DK3880692T3 - Nye tripel-helisk polypeptider uden bindingsaffinitet for fc-domænet af immunoglobulin og anvendelser deraf - Google Patents

Nye tripel-helisk polypeptider uden bindingsaffinitet for fc-domænet af immunoglobulin og anvendelser deraf Download PDF

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Publication number
DK3880692T3
DK3880692T3 DK19801877.2T DK19801877T DK3880692T3 DK 3880692 T3 DK3880692 T3 DK 3880692T3 DK 19801877 T DK19801877 T DK 19801877T DK 3880692 T3 DK3880692 T3 DK 3880692T3
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Prior art keywords
immunoglobulin
domain
binding affinity
novel triple
helical polypeptides
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DK19801877.2T
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English (en)
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DK3880692T5 (da
Inventor
Erik Fiedler
Ulrich Haupts
Madlen Zwarg
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Navigo Proteins Gmbh
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Publication of DK3880692T3 publication Critical patent/DK3880692T3/da
Publication of DK3880692T5 publication Critical patent/DK3880692T5/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
DK19801877.2T 2018-11-12 2019-11-12 Nye tripel-helisk polypeptider uden bindingsaffinitet for fc-domænet af immunoglobulin og anvendelser deraf DK3880692T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18205679 2018-11-12
EP19167107 2019-04-03
PCT/EP2019/081078 WO2020099442A1 (en) 2018-11-12 2019-11-12 Novel triple-helical polypeptides lacking binding affinity for the fc domain of immunoglobulin and uses thereof

Publications (2)

Publication Number Publication Date
DK3880692T3 true DK3880692T3 (da) 2024-02-12
DK3880692T5 DK3880692T5 (da) 2024-08-05

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ID=68536874

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19801877.2T DK3880692T5 (da) 2018-11-12 2019-11-12 Nye tripel-helisk polypeptider uden bindingsaffinitet for fc-domænet af immunoglobulin og anvendelser deraf

Country Status (14)

Country Link
US (1) US20220073564A1 (da)
EP (2) EP3880692B1 (da)
JP (2) JP2022504487A (da)
KR (1) KR20210092203A (da)
CN (1) CN112969708B (da)
AU (1) AU2019380620B2 (da)
BR (1) BR112021007530A2 (da)
CA (1) CA3116514A1 (da)
DK (1) DK3880692T5 (da)
IL (1) IL281849A (da)
LT (1) LT3880692T (da)
SG (1) SG11202103139PA (da)
WO (1) WO2020099442A1 (da)
ZA (1) ZA202102579B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3183655A1 (en) * 2020-06-23 2021-12-30 Mathias KAHL Binding protein specific for the spike protein of severe acute respiratory syndrome corona virus 2 (sars-cov-2)
EP4001301A1 (en) * 2020-11-13 2022-05-25 Navigo Proteins Gmbh Binding protein for complement factor h (cfh)
WO2023285164A1 (en) * 2021-07-13 2023-01-19 Navigo Proteins Gmbh Affinity ligands for the purification and detection of ubiquitin muteins
EP4413021A1 (en) * 2021-10-08 2024-08-14 Navigo Proteins Gmbh Specific baculovirus major envelope glycoprotein gp64 binding proteins

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2544785B1 (en) * 2010-03-08 2015-09-30 GE Healthcare Bio-Sciences AB Immunoglobulin g fc region binding polypeptide
EP2728000B1 (en) * 2011-06-03 2018-12-05 National Institute of Advanced Industrial Science And Technology Protein a mutant protein having reduced affinity in acidic region, and antibody capture agent
CN107429244A (zh) * 2015-03-26 2017-12-01 Jsr株式会社 免疫球蛋白结合蛋白质和使用其的亲和载体
KR20160126340A (ko) * 2015-04-23 2016-11-02 삼성전자주식회사 3중-나선 다발 단백질 및 이의 용도
BR112018000477A2 (pt) * 2015-07-16 2018-09-18 Navigo Proteins Gmbh proteína de ligação de imunoglobulina não natural, composição, uso da proteína de ligação de ig não natural, método de purificação de afinidade de imunoglobulinas, método de geração de uma proteína de ligação de imunoglobulina não natural, molécula de ácido nucleico, vetor, célula hospedeira ou um hospedeiro não humano, e método para a produção de uma proteína de ligação de imunoglobulina não natural
CN107849088A (zh) * 2015-07-22 2018-03-27 株式会社钟化 抗体样蛋白质的纯化方法
CN107849095A (zh) * 2015-07-22 2018-03-27 株式会社钟化 酸性pH范围内的抗体结合能力降低的抗体结合性蛋白质
EP4177260A1 (en) * 2016-08-11 2023-05-10 Repligen Corporation Alkaline stable fc-binding proteins for affinity chromatography
EP3650465A1 (en) * 2018-11-12 2020-05-13 Navigo Proteins Gmbh Novel populations of polypeptides having a triple-helical structure

Also Published As

Publication number Publication date
AU2019380620B2 (en) 2022-05-26
DK3880692T5 (da) 2024-08-05
EP3880692A1 (en) 2021-09-22
CA3116514A1 (en) 2020-05-22
ZA202102579B (en) 2023-01-25
EP3880692B1 (en) 2024-01-03
US20220073564A1 (en) 2022-03-10
JP2022504487A (ja) 2022-01-13
LT3880692T (lt) 2024-02-26
IL281849A (en) 2021-05-31
CN112969708B (zh) 2024-07-05
EP4349853A3 (en) 2024-07-03
EP4349853A2 (en) 2024-04-10
JP2024109778A (ja) 2024-08-14
SG11202103139PA (en) 2021-04-29
CN112969708A (zh) 2021-06-15
WO2020099442A1 (en) 2020-05-22
BR112021007530A2 (pt) 2021-08-31
WO2020099442A9 (en) 2020-07-09
AU2019380620A1 (en) 2021-04-29
KR20210092203A (ko) 2021-07-23

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