DK387187A - 11beta-(4-isopropenylphenyl)-oestra-4,9-diener, fremstilling deraf samt farmaceutiske praeparater indeholdende disse - Google Patents
11beta-(4-isopropenylphenyl)-oestra-4,9-diener, fremstilling deraf samt farmaceutiske praeparater indeholdende disseInfo
- Publication number
- DK387187A DK387187A DK387187A DK387187A DK387187A DK 387187 A DK387187 A DK 387187A DK 387187 A DK387187 A DK 387187A DK 387187 A DK387187 A DK 387187A DK 387187 A DK387187 A DK 387187A
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen atom
- group
- isopropenylphenyl
- meaning
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3625315 | 1986-07-25 | ||
DE19863625315 DE3625315A1 (de) | 1986-07-25 | 1986-07-25 | 11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate |
Publications (4)
Publication Number | Publication Date |
---|---|
DK387187D0 DK387187D0 (da) | 1987-07-24 |
DK387187A true DK387187A (da) | 1988-01-26 |
DK162101B DK162101B (da) | 1991-09-16 |
DK162101C DK162101C (da) | 1992-02-24 |
Family
ID=6306037
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK387187A DK162101C (da) | 1986-07-25 | 1987-07-24 | 11beta-(4-isopropenylphenyl)-oestra-4,9-diener, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse forbindelser samt anvendelsen af forbindelserne til fremstilling af laegemidler |
Country Status (20)
Country | Link |
---|---|
US (2) | US4814327A (da) |
EP (1) | EP0254670B1 (da) |
JP (1) | JPH0822871B2 (da) |
CN (1) | CN1026324C (da) |
AT (1) | ATE48003T1 (da) |
AU (1) | AU602521B2 (da) |
CA (1) | CA1289944C (da) |
DD (1) | DD263532A5 (da) |
DE (2) | DE3625315A1 (da) |
DK (1) | DK162101C (da) |
ES (1) | ES2014034B3 (da) |
FI (2) | FI85274C (da) |
GR (2) | GR890300034T1 (da) |
HU (1) | HU196829B (da) |
IE (1) | IE60316B1 (da) |
IL (1) | IL83301A (da) |
NO (2) | NO168891C (da) |
NZ (1) | NZ221185A (da) |
PT (1) | PT85385B (da) |
ZA (1) | ZA875518B (da) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3633244A1 (de) * | 1986-09-26 | 1988-03-31 | Schering Ag | Antigestagene zur hemmung der uterinen prostaglandinsynthese |
BE1004905A4 (fr) * | 1987-12-30 | 1993-02-23 | Roussel Uclaf | Nouveaux derives 17beta-oh 19-nor steroides substitues en 17alpha, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant. |
DE3822770A1 (de) * | 1988-07-01 | 1990-01-04 | Schering Ag | 13-alkyl-11ss-phenylgonane |
WO1990002781A1 (en) * | 1988-09-16 | 1990-03-22 | Lithium Corporation Of America | Thermally stable, reactive organometallic compositions containing copper |
US5316856A (en) * | 1988-12-03 | 1994-05-31 | Ngk Spark Plug Co., Ltd. | Silicon nitride base sintered body |
DE4000777C2 (de) * | 1989-01-12 | 2000-06-15 | Ngk Spark Plug Co | Sinterkörper auf Siliziumnitridbasis |
DK0411733T3 (da) * | 1989-08-04 | 1999-06-28 | Schering Ag | 11-beta-aryl-gona-4,9-dien-3-oner |
US5100575A (en) * | 1989-09-08 | 1992-03-31 | Fmc Corporation | Thermally stable, reactive organometallic compositions containing copper |
FR2659233B1 (fr) * | 1990-03-06 | 1994-01-21 | Roussel Uclaf | Nouvelle utilisation de composes anti-progestomimetiques chez les animaux d'elevage. |
DE4042004A1 (de) * | 1990-12-22 | 1992-06-25 | Schering Ag | 14(beta)-h-, 14- u. 15-en-11(beta)-aryl-4-estrene |
US5407928A (en) * | 1990-08-15 | 1995-04-18 | Schering Aktiengesellschaft | 11β-aryl-gona-4,9-dien-3-ones |
US5439913A (en) | 1992-05-12 | 1995-08-08 | Schering Aktiengesellschaft | Contraception method using competitive progesterone antagonists and novel compounds useful therein |
US5468741A (en) * | 1993-05-28 | 1995-11-21 | The Regents Of The University Of California | Use of low levels of mifepristone to treat leiomyomata |
US6407082B1 (en) * | 1996-09-13 | 2002-06-18 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a vitamin D compound |
US5504074A (en) | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
US6908910B2 (en) | 1993-08-06 | 2005-06-21 | The Children's Medical Center Corporation | Estrogenic compounds as anti-mitotic agents |
DK0683172T3 (da) * | 1994-05-19 | 1998-03-30 | Akzo Nobel Nv | 11,21-bisphenyl-19-norpregnanderivater |
US5639598A (en) * | 1994-05-19 | 1997-06-17 | The Trustees Of The University Of Pennsylvania | Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions |
US5780220A (en) * | 1994-05-19 | 1998-07-14 | Trustees Of The University Of Pennsylvania | Methods and compositions for inhibiting HIV replication |
DE4434488A1 (de) * | 1994-09-14 | 1996-03-21 | Schering Ag | Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
US6900193B1 (en) * | 1996-05-01 | 2005-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
HU230492B1 (hu) | 1996-05-01 | 2016-08-29 | The Government Of The United States Of America | Új progesztációt gátló szerként használható 21-helyzetben szubsztituált progeszteron-származékok, ezeket tartalmazó gyógyszerkészítmények, alkalmazásuk |
US6034074A (en) | 1996-09-13 | 2000-03-07 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a Vitamin D compound |
US6511970B1 (en) | 1996-09-13 | 2003-01-28 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium |
US6028064A (en) * | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
US6765002B2 (en) | 2000-03-21 | 2004-07-20 | Gustavo Rodriguez | Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium |
US6090798A (en) * | 1997-12-19 | 2000-07-18 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with glucocorticoid antagonists |
US6020328A (en) * | 1998-03-06 | 2000-02-01 | Research Triangle Institute | 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
US5962444A (en) * | 1998-05-29 | 1999-10-05 | Research Triangle Institute | 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
US6262042B1 (en) | 1998-05-29 | 2001-07-17 | Research Triangle Institute | 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
WO2000009101A2 (en) | 1998-08-11 | 2000-02-24 | Entremed, Inc. | Use of estrogenic compounds as anti-fungal agents |
US7087592B1 (en) | 1999-08-23 | 2006-08-08 | Entre Med, Inc. | Compositions comprising purified 2-methoxyestradiol and methods of producing same |
CN1117759C (zh) * | 1999-09-02 | 2003-08-13 | 上海中西药业股份有限公司 | 甾体化合物,其制备方法和其药物组合物及其应用 |
US20010044431A1 (en) * | 2000-03-21 | 2001-11-22 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
US7135581B2 (en) | 2000-08-18 | 2006-11-14 | Entremed, Inc. | Antiangiogenic agents |
US6995278B2 (en) | 2000-08-18 | 2006-02-07 | Entre Med, Inc. | Antiangiogenic agents |
CA2516319C (en) * | 2003-02-28 | 2012-09-18 | The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services | Method for preparing 17.alpha.-acetoxy-11.beta.-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates |
EP1643981A2 (en) * | 2003-06-20 | 2006-04-12 | Viral Genomix, Inc. | Antiviral compositions and methods of using the same |
AU2005222934B2 (en) | 2004-03-12 | 2010-06-17 | Entremed, Inc. | Antiangiogenic agents |
AU2007227256B2 (en) | 2006-03-20 | 2012-10-04 | Entremed, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
US9517240B2 (en) | 2006-09-26 | 2016-12-13 | The Regents Of The University Of California | Methods and compositions for cancer prevention and treatment |
WO2008039482A2 (en) * | 2006-09-26 | 2008-04-03 | The Regents Of The University Of California | Methods and compositions for cancer prevention and treatment |
PL3263112T3 (pl) | 2006-10-24 | 2021-01-11 | Allergan Pharmaceuticals International Limited | Kompozycje i sposoby tłumienia przerostów endometrium |
TWI539953B (zh) | 2008-04-28 | 2016-07-01 | 瑞波若斯治療學公司 | 用於治療乳癌之組成物和方法 |
DE102009034367A1 (de) * | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
CA2793712A1 (en) | 2010-03-22 | 2011-09-29 | Repros Therapeutics Inc. | Compositions and methods for non-toxic delivery of antiprogestins |
WO2011150209A1 (en) | 2010-05-26 | 2011-12-01 | Corcept Therapeutics, Inc. | Treatment of muscular dystrophy |
