IL61637A - Substituted 2-phenylamino-imidazolines-(2)and acid addition salts thereof,their production and pharmaceutical compositions containing them - Google Patents

Substituted 2-phenylamino-imidazolines-(2)and acid addition salts thereof,their production and pharmaceutical compositions containing them

Info

Publication number
IL61637A
IL61637A IL61637A IL6163780A IL61637A IL 61637 A IL61637 A IL 61637A IL 61637 A IL61637 A IL 61637A IL 6163780 A IL6163780 A IL 6163780A IL 61637 A IL61637 A IL 61637A
Authority
IL
Israel
Prior art keywords
acid addition
group
addition salts
imidazolines
phenylamino
Prior art date
Application number
IL61637A
Other versions
IL61637A0 (en
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of IL61637A0 publication Critical patent/IL61637A0/en
Publication of IL61637A publication Critical patent/IL61637A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1. Claims for the Contracting state : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P7,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof. 1. Claims for the Contracting state : AT Process for preparing substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P8,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof, characterised in that a) 2-(2,6-dibromo-4-methylphenyl-imino)-imidazolidine of formula II see diagramm : EP0030616,P8,F2 is reacted with a halide of general formula III Hal-R wherein Hal represents a chlorine, bromine or iodine atom and R is as hereinbefore defined, at 40 degrees C to 150 degrees C, or b) a compound of general formula IV see diagramm : EP0030616,P8,F3 wherein R is as hereinbefore defined and A represents a cyano group or the group see diagramm : EP0030616,P8,F4 wherein Y represents an alkoxy or alkylthio group with up to 4 carbon atoms or a mercapto group or an amino group, is reacted with ethylenediamine or the acid addition salts thereof at 60 to 180 degrees C, and the end product obtained according to one of these processes is optionally converted into a corresponding acid addition salt.
IL61637A 1979-12-07 1980-12-05 Substituted 2-phenylamino-imidazolines-(2)and acid addition salts thereof,their production and pharmaceutical compositions containing them IL61637A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792949287 DE2949287A1 (en) 1979-12-07 1979-12-07 NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF

Publications (2)

Publication Number Publication Date
IL61637A0 IL61637A0 (en) 1981-01-30
IL61637A true IL61637A (en) 1984-11-30

Family

ID=6087857

Family Applications (1)

Application Number Title Priority Date Filing Date
IL61637A IL61637A (en) 1979-12-07 1980-12-05 Substituted 2-phenylamino-imidazolines-(2)and acid addition salts thereof,their production and pharmaceutical compositions containing them

Country Status (12)

Country Link
EP (1) EP0030616B1 (en)
JP (1) JPS5692274A (en)
AT (1) ATE5818T1 (en)
AU (1) AU533756B2 (en)
DE (2) DE2949287A1 (en)
DK (1) DK521680A (en)
ES (1) ES8201978A1 (en)
FI (1) FI69068C (en)
IE (1) IE50485B1 (en)
IL (1) IL61637A (en)
NO (1) NO151412C (en)
ZA (1) ZA807611B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515800A (en) * 1981-11-20 1985-05-07 Icilio Cavero Method of lowering intraocular pressure using phenylimino-imidazoles
US4517199A (en) * 1981-11-20 1985-05-14 Alcon Laboratories, Inc. Method for lowering intraocular pressure using phenylimino-imidazoles
US4461904A (en) * 1981-11-20 1984-07-24 Alcon Laboratories, Inc. 2-(Trisubstituted phenylimino)-imidazolines
US4644007A (en) * 1981-11-20 1987-02-17 Alcon Laboratories, Inc. 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods
HU192986B (en) * 1984-05-23 1987-08-28 Egyt Gyogyszervegyeszeti Gyar Process for production of imidasodiline derivatives
DE19514579A1 (en) 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Use of alpha-1-olone agonists for the treatment of urinary incontinence

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT285599B (en) * 1968-06-21 1970-11-10 Boehringer Sohn Ingelheim Process for the preparation of new trisubstituted 2-arylaminoimidazolines and their salts
BE759048A (en) * 1969-11-17 1971-05-17 Boehringer Sohn Ingelheim NEW N-AMINOALCOYL-ARYLAMINO-IMIDAZOLINES- (2) SUBSTITUTES AND METHODS FOR MAKING THEM
DE2259160A1 (en) * 1972-12-02 1974-06-06 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE, THEIR ACID-ADDITIONAL SALTS AND METHOD FOR MANUFACTURING THE SAME AND THEIR USE AS A MEDICINAL PRODUCT
DE2523103C3 (en) * 1975-05-24 1979-11-29 C.H. Boehringer Sohn, 6507 Ingelheim Substituted 2- [N-Progargyl-N- (2-chlorophenyl) amino] -imidazoline- ^), their acid addition salts, processes for their preparation and their use
DE2636732A1 (en) * 1976-08-14 1978-02-16 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLAMINO IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
DK521680A (en) 1981-06-08
DE2949287A1 (en) 1981-06-11
FI69068B (en) 1985-08-30
IE50485B1 (en) 1986-04-30
NO803682L (en) 1981-06-09
FI803799L (en) 1981-06-08
EP0030616B1 (en) 1984-01-11
NO151412B (en) 1984-12-27
EP0030616A1 (en) 1981-06-24
ES497480A0 (en) 1982-01-01
ZA807611B (en) 1982-08-25
JPS5692274A (en) 1981-07-25
DE3066104D1 (en) 1984-02-16
IE802555L (en) 1981-06-07
AU533756B2 (en) 1983-12-08
NO151412C (en) 1985-04-10
IL61637A0 (en) 1981-01-30
ES8201978A1 (en) 1982-01-01
ATE5818T1 (en) 1984-01-15
FI69068C (en) 1985-12-10
AU6513680A (en) 1981-06-18

Similar Documents

Publication Publication Date Title
DE3068905D1 (en) Process for the preparation of cephalosporin derivatives; intermediates and their preparation
ES445928A1 (en) Quaternary imidazole compounds as microbicides
IL61637A (en) Substituted 2-phenylamino-imidazolines-(2)and acid addition salts thereof,their production and pharmaceutical compositions containing them
JPS5524194A (en) Manufacture of nnsubstituted alphaa halogenoacetanilide
ATE53034T1 (en) PROCESS FOR THE PREPARATION OF CEPHEM COMPOUNDS.
PL244610A1 (en) Process for preparing novel derivatives of benzazepine
ES440991A1 (en) Diaryl-pyridyl-imidazole methanes and their production
GB1490060A (en) 2-(3-substituted-4h-1,2,4-triazol-4-yl)benzo-phenones