SG10202106935UA - Analysis of fragmentation patterns of cell-free dna - Google Patents

Analysis of fragmentation patterns of cell-free dna

Info

Publication number
SG10202106935UA
SG10202106935UA SG10202106935UA SG10202106935UA SG10202106935UA SG 10202106935U A SG10202106935U A SG 10202106935UA SG 10202106935U A SG10202106935U A SG 10202106935UA SG 10202106935U A SG10202106935U A SG 10202106935UA SG 10202106935U A SG10202106935U A SG 10202106935UA
Authority
SG
Singapore
Prior art keywords
analysis
cell
free dna
fragmentation patterns
fragmentation
Prior art date
Application number
SG10202106935UA
Inventor
Yuk-Ming Dennis Lo
Rossa Wai Kwun Chiu
Kwan Chee Chan
Peiyong Jiang
Original Assignee
Univ Hong Kong Chinese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2016/073753 external-priority patent/WO2016127944A1/en
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of SG10202106935UA publication Critical patent/SG10202106935UA/en

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Data Mining & Analysis (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Detergent Compositions (AREA)
SG10202106935UA 2015-07-23 2016-07-25 Analysis of fragmentation patterns of cell-free dna SG10202106935UA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562196250P 2015-07-23 2015-07-23
US201662294948P 2016-02-12 2016-02-12
PCT/CN2016/073753 WO2016127944A1 (en) 2015-02-10 2016-02-14 Detecting mutations for cancer screening and fetal analysis

Publications (1)

Publication Number Publication Date
SG10202106935UA true SG10202106935UA (en) 2021-08-30

Family

ID=57833803

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10202106935UA SG10202106935UA (en) 2015-07-23 2016-07-25 Analysis of fragmentation patterns of cell-free dna

Country Status (17)

