DK3645565T3 - Bispecifikke antistoffer mod ROR1 og CD3 - Google Patents

Bispecifikke antistoffer mod ROR1 og CD3 Download PDF

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Publication number
DK3645565T3
DK3645565T3 DK18742577.2T DK18742577T DK3645565T3 DK 3645565 T3 DK3645565 T3 DK 3645565T3 DK 18742577 T DK18742577 T DK 18742577T DK 3645565 T3 DK3645565 T3 DK 3645565T3
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DK
Denmark
Prior art keywords
ror1
bispecific antibodies
bispecific
antibodies
Prior art date
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DK18742577.2T
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Danish (da)
English (en)
Inventor
Amit Nathwani
Satyen Gohil
Peruta Marco Della
Original Assignee
Ucl Business Ltd
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Publication of DK3645565T3 publication Critical patent/DK3645565T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK18742577.2T 2017-07-05 2018-07-05 Bispecifikke antistoffer mod ROR1 og CD3 DK3645565T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1710838.2A GB201710838D0 (en) 2017-07-05 2017-07-05 Bispecific antibodies
PCT/GB2018/051916 WO2019008379A1 (en) 2017-07-05 2018-07-05 BISPECIFIC ANTIBODIES DIRECTED AGAINST ROR1 AND CD3

Publications (1)

Publication Number Publication Date
DK3645565T3 true DK3645565T3 (da) 2022-02-14

Family

ID=59592717

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18742577.2T DK3645565T3 (da) 2017-07-05 2018-07-05 Bispecifikke antistoffer mod ROR1 og CD3

Country Status (11)

Country Link
US (2) US11306142B2 (cg-RX-API-DMAC7.html)
EP (2) EP3985026A1 (cg-RX-API-DMAC7.html)
JP (1) JP2020529839A (cg-RX-API-DMAC7.html)
CN (1) CN110891972B (cg-RX-API-DMAC7.html)
AU (1) AU2018295479A1 (cg-RX-API-DMAC7.html)
CA (1) CA3068200A1 (cg-RX-API-DMAC7.html)
DK (1) DK3645565T3 (cg-RX-API-DMAC7.html)
ES (1) ES2906361T3 (cg-RX-API-DMAC7.html)
GB (1) GB201710838D0 (cg-RX-API-DMAC7.html)
MX (1) MX2019015349A (cg-RX-API-DMAC7.html)
WO (1) WO2019008379A1 (cg-RX-API-DMAC7.html)

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TWI899079B (zh) * 2019-05-23 2025-10-01 美商維洛斯生物公司 抗ror1/抗cd3雙特異性結合分子
CN114127110B (zh) * 2019-05-30 2022-07-01 山东博安生物技术股份有限公司 抗cgrp抗体及其应用
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WO2022217048A1 (en) * 2021-04-09 2022-10-13 Sorrento Therapeutics, Inc. Oncolytic viruses expressing anti-ror1/anti-cd3 bispecific antibodies
JP2024520444A (ja) 2021-05-24 2024-05-24 プロヴェンション・バイオ・インコーポレイテッド １型糖尿病を治療するための方法
KR20240125944A (ko) * 2021-12-28 2024-08-20 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 항-ror1 항체 및 항-ror1 항체 약물 접합체 및 이의 의약적 용도
GB202216284D0 (en) 2022-11-02 2022-12-14 Ucl Business Ltd Self-regulation
TW202434635A (zh) * 2022-11-03 2024-09-01 美商翰森生物有限責任公司 多特異性抗體及其醫藥用途
CN120712345A (zh) * 2022-12-30 2025-09-26 上药生物治疗（香港）有限公司 表达趋化因子受体的细胞及其用途
CN116731178A (zh) * 2023-06-14 2023-09-12 北京大学深圳研究生院 抗人ror1抗体、基因及其应用
WO2025061032A1 (zh) * 2023-09-18 2025-03-27 南京蓬勃生物科技有限公司 靶向人源ror1和cd3的双特异性抗体

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Also Published As

Publication number Publication date
AU2018295479A1 (en) 2020-01-16
GB201710838D0 (en) 2017-08-16
MX2019015349A (es) 2020-07-20
EP3645565B1 (en) 2021-12-15
CN110891972B (zh) 2023-05-30
WO2019008379A1 (en) 2019-01-10
EP3645565A1 (en) 2020-05-06
US11306142B2 (en) 2022-04-19
US20200157218A1 (en) 2020-05-21
CA3068200A1 (en) 2019-01-10
ES2906361T3 (es) 2022-04-18
JP2020529839A (ja) 2020-10-15
US20220204621A1 (en) 2022-06-30
EP3985026A1 (en) 2022-04-20
CN110891972A (zh) 2020-03-17

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