US4206202A
(en)
*
|
1974-03-28 |
1980-06-03 |
Beecham Group Limited |
Antibiotics
|
US4146610A
(en)
*
|
1974-03-28 |
1979-03-27 |
Beecham Group Limited |
Antibiotics mm13902
|
US4189473A
(en)
*
|
1974-03-28 |
1980-02-19 |
Beecham Group Limited |
Antibiotic MM 13902
|
US4172129A
(en)
*
|
1974-03-28 |
1979-10-23 |
Beecham Group Limited |
Antibiotics
|
US4113856A
(en)
*
|
1974-03-28 |
1978-09-12 |
Beecham Group Limited |
Antibiotic mm 13902
|
GB1467413A
(en)
*
|
1974-03-28 |
1977-03-16 |
Beecham Group Ltd |
Antibiotics
|
US4181716A
(en)
*
|
1974-03-28 |
1980-01-01 |
Beecham Group Limited |
Antibiotics
|
US4006060A
(en)
*
|
1974-11-25 |
1977-02-01 |
Merck & Co., Inc. |
Thienamycin production
|
US4304867A
(en)
*
|
1974-11-25 |
1981-12-08 |
Merck & Co., Inc. |
Culture of Streptomyces cattleya
|
US4000161A
(en)
*
|
1974-12-19 |
1976-12-28 |
Merck & Co., Inc. |
Process for purifying thienamycin
|
US4163051A
(en)
*
|
1975-03-15 |
1979-07-31 |
Beecham Group Limited |
Streptomycetal antibiotic
|
US4162304A
(en)
*
|
1975-03-15 |
1979-07-24 |
Beecham Group Limited |
Streptomycetal antibiotic
|
US4179498A
(en)
*
|
1975-03-15 |
1979-12-18 |
Beecham Group Limited |
Streptomycetal antibiotic
|
AU512383B2
(en)
*
|
1975-11-21 |
1980-10-09 |
Merck & Co., Inc. |
Thinenamycin derivatives
|
US4181733A
(en)
*
|
1975-11-21 |
1980-01-01 |
Merck & Co., Inc. |
Carboxyl derivatives of thienamycin
|
US4839352A
(en)
*
|
1975-11-21 |
1989-06-13 |
Merck & Co., Inc. |
N-acyl derivatives of thienamycin
|
US4162324A
(en)
*
|
1975-11-21 |
1979-07-24 |
Merck & Co., Inc. |
Antibiotics 890A1 and 890A3
|
CH633554A5
(en)
*
|
1975-11-21 |
1982-12-15 |
Merck & Co Inc |
Process for the preparation of novel thienamycin derivatives.
|
DE2652676A1
(de)
*
|
1975-11-21 |
1977-06-02 |
Merck & Co Inc |
N-alkylierte derivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel
|
US4235920A
(en)
*
|
1975-11-21 |
1980-11-25 |
Merck & Co., Inc. |
N-Alkylated derivatives of thienamycin
|
US4208330A
(en)
*
|
1975-11-21 |
1980-06-17 |
Merck & Co., Inc. |
O-Derivatives of thienamycin
|
US4165379A
(en)
*
|
1975-11-21 |
1979-08-21 |
Merck & Co., Inc. |
N-acetyl thienamycin
|
US4282322A
(en)
*
|
1975-11-24 |
1981-08-04 |
Merck & Co., Inc. |
Process for enzymatic deacylation of antibiotics
|
US4196211A
(en)
*
|
1976-03-22 |
1980-04-01 |
Merck & Co., Inc. |
6-(α-Hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid and derivatives thereof
|
NL7704040A
(nl)
*
|
1976-04-28 |
1977-11-01 |
Merck & Co Inc |
Werkwijze voor het bereiden van nieuwe anti- biotica.
|
GB1577725A
(en)
*
|
1976-06-30 |
1980-10-29 |
Beecham Group Ltd |
Azetidinone derivatives
|
US4172144A
(en)
*
|
1976-10-18 |
1979-10-23 |
Merck & Co., Inc. |
Schiff's base derivatives of thienamycin
|
GB1593524A
(en)
*
|
1976-11-19 |
1981-07-15 |
Merck & Co Inc |
1-carba-2-penem-3-carboxylic acids
|
US4234596A
(en)
*
|
1976-11-19 |
1980-11-18 |
Merck & Co., Inc. |
3-(2-Aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
|
US4146633A
(en)
*
|
1976-11-19 |
1979-03-27 |
Merck & Co., Inc. |
Δ3 -Thienamycin
|
US4348320A
(en)
*
|
1976-11-19 |
1982-09-07 |
Merck & Co., Inc. |
Substituted azetidiones
|
US5055573A
(en)
*
|
1976-11-19 |
1991-10-08 |
Merck & Co., Inc. |
Process for preparing 1-carba-2-penem-3-carboxylic acid
|
US4210661A
(en)
*
|
1977-01-27 |
1980-07-01 |
Beecham Group Limited |
Synthetic β-lactam compounds, a process for their preparation and compositions containing them
|
US4168268A
(en)
*
|
1977-03-01 |
1979-09-18 |
Merck & Co., Inc. |
Process for isolating thienamycin
|
GR62185B
(en)
*
|
1977-03-31 |
1979-03-02 |
Panlabs Inc |
Preparation process of an antibiotic ps-5 and its derivatives with inhibitory activity of b-lactamase
|
GB1584762A
(en)
*
|
1977-04-01 |
1981-02-18 |
Beecham Group Ltd |
Azabicycloheptenes
|
NL7802826A
(nl)
*
|
1977-04-08 |
1978-10-10 |
Merck & Co Inc |
Thienamycinederivaat, werkwijze voor het bereiden daarvan, alsmede farmaceutische preparaten.
|
US4162323A
(en)
*
|
1977-04-18 |
1979-07-24 |
Merck & Co., Inc. |
Antibiotic N-acetyl-dehydro-thienamycin
|
US4235917A
(en)
*
|
1977-05-05 |
1980-11-25 |
Merck & Co., Inc. |
N-Alkyl-N-acyl derivatives of thienamycin
|
DK170778A
(da)
*
|
1977-05-05 |
1979-01-15 |
Merck & Co Inc |
Fremgangsmaade til fremstilling af n-alkyl-n-iminomethyl-derivater af thienamycin
|
DE2724560A1
(de)
*
|
1977-05-31 |
1978-12-21 |
Merck & Co Inc |
O-derivate von thienamycin
|
US4123547A
(en)
*
|
1977-08-04 |
1978-10-31 |
Merck & Co., Inc. |
Thienamycin sulfoxide and sulphone
|
US4162193A
(en)
*
|
1977-08-19 |
1979-07-24 |
Merck & Co., Inc. |
Enzymatic cleavage of N-acyl-thienamycins
|
US4135978A
(en)
*
|
1977-08-19 |
1979-01-23 |
Merck & Co., Inc. |
Production of n-acyl-thienamycins
|
US4150145A
(en)
*
|
1977-09-15 |
1979-04-17 |
Merck & Co., Inc. |
N-alkylated derivatives of thienamycin sulfoxide and sulfone
|
US4232030A
(en)
*
|
1977-09-15 |
1980-11-04 |
Merck & Co., Inc. |
Substituted N-methylene derivatives of thienamycin sulfoxide and sulfone
|
AU4061378A
(en)
*
|
1977-10-19 |
1980-04-17 |
Merck & Co., Inc. |
1-azabicyclo (3.2.0) hept-2-enes
|
AU531084B2
(en)
*
|
1977-10-19 |
1983-08-11 |
Merck & Co., Inc. |
Azetidine derivatives
|
US4168314A
(en)
*
|
1977-11-17 |
1979-09-18 |
Merck & Co., Inc. |
6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
|
US4155912A
(en)
*
|
1977-12-14 |
1979-05-22 |
Bristol-Myers Company |
2-Methylpenem-3-carboxylic acid antibiotics
|
US4172895A
(en)
*
|
1977-12-28 |
1979-10-30 |
Merck & Co., Inc. |
6-(1'-Hydroxyethyl)-2-aminoethylthio-oxapen-2-em-3-carboxylic acid
|
US4189493A
(en)
*
|
1977-12-28 |
1980-02-19 |
Merck & Co., Inc. |
N-heterocyclic derivatives of thienamycin
