DK3967775T3 - Analyse af fragmenteringsmønstre af cellefrit DNA - Google Patents
Analyse af fragmenteringsmønstre af cellefrit DNA Download PDFInfo
- Publication number
- DK3967775T3 DK3967775T3 DK21196292.3T DK21196292T DK3967775T3 DK 3967775 T3 DK3967775 T3 DK 3967775T3 DK 21196292 T DK21196292 T DK 21196292T DK 3967775 T3 DK3967775 T3 DK 3967775T3
- Authority
- DK
- Denmark
- Prior art keywords
- analysis
- cell
- free dna
- fragmentation patterns
- fragmentation
- Prior art date
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/10—Ploidy or copy number detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Databases & Information Systems (AREA)
- Epidemiology (AREA)
- Evolutionary Computation (AREA)
- Public Health (AREA)
- Software Systems (AREA)
- Data Mining & Analysis (AREA)
- Bioethics (AREA)
- Artificial Intelligence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562196250P | 2015-07-23 | 2015-07-23 | |
| US201662294948P | 2016-02-12 | 2016-02-12 | |
| PCT/CN2016/073753 WO2016127944A1 (en) | 2015-02-10 | 2016-02-14 | Detecting mutations for cancer screening and fetal analysis |
| EP16827283.9A EP3325664B1 (en) | 2015-07-23 | 2016-07-25 | Analysis of fragmentation patterns of cell-free dna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3967775T3 true DK3967775T3 (da) | 2023-10-02 |
Family
ID=57833803
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK21196292.3T DK3967775T3 (da) | 2015-07-23 | 2016-07-25 | Analyse af fragmenteringsmønstre af cellefrit DNA |
| DK16827283.9T DK3325664T3 (da) | 2015-07-23 | 2016-07-25 | Analyse af fragmenteringsmønstre for cellefrit DNA |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16827283.9T DK3325664T3 (da) | 2015-07-23 | 2016-07-25 | Analyse af fragmenteringsmønstre for cellefrit DNA |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US10453556B2 (da) |
| EP (3) | EP4279612B1 (da) |
| JP (3) | JP6931236B2 (da) |
| KR (1) | KR20180031742A (da) |
| CN (2) | CN108026572B (da) |
| AU (2) | AU2016295616B2 (da) |
| CA (1) | CA2993362A1 (da) |
| DK (2) | DK3967775T3 (da) |
| ES (2) | ES2960201T3 (da) |
| FI (1) | FI3967775T3 (da) |
| HU (2) | HUE057821T2 (da) |
| IL (3) | IL288622B2 (da) |
| PT (2) | PT3967775T (da) |
| SG (1) | SG10202106935UA (da) |
| TW (3) | TW202332776A (da) |
| WO (1) | WO2017012592A1 (da) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014093330A1 (en) | 2012-12-10 | 2014-06-19 | Clearfork Bioscience, Inc. | Methods for targeted genomic analysis |
| WO2016008451A1 (en) | 2014-07-18 | 2016-01-21 | The Chinese University Of Hong Kong | Methylation pattern analysis of tissues in dna mixture |
| KR102696857B1 (ko) | 2014-07-25 | 2024-08-19 | 유니버시티 오브 워싱톤 | 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법 |
| US20160053301A1 (en) | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| US10364467B2 (en) * | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| PT3967775T (pt) | 2015-07-23 | 2023-10-10 | Univ Hong Kong Chinese | Análise de padrões de fragmentação de adn sem células |
| IL285202B2 (en) | 2015-11-11 | 2025-03-01 | Resolution Bioscience Inc | High-efficiency construction of DNA libraries |
| US20190287645A1 (en) * | 2016-07-06 | 2019-09-19 | Guardant Health, Inc. | Methods for fragmentome profiling of cell-free nucleic acids |
| MX2019002093A (es) | 2016-08-25 | 2019-06-20 | Resolution Bioscience Inc | Métodos para la detección de cambios de copia genómica en muestras de adn. |
| KR20240155386A (ko) | 2016-09-30 | 2024-10-28 | 가던트 헬쓰, 인크. | 무세포 핵산의 다중-해상도 분석 방법 |
| US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| EP3535415A4 (en) | 2016-10-24 | 2020-07-01 | The Chinese University of Hong Kong | TUMOR DETECTION METHODS AND SYSTEMS |
