DK3967775T3 - Analyse af fragmenteringsmønstre af cellefrit DNA - Google Patents

Analyse af fragmenteringsmønstre af cellefrit DNA Download PDF

Info

Publication number
DK3967775T3
DK3967775T3 DK21196292.3T DK21196292T DK3967775T3 DK 3967775 T3 DK3967775 T3 DK 3967775T3 DK 21196292 T DK21196292 T DK 21196292T DK 3967775 T3 DK3967775 T3 DK 3967775T3
Authority
DK
Denmark
Prior art keywords
analysis
cell
free dna
fragmentation patterns
fragmentation
Prior art date
Application number
DK21196292.3T
Other languages
English (en)
Inventor
Yuk-Ming Dennis Lo
Rossa Wai Kwun Chiu
Kwan Chee Chan
Peiyong Jiang
Original Assignee
Univ Hong Kong Chinese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2016/073753 external-priority patent/WO2016127944A1/en
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Application granted granted Critical
Publication of DK3967775T3 publication Critical patent/DK3967775T3/da

Links

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10Sequence alignment; Homology search
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10Ploidy or copy number detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Bioethics (AREA)
  • Artificial Intelligence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK21196292.3T 2015-07-23 2016-07-25 Analyse af fragmenteringsmønstre af cellefrit DNA DK3967775T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562196250P 2015-07-23 2015-07-23
US201662294948P 2016-02-12 2016-02-12
PCT/CN2016/073753 WO2016127944A1 (en) 2015-02-10 2016-02-14 Detecting mutations for cancer screening and fetal analysis
EP16827283.9A EP3325664B1 (en) 2015-07-23 2016-07-25 Analysis of fragmentation patterns of cell-free dna

Publications (1)

Publication Number Publication Date
DK3967775T3 true DK3967775T3 (da) 2023-10-02

Family

ID=57833803

Family Applications (2)

Application Number Title Priority Date Filing Date
DK21196292.3T DK3967775T3 (da) 2015-07-23 2016-07-25 Analyse af fragmenteringsmønstre af cellefrit DNA
DK16827283.9T DK3325664T3 (da) 2015-07-23 2016-07-25 Analyse af fragmenteringsmønstre for cellefrit DNA

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK16827283.9T DK3325664T3 (da) 2015-07-23 2016-07-25 Analyse af fragmenteringsmønstre for cellefrit DNA

Country Status (16)

Country Link
US (5) US10453556B2 (da)
EP (3) EP4279612B1 (da)
JP (3) JP6931236B2 (da)
KR (1) KR20180031742A (da)
CN (2) CN108026572B (da)
AU (2) AU2016295616B2 (da)
CA (1) CA2993362A1 (da)
DK (2) DK3967775T3 (da)
ES (2) ES2960201T3 (da)
FI (1) FI3967775T3 (da)
HU (2) HUE057821T2 (da)
IL (3) IL288622B2 (da)
PT (2) PT3967775T (da)
SG (1) SG10202106935UA (da)
TW (3) TW202332776A (da)
WO (1) WO2017012592A1 (da)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014093330A1 (en) 2012-12-10 2014-06-19 Clearfork Bioscience, Inc. Methods for targeted genomic analysis
WO2016008451A1 (en) 2014-07-18 2016-01-21 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in dna mixture
KR102696857B1 (ko) 2014-07-25 2024-08-19 유니버시티 오브 워싱톤 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
US10364467B2 (en) * 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
PT3967775T (pt) 2015-07-23 2023-10-10 Univ Hong Kong Chinese Análise de padrões de fragmentação de adn sem células
IL285202B2 (en) 2015-11-11 2025-03-01 Resolution Bioscience Inc High-efficiency construction of DNA libraries
US20190287645A1 (en) * 2016-07-06 2019-09-19 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
MX2019002093A (es) 2016-08-25 2019-06-20 Resolution Bioscience Inc Métodos para la detección de cambios de copia genómica en muestras de adn.
KR20240155386A (ko) 2016-09-30 2024-10-28 가던트 헬쓰, 인크. 무세포 핵산의 다중-해상도 분석 방법
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
EP3535415A4 (en) 2016-10-24 2020-07-01 The Chinese University of Hong Kong TUMOR DETECTION METHODS AND SYSTEMS
AU2017369018B2 (en) 2016-11-30 2021-02-25 The Chinese University Of Hong Kong Analysis of cell-free DNA in urine and other samples
WO2018137685A1 (en) * 2017-01-25 2018-08-02 The Chinese University Of Hong Kong Diagnostic applications using nucleic acid fragments
EP3635133A4 (en) * 2017-06-09 2021-03-03 Bellwether Bio, Inc. DETERMINATION OF THE TYPE OF CANCER IN A SUBJECT BY PROBABILISTIC MODELING OF END POINTS OF CIRCULATING NUCLEIC ACID FRAGMENT
EP3635134A4 (en) * 2017-06-09 2021-03-03 Bellwether Bio, Inc. DIAGNOSTIC CANCER OR OTHER PHYSIOLOGICAL CONDITIONS USING CIRCULATING NUCLEIC ACID FRAGMENT SENTINEL END POINTS
CN111051536A (zh) 2017-07-26 2020-04-21 香港中文大学 利用不含细胞的病毒核酸改善癌症筛选
US20200263170A1 (en) 2017-09-14 2020-08-20 Grail, Inc. Methods for preparing a sequencing library from single-stranded dna
EP3688191B1 (en) 2017-09-28 2022-03-02 Grail, LLC Enrichment of short nucleic acid fragments in sequencing library preparation
CN119753091A (zh) 2018-04-02 2025-04-04 格里尔公司 用于扩增与癌症相关联的cfDNA分子的化验板
EP3784806A4 (en) * 2018-04-24 2022-01-19 Grail, LLC SYSTEMS AND METHODS OF USING A PATHOGENIC NUCLEIC ACID LOAD TO DETERMINE IF A SUBJECT HAS A CANCER CONDITION
WO2019210873A1 (en) 2018-05-03 2019-11-07 The Chinese University Of Hong Kong Size-tagged preferred ends and orientation-aware analysis for measuring properties of cell-free mixtures
CN112805563B (zh) 2018-05-18 2025-06-13 约翰·霍普金斯大学 用于评估和/或治疗癌症的无细胞dna
TW202022123A (zh) * 2018-07-23 2020-06-16 香港中文大學 游離dna損傷分析及其臨床應用
US20210207229A1 (en) * 2018-07-27 2021-07-08 Seekln, Inc. Hepatocellular carcinoma screening
EP3856903A4 (en) 2018-09-27 2022-07-27 Grail, LLC METHYLATION MARKER AND TARGETED METHYLATION PROBE PANEL
CA3123474A1 (en) * 2018-12-19 2020-06-25 The Chinese University Of Hong Kong Cell-free dna end characteristics
CN109767813B (zh) * 2018-12-27 2021-06-22 北京优迅医学检验实验室有限公司 测序深度的矫正方法及装置