|
US4218463A
(en)
*
|
1977-12-28 |
1980-08-19 |
Merck & Co., Inc. |
3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
|
US4198338A
(en)
*
|
1978-03-13 |
1980-04-15 |
Merck & Co., Inc. |
Process for purifying thienamycin
|
US4203902A
(en)
*
|
1978-04-21 |
1980-05-20 |
Merck & Co., Inc. |
Process for preparing 6- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
|
US4182711A
(en)
*
|
1978-04-27 |
1980-01-08 |
Bristol-Myers Company |
Antibacterial agents of the β-lactam type
|
SE7805032L
(sv)
*
|
1978-05-03 |
1979-11-03 |
Merck & Co Inc |
Karboxylsyror och derivat derav
|
PH16708A
(en)
*
|
1978-07-24 |
1984-01-20 |
Merck & Co Inc |
Z-2-acylamino-3-monosubstituted propenoates
|
US5147868A
(en)
*
|
1978-07-24 |
1992-09-15 |
Merck & Co., Inc. |
Thienamycin renal peptidase inhibitors
|
US4880793A
(en)
*
|
1978-07-24 |
1989-11-14 |
Merck & Co., Inc. |
Combination of thienamycin-type antibiotics with dipeptidase inhibitors
|
US4212807A
(en)
*
|
1978-08-10 |
1980-07-15 |
Merck & Co., Inc. |
Process for deacylating N-acyl-6-substituted-2-[2-aminoethylthio]-1-carbadethiapen-2-em-3-carboxylic acids
|
US4275207A
(en)
*
|
1978-08-14 |
1981-06-23 |
Merck & Co., Inc. |
Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and intermediate therefor
|
US4218462A
(en)
*
|
1978-10-24 |
1980-08-19 |
Merck & Co., Inc. |
6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1-substituted-1-carbade-thiapen-2-em-3-carboxylic acids
|
US4260627A
(en)
*
|
1978-10-24 |
1981-04-07 |
Merck & Co., Inc. |
1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
|
US4232036A
(en)
*
|
1978-10-24 |
1980-11-04 |
Merck & Co., Inc. |
6-, 1- and 2-Substituted-1-carbadethiapen-2-em-3-carboxylic acids
|
US4206219A
(en)
*
|
1978-10-24 |
1980-06-03 |
Merck & Co., Inc. |
6- and 1-Substituted-1-carbadethiapen-2-em-3-carboxylic acid
|
US4208422A
(en)
*
|
1978-10-24 |
1980-06-17 |
Merck & Co., Inc. |
1-Substituted-pen-2-em-3-carboxylic acids
|
US4282150A
(en)
*
|
1978-12-18 |
1981-08-04 |
Bristol-Myers Company |
2,6-Disubstituted penem compounds
|
US4272437A
(en)
*
|
1978-12-18 |
1981-06-09 |
Bristol-Myers Company |
Antibacterial agents, and 4-thio azetidinone intermediates
|
JPS55153789A
(en)
*
|
1979-04-11 |
1980-11-29 |
Sankyo Co Ltd |
Penem-3-carboxylic acid derivative and its preparation
|
US4376774A
(en)
*
|
1979-05-29 |
1983-03-15 |
Merck & Co., Inc. |
Antibiotic N-heterocyclyl thienamycin
|
US4264621A
(en)
*
|
1979-07-06 |
1981-04-28 |
Merck & Co., Inc. |
5-Substituted-3-(2-aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
|
US4247640A
(en)
*
|
1979-07-23 |
1981-01-27 |
Merck & Co., Inc. |
Fermentation process for 6-hydroxymethyl-2-(2-aminoethylthio)-1-carbadethiapen-2-em-3-carboxylic acid
|
JPS5622782A
(en)
*
|
1979-08-03 |
1981-03-03 |
Kyowa Hakko Kogyo Co Ltd |
Dc-38-v and its preparation
|
US4374065A
(en)
*
|
1979-09-21 |
1983-02-15 |
Bristol-Myers Company |
Antibacterial agents of the β-lactam type
|
US4378314A
(en)
*
|
1979-09-21 |
1983-03-29 |
Bristol Myers Company |
Antibacterial agents and metal containing azetidinone intermediates therefore
|
US4262010A
(en)
*
|
1979-12-03 |
1981-04-14 |
