IE802555L - Substituted 2-phenylamino-imidazolines-(2) - Google Patents
Substituted 2-phenylamino-imidazolines-(2)Info
- Publication number
- IE802555L IE802555L IE802555A IE255580A IE802555L IE 802555 L IE802555 L IE 802555L IE 802555 A IE802555 A IE 802555A IE 255580 A IE255580 A IE 255580A IE 802555 L IE802555 L IE 802555L
- Authority
- IE
- Ireland
- Prior art keywords
- group
- see diagramm
- general formula
- acid addition
- degrees
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1. Claims for the Contracting state : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P7,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof. 1. Claims for the Contracting state : AT Process for preparing substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P8,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof, characterised in that a) 2-(2,6-dibromo-4-methylphenyl-imino)-imidazolidine of formula II see diagramm : EP0030616,P8,F2 is reacted with a halide of general formula III Hal-R wherein Hal represents a chlorine, bromine or iodine atom and R is as hereinbefore defined, at 40 degrees C to 150 degrees C, or b) a compound of general formula IV see diagramm : EP0030616,P8,F3 wherein R is as hereinbefore defined and A represents a cyano group or the group see diagramm : EP0030616,P8,F4 wherein Y represents an alkoxy or alkylthio group with up to 4 carbon atoms or a mercapto group or an amino group, is reacted with ethylenediamine or the acid addition salts thereof at 60 to 180 degrees C, and the end product obtained according to one of these processes is optionally converted into a corresponding acid addition salt.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792949287 DE2949287A1 (en) | 1979-12-07 | 1979-12-07 | NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE802555L true IE802555L (en) | 1981-06-07 |
| IE50485B1 IE50485B1 (en) | 1986-04-30 |
Family
ID=6087857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2555/80A IE50485B1 (en) | 1979-12-07 | 1980-12-05 | Novel substituted 2-phenylamino-imidazolines-(2),the acid addition salts thereof,pharmaceuticals containing same and processes for the preparation thereof |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0030616B1 (en) |
| JP (1) | JPS5692274A (en) |
| AT (1) | ATE5818T1 (en) |
| AU (1) | AU533756B2 (en) |
| DE (2) | DE2949287A1 (en) |
| DK (1) | DK521680A (en) |
| ES (1) | ES497480A0 (en) |
| FI (1) | FI69068C (en) |
| IE (1) | IE50485B1 (en) |
| IL (1) | IL61637A (en) |
| NO (1) | NO151412C (en) |
| ZA (1) | ZA807611B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4644007A (en) * | 1981-11-20 | 1987-02-17 | Alcon Laboratories, Inc. | 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods |
| US4515800A (en) * | 1981-11-20 | 1985-05-07 | Icilio Cavero | Method of lowering intraocular pressure using phenylimino-imidazoles |
| US4517199A (en) * | 1981-11-20 | 1985-05-14 | Alcon Laboratories, Inc. | Method for lowering intraocular pressure using phenylimino-imidazoles |
| US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
| HU192986B (en) * | 1984-05-23 | 1987-08-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of imidasodiline derivatives |
| DE19514579A1 (en) | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Use of alpha-1-olone agonists for the treatment of urinary incontinence |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT285599B (en) * | 1968-06-21 | 1970-11-10 | Boehringer Sohn Ingelheim | Process for the preparation of new trisubstituted 2-arylaminoimidazolines and their salts |
| BE759048A (en) * | 1969-11-17 | 1971-05-17 | Boehringer Sohn Ingelheim | NEW N-AMINOALCOYL-ARYLAMINO-IMIDAZOLINES- (2) SUBSTITUTES AND METHODS FOR MAKING THEM |
| DE2259160A1 (en) * | 1972-12-02 | 1974-06-06 | Boehringer Sohn Ingelheim | NEW SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE, THEIR ACID-ADDITIONAL SALTS AND METHOD FOR MANUFACTURING THE SAME AND THEIR USE AS A MEDICINAL PRODUCT |
| DE2523103C3 (en) * | 1975-05-24 | 1979-11-29 | C.H. Boehringer Sohn, 6507 Ingelheim | Substituted 2- [N-Progargyl-N- (2-chlorophenyl) amino] -imidazoline- ^), their acid addition salts, processes for their preparation and their use |
| DE2636732A1 (en) * | 1976-08-14 | 1978-02-16 | Boehringer Sohn Ingelheim | NEW SUBSTITUTED 2-PHENYLAMINO IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF |
-
1979
- 1979-12-07 DE DE19792949287 patent/DE2949287A1/en not_active Withdrawn
-
1980
- 1980-11-03 AT AT80106725T patent/ATE5818T1/en not_active IP Right Cessation
- 1980-11-03 EP EP80106725A patent/EP0030616B1/en not_active Expired
- 1980-11-03 DE DE8080106725T patent/DE3066104D1/en not_active Expired
- 1980-12-05 ES ES497480A patent/ES497480A0/en active Granted
- 1980-12-05 IL IL61637A patent/IL61637A/en unknown
- 1980-12-05 JP JP17196380A patent/JPS5692274A/en active Pending
- 1980-12-05 NO NO803682A patent/NO151412C/en unknown
- 1980-12-05 ZA ZA00807611A patent/ZA807611B/en unknown
- 1980-12-05 DK DK521680A patent/DK521680A/en not_active Application Discontinuation
- 1980-12-05 IE IE2555/80A patent/IE50485B1/en unknown
- 1980-12-05 FI FI803799A patent/FI69068C/en not_active IP Right Cessation
- 1980-12-05 AU AU65136/80A patent/AU533756B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU6513680A (en) | 1981-06-18 |
| JPS5692274A (en) | 1981-07-25 |
| FI69068B (en) | 1985-08-30 |
| IE50485B1 (en) | 1986-04-30 |
| NO151412B (en) | 1984-12-27 |
| FI69068C (en) | 1985-12-10 |
| EP0030616A1 (en) | 1981-06-24 |
| ATE5818T1 (en) | 1984-01-15 |
| DE3066104D1 (en) | 1984-02-16 |
| ZA807611B (en) | 1982-08-25 |
| EP0030616B1 (en) | 1984-01-11 |
| DK521680A (en) | 1981-06-08 |
| IL61637A0 (en) | 1981-01-30 |
| NO151412C (en) | 1985-04-10 |
| FI803799L (en) | 1981-06-08 |
| AU533756B2 (en) | 1983-12-08 |
| ES8201978A1 (en) | 1982-01-01 |
| ES497480A0 (en) | 1982-01-01 |
| IL61637A (en) | 1984-11-30 |
| DE2949287A1 (en) | 1981-06-11 |
| NO803682L (en) | 1981-06-09 |
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