CN109584959B (zh) * 2018-12-27 2020-10-27 北京优迅医学检验实验室有限公司 测序深度的矫正方法及装置
KR20210119282A (ko) * 2019-01-24 2021-10-05 일루미나, 인코포레이티드 장기 건강 및 질환을 모니터링하기 위한 방법 및 시스템
ES3013495T3 (en) 2019-01-31 2025-04-14 Guardant Health Inc Method for isolating and sequencing cell-free dna
EP3696278A1 (en) * 2019-02-13 2020-08-19 Nipd Genetics Public Company Limited Method of determining the origin of nucleic acids in a mixed sample
EP3696279A1 (en) * 2019-02-13 2020-08-19 Nipd Genetics Public Company Limited Methods for noninvasive prenatal testing of fetal abnormalities
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
US11001898B2 (en) 2019-05-31 2021-05-11 Universal Diagnostics, S.L. Detection of colorectal cancer
KR102452413B1 (ko) * 2019-08-19 2022-10-11 주식회사 지씨지놈 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법
JP2022544626A (ja) * 2019-08-19 2022-10-19 グリーン クロス ゲノム コーポレーション 核酸断片間距離情報を用いた染色体異常検出方法
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
CN115298324A (zh) * 2019-12-18 2022-11-04 香港中文大学 游离dna断裂和核酸酶
US20230042332A1 (en) 2019-12-24 2023-02-09 Vib Vzw Disease Detection in Liquid Biopsies
JP2023510318A (ja) * 2020-01-08 2023-03-13 ザ チャイニーズ ユニバーシティ オブ ホンコン 無細胞試料の二末端dna断片タイプおよびその用途
US20230053409A1 (en) * 2020-01-09 2023-02-23 Seoul National University R&Db Foundation Atac-seq data normalization and method for utilizing same
GB2626687B (en) * 2020-02-05 2024-10-16 Univ Hong Kong Chinese Molecular analyses using long cell-free fragments in pregnancy
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
CN111383757B (zh) * 2020-03-04 2023-08-25 南京亿科人群健康研究院有限公司 一种计算机辅助开发包虫病诊断试剂盒的方法
WO2021228418A1 (en) 2020-05-15 2021-11-18 Universal Diagnostics, S.L. Methods and systems for identifying methylation biomarkers
CN111575347A (zh) * 2020-05-19 2020-08-25 清华大学 构建用于同时获得血浆中游离dna甲基化和片段化模式信息的文库的方法
EP4169025A4 (en) * 2020-06-22 2024-07-10 Children's Hospital Medical Center De novo characterization of cell-free dna fragmentation hotspots in healthy and early-stage cancers
WO2022002424A1 (en) 2020-06-30 2022-01-06 Universal Diagnostics, S.L. Systems and methods for detection of multiple cancer types
TW202242145A (zh) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析
TW202242130A (zh) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 循環轉錄因子分析
WO2022271730A1 (en) 2021-06-21 2022-12-29 Guardant Health, Inc. Methods and compositions for copy-number informed tissue-of-origin analysis
EP4409024A1 (en) 2021-09-30 2024-08-07 Guardant Health, Inc. Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements
US20250327130A1 (en) * 2022-05-12 2025-10-23 Delfi Diagnostics, Inc. Use of cell-free dna fragmentomes in the diagnostic evaluation of patients with signs and symptoms suggestive of cancer
US20240011105A1 (en) * 2022-07-08 2024-01-11 The Chinese University Of Hong Kong Analysis of microbial fragments in plasma
CN118028462B (zh) * 2022-11-02 2025-04-15 深圳湾实验室 一种泛癌种血液诊断标志物及其应用
TW202430650A (zh) * 2022-11-29 2024-08-01 香港商創新診斷科技中心 尿液及血漿中之片段組學
IL307784A (en) * 2023-10-16 2025-05-01 Identifai Genetics Ltd Variants in the embryo using fragmentomics-based classification
CN117106857B (zh) * 2023-10-24 2024-02-09 北京大学 一种血浆游离染色质的检测方法、试剂盒及其应用
WO2025113619A1 (en) * 2023-11-29 2025-06-05 Centre For Novostics Enrichment of clinically-relevant nucleic acids
WO2025137389A2 (en) 2023-12-22 2025-06-26 Guardant Health, Inc. Methods for targeted single-molecule genetic and epigenetic sequencing