Merck & Co., Inc. |
6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids
|
GR72296B
(US06368395-20020409-C00050.png)
*
|
1979-12-03 |
1983-10-18 |
Merck & Co Inc |
|
JPS56148297A
(en)
*
|
1980-04-17 |
1981-11-17 |
Shionogi & Co Ltd |
Novel preparation of thienamycin
|
US4357342A
(en)
*
|
1980-05-02 |
1982-11-02 |
Merck & Co., Inc. |
1-Azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylic acid
|
US4426390A
(en)
|
1980-10-01 |
1984-01-17 |
Sanraku-Ocean Co., Ltd. |
Novel β-lactam compounds, process for producing thereof, and use thereof as medicines
|
US4683301A
(en)
*
|
1982-04-08 |
1987-07-28 |
Bristol-Myers Company |
Carbapenem antibiotics
|
US4460689A
(en)
*
|
1982-04-15 |
1984-07-17 |
Merck & Co., Inc. |
DNA Cloning vector TG1, derivatives, and processes of making
|
US4508826A
(en)
*
|
1982-04-15 |
1985-04-02 |
Merck & Co., Inc. |
Bacteriophage DNA cloning vector TG1 and microorganisms containing TG1
|
US4544557A
(en)
*
|
1982-07-29 |
1985-10-01 |
Merck & Co., Inc. |
6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-3-tetrazoly-1-carbadethiapen-2-em
|
CA1220215A
(en)
*
|
1983-03-07 |
1987-04-07 |
Yasutsugu Ueda |
Carbapenem intermediates
|
US5310897A
(en)
*
|
1984-12-27 |
1994-05-10 |
Sumitomo Pharmaceuticals Co., Ltd. |
Beta-lactams and their production
|
US5104984A
(en)
*
|
1985-03-29 |
1992-04-14 |
Merck & Co., Inc. |
Enantioselective process for producing 1-beta-methyl carbapenem antibiotic intermediates
|
CA1276156C
(en)
|
1985-03-29 |
1990-11-13 |
Thomas N. Salzmann |
Enantioselective process for producing 1-beta- methylcarbapenem antibiotic intermediates
|
US4782051A
(en)
*
|
1985-06-10 |
1988-11-01 |
Merck & Co., Inc. |
2-aza-substituted 1-carbadethiapen-2-em-3 carboxylic acids
|
US4892869A
(en)
*
|
1985-06-10 |
1990-01-09 |
Merck & Co., Inc. |
2-aza substituted-1-carbadethiapen-2-em-3-carboxylic acids
|
US4783453A
(en)
*
|
1985-06-10 |
1988-11-08 |
Merck & Co., Inc. |
2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
|
US4833167A
(en)
*
|
1985-06-10 |
1989-05-23 |
Merck & Co., Inc. |
2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
|
US4665169A
(en)
*
|
1985-09-11 |
1987-05-12 |
Bristol-Myers Company |
Carbapenem antibiotics
|
EP0229384B1
(en)
*
|
1985-12-28 |
1994-08-10 |
Sumitomo Pharmaceuticals Company, Limited |
Beta-lactam compounds and their production
|
US5021566A
(en)
*
|
1989-03-06 |
1991-06-04 |
Merck & Co. Inc. |
6- and 6,6-disubstituted-3-substituted-1-azabicyclo(3.2.0)hept-2-en-7-one-2-carboxylic acids
|
US5672701A
(en)
*
|
1990-01-16 |
1997-09-30 |
Bristol-Myers Squibb Company |
4-substituted alkyl carbapenem antibiotics
|
CA2036941A1
(en)
*
|
1990-02-23 |
1991-08-24 |
Isao Kawamoto |
Carbapenem derivatives having antibiotic activity, their preparation and their use
|
US5241073A
(en)
*
|
1990-10-12 |
1993-08-31 |
Lederle (Japan) |
Process for preparing (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo [1,2-a][1,2,4]triazolium-6-yl)]thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate and starting materials thereof
|
US5712267A
(en)
*
|
1991-06-04 |
1998-01-27 |
Sankyo Company,. Limited |
