SG11202103139PA - Novel triple-helical polypeptides lacking binding affinity for the fc domain of immunoglobulin and uses thereof - Google Patents

Novel triple-helical polypeptides lacking binding affinity for the fc domain of immunoglobulin and uses thereof

Info

Publication number
SG11202103139PA
SG11202103139PA SG11202103139PA SG11202103139PA SG11202103139PA SG 11202103139P A SG11202103139P A SG 11202103139PA SG 11202103139P A SG11202103139P A SG 11202103139PA SG 11202103139P A SG11202103139P A SG 11202103139PA SG 11202103139P A SG11202103139P A SG 11202103139PA
Authority
SG
Singapore
Prior art keywords
immunoglobulin
domain
binding affinity
polypeptides lacking
novel triple
Prior art date
Application number
SG11202103139PA
Inventor
Erik Fiedler
Ulrich Haupts
Madlen Zwarg
Original Assignee
Navigo Proteins Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Navigo Proteins Gmbh filed Critical Navigo Proteins Gmbh
Publication of SG11202103139PA publication Critical patent/SG11202103139PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
SG11202103139PA 2018-11-12 2019-11-12 Novel triple-helical polypeptides lacking binding affinity for the fc domain of immunoglobulin and uses thereof SG11202103139PA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18205679 2018-11-12
EP19167107 2019-04-03
PCT/EP2019/081078 WO2020099442A1 (en) 2018-11-12 2019-11-12 Novel triple-helical polypeptides lacking binding affinity for the fc domain of immunoglobulin and uses thereof

Publications (1)

Publication Number Publication Date
SG11202103139PA true SG11202103139PA (en) 2021-04-29

Family

ID=68536874

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202103139PA SG11202103139PA (en) 2018-11-12 2019-11-12 Novel triple-helical polypeptides lacking binding affinity for the fc domain of immunoglobulin and uses thereof

Country Status (14)

Country Link
US (1) US20220073564A1 (en)
EP (2) EP4349853A3 (en)
JP (2) JP2022504487A (en)
KR (1) KR20210092203A (en)
CN (1) CN112969708B (en)
AU (1) AU2019380620B2 (en)
BR (1) BR112021007530A2 (en)
CA (1) CA3116514A1 (en)
DK (1) DK3880692T5 (en)
IL (1) IL281849A (en)
LT (1) LT3880692T (en)
SG (1) SG11202103139PA (en)
WO (1) WO2020099442A1 (en)
ZA (1) ZA202102579B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021260052A1 (en) * 2020-06-23 2021-12-30 Navigo Proteins Gmbh Binding protein specific for the spike protein of severe acute respiratory syndrome corona virus 2 (sars-cov-2)
EP4001301A1 (en) * 2020-11-13 2022-05-25 Navigo Proteins Gmbh Binding protein for complement factor h (cfh)
US20240309056A1 (en) * 2021-07-13 2024-09-19 Navigo Proteins Gmbh Affinity ligands for the purification and detection of ubiquitin muteins
EP4413021A1 (en) * 2021-10-08 2024-08-14 Navigo Proteins Gmbh Specific baculovirus major envelope glycoprotein gp64 binding proteins

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2977088T3 (en) * 2010-03-08 2017-10-09 Ge Healthcare Bioprocess R&D Ab IMMUNOGLOBULIN G FC REGION BINDING POLYPEPTIDE
EP2728000B1 (en) * 2011-06-03 2018-12-05 National Institute of Advanced Industrial Science And Technology Protein a mutant protein having reduced affinity in acidic region, and antibody capture agent
CN107429244A (en) * 2015-03-26 2017-12-01 Jsr株式会社 Immunoglobulin-binding proteins matter and use its affiliation carrier
KR20160126340A (en) * 2015-04-23 2016-11-02 삼성전자주식회사 Three-helix bundle protein and use thereof
CN107922483B (en) * 2015-07-16 2021-07-30 纳维格蛋白质有限公司 Novel immunoglobulin-binding proteins and their use in affinity purification
JP6861155B2 (en) * 2015-07-22 2021-04-21 株式会社カネカ Antibody-binding protein with reduced antibody-binding ability in the acidic pH range
CN107849088A (en) * 2015-07-22 2018-03-27 株式会社钟化 The purification process of antibody-like protein matter
EP3497118B1 (en) * 2016-08-11 2022-09-14 Repligen Corporation Alkaline stable fc binding proteins for affinity chromatography
EP3650465A1 (en) * 2018-11-12 2020-05-13 Navigo Proteins Gmbh Novel populations of polypeptides having a triple-helical structure

Also Published As

Publication number Publication date
LT3880692T (en) 2024-02-26
CN112969708B (en) 2024-07-05
IL281849A (en) 2021-05-31
AU2019380620A1 (en) 2021-04-29
JP2022504487A (en) 2022-01-13
AU2019380620B2 (en) 2022-05-26
CN112969708A (en) 2021-06-15
WO2020099442A1 (en) 2020-05-22
EP3880692B1 (en) 2024-01-03
EP4349853A2 (en) 2024-04-10
EP4349853A3 (en) 2024-07-03
US20220073564A1 (en) 2022-03-10
DK3880692T5 (en) 2024-08-05
JP2024109778A (en) 2024-08-14
WO2020099442A9 (en) 2020-07-09
EP3880692A1 (en) 2021-09-22
DK3880692T3 (en) 2024-02-12
ZA202102579B (en) 2023-01-25
BR112021007530A2 (en) 2021-08-31
KR20210092203A (en) 2021-07-23
CA3116514A1 (en) 2020-05-22

Similar Documents

Publication Publication Date Title
ZA202102579B (en) Novel triple-helical polypeptides lacking binding affinity for the fc domain of immunoglobulin and uses thereof
GB2613715B (en) Binding proteins specific for RAS neoantigens and uses thereof
IL278091A (en) Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15rα fc-fusion proteins and pd-1 antigen binding domains and uses thereof
IL278924A (en) Antibodies specific for gucy2c and uses thereof
IL279510A (en) Progranulin-fc polypeptide fusion proteins and uses thereof
IL277287A (en) Antibodies against mica and/or micb and uses thereof
EP3802831A4 (en) Polypeptide comprising il-1r1 binding domain and carrying moiety
ZA202100943B (en) Novel lilrb4 antibodies and uses thereof
EP3797164A4 (en) Chimeric antigen receptors with modified linker domains and uses thereof
SG11202101675UA (en) Anti-bcma single domain antibodies and application thereof
EP4249097A3 (en) Fc binding proteins with cysteine in the c-terminal helical region
PH12014501818A1 (en) Pseudomonas aeruginosa pcrv binding single variable domain antibodies
IL280995A (en) Antibodies binding to citrullinated histone 2a and/or 4
EP3708575A4 (en) Thioredoxin 1 epitope and monoclonal antibody specifically binding thereto
SG11202013217PA (en) Multifunctional protein molecules comprising decorin and use thereof
EP3995508A4 (en) Novel modified immunoglobulin fc-fusion protein and use thereof
SG11202103095RA (en) Anti-human vsig4 antibodies and uses thereof
IL286216A (en) Tsg-6 antibodies and uses therefor
SG11202007443XA (en) Cd38 protein antibody and application thereof
EP4081548A4 (en) Anti-sirp? monoclonal antibodies and uses thereof
IL275593B (en) Composition comprising probiotics and polypeptide having binding affinity for ige and use thereof
MX2020002934A (en) Antibody variants.
EP3655026A4 (en) Antigen binding regions against fibronectin type iii domains and methods of using the same
EP4017529A4 (en) Variant fc domains and uses thereof
ZA202200451B (en) Novel antibodies specific for cthrc1 and use thereof