CA2977591A1 (en) | 2015-03-02 | 2016-09-09 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor antagonist and somatostatin analogues to treat acth-secreting tumors |
SG11201707525TA (en) | 2015-03-30 | 2017-10-30 | Corcept Therapeutics Inc | Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency |
WO2017027851A1 (en) | 2015-08-13 | 2017-02-16 | Corcept Therapeutics, Inc. | Method for differentially diagnosing acth-dependent cushing's syndrome |
ES2861524T3 (es) | 2016-01-19 | 2021-10-06 | Corcept Therapeutics Inc | Diagnóstico diferencial del Síndrome de Cushing Ectópico |
US11213526B2 (en) | 2017-06-20 | 2022-01-04 | Corcept Therapeutics, Inc. | Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators |
EP4263807A2 (en) | 2020-12-18 | 2023-10-25 | Instil Bio (Uk) Limited | Processing of tumor infiltrating lymphocytes |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2377419A1 (fr) * | 1977-01-13 | 1978-08-11 | Roussel Uclaf | Nouveaux derives steroides 11b-substitues 1,3,5 (10) trieniques, leur procede de preparation et leur application comme medicament |
FR2377418A1 (fr) * | 1977-01-13 | 1978-08-11 | Roussel Uclaf | Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments |
ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
FR2528434B1 (fr) * | 1982-06-11 | 1985-07-19 | Roussel Uclaf | Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament |
DE3205686A1 (de) * | 1982-02-17 | 1983-08-25 | Robert Bosch Gmbh, 7000 Stuttgart | Hoergeraet |
FR2522328B1 (fr) * | 1982-03-01 | 1986-02-14 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments |
DE3231827A1 (de) * | 1982-08-24 | 1984-03-01 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-aryl-17(alpha)-alkinyl-17ss-hydroxy-4,9(10)- estradien-3-on-derivate, deren herstellung und diese enthaltende pharmazeutische praeparate |
DE3461090D1 (en) * | 1983-02-18 | 1986-12-04 | Schering Ag | 11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them |
DE3347126A1 (de) * | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
-
1986
- 1986-07-25 DE DE19863625315 patent/DE3625315A1/de not_active Withdrawn
-
1987
- 1987-07-07 FI FI873001A patent/FI85274C/fi not_active IP Right Cessation
- 1987-07-13 EP EP87730078A patent/EP0254670B1/de not_active Expired
- 1987-07-13 DE DE8787730078T patent/DE3760995D1/de not_active Expired
- 1987-07-13 ES ES87730078T patent/ES2014034B3/es not_active Expired - Lifetime
- 1987-07-13 AT AT87730078T patent/ATE48003T1/de not_active IP Right Cessation
- 1987-07-21 JP JP62180200A patent/JPH0822871B2/ja not_active Expired - Lifetime
- 1987-07-23 IL IL83301A patent/IL83301A/xx not_active IP Right Cessation
- 1987-07-23 DD DD87305297A patent/DD263532A5/de not_active IP Right Cessation
- 1987-07-23 PT PT85385A patent/PT85385B/pt not_active IP Right Cessation
- 1987-07-23 CN CN87105307A patent/CN1026324C/zh not_active Expired - Fee Related
- 1987-07-24 US US07/077,359 patent/US4814327A/en not_active Expired - Fee Related
- 1987-07-24 NO NO873117A patent/NO168891C/no unknown
- 1987-07-24 DK DK387187A patent/DK162101C/da not_active IP Right Cessation
- 1987-07-24 HU HU873412A patent/HU196829B/hu not_active IP Right Cessation
- 1987-07-24 CA CA000542897A patent/CA1289944C/en not_active Expired - Lifetime
- 1987-07-24 NZ NZ221185A patent/NZ221185A/xx unknown
- 1987-07-27 AU AU76218/87A patent/AU602521B2/en not_active Ceased
- 1987-07-27 ZA ZA875518A patent/ZA875518B/xx unknown
- 1987-07-27 IE IE201787A patent/IE60316B1/en not_active IP Right Cessation
-
1988
- 1988-02-19 NO NO880742A patent/NO167864C/no unknown
-
1989
- 1989-04-12 GR GR89300034T patent/GR890300034T1/el unknown
- 1989-12-29 GR GR89400316T patent/GR3000269T3/el unknown
-
1990
- 1990-10-11 US US07/596,616 patent/US5089488A/en not_active Expired - Fee Related
-
1991
- 1991-07-12 FI FI913387A patent/FI913387A0/fi not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |