HK1251264A1 - 游離dna的片段化模式的分析 - Google Patents

游離dna的片段化模式的分析

Info

Publication number
HK1251264A1
HK1251264A1 HK18110681.3A HK18110681A HK1251264A1 HK 1251264 A1 HK1251264 A1 HK 1251264A1 HK 18110681 A HK18110681 A HK 18110681A HK 1251264 A1 HK1251264 A1 HK 1251264A1
Authority
HK
Hong Kong
Prior art keywords
analysis
cell
free dna
fragmentation patterns
fragmentation
Prior art date
Application number
HK18110681.3A
Other languages
English (en)
Inventor
盧煜明
趙慧君
陳君賜
江培勇
Original Assignee
香港中文大學
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2016/073753 external-priority patent/WO2016127944A1/en
Application filed by 香港中文大學 filed Critical 香港中文大學
Publication of HK1251264A1 publication Critical patent/HK1251264A1/zh

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HK18110681.3A 2015-07-23 2018-08-20 游離dna的片段化模式的分析 HK1251264A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562196250P 2015-07-23 2015-07-23
US201662294948P 2016-02-12 2016-02-12
PCT/CN2016/073753 WO2016127944A1 (en) 2015-02-10 2016-02-14 Detecting mutations for cancer screening and fetal analysis
PCT/CN2016/091531 WO2017012592A1 (en) 2015-07-23 2016-07-25 Analysis of fragmentation patterns of cell-free dna

Publications (1)

Publication Number Publication Date
HK1251264A1 true HK1251264A1 (zh) 2019-01-25

Family

ID=57833803

Family Applications (2)

Application Number Title Priority Date Filing Date
HK18107189.6A HK1247645A1 (zh) 2015-07-23 2018-05-31 游離dna的片段化模式的分析
HK18110681.3A HK1251264A1 (zh) 2015-07-23 2018-08-20 游離dna的片段化模式的分析

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK18107189.6A HK1247645A1 (zh) 2015-07-23 2018-05-31 游離dna的片段化模式的分析

Country Status (17)

Country Link
US (5) US10453556B2 (zh)
EP (3) EP3325664B1 (zh)
JP (3) JP6931236B2 (zh)
KR (1) KR20180031742A (zh)
CN (2) CN114999567A (zh)
AU (2) AU2016295616B2 (zh)
CA (1) CA2993362A1 (zh)
DK (2) DK3967775T3 (zh)
ES (2) ES2907697T3 (zh)
FI (1) FI3967775T3 (zh)
HK (2) HK1247645A1 (zh)
HU (2) HUE064231T2 (zh)
IL (3) IL288622B2 (zh)
PT (2) PT3325664T (zh)
SG (1) SG10202106935UA (zh)
TW (3) TWI730973B (zh)
WO (1) WO2017012592A1 (zh)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105531375B (zh) 2012-12-10 2020-03-03 分析生物科学有限公司 靶向基因组分析的方法
TWI758011B (zh) 2014-07-18 2022-03-11 香港中文大學 Ｄｎａ混合物中之組織甲基化模式分析
US20170211143A1 (en) 2014-07-25 2017-07-27 University Of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
US10364467B2 (en) * 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
WO2017012592A1 (en) 2015-07-23 2017-01-26 The Chinese University Of Hong Kong Analysis of fragmentation patterns of cell-free dna
EP3889257A1 (en) 2015-11-11 2021-10-06 Resolution Bioscience, Inc. High efficiency construction of dna libraries
US20190287645A1 (en) * 2016-07-06 2019-09-19 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
BR112019003704A2 (pt) 2016-08-25 2019-05-28 Resolution Bioscience Inc métodos para a detecção de alterações na cópia genômica em amostras de dna
US20200013482A1 (en) 2016-09-30 2020-01-09 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
MY195527A (en) 2016-10-24 2023-01-30 Grail Inc Methods And Systems For Tumor Detection
EP3548632A4 (en) 2016-11-30 2020-06-24 The Chinese University Of Hong Kong ANALYSIS OF CELLULAR DNA IN URINE AND OTHER SAMPLES
EP3574108A4 (en) 2017-01-25 2020-12-23 The Chinese University Of Hong Kong DIAGNOSTIC APPLICATIONS WITH THE USE OF NUCLEIC ACID FRAGMENTS
EP3635133A4 (en) * 2017-06-09 2021-03-03 Bellwether Bio, Inc. DETERMINATION OF THE TYPE OF CANCER IN A SUBJECT BY PROBABILISTIC MODELING OF END POINTS OF CIRCULATING NUCLEIC ACID FRAGMENT
WO2018227211A1 (en) * 2017-06-09 2018-12-13 Bellwether Bio, Inc. Diagnosis of cancer or other physiological condition using circulating nucleic acid fragment sentinel endpoints
KR20200035427A (ko) * 2017-07-26 2020-04-03 더 차이니즈 유니버시티 오브 홍콩 세포-무함유 바이러스 핵산을 사용하는 암 스크리닝의 증강
US20200263170A1 (en) 2017-09-14 2020-08-20 Grail, Inc. Methods for preparing a sequencing library from single-stranded dna
EP4269583A3 (en) 2017-09-28 2024-01-17 Grail, LLC Enrichment of short nucleic acid fragments in sequencing library preparation
TW202012639A (zh) * 2018-04-24 2020-04-01 美商格瑞爾公司 使用病原體核酸負荷確定個體是否患有癌症病況的系統及方法
US20190341127A1 (en) * 2018-05-03 2019-11-07 The Chinese University Of Hong Kong Size-tagged preferred ends and orientation-aware analysis for measuring properties of cell-free mixtures
JP2021525069A (ja) 2018-05-18 2021-09-24 ザ ジョンズ ホプキンス ユニバーシティ 癌を査定および／または処置するためのセルフリーｄｎａ
KR20210039406A (ko) * 2018-07-23 2021-04-09 더 차이니즈 유니버시티 오브 홍콩 세포-프리 dna 손상 분석 및 이의 임상적 적용
CN111742063A (zh) * 2018-07-27 2020-10-02 思勤有限公司 肝细胞癌筛查
EP3856903A4 (en) 2018-09-27 2022-07-27 Grail, LLC METHYLATION MARKER AND TARGETED METHYLATION PROBE PANEL
JP2022514879A (ja) 2018-12-19 2022-02-16 ザ チャイニーズ ユニバーシティ オブ ホンコン 無細胞ｄｎａ末端特性
CN109584959B (zh) * 2018-12-27 2020-10-27 北京优迅医学检验实验室有限公司 测序深度的矫正方法及装置
CN109767813B (zh) * 2018-12-27 2021-06-22 北京优迅医学检验实验室有限公司 测序深度的矫正方法及装置
CN112424372A (zh) * 2019-01-24 2021-02-26 Illumina公司 用于监测器官健康和疾病的方法和系统
WO2020160414A1 (en) 2019-01-31 2020-08-06 Guardant Health, Inc. Compositions and methods for isolating cell-free dna
EP3696278A1 (en) * 2019-02-13 2020-08-19 Nipd Genetics Public Company Limited Method of determining the origin of nucleic acids in a mixed sample
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
US11001898B2 (en) 2019-05-31 2021-05-11 Universal Diagnostics, S.L. Detection of colorectal cancer
EP4020484A4 (en) * 2019-08-19 2023-08-30 Green Cross Genome Corporation METHOD FOR DETECTING A CHROMOSOME ABNORMALITY USING INFORMATION CONCERNING THE DISTANCE BETWEEN NUCLEIC ACID FRAGMENTS
KR102452413B1 (ko) * 2019-08-19 2022-10-11 주식회사 지씨지놈 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
CN115298324A (zh) * 2019-12-18 2022-11-04 香港中文大学 游离dna断裂和核酸酶
WO2021130356A1 (en) 2019-12-24 2021-07-01 Vib Vzw Disease detection in liquid biopsies
AU2021205853A1 (en) * 2020-01-08 2023-11-23 Grail, Inc. Biterminal dna fragment types in cell-free samples and uses thereof
WO2021141220A1 (ko) * 2020-01-09 2021-07-15 서울대학교 산학협력단 ATAC-seq 데이터 정규화 및 이의 활용 방법
CA3164433A1 (en) * 2020-02-05 2021-08-12 Yuk-Ming Dennis Lo Molecular analyses using long cell-free fragments in pregnancy
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
CN111383757B (zh) * 2020-03-04 2023-08-25 南京亿科人群健康研究院有限公司 一种计算机辅助开发包虫病诊断试剂盒的方法
CN111575347A (zh) * 2020-05-19 2020-08-25 清华大学 构建用于同时获得血浆中游离dna甲基化和片段化模式信息的文库的方法
WO2021262770A1 (en) * 2020-06-22 2021-12-30 Children's Hospital Medical Center De novo characterization of cell-free dna fragmentation hotspots in healthy and early-stage cancers
WO2022002424A1 (en) 2020-06-30 2022-01-06 Universal Diagnostics, S.L. Systems and methods for detection of multiple cancer types
TW202242130A (zh) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 循環轉錄因子分析
TW202242145A (zh) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析
EP4359562A1 (en) 2021-06-21 2024-05-01 Guardant Health, Inc. Methods and compositions for copy-number informed tissue-of-origin analysis
WO2023056065A1 (en) 2021-09-30 2023-04-06 Guardant Health, Inc. Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements
WO2023220414A1 (en) * 2022-05-12 2023-11-16 Delfi Diagnostics, Inc. Use of cell-free dna fragmentomes in the diagnostic evaluation of patients with signs and symptoms suggestive of cancer
US20240011105A1 (en) * 2022-07-08 2024-01-11 The Chinese University Of Hong Kong Analysis of microbial fragments in plasma
CN118028462A (zh) * 2022-11-02 2024-05-14 深圳湾实验室 一种泛癌种血液诊断标志物及其应用
US20240182982A1 (en) * 2022-11-29 2024-06-06 Centre For Novostics Fragmentomics in urine and plasma
CN117106857B (zh) * 2023-10-24 2024-02-09 北京大学 一种血浆游离染色质的检测方法、试剂盒及其应用

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2308976T3 (es) 1999-04-02 2008-12-16 Corixa Corporation Compuestos y metodos para la terapia y el diagnostico del cancer de pulmon.
US20030219765A1 (en) 2000-03-23 2003-11-27 Jose Costa Methods for evaluating cancer risk
WO2003062441A1 (en) 2002-01-18 2003-07-31 Genzyme Corporation Methods for fetal dna detection and allele quantitation
PL201608B1 (pl) 2003-06-13 2009-04-30 Cezary Cybulski Sposób i zestaw do wykrywania wysokiej genetycznie uwarunkowanej predyspozycji do raka prostaty oraz zastosowanie zmiany germinalnej w obrębie genu NBS1
WO2005108621A1 (en) 2004-04-30 2005-11-17 Yale University Methods and compositions for cancer diagnosis
WO2008024009A1 (fr) 2006-08-15 2008-02-28 Institut Molekulyarnoi Genetiki Rossiiskoi Akademii Nauk (Img Ran) Niveau de transcription du gène timp3 utilisé en tant que marqueur servant à diagnostiquer le cancer du poumon non à petites cellules
NZ581858A (en) 2007-05-25 2012-07-27 Decode Genetics Ehf Genetic variants on chr 5p12 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment
PL2557520T3 (pl) 2007-07-23 2021-10-11 The Chinese University Of Hong Kong Określanie zaburzenia równowagi sekwencji kwasu nukleinowego
EP2494065B1 (en) 2009-10-26 2015-12-23 Lifecodexx AG Means and methods for non-invasive diagnosis of chromosomal aneuploidy
HUE061110T2 (hu) 2009-11-05 2023-05-28 Univ Hong Kong Chinese Magzati genomelemzés anyai biológiai mintából
JP5770737B2 (ja) 2009-11-06 2015-08-26 ザ チャイニーズ ユニバーシティ オブ ホンコン サイズに基づくゲノム分析
CA2817370C (en) 2010-11-30 2022-02-01 The Chinese University Of Hong Kong Detection of genetic or molecular aberrations associated with cancer
JP6073902B2 (ja) 2011-10-06 2017-02-01 セクエノム， インコーポレイテッド 遺伝的変異の非侵襲的評価のための方法およびプロセス
EP2771483A1 (en) 2011-10-25 2014-09-03 ONCOTYROL - Center for Personalized Cancer Medicine GmbH Method for diagnosing a disease based on plasma-dna distribution
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
WO2013177581A2 (en) 2012-05-24 2013-11-28 University Of Washington Through Its Center For Commercialization Whole genome sequencing of a human fetus
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
EP4036247B1 (en) 2012-09-04 2024-04-10 Guardant Health, Inc. Methods to detect rare mutations and copy number variation
NZ717423A (en) * 2012-09-20 2017-08-25 Univ Hong Kong Chinese Non-invasive determination of methylome of fetus or tumor from plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US20160186267A1 (en) 2013-02-21 2016-06-30 Toma Biosciences, Inc. Methods, compositions, and kits for nucleic acid analysis
EP2971097B1 (en) 2013-03-15 2018-08-01 Verinata Health, Inc Generating cell-free dna libraries directly from blood
CN103215350B (zh) * 2013-03-26 2016-11-02 苏州贝康医疗器械有限公司 一种基于单核苷酸多态性位点的孕妇血浆中胎儿dna含量的测定方法
US10174375B2 (en) 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
EP3495496B1 (en) 2013-10-07 2020-11-25 Sequenom, Inc. Methods and processes for non-invasive assessment of chromosome alterations
US20160002717A1 (en) 2014-07-02 2016-01-07 Boreal Genomics, Inc. Determining mutation burden in circulating cell-free nucleic acid and associated risk of disease
TWI758011B (zh) 2014-07-18 2022-03-11 香港中文大學 Ｄｎａ混合物中之組織甲基化模式分析
US20170211143A1 (en) 2014-07-25 2017-07-27 University Of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
US10683552B2 (en) 2014-11-25 2020-06-16 Presidents And Fellows Of Harvard College Clonal haematopoiesis
EP3227464B1 (en) 2014-12-05 2022-04-20 Foundation Medicine, Inc. Multigene analysis of tumor samples
ES2923602T3 (es) 2014-12-31 2022-09-28 Guardant Health Inc Detección y tratamiento de enfermedades que muestran heterogeneidad celular de enfermedad y sistemas y métodos para comunicar los resultados de las pruebas
WO2016127944A1 (en) 2015-02-10 2016-08-18 The Chinese University Of Hong Kong Detecting mutations for cancer screening and fetal analysis
US20160273049A1 (en) 2015-03-16 2016-09-22 Personal Genome Diagnostics, Inc. Systems and methods for analyzing nucleic acid
WO2017012592A1 (en) 2015-07-23 2017-01-26 The Chinese University Of Hong Kong Analysis of fragmentation patterns of cell-free dna
EP3365441A1 (en) 2015-10-22 2018-08-29 The Broad Institute Inc. Type vi-b crispr enzymes and systems
WO2018009723A1 (en) 2016-07-06 2018-01-11 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
EP3555311B1 (en) 2016-12-13 2024-06-26 Bellwether Bio, Inc. Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample
US20220259647A1 (en) 2019-07-09 2022-08-18 The Translational Genomics Research Institute METHODS OF DETECTING DISEASE AND TREATMENT RESPONSE IN cfDNA