| AU2017369018B2 (en) | 2016-11-30 | 2021-02-25 | The Chinese University Of Hong Kong | Analysis of cell-free DNA in urine and other samples |
| WO2018137685A1 (en) * | 2017-01-25 | 2018-08-02 | The Chinese University Of Hong Kong | Diagnostic applications using nucleic acid fragments |
| EP3635133A4 (en) * | 2017-06-09 | 2021-03-03 | Bellwether Bio, Inc. | DETERMINATION OF THE TYPE OF CANCER IN A SUBJECT BY PROBABILISTIC MODELING OF END POINTS OF CIRCULATING NUCLEIC ACID FRAGMENT |
| EP3635134A4 (en) * | 2017-06-09 | 2021-03-03 | Bellwether Bio, Inc. | DIAGNOSTIC CANCER OR OTHER PHYSIOLOGICAL CONDITIONS USING CIRCULATING NUCLEIC ACID FRAGMENT SENTINEL END POINTS |
| CN111051536A (zh) | 2017-07-26 | 2020-04-21 | 香港中文大学 | 利用不含细胞的病毒核酸改善癌症筛选 |
| US20200263170A1 (en) | 2017-09-14 | 2020-08-20 | Grail, Inc. | Methods for preparing a sequencing library from single-stranded dna |
| EP3688191B1 (en) | 2017-09-28 | 2022-03-02 | Grail, LLC | Enrichment of short nucleic acid fragments in sequencing library preparation |
| CN119753091A (zh) | 2018-04-02 | 2025-04-04 | 格里尔公司 | 用于扩增与癌症相关联的cfDNA分子的化验板 |
| EP3784806A4 (en) * | 2018-04-24 | 2022-01-19 | Grail, LLC | SYSTEMS AND METHODS OF USING A PATHOGENIC NUCLEIC ACID LOAD TO DETERMINE IF A SUBJECT HAS A CANCER CONDITION |
| WO2019210873A1 (en) | 2018-05-03 | 2019-11-07 | The Chinese University Of Hong Kong | Size-tagged preferred ends and orientation-aware analysis for measuring properties of cell-free mixtures |
| CN112805563B (zh) | 2018-05-18 | 2025-06-13 | 约翰·霍普金斯大学 | 用于评估和/或治疗癌症的无细胞dna |
| TW202022123A (zh) * | 2018-07-23 | 2020-06-16 | 香港中文大學 | 游離dna損傷分析及其臨床應用 |
| US20210207229A1 (en) * | 2018-07-27 | 2021-07-08 | Seekln, Inc. | Hepatocellular carcinoma screening |
| EP3856903A4 (en) | 2018-09-27 | 2022-07-27 | Grail, LLC | METHYLATION MARKER AND TARGETED METHYLATION PROBE PANEL |
| CA3123474A1 (en) * | 2018-12-19 | 2020-06-25 | The Chinese University Of Hong Kong | Cell-free dna end characteristics |
| CN109767813B (zh) * | 2018-12-27 | 2021-06-22 | 北京优迅医学检验实验室有限公司 | 测序深度的矫正方法及装置 |
| CN109584959B (zh) * | 2018-12-27 | 2020-10-27 | 北京优迅医学检验实验室有限公司 | 测序深度的矫正方法及装置 |
| KR20210119282A (ko) * | 2019-01-24 | 2021-10-05 | 일루미나, 인코포레이티드 | 장기 건강 및 질환을 모니터링하기 위한 방법 및 시스템 |
| ES3013495T3 (en) | 2019-01-31 | 2025-04-14 | Guardant Health Inc | Method for isolating and sequencing cell-free dna |
| EP3696278A1 (en) * | 2019-02-13 | 2020-08-19 | Nipd Genetics Public Company Limited | Method of determining the origin of nucleic acids in a mixed sample |
| EP3696279A1 (en) * | 2019-02-13 | 2020-08-19 | Nipd Genetics Public Company Limited | Methods for noninvasive prenatal testing of fetal abnormalities |
| US11396679B2 (en) | 2019-05-31 | 2022-07-26 | Universal Diagnostics, S.L. | Detection of colorectal cancer |
| US11001898B2 (en) | 2019-05-31 | 2021-05-11 | Universal Diagnostics, S.L. | Detection of colorectal cancer |
| KR102452413B1 (ko) * | 2019-08-19 | 2022-10-11 | 주식회사 지씨지놈 | 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법 |
| JP2022544626A (ja) * | 2019-08-19 | 2022-10-19 | グリーン クロス ゲノム コーポレーション | 核酸断片間距離情報を用いた染色体異常検出方法 |
| US11898199B2 (en) | 2019-11-11 | 2024-02-13 | Universal Diagnostics, S.A. | Detection of colorectal cancer and/or advanced adenomas |
| CN115298324A (zh) * | 2019-12-18 | 2022-11-04 | 香港中文大学 | 游离dna断裂和核酸酶 |
| US20230042332A1 (en) | 2019-12-24 | 2023-02-09 | Vib Vzw | Disease Detection in Liquid Biopsies |
| JP2023510318A (ja) * | 2020-01-08 | 2023-03-13 | ザ チャイニーズ ユニバーシティ オブ ホンコン | 無細胞試料の二末端dna断片タイプおよびその用途 |
