DK3952872T3 - Carbamoyl cyclohexan-derivater til behandling af autismespektrumforstyrrelse - Google Patents

Carbamoyl cyclohexan-derivater til behandling af autismespektrumforstyrrelse Download PDF

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Publication number
DK3952872T3
DK3952872T3 DK20719737.7T DK20719737T DK3952872T3 DK 3952872 T3 DK3952872 T3 DK 3952872T3 DK 20719737 T DK20719737 T DK 20719737T DK 3952872 T3 DK3952872 T3 DK 3952872T3
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Prior art keywords
treatment
autism spectrum
spectrum disorder
cyclohexane derivatives
carbamoyl
Prior art date
Application number
DK20719737.7T
Other languages
English (en)
Inventor
Nika Adham-Parangi
Yeung Paul Po-Jen
Earley Willie Roger
Viktor Román
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Application granted granted Critical
Publication of DK3952872T3 publication Critical patent/DK3952872T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK20719737.7T 2019-04-10 2020-04-09 Carbamoyl cyclohexan-derivater til behandling af autismespektrumforstyrrelse DK3952872T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP1900121A HU231500B1 (hu) 2019-04-10 2019-04-10 Karbamoil-ciklohexán származékok autizmus spektrum betegség kezelésére
PCT/IB2020/053382 WO2020208564A1 (en) 2019-04-10 2020-04-09 Carbamoyl cyclohexane derivatives for treating autism spectrum disorder

Publications (1)

Publication Number Publication Date
DK3952872T3 true DK3952872T3 (da) 2024-05-27

Family

ID=89992883

Family Applications (1)

Application Number Title Priority Date Filing Date
DK20719737.7T DK3952872T3 (da) 2019-04-10 2020-04-09 Carbamoyl cyclohexan-derivater til behandling af autismespektrumforstyrrelse

Country Status (20)

Country Link
EP (1) EP3952872B1 (da)
JP (1) JP2022527386A (da)
KR (1) KR20210151162A (da)
CN (1) CN113677345A (da)
AR (1) AR118634A1 (da)
AU (1) AU2020271363A1 (da)
BR (1) BR112021019367A2 (da)
CL (1) CL2021002632A1 (da)
DK (1) DK3952872T3 (da)
EA (1) EA202192717A1 (da)
GE (1) GEP20237554B (da)
HU (1) HU231500B1 (da)
IL (1) IL287076A (da)
LT (1) LT3952872T (da)
MX (1) MX2021012321A (da)
SG (1) SG11202110421YA (da)
TW (1) TW202103701A (da)
UY (1) UY38657A (da)
WO (1) WO2020208564A1 (da)
ZA (1) ZA202108429B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114588162B (zh) * 2022-03-30 2023-10-27 中国人民解放军空军军医大学 拉莫三嗪治疗孤独症触觉异常的应用
US11980603B2 (en) 2022-06-11 2024-05-14 AMS Therapeutics, LLC Method of treating expressive language deficit in autistic humans

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227534B1 (en) 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
HU230748B1 (hu) 2007-05-11 2018-02-28 Richter Gedeon Nyrt Új piperazin só és előállítási eljárása
LT2155200T (lt) 2007-05-11 2017-02-10 Richter Gedeon Nyrt. Karbamoil-cikloheksano darinio kristalinė forma
HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
JP5460594B2 (ja) 2007-08-03 2014-04-02 リチュテル・ゲデオン・ヴェジェーセティ・ジャール・ニュイルヴァーノシャン・ミューコェデー・レースヴェーニュタールシャシャーグ ドーパミン受容体リガンドを含有する医薬組成物およびドーパミン受容体リガンドを用いる処置方法
BRPI0916241A2 (pt) 2008-07-16 2017-06-27 Richter Gedeon Nyrt formulações farmacêuticas contendo ligantes de receptores de dopamina
WO2011060363A2 (en) * 2009-11-16 2011-05-19 Auspex Pharmaceuticals, Inc. Cyclohexyl urea modulators of d2 receptors and/or d3 receptors
MX2016007612A (es) 2013-12-13 2016-09-09 Pf Medicament Un derivado de la cromona como el antagonista del receptor de la dopamina d3 para su uso en el tratamiento del trastorno del espectro autista.

Also Published As

Publication number Publication date
WO2020208564A1 (en) 2020-10-15
EP3952872A1 (en) 2022-02-16
SG11202110421YA (en) 2021-10-28
MX2021012321A (es) 2021-11-12
EA202192717A1 (ru) 2022-01-17
EP3952872B1 (en) 2024-03-13
TW202103701A (zh) 2021-02-01
KR20210151162A (ko) 2021-12-13
AR118634A1 (es) 2021-10-20
ZA202108429B (en) 2022-09-28
HU231500B1 (hu) 2024-04-28
UY38657A (es) 2020-10-30
CL2021002632A1 (es) 2022-05-06
CN113677345A (zh) 2021-11-19
LT3952872T (lt) 2024-05-27
IL287076A (en) 2021-12-01
HUP1900121A1 (hu) 2020-10-28
GEP20237554B (en) 2023-10-25
BR112021019367A2 (pt) 2021-12-07
JP2022527386A (ja) 2022-06-01
AU2020271363A1 (en) 2021-11-18

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