Also Published As

Publication number Publication date
KR20180031742A (ko) 2018-03-28
US20200005895A1 (en) 2020-01-02
JP2023109862A (ja) 2023-08-08
US20200005896A1 (en) 2020-01-02
IL257055A (en) 2018-03-29
US11615865B2 (en) 2023-03-28
ES2960201T3 (es) 2024-03-01
US10453556B2 (en) 2019-10-22
US20170024513A1 (en) 2017-01-26
EP3967775A1 (en) 2022-03-16
US11605445B2 (en) 2023-03-14
HUE057821T2 (hu) 2022-06-28
TWI802886B (zh) 2023-05-21
PT3325664T (pt) 2022-03-03
WO2017012592A1 (en) 2017-01-26
TWI730973B (zh) 2021-06-21
ES2907697T3 (es) 2022-04-26
HK1247645A1 (zh) 2018-09-28
AU2022224861A1 (en) 2022-10-20
EP3325664A1 (en) 2018-05-30
TW201718872A (zh) 2017-06-01
IL305462A (en) 2023-10-01
IL288622B2 (en) 2024-03-01
US11581063B2 (en) 2023-02-14
EP3967775B1 (en) 2023-08-23
US20230197201A1 (en) 2023-06-22
DK3325664T3 (da) 2022-03-07
TW202332776A (zh) 2023-08-16
PT3967775T (pt) 2023-10-10
IL257055B (en) 2022-01-01
IL288622A (en) 2022-02-01
EP3325664B1 (en) 2021-12-29
CA2993362A1 (en) 2017-01-26
EP4279612A2 (en) 2023-11-22
TW202142697A (zh) 2021-11-16
AU2016295616B2 (en) 2022-06-02
JP7284522B2 (ja) 2023-05-31
CN108026572A (zh) 2018-05-11
DK3967775T3 (da) 2023-10-02
FI3967775T3 (fi) 2023-09-25
CN114999567A (zh) 2022-09-02
EP3325664A4 (en) 2019-01-02
US20200005897A1 (en) 2020-01-02
AU2016295616A1 (en) 2018-02-15
JP2021184732A (ja) 2021-12-09
SG10202106935UA (en) 2021-08-30
EP4279612A3 (en) 2024-02-28
IL288622B1 (en) 2023-11-01
HUE064231T2 (hu) 2024-02-28
CN108026572B (zh) 2022-07-01
JP2018524991A (ja) 2018-09-06
JP6931236B2 (ja) 2021-09-01

Similar Documents

Publication Publication Date Title
IL288622A (en) DNA fragmentation pattern analysis suitable clean
ZA201905396B (en) Trans-replicating rna
HK1258539A1 (zh) 微瞬間分析
SG11201608605QA (en) Methods and means for enhancing rna production
HUE049094T2 (hu) Sejtmentes DNS kvantifikálási módszerei
GB201616445D0 (en) Method of targeted mass spectrometric analysis
GB201408392D0 (en) Mass Analyser
ZA201706282B (en) Solid forms of menaquinols
GB201904142D0 (en) Improved method of FT-IMS
GB201418395D0 (en) Cyclo-depolymerisation of polybutadiene
GB201517241D0 (en) DNA modification
GB2537552B (en) Penetrator
GB2556529B (en) Methods of drilling
GB201706346D0 (en) Method of scoring
GB201509773D0 (en) Construction brick matching app
GB201509021D0 (en) Methods of screening