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1169347B1 (en) 1999-04-02 2008-07-02 Corixa Corporation Compounds and methods for therapy and diagnosis of lung cancer
US20030219765A1 (en) 2000-03-23 2003-11-27 Jose Costa Methods for evaluating cancer risk
WO2003062441A1 (en) 2002-01-18 2003-07-31 Genzyme Corporation Methods for fetal dna detection and allele quantitation
PL201608B1 (pl) 2003-06-13 2009-04-30 Cezary Cybulski Sposób i zestaw do wykrywania wysokiej genetycznie uwarunkowanej predyspozycji do raka prostaty oraz zastosowanie zmiany germinalnej w obrębie genu NBS1
CA2562310A1 (en) 2004-04-30 2005-11-17 Yale University Methods and compositions for cancer diagnosis
EA010571B1 (ru) 2006-08-15 2008-10-30 Институт Молекулярной Генетики Российской Академии Наук (Имг Ран) Способ диагностики немелкоклеточного рака легких и набор для его осуществления
US8580501B2 (en) 2007-05-25 2013-11-12 Decode Genetics Ehf. Genetic variants on chr 5p12 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment
CN106834481A (zh) 2007-07-23 2017-06-13 香港中文大学 用于分析遗传变异的方法
EP2824191A3 (en) 2009-10-26 2015-02-18 Lifecodexx AG Means and methods for non-invasive diagnosis of chromosomal aneuploidy
EP2496717B1 (en) 2009-11-05 2017-06-07 The Chinese University of Hong Kong Fetal genomic analysis from a maternal biological sample
ES3026544T3 (en) 2009-11-06 2025-06-11 Univ Hong Kong Chinese Size-based genomic analysis for prenatal diagnosis
KR102040307B1 (ko) 2010-11-30 2019-11-27 더 차이니즈 유니버시티 오브 홍콩 암과 연관된 유전적 또는 분자적 이상들의 검출
WO2013052913A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013060762A1 (en) 2011-10-25 2013-05-02 Roche Diagnostics Gmbh Method for diagnosing a disease based on plasma-dna distribution
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
WO2013177581A2 (en) 2012-05-24 2013-11-28 University Of Washington Through Its Center For Commercialization Whole genome sequencing of a human fetus
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
EP4424826A3 (en) * 2012-09-04 2024-11-27 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US9732390B2 (en) * 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
CA2884066C (en) * 2012-09-20 2021-08-10 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
CN105339507A (zh) 2013-02-21 2016-02-17 托马生物科学公司 用于核酸分析的方法、组合物和试剂盒
CA2906818C (en) 2013-03-15 2022-08-16 Verinata Health, Inc. Generating cell-free dna libraries directly from blood
CN103215350B (zh) * 2013-03-26 2016-11-02 苏州贝康医疗器械有限公司 一种基于单核苷酸多态性位点的孕妇血浆中胎儿dna含量的测定方法
US10174375B2 (en) 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
EP3055427B1 (en) 2013-10-07 2018-09-12 Sequenom, Inc. Methods and processes for non-invasive assessment of chromosome alterations
US20160002717A1 (en) 2014-07-02 2016-01-07 Boreal Genomics, Inc. Determining mutation burden in circulating cell-free nucleic acid and associated risk of disease
WO2016008451A1 (en) 2014-07-18 2016-01-21 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in dna mixture
KR102696857B1 (ko) 2014-07-25 2024-08-19 유니버시티 오브 워싱톤 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법
EP3224380A1 (en) 2014-11-25 2017-10-04 The Broad Institute Inc. Clonal haematopoiesis
ES2989276T3 (es) 2014-12-05 2024-11-25 Found Medicine Inc Análisis multigénico de muestras tumorales
EP4574996B1 (en) 2014-12-31 2025-11-05 Guardant Health, Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
ES2908347T3 (es) 2015-02-10 2022-04-28 Univ Hong Kong Chinese Detección de mutaciones para cribado de cáncer y análisis fetal
WO2016149261A1 (en) 2015-03-16 2016-09-22 Personal Genome Diagnostics, Inc. Systems and methods for analyzing nucleic acid
PT3967775T (pt) 2015-07-23 2023-10-10 Univ Hong Kong Chinese Análise de padrões de fragmentação de adn sem células
US12234454B2 (en) 2015-10-22 2025-02-25 The Broad Institute, Inc. Crispr enzymes and systems
EP4322168A3 (en) 2016-07-06 2024-05-15 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
ES2983411T3 (es) 2016-12-13 2024-10-23 Bellwether Bio Inc Determinación de un estado fisiológico en un individuo analizando los puntos finales de fragmentos de ADN libre de células en una muestra biológica
EP3997242A4 (en) 2019-07-09 2023-08-02 The Translational Genomics Research Institute Methods of detecting disease and treatment response in cfdna

