DK54081A - PROCEDURE FOR THE PREPARATION OF INSULIN DERIVATIVES - Google Patents
PROCEDURE FOR THE PREPARATION OF INSULIN DERIVATIVESInfo
- Publication number
- DK54081A DK54081A DK54081A DK54081A DK54081A DK 54081 A DK54081 A DK 54081A DK 54081 A DK54081 A DK 54081A DK 54081 A DK54081 A DK 54081A DK 54081 A DK54081 A DK 54081A
- Authority
- DK
- Denmark
- Prior art keywords
- insulin
- salt
- preparation
- water
- threonine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Preparation of human insulin or threonine<B30> esters of human insulin, or a salt or complex thereof, by means of transpeptidating an insulin compound containing the human des(Thr<B30>) insulin moiety, or a salt or complex thereof which can be converted into it, with a L- threonine ester, or a salt thereof, in a mixture of water, a water-miscible, organic solvent and trypsin or an active trypsin derivative, with the content of water in the reaction mixture being less than 50% (volume/volume), and the reaction temperature being less than 50degreeC and, where appropriate, in the presence of an acid, after which the resulting threonine<B30> ester of human insulin is cleaved, if required.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK54081A DK147437C (en) | 1980-02-11 | 1981-02-09 | METHOD FOR PREPARING HUMAN INSULIN OR THREON INBESTERS OF HUMAN INSULIN OR A SALT OR COMPLEX THEREOF |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK57480A DK147109C (en) | 1980-02-11 | 1980-02-11 | METHOD FOR PREPARING HUMAN INSULIN OR HUMAN INSULINESTERS OR A SALT OR COMPLEX THEREOF |
DK57480 | 1980-02-11 | ||
DK54081 | 1981-02-09 | ||
DK54081A DK147437C (en) | 1980-02-11 | 1981-02-09 | METHOD FOR PREPARING HUMAN INSULIN OR THREON INBESTERS OF HUMAN INSULIN OR A SALT OR COMPLEX THEREOF |
Publications (3)
Publication Number | Publication Date |
---|---|
DK54081A true DK54081A (en) | 1981-08-12 |
DK147437B DK147437B (en) | 1984-08-06 |
DK147437C DK147437C (en) | 1986-12-08 |
Family
ID=8095095
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK147437D DK147437A (en) | 1980-02-11 | Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof | |
DK57480A DK147109C (en) | 1980-02-11 | 1980-02-11 | METHOD FOR PREPARING HUMAN INSULIN OR HUMAN INSULINESTERS OR A SALT OR COMPLEX THEREOF |
DK54081A DK147437C (en) | 1980-02-11 | 1981-02-09 | METHOD FOR PREPARING HUMAN INSULIN OR THREON INBESTERS OF HUMAN INSULIN OR A SALT OR COMPLEX THEREOF |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK147437D DK147437A (en) | 1980-02-11 | Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof | |
DK57480A DK147109C (en) | 1980-02-11 | 1980-02-11 | METHOD FOR PREPARING HUMAN INSULIN OR HUMAN INSULINESTERS OR A SALT OR COMPLEX THEREOF |
Country Status (19)
Country | Link |
---|---|
JP (1) | JPS56135452A (en) |
AR (1) | AR231277A1 (en) |
AU (1) | AU541528B2 (en) |
BE (1) | BE887480A (en) |
CA (1) | CA1162868A (en) |
CH (1) | CH655949A5 (en) |
DE (1) | DE3104949C2 (en) |
DK (3) | DK147109C (en) |
ES (1) | ES8205858A1 (en) |
FI (1) | FI77876C (en) |
GB (1) | GB2069502B (en) |
GR (1) | GR73844B (en) |
IT (1) | IT1195038B (en) |
NL (1) | NL178797C (en) |
NO (1) | NO156247C (en) |
NZ (1) | NZ196224A (en) |
PT (1) | PT72485B (en) |
SE (2) | SE427025B (en) |
ZA (1) | ZA81898B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4601852A (en) * | 1981-01-17 | 1986-07-22 | Hoechst Aktiengesellschaft | Process for the preparation of human or the derivatives thereof from pig insulin or the derivatives thereof |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK147437A (en) | 1980-02-11 | 1900-01-01 | Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof | |
CA1174623A (en) * | 1981-09-15 | 1984-09-18 | Finn H. Andresen | Process for preparing human insulin or b-30 esters thereof |
DK149824C (en) * | 1982-01-22 | 1987-03-16 | Carlsberg Biotechnology Ltd | PROCEDURE FOR ENZYMATIC REPLACEMENT OF B-30 AMINO ACIDS IN INSULINES |
WO1983002772A1 (en) * | 1982-02-08 | 1983-08-18 | Robin Ewart Offord | An improved method for preparing human insulin from non-human insulin |
DE3209184A1 (en) * | 1982-03-13 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | METHOD FOR CONVERTING PRAEPROINSULIN ANALOGS TO INSULINES |
NL8201650A (en) * | 1982-04-21 | 1983-11-16 | Akzo Nv | SEMISYNTHETIC PREPARATION OF HUMANE INSULIN. |
DK182483A (en) * | 1982-04-23 | 1983-10-24 | Wako Pure Chem Ind Ltd | METHOD OF SEMI SYNTHESIS OF HUMAN INSULIN AND ALKALIC PROTEASE FOR USE THEREOF |
DK55183D0 (en) * | 1983-02-09 | 1983-02-09 | Nordisk Insulinlab | METHOD OF MANUFACTURING HUMAN INSULIN |
DE3334407A1 (en) * | 1983-09-23 | 1985-04-04 | Hoechst Ag, 6230 Frankfurt | INSULINE DERIVATIVES MODIFIED IN POSITION B 30, METHOD FOR THE PRODUCTION AND USE THEREOF AND PHARMACEUTICAL AGENTS FOR THE TREATMENT OF THE DIABETES MELLITUS |
US5157021A (en) * | 1985-03-15 | 1992-10-20 | Novo Nordisk A/S | Insulin derivatives and pharmaceutical preparations containing these derivatives |
DK119785D0 (en) * | 1985-03-15 | 1985-03-15 | Nordisk Gentofte | INSULIN PREPARATION |
SE449472B (en) * | 1985-10-15 | 1987-05-04 | Mth Gruppen Ab | EQUIPMENT AT FLOOR STORES |
AU612141B2 (en) * | 1987-02-25 | 1991-07-04 | Novo Nordisk A/S | Novel insulin derivatives |
DK134189D0 (en) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | INSULIN COMPOUNDS |
FI96503C (en) * | 1994-08-26 | 1996-07-10 | Hymatic Ltd Oy | Method and apparatus for controlling a mast |
EP1711220A1 (en) | 2004-01-16 | 2006-10-18 | Biodel, Inc. | Sublingual drug delivery device |
US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US8084420B2 (en) | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
WO2007121256A2 (en) | 2006-04-12 | 2007-10-25 | Biodel, Inc. | Rapid acting and long acting insulin combination formulations |
US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO153061C (en) * | 1979-04-13 | 1986-01-08 | Shionogi & Co | PROCEDURE FOR THE PREPARATION OF A B30 THREON INSULIN |
DK147437A (en) | 1980-02-11 | 1900-01-01 | Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof | |
DE3101382A1 (en) * | 1981-01-17 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "METHOD FOR PRODUCING HUMANISULIN OR ITS DERIVATIVES FROM PIG INSULIN OR ITS DERIVATIVES" |
-
0
- DK DK147437D patent/DK147437A/en unknown
-
1980
- 1980-02-11 DK DK57480A patent/DK147109C/en not_active IP Right Cessation
-
1981
- 1981-02-09 DK DK54081A patent/DK147437C/en not_active IP Right Cessation
- 1981-02-09 ES ES499238A patent/ES8205858A1/en not_active Expired
- 1981-02-10 JP JP1758081A patent/JPS56135452A/en active Granted
- 1981-02-10 SE SE8100926A patent/SE427025B/en not_active IP Right Cessation
- 1981-02-10 NZ NZ196224A patent/NZ196224A/en unknown
- 1981-02-10 NO NO810443A patent/NO156247C/en unknown
- 1981-02-10 NL NLAANVRAGE8100624,A patent/NL178797C/en not_active IP Right Cessation
- 1981-02-10 FI FI810385A patent/FI77876C/en not_active IP Right Cessation
- 1981-02-10 PT PT72485A patent/PT72485B/en not_active IP Right Cessation
- 1981-02-10 CA CA000370483A patent/CA1162868A/en not_active Expired
- 1981-02-10 SE SE8100928A patent/SE451143B/en not_active IP Right Cessation
- 1981-02-10 AR AR284258A patent/AR231277A1/en active
- 1981-02-10 IT IT19620/81A patent/IT1195038B/en active
- 1981-02-10 GB GB8104114A patent/GB2069502B/en not_active Expired
- 1981-02-11 DE DE3104949A patent/DE3104949C2/en not_active Expired
- 1981-02-11 GR GR64097A patent/GR73844B/el unknown
- 1981-02-11 ZA ZA00810898A patent/ZA81898B/en unknown
- 1981-02-11 BE BE6/47396A patent/BE887480A/en not_active IP Right Cessation
- 1981-02-11 CH CH910/81A patent/CH655949A5/en not_active IP Right Cessation
- 1981-02-11 AU AU67180/81A patent/AU541528B2/en not_active Ceased
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4601852A (en) * | 1981-01-17 | 1986-07-22 | Hoechst Aktiengesellschaft | Process for the preparation of human or the derivatives thereof from pig insulin or the derivatives thereof |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |