IL61637A - Substituted 2-phenylamino-imidazolines-(2)and acid addition salts thereof,their production and pharmaceutical compositions containing them - Google Patents
Substituted 2-phenylamino-imidazolines-(2)and acid addition salts thereof,their production and pharmaceutical compositions containing themInfo
- Publication number
- IL61637A IL61637A IL61637A IL6163780A IL61637A IL 61637 A IL61637 A IL 61637A IL 61637 A IL61637 A IL 61637A IL 6163780 A IL6163780 A IL 6163780A IL 61637 A IL61637 A IL 61637A
- Authority
- IL
- Israel
- Prior art keywords
- acid addition
- group
- addition salts
- imidazolines
- phenylamino
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 5
- 150000003839 salts Chemical class 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 abstract 2
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 2
- 125000005394 methallyl group Chemical group 0.000 abstract 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- DZHUQIOYWZHKQP-UHFFFAOYSA-N n-(2,6-dibromo-4-methylphenyl)-4,5-dihydro-1h-imidazol-2-amine Chemical compound BrC1=CC(C)=CC(Br)=C1N=C1NCCN1 DZHUQIOYWZHKQP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1. Claims for the Contracting state : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P7,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof. 1. Claims for the Contracting state : AT Process for preparing substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P8,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof, characterised in that a) 2-(2,6-dibromo-4-methylphenyl-imino)-imidazolidine of formula II see diagramm : EP0030616,P8,F2 is reacted with a halide of general formula III Hal-R wherein Hal represents a chlorine, bromine or iodine atom and R is as hereinbefore defined, at 40 degrees C to 150 degrees C, or b) a compound of general formula IV see diagramm : EP0030616,P8,F3 wherein R is as hereinbefore defined and A represents a cyano group or the group see diagramm : EP0030616,P8,F4 wherein Y represents an alkoxy or alkylthio group with up to 4 carbon atoms or a mercapto group or an amino group, is reacted with ethylenediamine or the acid addition salts thereof at 60 to 180 degrees C, and the end product obtained according to one of these processes is optionally converted into a corresponding acid addition salt.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792949287 DE2949287A1 (en) | 1979-12-07 | 1979-12-07 | NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL61637A0 IL61637A0 (en) | 1981-01-30 |
| IL61637A true IL61637A (en) | 1984-11-30 |
Family
ID=6087857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL61637A IL61637A (en) | 1979-12-07 | 1980-12-05 | Substituted 2-phenylamino-imidazolines-(2)and acid addition salts thereof,their production and pharmaceutical compositions containing them |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0030616B1 (en) |
| JP (1) | JPS5692274A (en) |
| AT (1) | ATE5818T1 (en) |
| AU (1) | AU533756B2 (en) |
| DE (2) | DE2949287A1 (en) |
| DK (1) | DK521680A (en) |
| ES (1) | ES8201978A1 (en) |
| FI (1) | FI69068C (en) |
| IE (1) | IE50485B1 (en) |
| IL (1) | IL61637A (en) |
| NO (1) | NO151412C (en) |
| ZA (1) | ZA807611B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4644007A (en) * | 1981-11-20 | 1987-02-17 | Alcon Laboratories, Inc. | 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods |
| US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
| US4517199A (en) * | 1981-11-20 | 1985-05-14 | Alcon Laboratories, Inc. | Method for lowering intraocular pressure using phenylimino-imidazoles |
| US4515800A (en) * | 1981-11-20 | 1985-05-07 | Icilio Cavero | Method of lowering intraocular pressure using phenylimino-imidazoles |
| HU192986B (en) * | 1984-05-23 | 1987-08-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of imidasodiline derivatives |
| DE19514579A1 (en) | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Use of alpha-1-olone agonists for the treatment of urinary incontinence |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT285599B (en) * | 1968-06-21 | 1970-11-10 | Boehringer Sohn Ingelheim | Process for the preparation of new trisubstituted 2-arylaminoimidazolines and their salts |
| BE759048A (en) * | 1969-11-17 | 1971-05-17 | Boehringer Sohn Ingelheim | NEW N-AMINOALCOYL-ARYLAMINO-IMIDAZOLINES- (2) SUBSTITUTES AND METHODS FOR MAKING THEM |
| DE2259160A1 (en) * | 1972-12-02 | 1974-06-06 | Boehringer Sohn Ingelheim | NEW SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE, THEIR ACID-ADDITIONAL SALTS AND METHOD FOR MANUFACTURING THE SAME AND THEIR USE AS A MEDICINAL PRODUCT |
| DE2523103C3 (en) * | 1975-05-24 | 1979-11-29 | C.H. Boehringer Sohn, 6507 Ingelheim | Substituted 2- [N-Progargyl-N- (2-chlorophenyl) amino] -imidazoline- ^), their acid addition salts, processes for their preparation and their use |
| DE2636732A1 (en) * | 1976-08-14 | 1978-02-16 | Boehringer Sohn Ingelheim | NEW SUBSTITUTED 2-PHENYLAMINO IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF |
-
1979
- 1979-12-07 DE DE19792949287 patent/DE2949287A1/en not_active Withdrawn
-
1980
- 1980-11-03 DE DE8080106725T patent/DE3066104D1/en not_active Expired
- 1980-11-03 EP EP80106725A patent/EP0030616B1/en not_active Expired
- 1980-11-03 AT AT80106725T patent/ATE5818T1/en not_active IP Right Cessation
- 1980-12-05 IE IE2555/80A patent/IE50485B1/en unknown
- 1980-12-05 NO NO803682A patent/NO151412C/en unknown
- 1980-12-05 DK DK521680A patent/DK521680A/en not_active Application Discontinuation
- 1980-12-05 ZA ZA00807611A patent/ZA807611B/en unknown
- 1980-12-05 JP JP17196380A patent/JPS5692274A/en active Pending
- 1980-12-05 FI FI803799A patent/FI69068C/en not_active IP Right Cessation
- 1980-12-05 IL IL61637A patent/IL61637A/en unknown
- 1980-12-05 ES ES497480A patent/ES8201978A1/en not_active Expired
- 1980-12-05 AU AU65136/80A patent/AU533756B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| NO803682L (en) | 1981-06-09 |
| FI69068B (en) | 1985-08-30 |
| EP0030616A1 (en) | 1981-06-24 |
| EP0030616B1 (en) | 1984-01-11 |
| ES497480A0 (en) | 1982-01-01 |
| AU533756B2 (en) | 1983-12-08 |
| IE50485B1 (en) | 1986-04-30 |
| ES8201978A1 (en) | 1982-01-01 |
| DE3066104D1 (en) | 1984-02-16 |
| DE2949287A1 (en) | 1981-06-11 |
| AU6513680A (en) | 1981-06-18 |
| FI803799L (en) | 1981-06-08 |
| FI69068C (en) | 1985-12-10 |
| DK521680A (en) | 1981-06-08 |
| JPS5692274A (en) | 1981-07-25 |
| ZA807611B (en) | 1982-08-25 |
| ATE5818T1 (en) | 1984-01-15 |
| IL61637A0 (en) | 1981-01-30 |
| NO151412B (en) | 1984-12-27 |
| NO151412C (en) | 1985-04-10 |
| IE802555L (en) | 1981-06-07 |
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