Country Link
US (5) US10453556B2 (en)
EP (3) EP3967775B1 (en)
JP (3) JP6931236B2 (en)
KR (1) KR20180031742A (en)
CN (2) CN114999567A (en)
AU (2) AU2016295616B2 (en)
CA (1) CA2993362A1 (en)
DK (2) DK3967775T3 (en)
ES (2) ES2907697T3 (en)
FI (1) FI3967775T3 (en)
HK (2) HK1247645A1 (en)
HU (2) HUE064231T2 (en)
IL (3) IL305462A (en)
PT (2) PT3967775T (en)
SG (1) SG10202106935UA (en)
TW (3) TWI730973B (en)
WO (1) WO2017012592A1 (en)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI703216B (en) 2014-07-18 2020-09-01 香港中文大學 Methylation pattern analysis of tissues in a dna mixture
EP3172341A4 (en) 2014-07-25 2018-03-28 University of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
US10364467B2 (en) * 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
TWI730973B (en) 2015-07-23 2021-06-21 香港中文大學 Analysis of fragmentation patterns of cell-free dna
KR20180113973A (en) 2015-11-11 2018-10-17 레졸루션 바이오사이언스, 인크. High-efficiency construction of DNA library
US20190287645A1 (en) * 2016-07-06 2019-09-19 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
RU2019108294A (en) 2016-08-25 2020-09-25 Резолюшн Байосайенс, Инк. METHODS FOR DETECTING CHANGES IN THE AMOUNT OF GENOMIC COPIES IN DNA SAMPLES
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
CA3027919C (en) 2016-09-30 2023-02-28 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
EP3535415A4 (en) 2016-10-24 2020-07-01 The Chinese University of Hong Kong Methods and systems for tumor detection
KR20230062684A (en) 2016-11-30 2023-05-09 더 차이니즈 유니버시티 오브 홍콩 Analysis of cell-free dna in urine and other samples
TW202348802A (en) 2017-01-25 2023-12-16 香港中文大學 Diagnostic applications using nucleic acid fragments
WO2018227211A1 (en) * 2017-06-09 2018-12-13 Bellwether Bio, Inc. Diagnosis of cancer or other physiological condition using circulating nucleic acid fragment sentinel endpoints
WO2018227202A1 (en) * 2017-06-09 2018-12-13 Bellwether Bio, Inc. Determination of cancer type in a subject by probabilistic modeling of circulating nucleic acid fragment endpoints
EP3658684B1 (en) * 2017-07-26 2023-08-30 The Chinese University Of Hong Kong Enhancement of cancer screening using cell-free viral nucleic acids
US20200263170A1 (en) 2017-09-14 2020-08-20 Grail, Inc. Methods for preparing a sequencing library from single-stranded dna
WO2019067973A1 (en) 2017-09-28 2019-04-04 Grail, Inc. Enrichment of short nucleic acid fragments in sequencing library preparation
WO2019209954A1 (en) * 2018-04-24 2019-10-31 Grail, Inc. Systems and methods for using pathogen nucleic acid load to determine whether a subject has a cancer condition
EP3788172A4 (en) * 2018-05-03 2022-01-19 The Chinese University Of Hong Kong Size-tagged preferred ends and orientation-aware analysis for measuring properties of cell-free mixtures
AU2019269679A1 (en) 2018-05-18 2020-12-17 The Johns Hopkins University Cell-free DNA for assessing and/or treating cancer
SG11202100564PA (en) * 2018-07-23 2021-02-25 Univ Hong Kong Chinese Cell-free dna damage analysis and its clinical applications
CN111742063A (en) * 2018-07-27 2020-10-02 思勤有限公司 Hepatocellular carcinoma screening
EP3856903A4 (en) 2018-09-27 2022-07-27 Grail, LLC Methylation markers and targeted methylation probe panel
CN113366122B (en) * 2018-12-19 2024-01-12 香港中文大学 Free DNA end characterization
CN109584959B (en) * 2018-12-27 2020-10-27 北京优迅医学检验实验室有限公司 Method and device for correcting sequencing depth
CN109767813B (en) * 2018-12-27 2021-06-22 北京优迅医学检验实验室有限公司 Method and device for correcting sequencing depth
JP2022517456A (en) * 2019-01-24 2022-03-09 イルミナ インコーポレイテッド Methods and systems for monitoring organ health and disease
AU2020216438A1 (en) 2019-01-31 2021-07-29 Guardant Health, Inc. Compositions and methods for isolating cell-free DNA
EP3696278A1 (en) * 2019-02-13 2020-08-19 Nipd Genetics Public Company Limited Method of determining the origin of nucleic acids in a mixed sample
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
US11001898B2 (en) 2019-05-31 2021-05-11 Universal Diagnostics, S.L. Detection of colorectal cancer
AU2020333348B2 (en) * 2019-08-19 2023-11-23 Green Cross Genome Corporation Method for detecting chromosomal abnormality by using information about distance between nucleic acid fragments
KR102452413B1 (en) * 2019-08-19 2022-10-11 주식회사 지씨지놈 Method for detecting chromosomal abnormality using distance information between nucleic acid fragments
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
EP4077721A4 (en) * 2019-12-18 2024-01-17 Univ Hong Kong Chinese Cell-free dna fragmentation and nucleases
US20230042332A1 (en) 2019-12-24 2023-02-09 Vib Vzw Disease Detection in Liquid Biopsies
US20210238668A1 (en) * 2020-01-08 2021-08-05 The Chinese University Of Hong Kong Biterminal dna fragment types in cell-free samples and uses thereof
WO2021141220A1 (en) * 2020-01-09 2021-07-15 서울대학교 산학협력단 Atac-seq data normalization and method for utilizing same
BR122022015680A2 (en) * 2020-02-05 2022-12-06 The Chinese University Of Hong Kong METHOD OF ANALYSIS OF A BIOLOGICAL SAMPLE AND NON-TRAINER COMPUTER READABLE MEDIA
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
CN111383757B (en) * 2020-03-04 2023-08-25 南京亿科人群健康研究院有限公司 Method for developing echinococcosis diagnostic kit in computer-aided manner
CN111575347A (en) * 2020-05-19 2020-08-25 清华大学 Method for constructing library for simultaneously obtaining free DNA methylation and fragmentation pattern information in plasma
EP4169025A1 (en) * 2020-06-22 2023-04-26 Children's Hospital Medical Center De novo characterization of cell-free dna fragmentation hotspots in healthy and early-stage cancers
EP4150121A1 (en) 2020-06-30 2023-03-22 Universal Diagnostics, S.A. Systems and methods for detection of multiple cancer types
TW202242130A (en) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 Circulating transcription factor analysis
TW202242145A (en) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 Transcription factor binding site analysis of nucleosome depleted circulating cell free chromatin fragments
EP4359562A1 (en) 2021-06-21 2024-05-01 Guardant Health, Inc. Methods and compositions for copy-number informed tissue-of-origin analysis
WO2023056065A1 (en) 2021-09-30 2023-04-06 Guardant Health, Inc. Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements
WO2023220414A1 (en) * 2022-05-12 2023-11-16 Delfi Diagnostics, Inc. Use of cell-free dna fragmentomes in the diagnostic evaluation of patients with signs and symptoms suggestive of cancer
US20240011105A1 (en) * 2022-07-08 2024-01-11 The Chinese University Of Hong Kong Analysis of microbial fragments in plasma
CN117106857B (en) * 2023-10-24 2024-02-09 北京大学 Detection method and kit for plasma free chromatin and application of detection method and kit

