DK3535393T3 - Todelt anordning til t-cellereceptorsyntese og stabil genomisk integration til tcr-præsenterende celler - Google Patents

Todelt anordning til t-cellereceptorsyntese og stabil genomisk integration til tcr-præsenterende celler Download PDF

Info

Publication number
DK3535393T3
DK3535393T3 DK17800760.5T DK17800760T DK3535393T3 DK 3535393 T3 DK3535393 T3 DK 3535393T3 DK 17800760 T DK17800760 T DK 17800760T DK 3535393 T3 DK3535393 T3 DK 3535393T3
Authority
DK
Denmark
Prior art keywords
presenting cells
part device
genomic integration
cell receiver
stable genomic
Prior art date
Application number
DK17800760.5T
Other languages
English (en)
Inventor
Reagan Micheal Jarvis
Ryan Edward Hill
Luke Benjamin Pase
Original Assignee
Genovie Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genovie Ab filed Critical Genovie Ab
Application granted granted Critical
Publication of DK3535393T3 publication Critical patent/DK3535393T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4614—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4615—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
DK17800760.5T 2016-11-07 2017-11-07 Todelt anordning til t-cellereceptorsyntese og stabil genomisk integration til tcr-præsenterende celler DK3535393T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA201670875 2016-11-07
EP17181798 2017-07-18
DKPA201770577 2017-07-18
PCT/EP2017/078378 WO2018083318A1 (en) 2016-11-07 2017-11-07 A two-part device for t-cell receptor synthesis and stable genomic integration to tcr-presenting cells

Publications (1)

Publication Number Publication Date
DK3535393T3 true DK3535393T3 (da) 2021-11-22

Family

ID=60388010

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17800760.5T DK3535393T3 (da) 2016-11-07 2017-11-07 Todelt anordning til t-cellereceptorsyntese og stabil genomisk integration til tcr-præsenterende celler

Country Status (11)

Country Link
US (1) US11274309B2 (da)
EP (1) EP3535393B1 (da)
JP (1) JP6803480B2 (da)
KR (1) KR102614328B1 (da)
CN (1) CN110023497B (da)
AU (1) AU2017352591B2 (da)
CA (1) CA3039420A1 (da)
DK (1) DK3535393T3 (da)
ES (1) ES2900151T3 (da)
NZ (1) NZ752583A (da)
WO (1) WO2018083318A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109996813B (zh) * 2016-11-07 2021-03-19 杰诺维有限公司 用于鉴定和表征t细胞受体、t细胞抗原及其功能性相互作用的工程化的多组件系统
EP4019625A1 (en) 2016-11-07 2022-06-29 Genovie AB An engineered multi-component system used for selecting t-cell receptors, t-cells and engineered antigen presenting cells.
CN111315883B (zh) 2017-07-18 2024-06-18 杰诺维有限公司 用于全长t细胞受体可读框的快速装配和多样化的两组分载体文库系统
CA3135850A1 (en) * 2019-04-05 2020-10-08 Rootpath Genomics, Inc. Compositions and methods for t-cell receptor gene assembly
KR102152189B1 (ko) * 2020-02-11 2020-09-04 재단법인 아산사회복지재단 T 세포 내 표적 위치로의 t 세포 수용체 삽입을 위한 재조합벡터 및 이를 이용한 t 세포 내 표적 위치로의 t 세포 수용체 삽입용 조성물
JP2023527658A (ja) 2020-04-27 2023-06-30 ジェノヴィー エービー ウイルス性非ビリオン膜タンパク質由来エピトープに対するヒト白血球抗原クラスｉ制限ｃｄ８ ｔ細胞応答をプライムするワクチン組成物を製造する方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003065977A2 (en) 2001-11-20 2003-08-14 Dana-Farber Cancer Institute Modified antigen-presenting cells
US20100291633A1 (en) * 2007-09-03 2010-11-18 Thorsten Selmer Method of cloning at least one nucleic acid molecule of interest using type iis restriction endonucleases, and corresponding cloning vectors, kits and system using type iis restriction endonucleases
EP2395087A1 (en) * 2010-06-11 2011-12-14 Icon Genetics GmbH System and method of modular cloning
EP3376225A1 (en) 2010-08-06 2018-09-19 Ludwig-Maximilians-Universität München Identification of t cell target antigens
WO2013144257A1 (en) 2012-03-27 2013-10-03 Dsm Ip Assets B.V. Cloning method
JP6126804B2 (ja) * 2012-07-25 2017-05-10 国立大学法人富山大学 Ｔ細胞受容体のクローニング方法
WO2014153470A2 (en) 2013-03-21 2014-09-25 Sangamo Biosciences, Inc. Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases
CN106164091A (zh) 2014-03-14 2016-11-23 英美偌科有限公司 Tcr文库
MX2017005698A (es) 2014-10-31 2017-06-29 Univ Pennsylvania Alteracion de la expresion genetica en celulas t modificadas con el receptor de antigeno quimerico (cart) y usos de las mismas.
AU2015343013B2 (en) 2014-11-05 2020-07-16 Board Of Regents, The University Of Texas System Gene modified immune effector cells and engineered cells for expansion of immune effector cells
SG11201707540QA (en) 2015-03-16 2017-10-30 Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft Method of detecting new immunogenic t cell epitopes and isolating new antigen-specific t cell receptors by means of an mhc cell library
WO2016193299A1 (en) * 2015-06-01 2016-12-08 Medigene Immunotherapies Gmbh T cell receptor library
CN105316362B (zh) * 2015-08-19 2020-03-17 暨南大学 一种Dual-RMCE介导的TCR基因置换系统及其方法
EP4019625A1 (en) 2016-11-07 2022-06-29 Genovie AB An engineered multi-component system used for selecting t-cell receptors, t-cells and engineered antigen presenting cells.
CN109996813B (zh) 2016-11-07 2021-03-19 杰诺维有限公司 用于鉴定和表征t细胞受体、t细胞抗原及其功能性相互作用的工程化的多组件系统
KR102606929B1 (ko) 2016-11-07 2023-11-27 제노비에 에이비 동족 항원과 t-세포 수용체 상호작용의 발견 및 특징규명을 위한 조작된 2-부분 세포 디바이스

Also Published As

Publication number Publication date
CN110023497A (zh) 2019-07-16
JP2019534048A (ja) 2019-11-28
US11274309B2 (en) 2022-03-15
KR102614328B1 (ko) 2023-12-14
CA3039420A1 (en) 2018-05-11
CN110023497B (zh) 2021-07-13
ES2900151T3 (es) 2022-03-16
AU2017352591B2 (en) 2024-07-11
NZ752583A (en) 2023-10-27
WO2018083318A1 (en) 2018-05-11
EP3535393B1 (en) 2021-09-22
JP6803480B2 (ja) 2020-12-23
KR20190076995A (ko) 2019-07-02
EP3535393A1 (en) 2019-09-11
US20190283017A1 (en) 2019-09-19
AU2017352591A1 (en) 2019-05-02

Similar Documents

Publication Publication Date Title
DK3535393T3 (da) Todelt anordning til t-cellereceptorsyntese og stabil genomisk integration til tcr-præsenterende celler
DK3795177T3 (da) Claudin-18.2-specifikke immunoreceptorer og t-celleepitoper
DK3215601T3 (da) Fremgangsmåder til transduktion og celleforarbejdning
EP3223368A4 (en) Baffle board for base station antenna and base station antenna array structure
HK1258218A1 (zh) T細胞受體(tcr)結合抗體及其應用
DK3126381T4 (da) Claudin-6-specifikke immunoreceptorer og t-celleepitoper
DK3100438T3 (da) Anycast-baseret, storområde system til fordelt kortlægning og belastningsbalancering
EP3319176A4 (en) Antenna array and network device
DK3496531T3 (da) Teknologisk linje til avl eller opdræt af insekter, modulsystem til sådanne teknologiske linjer, fremgangsmåde og anvendelse deraf
EP3638987A4 (en) DEVICES AND METHODS FOR CELL ANALYSIS
DK3125872T3 (da) Amorf fast dispersion, der omfatter taxan, tablet, der omfatter samme, og fremgangsmåde til fremstilling deraf
EP3603477A4 (en) MEASUREMENT SUPPORT DEVICE, ENDOSCOPIC SYSTEM AND PROCESSOR
EP3259066A4 (en) Device, platform, and assay for assessing cells
DK3302975T3 (da) Anordning og fremgangsmåde til skæring, trykning eller prægning
EP3253111A4 (en) User device and cell measurement method
EP3142188A4 (en) Array antenna calibration method, device and system
IL269168A (en) single cell diagnosis
EP3590407A4 (en) MEASUREMENT SUPPORT DEVICE, ENDOSCOPE SYSTEM, AND ENDOSCOPE SYSTEM PROCESSOR
EP3514536A4 (en) PORTABLE URINE ANALYSIS DEVICE
EP3495824A4 (en) ANALYSIS CELL, ANALYSIS DEVICE, ANALYSIS EQUIPMENT AND ANALYSIS SYSTEM
EP3690015A4 (en) CELL TRANSPLANTATION DEVICE AND CELL TRANSPLANTATION UNIT
IL262484A (en) Sampling array devices and a system for spectral analysis
DK3328993T3 (da) Haploide humane embryonale stamcellelinjer og somatiske cellelinjer og fremgangsmåder til fremstilling deraf
DK3098298T3 (da) Indretning til podning og dyrkning af celler
DK3709459T3 (da) Forbindelsesindretning til at forbinde gitterkabelbakker og gitterkabelbakkeafsnit