Also Published As

Publication number Publication date
IL288622A (en) 2022-02-01
IL288622B2 (en) 2024-03-01
TW201718872A (zh) 2017-06-01
US20230197201A1 (en) 2023-06-22
EP3967775A1 (en) 2022-03-16
CN108026572A (zh) 2018-05-11
JP7645558B2 (ja) 2025-03-14
WO2017012592A1 (en) 2017-01-26
EP3325664B1 (en) 2021-12-29
TW202142697A (zh) 2021-11-16
US20200005895A1 (en) 2020-01-02
EP3325664A1 (en) 2018-05-30
KR20180031742A (ko) 2018-03-28
JP6931236B2 (ja) 2021-09-01
AU2016295616A1 (en) 2018-02-15
IL288622B1 (en) 2023-11-01
ES2960201T3 (es) 2024-03-01
HK1247645A1 (en) 2018-09-28
EP3967775B1 (en) 2023-08-23
HUE064231T2 (hu) 2024-02-28
US11581063B2 (en) 2023-02-14
US11615865B2 (en) 2023-03-28
EP4279612B1 (en) 2025-07-02
PT3325664T (pt) 2022-03-03
TWI802886B (zh) 2023-05-21
HK1251264A1 (zh) 2019-01-25
US20200005896A1 (en) 2020-01-02
US11605445B2 (en) 2023-03-14
AU2022224861B2 (en) 2025-04-03
US10453556B2 (en) 2019-10-22
AU2016295616B2 (en) 2022-06-02
JP2023109862A (ja) 2023-08-08
IL257055B (en) 2022-01-01
TWI730973B (zh) 2021-06-21
US20170024513A1 (en) 2017-01-26
FI3967775T3 (fi) 2023-09-25
IL257055A (en) 2018-03-29
EP3325664A4 (en) 2019-01-02
TW202332776A (zh) 2023-08-16
HUE057821T2 (hu) 2022-06-28
CN108026572B (zh) 2022-07-01
JP7284522B2 (ja) 2023-05-31
AU2022224861A1 (en) 2022-10-20
JP2018524991A (ja) 2018-09-06
IL305462A (en) 2023-10-01
EP4279612A3 (en) 2024-02-28
DK3325664T3 (da) 2022-03-07
CN114999567A (zh) 2022-09-02
US20200005897A1 (en) 2020-01-02
PT3967775T (pt) 2023-10-10
EP4279612A2 (en) 2023-11-22
JP2021184732A (ja) 2021-12-09
SG10202106935UA (en) 2021-08-30
CA2993362A1 (en) 2017-01-26
ES2907697T3 (es) 2022-04-26

Similar Documents

Publication Publication Date Title
DK3967775T3 (da) Analyse af fragmenteringsmønstre af cellefrit DNA
EP3323070A4 (en) Neo-antigen-ANALYSIS
MA42847A (fr) Analyse de micro-moment
DK3433368T3 (da) Transreplikerende rna
PL3445850T3 (pl) Sposoby otrzymywania jednoniciowego rna
DK3497117T5 (da) Nye alkalisk stabile immunglobulin-bindende proteiner
IL255238B (en) Combinations of cannabinoids and n-acylethanolamines
EP3108229C0 (en) NANOPORES-BASED ANALYSIS OF PROTEIN CHARACTERISTICS
DK3384287T3 (da) Forbedrede cytometriske analyser
MA43957A (fr) Biomarqueurs de copanlisib
DK3307436T3 (da) Mikrofluidanordning
EP3535230A4 (en) IMPROVED PERFORMANCE OF TECHNICAL CERAMICS
EP3342870A4 (en) CORYNEBACTERIUM
DK3325502T3 (da) Ny art af tobamovirus
EP3338088A4 (en) BIOMARKER FOR CORONARY DISEASE
IL254502B (en) Solid forms of menaquinols
DK3430004T3 (da) Faststofformer af nilotinibsalte
EP3374042A4 (en) ANALYSIS OF SWIMMING TECHNOLOGY
EP3342869A4 (en) CORYNEBACTERIUM
ES1214960Y (es) Cilindro de gas
DK3073409T3 (da) Maskering af forskellige indholdstyper
EP3308892A4 (en) REIBE
DK3253769T3 (da) Hidtil ukendte polymorfer
LT3493849T (lt) N,n-bis-2-merkaptoetilizoftalamido naujas panaudojimas
ITUB20153989A1 (it) Marcatrice