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL145731A0 (en) 1999-04-02 2002-07-25 Corixa Corp A polypetide containing an immunogenic portion of a breast tumor protein and pharmaceutical compositions containing the same
US20030219765A1 (en) 2000-03-23 2003-11-27 Jose Costa Methods for evaluating cancer risk
WO2003062441A1 (en) 2002-01-18 2003-07-31 Genzyme Corporation Methods for fetal dna detection and allele quantitation
PL201608B1 (en) 2003-06-13 2009-04-30 Cezary Cybulski Method and set designed for detection of high genetic predisposition for prostate gland cancer as well as use of germinal change within the NBS1 gene
WO2005108621A1 (en) 2004-04-30 2005-11-17 Yale University Methods and compositions for cancer diagnosis
EA010571B1 (en) 2006-08-15 2008-10-30 Институт Молекулярной Генетики Российской Академии Наук (Имг Ран) Method for diagnosis of non-small cell carcinoma of lung and a kit therefor
EP2535425A1 (en) 2007-05-25 2012-12-19 Decode Genetics EHF. Variantes génétiques sur les chr 10q26 utilisées comme marqueurs dans l'évaluation, le diagnostic, le pronostic et le traitement d'un risque de cancer du sein
CN103902809B (en) 2007-07-23 2017-11-28 香港中文大学 Determine that nucleotide sequence is unbalance using multiple labels
AU2010311535B2 (en) 2009-10-26 2015-05-21 Lifecodexx Ag Means and methods for non-invasive diagnosis of chromosomal aneuploidy
RS58879B1 (en) 2009-11-05 2019-08-30 Univ Hong Kong Chinese Fetal genomic analysis from a maternal biological sample
EP4212630A1 (en) 2009-11-06 2023-07-19 The Chinese University of Hong Kong Size-based genomic analysis
EP2646579B1 (en) 2010-11-30 2017-06-14 The Chinese University Of Hong Kong Detection of genetic or molecular aberrations associated with cancer
EP2764459B1 (en) 2011-10-06 2021-06-30 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2771483A1 (en) 2011-10-25 2014-09-03 ONCOTYROL - Center for Personalized Cancer Medicine GmbH Method for diagnosing a disease based on plasma-dna distribution
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
WO2013177581A2 (en) 2012-05-24 2013-11-28 University Of Washington Through Its Center For Commercialization Whole genome sequencing of a human fetus
US11261494B2 (en) * 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
PT2893040T (en) * 2012-09-04 2019-04-01 Guardant Health Inc Systems and methods to detect rare mutations and copy number variation
JP6317354B2 (en) * 2012-09-20 2018-04-25 ザ チャイニーズ ユニバーシティ オブ ホンコン Non-invasive determination of fetal or tumor methylomes by plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
GB2526736A (en) 2013-02-21 2015-12-02 Toma Biosciences Inc Methods, compositions, and kits for nucleic acid analysis
AU2014233373B2 (en) 2013-03-15 2019-10-24 Verinata Health, Inc. Generating cell-free DNA libraries directly from blood
CN103215350B (en) * 2013-03-26 2016-11-02 苏州贝康医疗器械有限公司 A kind of assay method of the fetal DNA in maternal plasma DNA content based on mononucleotide polymorphism site
US10174375B2 (en) 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
JP6680680B2 (en) 2013-10-07 2020-04-15 セクエノム， インコーポレイテッド Methods and processes for non-invasive assessment of chromosomal alterations
US20160002717A1 (en) 2014-07-02 2016-01-07 Boreal Genomics, Inc. Determining mutation burden in circulating cell-free nucleic acid and associated risk of disease
TWI703216B (en) 2014-07-18 2020-09-01 香港中文大學 Methylation pattern analysis of tissues in a dna mixture
EP3172341A4 (en) 2014-07-25 2018-03-28 University of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
US10683552B2 (en) 2014-11-25 2020-06-16 Presidents And Fellows Of Harvard College Clonal haematopoiesis
JP6905934B2 (en) 2014-12-05 2021-07-21 ファウンデーション・メディシン・インコーポレイテッド Multiple gene analysis of tumor samples
AU2015374259B2 (en) 2014-12-31 2020-08-13 Guardant Health, Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
AU2016218631B2 (en) 2015-02-10 2022-03-10 The Chinese University Of Hong Kong Detecting mutations for cancer screening and fetal analysis
JP2018513508A (en) 2015-03-16 2018-05-24 パーソナル ジノーム ダイアグノスティクス， インコーポレイテッド Systems and methods for analyzing nucleic acids
TWI730973B (en) 2015-07-23 2021-06-21 香港中文大學 Analysis of fragmentation patterns of cell-free dna
EP3365441A1 (en) 2015-10-22 2018-08-29 The Broad Institute Inc. Type vi-b crispr enzymes and systems
CA3030038A1 (en) 2016-07-06 2018-01-11 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
EP3555311A4 (en) 2016-12-13 2020-08-12 Bellwether Bio, Inc. Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample
US20220259647A1 (en) 2019-07-09 2022-08-18 The Translational Genomics Research Institute METHODS OF DETECTING DISEASE AND TREATMENT RESPONSE IN cfDNA

