DK521680A - Fremgangsmaade til fremstilling af substituerede 2-phenalamino-imidazoliner - Google Patents
Fremgangsmaade til fremstilling af substituerede 2-phenalamino-imidazolinerInfo
- Publication number
- DK521680A DK521680A DK521680A DK521680A DK521680A DK 521680 A DK521680 A DK 521680A DK 521680 A DK521680 A DK 521680A DK 521680 A DK521680 A DK 521680A DK 521680 A DK521680 A DK 521680A
- Authority
- DK
- Denmark
- Prior art keywords
- group
- see diagramm
- general formula
- acid addition
- imidazolines
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 abstract 2
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 2
- 125000005394 methallyl group Chemical group 0.000 abstract 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- DZHUQIOYWZHKQP-UHFFFAOYSA-N n-(2,6-dibromo-4-methylphenyl)-4,5-dihydro-1h-imidazol-2-amine Chemical compound BrC1=CC(C)=CC(Br)=C1N=C1NCCN1 DZHUQIOYWZHKQP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792949287 DE2949287A1 (de) | 1979-12-07 | 1979-12-07 | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK521680A true DK521680A (da) | 1981-06-08 |
Family
ID=6087857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK521680A DK521680A (da) | 1979-12-07 | 1980-12-05 | Fremgangsmaade til fremstilling af substituerede 2-phenalamino-imidazoliner |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0030616B1 (da) |
| JP (1) | JPS5692274A (da) |
| AT (1) | ATE5818T1 (da) |
| AU (1) | AU533756B2 (da) |
| DE (2) | DE2949287A1 (da) |
| DK (1) | DK521680A (da) |
| ES (1) | ES8201978A1 (da) |
| FI (1) | FI69068C (da) |
| IE (1) | IE50485B1 (da) |
| IL (1) | IL61637A (da) |
| NO (1) | NO151412C (da) |
| ZA (1) | ZA807611B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4644007A (en) * | 1981-11-20 | 1987-02-17 | Alcon Laboratories, Inc. | 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods |
| US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
| US4517199A (en) * | 1981-11-20 | 1985-05-14 | Alcon Laboratories, Inc. | Method for lowering intraocular pressure using phenylimino-imidazoles |
| US4515800A (en) * | 1981-11-20 | 1985-05-07 | Icilio Cavero | Method of lowering intraocular pressure using phenylimino-imidazoles |
| HU192986B (en) * | 1984-05-23 | 1987-08-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of imidasodiline derivatives |
| DE19514579A1 (de) | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT285599B (de) * | 1968-06-21 | 1970-11-10 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen trisubstituierten 2-Arylaminoimidazolinen und ihren Salzen |
| BE759048A (fr) * | 1969-11-17 | 1971-05-17 | Boehringer Sohn Ingelheim | Nouvelles n-aminoalcoyl-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer |
| DE2259160A1 (de) * | 1972-12-02 | 1974-06-06 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylaminoimidazoline, deren saeureadditionssalze und verfahren zur herstellung derselben sowie ihre verwendung als arzneimittel |
| DE2523103C3 (de) * | 1975-05-24 | 1979-11-29 | C.H. Boehringer Sohn, 6507 Ingelheim | Substituierte 2-[N-Progargyl-N-(2-chlorphenyl)amino] -imidazoline-^), deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung |
| DE2636732A1 (de) * | 1976-08-14 | 1978-02-16 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylamino- imidazoline- (2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
-
1979
- 1979-12-07 DE DE19792949287 patent/DE2949287A1/de not_active Withdrawn
-
1980
- 1980-11-03 DE DE8080106725T patent/DE3066104D1/de not_active Expired
- 1980-11-03 EP EP80106725A patent/EP0030616B1/de not_active Expired
- 1980-11-03 AT AT80106725T patent/ATE5818T1/de not_active IP Right Cessation
- 1980-12-05 IE IE2555/80A patent/IE50485B1/en unknown
- 1980-12-05 NO NO803682A patent/NO151412C/no unknown
- 1980-12-05 DK DK521680A patent/DK521680A/da not_active Application Discontinuation
- 1980-12-05 ZA ZA00807611A patent/ZA807611B/xx unknown
- 1980-12-05 JP JP17196380A patent/JPS5692274A/ja active Pending
- 1980-12-05 FI FI803799A patent/FI69068C/fi not_active IP Right Cessation
- 1980-12-05 IL IL61637A patent/IL61637A/xx unknown
- 1980-12-05 ES ES497480A patent/ES8201978A1/es not_active Expired
- 1980-12-05 AU AU65136/80A patent/AU533756B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| NO803682L (no) | 1981-06-09 |
| FI69068B (fi) | 1985-08-30 |
| EP0030616A1 (de) | 1981-06-24 |
| EP0030616B1 (de) | 1984-01-11 |
| IL61637A (en) | 1984-11-30 |
| ES497480A0 (es) | 1982-01-01 |
| AU533756B2 (en) | 1983-12-08 |
| IE50485B1 (en) | 1986-04-30 |
| ES8201978A1 (es) | 1982-01-01 |
| DE3066104D1 (en) | 1984-02-16 |
| DE2949287A1 (de) | 1981-06-11 |
| AU6513680A (en) | 1981-06-18 |
| FI803799L (fi) | 1981-06-08 |
| FI69068C (fi) | 1985-12-10 |
| JPS5692274A (en) | 1981-07-25 |
| ZA807611B (en) | 1982-08-25 |
| ATE5818T1 (de) | 1984-01-15 |
| IL61637A0 (en) | 1981-01-30 |
| NO151412B (no) | 1984-12-27 |
| NO151412C (no) | 1985-04-10 |
| IE802555L (en) | 1981-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |