US4613676A
(en)
*
|
1983-11-23 |
1986-09-23 |
Ciba-Geigy Corporation |
Substituted 5-amino-4-hydroxyvaleryl derivatives
|
EP0144290A3
(de)
*
|
1983-12-01 |
1987-05-27 |
Ciba-Geigy Ag |
Substituierte Aethylendiaminderivate
|
JPS60163899A
(ja)
*
|
1984-02-03 |
1985-08-26 |
Sankyo Co Ltd |
レニン阻害ペプチド類
|
CA1254699A
(en)
*
|
1984-03-12 |
1989-05-23 |
Jasjit S. Bindra |
Renin inhibitors containing statine or derivatives thereof
|
US4661473A
(en)
*
|
1984-03-27 |
1987-04-28 |
Merck & Co., Inc. |
Renin inhibitors containing peptide isosteres
|
US4636491A
(en)
*
|
1984-03-27 |
1987-01-13 |
Merck & Co., Inc. |
Renin inhibitory peptides having improved solubility
|
US4663310A
(en)
*
|
1984-04-04 |
1987-05-05 |
Merck & Co., Inc. |
Renin inhibitors containing 2-substituted statine
|
DE3418491A1
(de)
*
|
1984-05-18 |
1985-11-21 |
Merck Patent Gmbh, 6100 Darmstadt |
Diaminosaeurederivate
|
EP0163237A3
(de)
*
|
1984-05-29 |
1988-04-27 |
Merck & Co. Inc. |
Di- und tripeptidale Renin-Hemmungsstoffe
|
DK356085A
(da)
*
|
1984-08-06 |
1986-02-07 |
Upjohn Co |
Reninhaemmende peptid eller et farmaceutisk acceptabelt syreadditionssalt deraf
|
US4880781A
(en)
*
|
1984-08-06 |
1989-11-14 |
The Upjohn Company |
Renin inhibitory peptides containing an N-alkyl-histidine moiety
|
DE3438545A1
(de)
*
|
1984-10-20 |
1986-04-24 |
Merck Patent Gmbh, 6100 Darmstadt |
Peptide
|
US4616088A
(en)
*
|
1984-10-29 |
1986-10-07 |
E. R. Squibb & Sons, Inc. |
Amino acid ester and amide renin inhibitor
|
US4727060A
(en)
*
|
1984-11-13 |
1988-02-23 |
Ciba-Geigy Corporation |
Novel 5-amino-4-hydroxyvaleryl derivatives
|
US4629724A
(en)
*
|
1984-12-03 |
1986-12-16 |
E. R. Squibb & Sons, Inc. |
Amino acid ester and amide renin inhibitors
|
DE3512128A1
(de)
*
|
1985-04-03 |
1986-10-09 |
Merck Patent Gmbh, 6100 Darmstadt |
Peptide
|
EP0218688B1
(de)
|
1985-04-19 |
1990-09-12 |
The Upjohn Company |
Substituierte dihalo-statin-reninhemmungsmittel
|
US4882420A
(en)
*
|
1985-04-19 |
1989-11-21 |
The Upjohn Company |
Dihalo-statine substituted renin inhibitors
|
US4777286A
(en)
*
|
1985-06-18 |
1988-10-11 |
The Upjohn Company |
Certain aryl or hetero-hydroxamic acid esters useful as renin inhibitors
|
CA1290097C
(en)
*
|
1985-07-24 |
1991-10-01 |
Merck & Co., Inc. |
Peptide enzyme inhibitors
|
US4599198A
(en)
*
|
1985-08-02 |
1986-07-08 |
Pfizer Inc. |
Intermediates in polypeptide synthesis
|
US4729985A
(en)
*
|
1985-08-09 |
1988-03-08 |
Pfizer Inc. |
Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
|
US4992562A
(en)
*
|
1985-08-09 |
1991-02-12 |
Pfizer Inc. |
Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
|
US4749781A
(en)
*
|
1985-11-12 |
1988-06-07 |
E. R. Squibb & Sons, Inc. |
Aminocarbonyl renin inhibitors
|
DE3540495A1
(de)
*
|
1985-11-15 |
1987-05-21 |
Merck Patent Gmbh |
Aminosaeurederivate
|
US4894437A
(en)
*
|
1985-11-15 |
1990-01-16 |
The Upjohn Company |
Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
|
WO1987002986A1
(en)
*
|
1985-11-15 |
1987-05-21 |
The Upjohn Company |
Novel renin inhibiting polypeptide analogs containing s-aryl-d- or l- or dl-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
|
KR870005013A
(ko)
*
|
1985-11-29 |
1987-06-04 |
가와무라 요시부미 |
레닌-억제 올리고펩티드, 그의 제조방법 및 용도
|
US4757050A
(en)
*
|
1985-12-23 |
1988-07-12 |
E. R. Squibb Sons, Inc. |
Ureido renin inhibitors
|
CA1297631C
(en)
*
|
1985-12-23 |
1992-03-17 |
Sesha I. Natarajan |
Ureido renin inhibitors
|
DE3601248A1
(de)
*
|
1986-01-17 |
1987-07-23 |
Hoechst Ag |
Substituierte 4-amino-3-hydroxybuttersaeure-derivate, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
|
FI870474A
(fi)
*
|
1986-02-07 |
1987-08-08 |
Ciba Geigy Ag |
Med svavelhaltiga grupper substituerade 5-amino-4-hydroxivalerylderivat.
|
US4705846A
(en)
*
|
1986-03-27 |
1987-11-10 |
The Upjohn Company |
Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert
|
US4999186A
(en)
*
|
1986-06-27 |
1991-03-12 |
The Procter & Gamble Company |
Novel sunscreen agents, sunscreen compositions and methods for preventing sunburn
|
DE3626130A1
(de)
*
|
1986-08-01 |
1988-02-11 |
Merck Patent Gmbh |
Aminosaeurederivate
|
US4743585A
(en)
*
|
1986-11-21 |
1988-05-10 |
Warner-Lambert Company |
Renin inhibitors
|
DE3640535A1
(de)
*
|
1986-11-27 |
1988-06-01 |
Merck Patent Gmbh |
Peptide
|
SE8605573D0
(sv)
*
|
1986-12-29 |
1986-12-29 |
Haessle Ab |
Novel compounds
|
US5032577A
(en)
*
|
1986-12-31 |
1991-07-16 |
Abbott Laboratories |
Peptidylaminodiols
|
US4804743A
(en)
*
|
1987-01-29 |
1989-02-14 |
Warner-Lambert Copmany |
Proline-containing renin inhibitors
|
US4863905A
(en)
*
|
1987-02-04 |
1989-09-05 |
Warner-Lambert Company |
Renin inhibitors II
|
US4758584A
(en)
*
|
1987-02-05 |
1988-07-19 |
Ciba-Geigy Corporation |
Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups
|
AU1780588A
(en)
*
|
1987-06-29 |
1989-01-30 |
Upjohn Company, The |
Malic acid derivative containing renin inhibiting peptides
|
US5055466A
(en)
*
|
1987-11-23 |
1991-10-08 |
E. R. Squibb & Sons, Inc. |
N-morpholino derivatives and their use as anti-hypertensive agents
|
GB8728561D0
(en)
*
|
1987-12-07 |
1988-01-13 |
Glaxo Group Ltd |
Chemical compounds
|
GB8728560D0
(en)
*
|
1987-12-07 |
1988-01-13 |
Glaxo Group Ltd |
Chemical compounds
|
FR2624513A1
(fr)
*
|
1987-12-15 |
1989-06-16 |
Sandoz Sa |
Peptides contenant du silicium, leur preparation et leur utilisation comme medicaments
|
IL90872A0
(en)
*
|
1988-07-08 |
1990-02-09 |
Smithkline Beckman Corp |
Retroviral protease binding peptides
|
DE3840289A1
(de)
*
|
1988-11-30 |
1990-05-31 |
Merck Patent Gmbh |
Aminosaeurederivate
|
EP0374097A3
(de)
*
|
1988-12-15 |
1991-06-12 |
Ciba-Geigy Ag |
Verwendung von Peptidisosteren als retrovirale Proteasehemmer
|
US5126326A
(en)
*
|
1989-06-06 |
1992-06-30 |
Bio-Mega, Inc. |