Also Published As

Publication number Publication date
TW201718872A (en) 2017-06-01
IL257055B (en) 2022-01-01
HK1247645A1 (en) 2018-09-28
JP2018524991A (en) 2018-09-06
IL305462A (en) 2023-10-01
US20230197201A1 (en) 2023-06-22
JP2021184732A (en) 2021-12-09
EP3967775A1 (en) 2022-03-16
KR20180031742A (en) 2018-03-28
EP3325664A1 (en) 2018-05-30
TW202332776A (en) 2023-08-16
PT3967775T (en) 2023-10-10
US20170024513A1 (en) 2017-01-26
JP7284522B2 (en) 2023-05-31
CN108026572B (en) 2022-07-01
WO2017012592A1 (en) 2017-01-26
EP3325664B1 (en) 2021-12-29
AU2016295616A1 (en) 2018-02-15
US11615865B2 (en) 2023-03-28
CN108026572A (en) 2018-05-11
TWI802886B (en) 2023-05-21
US20200005896A1 (en) 2020-01-02
EP3325664A4 (en) 2019-01-02
FI3967775T3 (en) 2023-09-25
PT3325664T (en) 2022-03-03
EP3967775B1 (en) 2023-08-23
HUE064231T2 (en) 2024-02-28
CN114999567A (en) 2022-09-02
ES2960201T3 (en) 2024-03-01
AU2022224861A1 (en) 2022-10-20
US10453556B2 (en) 2019-10-22
DK3325664T3 (en) 2022-03-07
IL288622B1 (en) 2023-11-01
JP2023109862A (en) 2023-08-08
DK3967775T3 (en) 2023-10-02
IL288622A (en) 2022-02-01
AU2016295616B2 (en) 2022-06-02
ES2907697T3 (en) 2022-04-26
US11605445B2 (en) 2023-03-14
TW202142697A (en) 2021-11-16
US11581063B2 (en) 2023-02-14
HK1251264A1 (en) 2019-01-25
CA2993362A1 (en) 2017-01-26
HUE057821T2 (en) 2022-06-28
IL257055A (en) 2018-03-29
US20200005897A1 (en) 2020-01-02
US20200005895A1 (en) 2020-01-02
EP4279612A3 (en) 2024-02-28
IL288622B2 (en) 2024-03-01
EP4279612A2 (en) 2023-11-22
TWI730973B (en) 2021-06-21
JP6931236B2 (en) 2021-09-01

Similar Documents

Publication Publication Date Title
IL288622A (en) Analysis of fragmentation patterns of cell-free dna
ZA201905396B (en) Trans-replicating rna
HK1258539A1 (en) Micro-moment analysis
SG11201608605QA (en) Methods and means for enhancing rna production
HUE049094T2 (en) Methods of quantifying cell-free dna
GB201616445D0 (en) Method of targeted mass spectrometric analysis
GB201408392D0 (en) Mass Analyser
ZA201706282B (en) Solid forms of menaquinols
GB201904142D0 (en) Improved method of FT-IMS
GB201418395D0 (en) Cyclo-depolymerisation of polybutadiene
GB201517241D0 (en) DNA modification
GB2537552B (en) Penetrator
GB2556529B (en) Methods of drilling
GB201706346D0 (en) Method of scoring