Carbapenem derivatives, their preparation and their use as antibiotics
|
US5496816A
(en)
*
|
1994-03-14 |
1996-03-05 |
Merck & Co., Inc. |
Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
|
JP3848693B2
(ja)
*
|
1994-07-06 |
2006-11-22 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
新規カルバペネム誘導体
|
WO2000015640A1
(fr)
|
1998-09-10 |
2000-03-23 |
Wyeth Lederle Japan, Ltd. |
Composes de carbapenem
|
US10539561B1
(en)
|
2001-08-30 |
2020-01-21 |
Customarray, Inc. |
Enzyme-amplified redox microarray detection process
|
WO2003062458A2
(en)
*
|
2002-01-24 |
2003-07-31 |
Ecopia Biosciences Inc. |
Method, system and knowledge repository for identifying a secondary metabolite from a microorganism
|
EP1765326A4
(en)
|
2004-06-10 |
2009-05-13 |
Fob Synthesis Inc |
CARBAPENEM BACTERICIDES WITH GRAM-NEGATIVE ACTIVITY AND CORRESPONDING METHODS OF PREPARATION
|
US20060102471A1
(en)
|
2004-11-18 |
2006-05-18 |
Karl Maurer |
Electrode array device having an adsorbed porous reaction layer
|
US20070034513A1
(en)
|
2005-03-25 |
2007-02-15 |
Combimatrix Corporation |
Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
|
US9394167B2
(en)
|
2005-04-15 |
2016-07-19 |
Customarray, Inc. |
Neutralization and containment of redox species produced by circumferential electrodes
|
US20070065877A1
(en)
|
2005-09-19 |
2007-03-22 |
Combimatrix Corporation |
Microarray having a base cleavable succinate linker
|
US8855955B2
(en)
*
|
2005-09-29 |
2014-10-07 |
Custom Array, Inc. |
Process and apparatus for measuring binding events on a microarray of electrodes
|
US20110046101A1
(en)
*
|
2008-03-17 |
2011-02-24 |
Dmitrienko Gary I |
Bate-lactamase inhibitors
|
US9637746B2
(en)
|
2008-12-15 |
2017-05-02 |
Greenlight Biosciences, Inc. |
Methods for control of flux in metabolic pathways
|
KR20110134380A
(ko)
*
|
2008-12-22 |
2011-12-14 |
그린라이트 바이오사이언시스, 아이엔씨. |
화합물의 제조를 위한 조성물 및 방법
|
US9927434B2
(en)
|
2010-01-20 |
2018-03-27 |
Customarray, Inc. |
Multiplex microarray of serially deposited biomolecules on a microarray
|
US8956833B2
(en)
|
2010-05-07 |
2015-02-17 |
Greenlight Biosciences, Inc. |
Methods for control of flux in metabolic pathways through enzyme relocation
|
ES2653837T3
(es)
|
2010-06-18 |
2018-02-09 |
Fob Synthesis, Inc. |
Antibacterianos carbapenem con actividad gramo-negativa
|
JP6280367B2
(ja)
|
2010-08-31 |
2018-02-14 |
グリーンライト バイオサイエンシーズ インコーポレーテッドGreenlight Biosciences,Inc. |
プロテアーゼ操作を介した代謝経路におけるフラックスの制御のための方法
|
CN104093848A
(zh)
|
2011-09-09 |
2014-10-08 |
绿光生物科学公司 |
碳青霉烯(carbapenem)的无细胞制备
|
CN105658807A
(zh)
|
2013-08-05 |
2016-06-08 |
绿光生物科技股份有限公司 |
具有蛋白酶切割位点的工程化蛋白
|
SG11201707370WA
(en)
|
2015-03-30 |
2017-10-30 |
Greenlight Biosciences Inc |
Cell-free production of ribonucleic acid
|
KR102536687B1
(ko)
|
2016-04-06 |
2023-05-25 |
그린라이트 바이오사이언시스, 아이엔씨. |
리보핵산의 무세포 생산
|
WO2018227178A1
(en)
|
2017-06-09 |
2018-12-13 |
Fob Synthesis, Inc. |
Carbapenem compounds and compositions for the treatment of bacterial infections
|
MX2020003841A
(es)
|
2017-10-11 |
2020-11-06 |
Greenlight Biosciences Inc |
Métodos y composiciones para la producción de nucleósido trifosfatos y ácidos ribonucleicos.
|