Enzyme inhibiting peptide derivatives
|
GB8927915D0
(en)
*
|
1989-12-11 |
1990-02-14 |
Hoffmann La Roche |
Novel alcohols
|
DE4014421A1
(de)
*
|
1990-05-05 |
1991-11-07 |
Merck Patent Gmbh |
Aminosaeurederivate
|
US5648511A
(en)
*
|
1990-11-19 |
1997-07-15 |
G.D. Searle & Co. |
Method for making intermediates useful in the synthesis of retroviral protease inhibitors
|
US5475013A
(en)
*
|
1990-11-19 |
1995-12-12 |
Monsanto Company |
Retroviral protease inhibitors
|
US5475027A
(en)
*
|
1990-11-19 |
1995-12-12 |
G.D. Searle & Co. |
Retroviral protease inhibitors
|
US5708004A
(en)
*
|
1990-11-19 |
1998-01-13 |
Monsanto Company |
Retroviral protease inhibitors
|
US5614522A
(en)
*
|
1990-11-19 |
1997-03-25 |
G.D. Searle & Co. |
Retroviral protease inhibitors
|
US5583238A
(en)
*
|
1990-11-19 |
1996-12-10 |
G. D. Searle & Co. |
Method for making intermediates useful in synthesis of retroviral protease inhibitors
|
US5482947A
(en)
|
1990-11-19 |
1996-01-09 |
Talley; John J. |
Retroviral protease inhibitors
|
US5278326A
(en)
*
|
1991-03-18 |
1994-01-11 |
Warner-Lambert Company |
Substituted beta-ketoamide ACAT inhibitors
|
US5643878A
(en)
*
|
1991-09-12 |
1997-07-01 |
Ciba-Geigy Corporation |
5-amino-4-hydroxyhexanoic acid derivatives
|
TW217410B
(de)
*
|
1992-04-01 |
1993-12-11 |
Ciba Geigy |
|
JPH07508020A
(ja)
|
1992-05-21 |
1995-09-07 |
ジー.ディー.サール アンド カンパニー |
レトロウイルスプロテアーゼインヒビター
|
US6046190A
(en)
*
|
1992-08-25 |
2000-04-04 |
G.D. Searle & Co. |
Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
|
US6743929B1
(en)
|
1992-08-25 |
2004-06-01 |
G. D. Searle & Co. |
Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
|
US5760076A
(en)
*
|
1992-08-25 |
1998-06-02 |
G.D Searle & Co. |
Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
|
US6022994A
(en)
|
1992-08-25 |
2000-02-08 |
G. D. Searle &. Co. |
Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
|
US5968942A
(en)
|
1992-08-25 |
1999-10-19 |
G. D. Searle & Co. |
α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
|
RU2146668C1
(ru)
*
|
1992-08-25 |
2000-03-20 |
Джи Ди Сирл энд Компани |
Сульфонилалканоиламино-гидроксиэтиламино-сульфонамидное соединение, фармацевтические композиции и способы лечения и ингибирования ретровирусных протеаз
|
US7141609B2
(en)
|
1992-08-25 |
2006-11-28 |
G.D. Searle & Co. |
α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
|
DK0656887T3
(da)
|
1992-08-25 |
1999-07-05 |
Searle & Co |
Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
|
US5463104A
(en)
*
|
1992-08-25 |
1995-10-31 |
G. D. Searle & Co. |
Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
|
US5830897A
(en)
*
|
1992-08-27 |
1998-11-03 |
G. D. Searle & Co. |
α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
|
ES2134924T3
(es)
*
|
1992-10-30 |
1999-10-16 |
Searle & Co |
Acidos sulfonilalcanoilamino-hidroxietilamino-sulfamicos utiles como inhibidores de proteasas retrovirales.
|
DE69331421T2
(de)
|
1992-10-30 |
2002-08-01 |
G.D. SEARLE & CO., CHICAGO |
N-substituierte Hydroxyethylaminosulfamidsäure-Derivate verwendbar als Inhibitoren retroviraler Proteasen
|
US5756498A
(en)
*
|
1992-10-30 |
1998-05-26 |
G.D. Searle & Co. |
Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
|
US6337398B1
(en)
|
1992-10-30 |
2002-01-08 |
G.D. Searle & Co. |
Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
|
US5578606A
(en)
|
1992-10-30 |
1996-11-26 |
G. D. Searle & Co. |
α- and β-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
|
US5514801A
(en)
|
1992-12-29 |
1996-05-07 |
Monsanto Company |
Cyclic sulfone containing retroviral protease inhibitors
|
US5750648A
(en)
*
|
1993-08-20 |
1998-05-12 |
G.D. Searle & Co. |
Retroviral protease inhibitors and combinations thereof
|
US5602119A
(en)
*
|
1993-10-29 |
1997-02-11 |
Vazquez; Michael L. |
Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
|
US6133444A
(en)
*
|
1993-12-22 |
2000-10-17 |
Perseptive Biosystems, Inc. |
Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
|
US5831117A
(en)
|
1995-01-20 |
1998-11-03 |
G. D. Searle & Co. |
Method of preparing retroviral protease inhibitor intermediates
|
JP4014220B2
(ja)
|
1995-01-20 |
2007-11-28 |
ジー.ディー.サール アンド カンパニー |
ビス−スルホンアミドヒドロキシエチルアミノ レトロ ウイルスプロテアーゼインヒビター
|
US5756533A
(en)
*
|
1995-03-10 |
1998-05-26 |
G.D. Searle & Co. |
Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
|
US6140505A
(en)
|
1995-03-10 |
2000-10-31 |
G. D. Searle & Co. |
Synthesis of benzo fused heterocyclic sulfonyl chlorides
|
US6407134B1
(en)
|
1995-03-10 |
2002-06-18 |
G. D. Searle & Co. |
Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
|
US6667307B2
(en)
|
1997-12-19 |
2003-12-23 |
G.D. Searle & Co. |
Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
|
EP1188766A1
(de)
|
1995-03-10 |
2002-03-20 |
G.D. Searle & Co. |
Verbindungen der Struktur bis-Aminosäure-Hydroxyethylamino-Sulfonamid als Inhibitoren der retroviralen Protease
|
JP4124818B2
(ja)
*
|
1995-03-10 |
2008-07-23 |
ジー.ディー.サール アンド カンパニー |
ヘテロシクロカルボニルアミノ酸ヒドロキシエチルアミノスルホンアミドレトロウイルスプロテアーゼインヒビター
|
US5985870A
(en)
*
|
1995-03-10 |
1999-11-16 |
G.D. Searle & Co. |
Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
|
US5705500A
(en)
*
|
1995-03-10 |
1998-01-06 |
G.D. Searle & Co. |
Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
|
US7339078B2
(en)
|
1995-03-10 |
2008-03-04 |
G.D. Searle Llc |
Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
|
US6861539B1
(en)
|
1995-03-10 |
2005-03-01 |
G. D. Searle & Co. |
Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
|
US6169085B1
(en)
|
1995-03-10 |
2001-01-02 |
G. D. Searle & Company |
Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
|
US5776971A
(en)
*
|
1995-03-10 |
1998-07-07 |
G.D. Searle & Co. |
Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
|
US6150556A
(en)
|
1995-03-10 |
2000-11-21 |
G. D. Dearle & Co. |
Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
|
CA2236236A1
(en)
*
|
1995-11-15 |
1997-05-22 |
G.D. Searle & Co. |
Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
|
US7132568B2
(en)
|
2002-06-17 |
2006-11-07 |
Sunesis Pharmaceuticals, Inc. |
Aspartyl protease inhibitors
|
US7115652B2
(en)
|
2002-06-17 |
2006-10-03 |
Sunesis Pharmaceuticals, Inc. |
Aspartyl protease inhibitors
|
EP1644322A1
(de)
*
|
2003-06-16 |
2006-04-12 |
Sunesis Pharmaceuticals, Inc. |
Aspartyl protease inhibitoren
|
WO2005113582A1
(en)
*
|
2004-05-22 |
2005-12-01 |
Boehringer Ingelheim International Gmbh |
Substituted ethane-1,2-diamines for the treatment of alzheimer's disease
|