| US20230053409A1 (en) * | 2020-01-09 | 2023-02-23 | Seoul National University R&Db Foundation | Atac-seq data normalization and method for utilizing same |
| GB2626687B (en) * | 2020-02-05 | 2024-10-16 | Univ Hong Kong Chinese | Molecular analyses using long cell-free fragments in pregnancy |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| CN111383757B (zh) * | 2020-03-04 | 2023-08-25 | 南京亿科人群健康研究院有限公司 | 一种计算机辅助开发包虫病诊断试剂盒的方法 |
| WO2021228418A1 (en) | 2020-05-15 | 2021-11-18 | Universal Diagnostics, S.L. | Methods and systems for identifying methylation biomarkers |
| CN111575347A (zh) * | 2020-05-19 | 2020-08-25 | 清华大学 | 构建用于同时获得血浆中游离dna甲基化和片段化模式信息的文库的方法 |
| EP4169025A4 (en) * | 2020-06-22 | 2024-07-10 | Children's Hospital Medical Center | De novo characterization of cell-free dna fragmentation hotspots in healthy and early-stage cancers |
| WO2022002424A1 (en) | 2020-06-30 | 2022-01-06 | Universal Diagnostics, S.L. | Systems and methods for detection of multiple cancer types |
| TW202242145A (zh) | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析 |
| TW202242130A (zh) | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 循環轉錄因子分析 |
| WO2022271730A1 (en) | 2021-06-21 | 2022-12-29 | Guardant Health, Inc. | Methods and compositions for copy-number informed tissue-of-origin analysis |
| EP4409024A1 (en) | 2021-09-30 | 2024-08-07 | Guardant Health, Inc. | Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements |
| US20250327130A1 (en) * | 2022-05-12 | 2025-10-23 | Delfi Diagnostics, Inc. | Use of cell-free dna fragmentomes in the diagnostic evaluation of patients with signs and symptoms suggestive of cancer |
| US20240011105A1 (en) * | 2022-07-08 | 2024-01-11 | The Chinese University Of Hong Kong | Analysis of microbial fragments in plasma |
| CN118028462B (zh) * | 2022-11-02 | 2025-04-15 | 深圳湾实验室 | 一种泛癌种血液诊断标志物及其应用 |
| TW202430650A (zh) * | 2022-11-29 | 2024-08-01 | 香港商創新診斷科技中心 | 尿液及血漿中之片段組學 |
| IL307784A (en) * | 2023-10-16 | 2025-05-01 | Identifai Genetics Ltd | Variants in the embryo using fragmentomics-based classification |
| CN117106857B (zh) * | 2023-10-24 | 2024-02-09 | 北京大学 | 一种血浆游离染色质的检测方法、试剂盒及其应用 |
| WO2025113619A1 (en) * | 2023-11-29 | 2025-06-05 | Centre For Novostics | Enrichment of clinically-relevant nucleic acids |
| WO2025137389A2 (en) | 2023-12-22 | 2025-06-26 | Guardant Health, Inc. | Methods for targeted single-molecule genetic and epigenetic sequencing |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1169347B1 (en) | 1999-04-02 | 2008-07-02 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
| US20030219765A1 (en) | 2000-03-23 | 2003-11-27 | Jose Costa | Methods for evaluating cancer risk |
| WO2003062441A1 (en) | 2002-01-18 | 2003-07-31 | Genzyme Corporation | Methods for fetal dna detection and allele quantitation |
| PL201608B1 (pl) | 2003-06-13 | 2009-04-30 | Cezary Cybulski | Sposób i zestaw do wykrywania wysokiej genetycznie uwarunkowanej predyspozycji do raka prostaty oraz zastosowanie zmiany germinalnej w obrębie genu NBS1 |
| CA2562310A1 (en) | 2004-04-30 | 2005-11-17 | Yale University | Methods and compositions for cancer diagnosis |
| EA010571B1 (ru) | 2006-08-15 | 2008-10-30 | Институт Молекулярной Генетики Российской Академии Наук (Имг Ран) | Способ диагностики немелкоклеточного рака легких и набор для его осуществления |
| US8580501B2 (en) | 2007-05-25 | 2013-11-12 | Decode Genetics Ehf. | Genetic variants on chr 5p12 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment |
| CN106834481A (zh) | 2007-07-23 | 2017-06-13 | 香港中文大学 | 用于分析遗传变异的方法 |
| EP2824191A3 (en) | 2009-10-26 | 2015-02-18 | Lifecodexx AG | Means and methods for non-invasive diagnosis of chromosomal aneuploidy |
