DK409986A - 3-desmethyl-mevalonsyrederivater, fremgangsmaade til fremstillingderaf, pharmaceutiske praeparater paa basis af disse forbindelser, anvendelse deraf samt mellemprodukter - Google Patents
3-desmethyl-mevalonsyrederivater, fremgangsmaade til fremstillingderaf, pharmaceutiske praeparater paa basis af disse forbindelser, anvendelse deraf samt mellemprodukter Download PDFInfo
- Publication number
- DK409986A DK409986A DK409986A DK409986A DK409986A DK 409986 A DK409986 A DK 409986A DK 409986 A DK409986 A DK 409986A DK 409986 A DK409986 A DK 409986A DK 409986 A DK409986 A DK 409986A
- Authority
- DK
- Denmark
- Prior art keywords
- desmethyl
- intermediates
- procedures
- compounds
- preparation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5456—Arylalkanephosphonium compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853530797 DE3530797A1 (de) | 1985-08-29 | 1985-08-29 | 3-desmethyl-mevalonsaeurederivate, verfahren zu ihrer herstellung pharmazeutische praeparate auf basis dieser verbindungen, ihre verwendung sowie zwischenprodukte |
| DE3530797 | 1985-08-29 | ||
| DE3615446 | 1986-05-07 | ||
| DE19863615446 DE3615446A1 (de) | 1986-05-07 | 1986-05-07 | 3-desmethyl-mevalonsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen, ihrer verwendung sowie zwischenprodukte |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK409986D0 DK409986D0 (da) | 1986-08-28 |
| DK409986A true DK409986A (da) | 1987-03-01 |
| DK169127B1 DK169127B1 (da) | 1994-08-22 |
Family
ID=25835463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK409986A DK169127B1 (da) | 1985-08-29 | 1986-08-28 | 3-Desmethyl-mevalonsyrederivater, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende disse forbindelser |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4914127A (da) |
| EP (1) | EP0217092B1 (da) |
| JP (1) | JPH0830027B2 (da) |
| KR (1) | KR870002114A (da) |
| AR (1) | AR242206A1 (da) |
| AU (1) | AU583943B2 (da) |
| CA (1) | CA1294284C (da) |
| DE (1) | DE3669874D1 (da) |
| DK (1) | DK169127B1 (da) |
| ES (1) | ES2001595A6 (da) |
| FI (1) | FI90868C (da) |
| GR (1) | GR862210B (da) |
| HU (1) | HU195799B (da) |
| IE (1) | IE59312B1 (da) |
| IL (1) | IL79855A0 (da) |
| NO (1) | NO171108C (da) |
| PT (1) | PT83269B (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4789682A (en) * | 1987-03-17 | 1988-12-06 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| DE3722809A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | 3-desmethyl-4-fluor-mevalonsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen, ihre verwendung und zwischenprodukte |
| US4863957A (en) * | 1987-12-21 | 1989-09-05 | Rorer Pharmaceutical Corporation | Novel HMG-CoA reductase inhibitors |
| US5470982A (en) * | 1988-01-20 | 1995-11-28 | Bayer Aktiengesellschaft | Disubstituted pyridines |
| FR2669031A1 (fr) * | 1990-11-09 | 1992-05-15 | Rhone Poulenc Sante | Procede de preparation de derives du tetrahydropyranne. |
| US5840620A (en) * | 1994-06-15 | 1998-11-24 | Seager; Carleton H. | Method for restoring the resistance of indium oxide semiconductors after heating while in sealed structures |
| CN101570510B (zh) * | 2008-04-30 | 2011-08-31 | 上海医药工业研究院 | 喹啉类化合物及其药物组合物、制备方法和应用 |
| JP5789430B2 (ja) * | 2011-06-27 | 2015-10-07 | イハラニッケイ化学工業株式会社 | ２−クロロメチルベンズアルデヒドの製造方法、２−クロロメチルベンズアルデヒド含有組成物及びその保管方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4710513A (en) * | 1979-08-17 | 1987-12-01 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
| US4440927A (en) * | 1981-06-19 | 1984-04-03 | Merck & Co., Inc. | Process for preparing inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase via a chiral synthon |
| CA1282425C (en) * | 1984-06-04 | 1991-04-02 | Meyer Sletzinger | Process for preparing hmg-coa reductase inhibitors with a 3,5-dihydroxypentanoate subunit |
| US4588715A (en) * | 1984-06-04 | 1986-05-13 | Sandoz, Inc. | Heptenoic acid derivatives |
| US4622338A (en) * | 1985-03-11 | 1986-11-11 | G. D. Searle & Co. | Substituted glutaric acid lactones in the treatment of hyperlipidemia |
| FR2719387B1 (fr) * | 1994-04-28 | 1996-05-24 | Commissariat Energie Atomique | Dispositif de contrôle de la position et/ou de la focalisation d'un faisceau lumineux focalisé. |
-
1986
- 1986-08-18 DE DE8686111384T patent/DE3669874D1/de not_active Expired - Fee Related
- 1986-08-18 EP EP86111384A patent/EP0217092B1/de not_active Expired - Lifetime
- 1986-08-27 FI FI863471A patent/FI90868C/fi not_active IP Right Cessation
- 1986-08-27 GR GR862210A patent/GR862210B/el unknown
- 1986-08-27 HU HU863706A patent/HU195799B/hu not_active IP Right Cessation
- 1986-08-27 AR AR86305072A patent/AR242206A1/es active
- 1986-08-27 IL IL79855A patent/IL79855A0/xx not_active IP Right Cessation
- 1986-08-27 ES ES8601385A patent/ES2001595A6/es not_active Expired
- 1986-08-28 CA CA000517119A patent/CA1294284C/en not_active Expired - Fee Related
- 1986-08-28 KR KR1019860007168A patent/KR870002114A/ko not_active Application Discontinuation
- 1986-08-28 JP JP61200264A patent/JPH0830027B2/ja not_active Expired - Lifetime
- 1986-08-28 PT PT83269A patent/PT83269B/pt unknown
- 1986-08-28 IE IE230286A patent/IE59312B1/en not_active IP Right Cessation
- 1986-08-28 NO NO863461A patent/NO171108C/no unknown
- 1986-08-28 DK DK409986A patent/DK169127B1/da not_active IP Right Cessation
- 1986-08-28 AU AU62028/86A patent/AU583943B2/en not_active Ceased
-
1989
- 1989-03-08 US US07/320,924 patent/US4914127A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IE59312B1 (en) | 1994-02-09 |
| KR870002114A (ko) | 1987-03-30 |
| PT83269A (de) | 1986-09-01 |
| HU195799B (en) | 1988-07-28 |
| DK409986D0 (da) | 1986-08-28 |
| US4914127A (en) | 1990-04-03 |
| EP0217092B1 (de) | 1990-03-28 |
| NO171108C (no) | 1993-01-27 |
| ES2001595A6 (es) | 1988-06-01 |
| FI863471A0 (fi) | 1986-08-27 |
| FI90868B (fi) | 1993-12-31 |
| IL79855A0 (en) | 1986-11-30 |
| EP0217092A2 (de) | 1987-04-08 |
| FI90868C (fi) | 1994-04-11 |
| GR862210B (en) | 1986-12-23 |
| CA1294284C (en) | 1992-01-14 |
| AU583943B2 (en) | 1989-05-11 |
| HUT41757A (en) | 1987-05-28 |
| DK169127B1 (da) | 1994-08-22 |
| EP0217092A3 (en) | 1987-06-16 |
| IE862302L (en) | 1987-02-28 |
| FI863471A (fi) | 1987-03-01 |
| PT83269B (pt) | 1989-05-12 |
| DE3669874D1 (de) | 1990-05-03 |
| AR242206A1 (es) | 1993-03-31 |
| NO863461L (no) | 1987-03-02 |
| JPH0830027B2 (ja) | 1996-03-27 |
| JPS6251641A (ja) | 1987-03-06 |
| NO863461D0 (no) | 1986-08-28 |
| NO171108B (no) | 1992-10-19 |
| AU6202886A (en) | 1987-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |