DK3607055T3 - Sammensætninger til omprogrammering af celler til dendritiske celler eller antigenpræsenterende celler, fremgangsmåder og anvendelser deraf - Google Patents

Sammensætninger til omprogrammering af celler til dendritiske celler eller antigenpræsenterende celler, fremgangsmåder og anvendelser deraf

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Publication number
DK3607055T3
DK3607055T3 DK18723960.3T DK18723960T DK3607055T3 DK 3607055 T3 DK3607055 T3 DK 3607055T3 DK 18723960 T DK18723960 T DK 18723960T DK 3607055 T3 DK3607055 T3 DK 3607055T3
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Denmark
Prior art keywords
cells
compositions
methods
antigen presenting
reprogramming
Prior art date
Application number
DK18723960.3T
Other languages
English (en)
Inventor
Lemos Pereira Carlos Filipe Ribeiro
Pires Cristiana Ferreira
Rosa Fábio Alexandre Fiúza
Original Assignee
Asgard Therapeutics Ab
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Filing date
Publication date
Priority claimed from EP17171166.6A external-priority patent/EP3385373A1/en
Application filed by Asgard Therapeutics Ab filed Critical Asgard Therapeutics Ab
Application granted granted Critical
Publication of DK3607055T3 publication Critical patent/DK3607055T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • C12N2500/00—Specific components of cell culture medium
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    • C12N2500/32—Amino acids
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/05—Adjuvants
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2304—Interleukin-4 (IL-4)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/604—Klf-4
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1394—Bone marrow stromal cells; whole marrow
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/25—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from renal cells, from cells of the urinary tract

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  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK18723960.3T 2017-04-05 2018-04-05 Sammensætninger til omprogrammering af celler til dendritiske celler eller antigenpræsenterende celler, fremgangsmåder og anvendelser deraf DK3607055T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PT11001217 2017-04-05
EP17171166.6A EP3385373A1 (en) 2017-04-05 2017-05-15 Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof
PT11026317 2017-08-24
PT11026717 2017-08-25
PCT/IB2018/052378 WO2018185709A1 (en) 2017-04-05 2018-04-05 Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof

Publications (1)

Publication Number Publication Date
DK3607055T3 true DK3607055T3 (da) 2025-08-18

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DK18723960.3T DK3607055T3 (da) 2017-04-05 2018-04-05 Sammensætninger til omprogrammering af celler til dendritiske celler eller antigenpræsenterende celler, fremgangsmåder og anvendelser deraf

Country Status (9)

Country Link
US (2) US11345891B2 (da)
EP (1) EP3607055B1 (da)
JP (1) JP7303743B2 (da)
CN (1) CN110088272B (da)
CA (1) CA3040626A1 (da)
DK (1) DK3607055T3 (da)
IL (1) IL266131A (da)
SG (1) SG11201903353WA (da)
WO (1) WO2018185709A1 (da)

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SG11202112475QA (en) * 2019-05-27 2021-12-30 Univ Muenster Westfaelische Wilhelms Rapid and deterministic generation of microglia from human pluripotent stem cells
US20240052312A1 (en) * 2019-10-10 2024-02-15 Asgard Therapeutics Ab Composition for reprogramming cells into plasmacytoid dendritic cells or interferon type i-producing cells, methods and uses thereof
WO2021087234A1 (en) * 2019-11-01 2021-05-06 The Board Of Trustees Of The Leland Stanford Junior University Lineage reprogramming as a cancer immunotherapy
JP7770028B2 (ja) * 2019-11-25 2025-11-14 アスガード セラピューティクス エービー 細胞を抗原提示に有能な樹状細胞２型に初期化するための組成物、その方法及び使用
JP2023506501A (ja) * 2019-12-16 2023-02-16 ワシントン・ユニバーシティ キメラ抗原受容体樹状細胞（ｃａｒ－ｄｃ）ならびにこれを作製および使用する方法
WO2021133775A1 (en) * 2019-12-23 2021-07-01 University Of Florida Research Foundation, Incorporated Immunotherapy for direct reprogramming of cancer cells into immune cells/antigen presenting cells/dendritic cells
AU2022216607A1 (en) * 2021-02-05 2023-07-27 Duke University Methods to detect and treat a fungal infection
EP4341384A1 (en) * 2021-05-19 2024-03-27 Asgard Therapeutics AB Reprogramming of cells to type 1 conventional dendritic cells or antigen-presenting cells
CN114252611B (zh) * 2021-12-07 2022-09-27 暨南大学附属第一医院（广州华侨医院） 一种筛选前列腺癌潜在生物标志物的方法及其应用
CN114324126B (zh) * 2022-01-07 2024-03-19 南京鼓楼医院 一种改变早期b细胞分化的方法
CN118871574A (zh) 2022-03-18 2024-10-29 国立研究开发法人产业技术综合研究所 一种用于将成纤维细胞或成纤维细胞样细胞重编程为常规2型树突状细胞的方法
WO2025120097A1 (en) * 2023-12-05 2025-06-12 Asgard Therapeutics Ab Rna-based strategies for dendritic cell reprogramming and uses thereof

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JP7303743B2 (ja) 2023-07-05
EP3607055A1 (en) 2020-02-12
US11345891B2 (en) 2022-05-31
IL266131A (en) 2019-06-30
US20200017832A1 (en) 2020-01-16
EP3607055B1 (en) 2025-05-14
CA3040626A1 (en) 2018-10-11
SG11201903353WA (en) 2019-05-30
CN110088272B (zh) 2023-08-04
WO2018185709A1 (en) 2018-10-11
JP2020513191A (ja) 2020-05-07
WO2018185709A9 (en) 2019-08-22
CN110088272A (zh) 2019-08-02
US20220325244A1 (en) 2022-10-13

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