ES8307248A1 - Novel manufacture of benzodiazepine compound - Google Patents

Novel manufacture of benzodiazepine compound

Info

Publication number
ES8307248A1
ES8307248A1 ES513293A ES513293A ES8307248A1 ES 8307248 A1 ES8307248 A1 ES 8307248A1 ES 513293 A ES513293 A ES 513293A ES 513293 A ES513293 A ES 513293A ES 8307248 A1 ES8307248 A1 ES 8307248A1
Authority
ES
Spain
Prior art keywords
compound
benzodiazepine compound
halogen
temperatures
novel manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513293A
Other languages
Spanish (es)
Other versions
ES513293A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES513293A0 publication Critical patent/ES513293A0/en
Publication of ES8307248A1 publication Critical patent/ES8307248A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

Procedure for the preparation of 5,11-dihydro-6h-pirido- (2,3-b) (1,4) benzodiazepin-6-onas. A 2-halogen-3-aminopyridine is reactioned with an ester of an antranilitic acid, in an organic solvent in the presence of a basic condensation agent at temperatures of 10 to 120 c. Compound (II) is obtained then below. Cyclize at a value of ph 7 or bottom and temperatures of 100 to 200 c. Compound (I) is obtained in which r is hydrogen, halogen or a group methyl. (Machine-translation by Google Translate, not legally binding)
ES513293A 1981-07-15 1982-06-21 Novel manufacture of benzodiazepine compound Expired ES8307248A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3127849 1981-07-15

Publications (2)

Publication Number Publication Date
ES513293A0 ES513293A0 (en) 1983-06-16
ES8307248A1 true ES8307248A1 (en) 1983-06-16

Family

ID=6136912

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513293A Expired ES8307248A1 (en) 1981-07-15 1982-06-21 Novel manufacture of benzodiazepine compound

Country Status (16)

Country Link
JP (1) JPS5818383A (en)
AT (1) AT379394B (en)
CH (1) CH649085A5 (en)
CS (1) CS226745B2 (en)
DD (1) DD202571A5 (en)
DK (1) DK157999C (en)
ES (1) ES8307248A1 (en)
FI (1) FI77860C (en)
GR (1) GR76198B (en)
HU (1) HU186090B (en)
NL (1) NL8202145A (en)
NO (1) NO160140C (en)
PL (1) PL237471A1 (en)
PT (1) PT75244B (en)
SE (1) SE449102B (en)
YU (1) YU43724B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5973081A (en) * 1994-10-27 1999-10-26 Polyplastics Co., Ltd. Modified polyacetal and method of producing the same
KR100358667B1 (en) * 1995-04-27 2003-04-16 폴리플라스틱스 가부시키가이샤 Thermoplastic Composition and Manufacturing Method thereof

Also Published As

Publication number Publication date
HU186090B (en) 1985-05-28
FI77860C (en) 1989-05-10
FI77860B (en) 1989-01-31
JPS5818383A (en) 1983-02-02
FI822391L (en) 1983-01-16
DD202571A5 (en) 1983-09-21
JPH0330596B2 (en) 1991-04-30
ES513293A0 (en) 1983-06-16
PL237471A1 (en) 1983-01-17
NL8202145A (en) 1983-02-01
DK157999C (en) 1990-08-13
NO160140B (en) 1988-12-05
YU151982A (en) 1986-04-30
SE8204330D0 (en) 1982-07-14
AT379394B (en) 1985-12-27
PT75244A (en) 1982-08-01
PT75244B (en) 1985-10-04
FI822391A0 (en) 1982-07-06
NO160140C (en) 1989-03-15
YU43724B (en) 1989-10-31
NO822182L (en) 1983-01-17
CH649085A5 (en) 1985-04-30
CS226745B2 (en) 1984-04-16
DK157999B (en) 1990-03-12
SE8204330L (en) 1983-01-16
SE449102B (en) 1987-04-06
DK311982A (en) 1983-01-16
ATA263482A (en) 1985-05-15
GR76198B (en) 1984-08-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970505