| EP2496717B1 (en) | 2009-11-05 | 2017-06-07 | The Chinese University of Hong Kong | Fetal genomic analysis from a maternal biological sample |
| ES3026544T3 (en) | 2009-11-06 | 2025-06-11 | Univ Hong Kong Chinese | Size-based genomic analysis for prenatal diagnosis |
| KR102040307B1 (ko) | 2010-11-30 | 2019-11-27 | 더 차이니즈 유니버시티 오브 홍콩 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| WO2013052913A2 (en) | 2011-10-06 | 2013-04-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| WO2013060762A1 (en) | 2011-10-25 | 2013-05-02 | Roche Diagnostics Gmbh | Method for diagnosing a disease based on plasma-dna distribution |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| WO2013177581A2 (en) | 2012-05-24 | 2013-11-28 | University Of Washington Through Its Center For Commercialization | Whole genome sequencing of a human fetus |
| US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| EP4424826A3 (en) * | 2012-09-04 | 2024-11-27 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US9732390B2 (en) * | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| CA2884066C (en) * | 2012-09-20 | 2021-08-10 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| CN105339507A (zh) | 2013-02-21 | 2016-02-17 | 托马生物科学公司 | 用于核酸分析的方法、组合物和试剂盒 |
| CA2906818C (en) | 2013-03-15 | 2022-08-16 | Verinata Health, Inc. | Generating cell-free dna libraries directly from blood |
| CN103215350B (zh) * | 2013-03-26 | 2016-11-02 | 苏州贝康医疗器械有限公司 | 一种基于单核苷酸多态性位点的孕妇血浆中胎儿dna含量的测定方法 |
| US10174375B2 (en) | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
| US10262755B2 (en) | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
| EP3055427B1 (en) | 2013-10-07 | 2018-09-12 | Sequenom, Inc. | Methods and processes for non-invasive assessment of chromosome alterations |
| US20160002717A1 (en) | 2014-07-02 | 2016-01-07 | Boreal Genomics, Inc. | Determining mutation burden in circulating cell-free nucleic acid and associated risk of disease |
| WO2016008451A1 (en) | 2014-07-18 | 2016-01-21 | The Chinese University Of Hong Kong | Methylation pattern analysis of tissues in dna mixture |
| KR102696857B1 (ko) | 2014-07-25 | 2024-08-19 | 유니버시티 오브 워싱톤 | 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법 |
| EP3224380A1 (en) | 2014-11-25 | 2017-10-04 | The Broad Institute Inc. | Clonal haematopoiesis |
| ES2989276T3 (es) | 2014-12-05 | 2024-11-25 | Found Medicine Inc | Análisis multigénico de muestras tumorales |
| EP4574996B1 (en) | 2014-12-31 | 2025-11-05 | Guardant Health, Inc. | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
| ES2908347T3 (es) | 2015-02-10 | 2022-04-28 | Univ Hong Kong Chinese | Detección de mutaciones para cribado de cáncer y análisis fetal |
| WO2016149261A1 (en) | 2015-03-16 | 2016-09-22 | Personal Genome Diagnostics, Inc. | Systems and methods for analyzing nucleic acid |
| PT3967775T (pt) | 2015-07-23 | 2023-10-10 | Univ Hong Kong Chinese | Análise de padrões de fragmentação de adn sem células |
| US12234454B2 (en) | 2015-10-22 | 2025-02-25 | The Broad Institute, Inc. | Crispr enzymes and systems |
| EP4322168A3 (en) | 2016-07-06 | 2024-05-15 | Guardant Health, Inc. | Methods for fragmentome profiling of cell-free nucleic acids |
| ES2983411T3 (es) | 2016-12-13 | 2024-10-23 | Bellwether Bio Inc | Determinación de un estado fisiológico en un individuo analizando los puntos finales de fragmentos de ADN libre de células en una muestra biológica |
| EP3997242A4 (en) | 2019-07-09 | 2023-08-02 | The Translational Genomics Research Institute | Methods of detecting disease and treatment response in cfdna |
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