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2002597C (en) * 1988-11-14 1999-03-23 Thomas M. Eckrich Solvates of b-lactam antibiotic
CA2034592C (en) * 1990-01-26 2001-06-05 Ralph R. Pfeiffer Crystalline hydrochloride of new beta-lactam antibiotic and process therefor
US5399686A (en) * 1993-06-04 1995-03-21 Eli Lilly And Company Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate
US5374719A (en) * 1993-06-04 1994-12-20 Eli Lilly And Company Process for converting loracarbef dihydrate to loracarbef monohydrate
US5352782A (en) * 1993-06-04 1994-10-04 Eli Lilly And Company Process for preparing crystalline β-lactam monohydrate
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5412094A (en) * 1993-06-28 1995-05-02 Eli Lilly And Company Bicyclic beta-lactam/paraben complexes
US5580977A (en) * 1995-03-01 1996-12-03 Eli Lilly And Company Process for preparing loracarbef monohydrate
US6001996A (en) * 1995-05-11 1999-12-14 Eli Lilly And Company Complexes of cephalosporins and carbacephalosporins with parabens
ZA978515B (en) * 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
WO2004046142A1 (en) * 2002-11-21 2004-06-03 Ranbaxy Laboratories Limited Monohydrate solvates of loracarbef
ATE418551T1 (de) 2003-03-07 2009-01-15 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
DE602004016123D1 (de) 2003-03-07 2008-10-09 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO155548C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger.
EG18529A (en) * 1987-10-06 1993-04-30 Lilly Co Eli Process for preparing b-lactam hydrate
KR890012960A (ko) * 1988-02-05 1989-09-20 매리 앤 터커 결정성 β-락탐 용매화물
CA2002597C (en) * 1988-11-14 1999-03-23 Thomas M. Eckrich Solvates of b-lactam antibiotic

Also Published As

Publication number Publication date
JPH02178281A (ja) 1990-07-11
DK563789D0 (da) 1989-11-10
NZ231368A (en) 1990-12-21
CN1042712A (zh) 1990-06-06
ZA898611B (en) 1991-07-31
HU205113B (en) 1992-03-30
HUT52508A (en) 1990-07-28
KR900007840A (ko) 1990-06-02
AU4457089A (en) 1990-05-31
AU620659B2 (en) 1992-02-20
PT92275A (pt) 1990-05-31
CA2002596A1 (en) 1990-05-14
SU1757468A3 (ru) 1992-08-23
IL92271A0 (en) 1990-07-26
EP0369686A1 (en) 1990-05-23

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Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment