DK3486248T3 - Forbedrede fremgangsmåder til acylering af maytansinol - Google Patents
Forbedrede fremgangsmåder til acylering af maytansinol Download PDFInfo
- Publication number
- DK3486248T3 DK3486248T3 DK18213678.8T DK18213678T DK3486248T3 DK 3486248 T3 DK3486248 T3 DK 3486248T3 DK 18213678 T DK18213678 T DK 18213678T DK 3486248 T3 DK3486248 T3 DK 3486248T3
- Authority
- DK
- Denmark
- Prior art keywords
- maytansinol
- acylation
- improved procedures
- procedures
- improved
- Prior art date
Links
- QWPXBEHQFHACTK-RZKXNLMUSA-N CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](O)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 Chemical compound CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](O)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-RZKXNLMUSA-N 0.000 title 1
- QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 title 1
- 230000010933 acylation Effects 0.000 title 1
- 238000005917 acylation reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
- H01R12/00—Structural associations of a plurality of mutually-insulated electrical connecting elements, specially adapted for printed circuits, e.g. printed circuit boards [PCB], flat or ribbon cables, or like generally planar structures, e.g. terminal strips, terminal blocks; Coupling devices specially adapted for printed circuits, flat or ribbon cables, or like generally planar structures; Terminals specially adapted for contact with, or insertion into, printed circuits, flat or ribbon cables, or like generally planar structures
- H01R12/50—Fixed connections
- H01R12/51—Fixed connections for rigid printed circuits or like structures
- H01R12/55—Fixed connections for rigid printed circuits or like structures characterised by the terminals
- H01R12/58—Fixed connections for rigid printed circuits or like structures characterised by the terminals terminals for insertion into holes
- H01R12/585—Terminals having a press fit or a compliant portion and a shank passing through a hole in the printed circuit board
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K1/00—Printed circuits
- H05K1/02—Details
- H05K1/0201—Thermal arrangements, e.g. for cooling, heating or preventing overheating
- H05K1/0203—Cooling of mounted components
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K1/00—Printed circuits
- H05K1/02—Details
- H05K1/11—Printed elements for providing electric connections to or between printed circuits
- H05K1/115—Via connections; Lands around holes or via connections
- H05K1/116—Lands, clearance holes or other lay-out details concerning the surrounding of a via
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K1/00—Printed circuits
- H05K1/18—Printed circuits structurally associated with non-printed electric components
- H05K1/181—Printed circuits structurally associated with non-printed electric components associated with surface mounted components
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261705731P | 2012-09-26 | 2012-09-26 | |
| EP13774881.0A EP2900676B1 (en) | 2012-09-26 | 2013-09-26 | Improved method for the acylation of maytansinol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3486248T3 true DK3486248T3 (da) | 2021-07-12 |
Family
ID=49328648
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18213678.8T DK3486248T3 (da) | 2012-09-26 | 2013-09-26 | Forbedrede fremgangsmåder til acylering af maytansinol |
| DK13774881.0T DK2900676T3 (en) | 2012-09-26 | 2013-09-26 | IMPROVED PROCEDURES FOR ACYLATION OF MAYTANSINOL |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13774881.0T DK2900676T3 (en) | 2012-09-26 | 2013-09-26 | IMPROVED PROCEDURES FOR ACYLATION OF MAYTANSINOL |
Country Status (27)
| Country | Link |
|---|---|
| US (9) | US9012629B2 (enExample) |
| EP (3) | EP3904358A1 (enExample) |
| JP (7) | JP6517693B2 (enExample) |
| CN (2) | CN104768955B (enExample) |
| AU (4) | AU2013323572B2 (enExample) |
| BR (2) | BR112015006505B1 (enExample) |
| CA (2) | CA2884873C (enExample) |
| CY (2) | CY1121415T1 (enExample) |
| DK (2) | DK3486248T3 (enExample) |
| ES (2) | ES2880754T3 (enExample) |
| HR (2) | HRP20190473T1 (enExample) |
| HU (2) | HUE055443T2 (enExample) |
| IL (2) | IL237899A (enExample) |
| LT (2) | LT3486248T (enExample) |
| MX (2) | MX390615B (enExample) |
| MY (1) | MY169250A (enExample) |
| NZ (2) | NZ739573A (enExample) |
| PL (2) | PL2900676T3 (enExample) |
| PT (2) | PT3486248T (enExample) |
| RS (2) | RS62075B1 (enExample) |
| RU (2) | RU2648992C2 (enExample) |
| SG (1) | SG11201501918UA (enExample) |
| SI (2) | SI3486248T1 (enExample) |
| SM (2) | SMT201900170T1 (enExample) |
| TR (1) | TR201903625T4 (enExample) |
| WO (1) | WO2014052537A1 (enExample) |
| ZA (1) | ZA201501898B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT201900170T1 (it) * | 2012-09-26 | 2019-05-10 | Immunogen Inc | Metodo migliorato per l'acilazione di maytansinolo |
| CN105585579A (zh) * | 2014-10-24 | 2016-05-18 | 南京联宁生物制药有限公司 | 一种化合物及其制备方法以及美登素dm1的制备方法 |
| WO2016149464A1 (en) * | 2015-03-17 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Amino acid acylation reagents and methods of using the same |
| EP3554544A4 (en) | 2016-12-16 | 2020-07-29 | Bluefin Biomedicine, Inc. | ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE |
| EP3956332B1 (en) | 2019-04-18 | 2023-02-22 | Indena S.p.A. | Diasteroselective process for the preparation of thiol- or disulfide-containing maytansinoid esters and intermediates thereof |
| US12473579B2 (en) | 2019-11-29 | 2025-11-18 | Microbiopharm Japan Co., Ltd. | Method for enzymatically producing maytansinol |
| EP4685150A1 (en) | 2023-04-28 | 2026-01-28 | Chugai Seiyaku Kabushiki Kaisha | Method for producing amide group-containing compound using n-carboxyamino acid anhydride |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
| JPS6034556B2 (ja) * | 1977-03-31 | 1985-08-09 | 武田薬品工業株式会社 | 抗生物質ｃ−１５００３ |
| US4137230A (en) | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
| US4265814A (en) | 1978-03-24 | 1981-05-05 | Takeda Chemical Industries | Matansinol 3-n-hexadecanoate |
| JPS5562090A (en) | 1978-10-27 | 1980-05-10 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS5566585A (en) | 1978-11-14 | 1980-05-20 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164687A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS55164685A (en) | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164686A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| US4309428A (en) | 1979-07-30 | 1982-01-05 | Takeda Chemical Industries, Ltd. | Maytansinoids |
| JPS5622790A (en) * | 1979-07-31 | 1981-03-03 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| JP3054741B2 (ja) * | 1989-09-29 | 2000-06-19 | 武田薬品工業株式会社 | Ｔａｎ―１３１３およびそのアシル誘導体 |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| JP4776843B2 (ja) * | 1999-10-01 | 2011-09-21 | イムノゲン インコーポレーティッド | 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法 |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| TWI298067B (en) * | 2002-01-31 | 2008-06-21 | Daiso Co Ltd | New optically active compound, method for kinetic resolution of carbonic acid derivatives and catalyst thereof |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| EP1651162B1 (en) * | 2003-05-20 | 2015-10-21 | ImmunoGen, Inc. | Improved cytotoxic agents comprising new maytansinoids |
| MXPA06002088A (es) * | 2003-08-22 | 2006-08-11 | Activbiotics Inc | Analogos de rifamicina y usos de los mismos. |
| TR201808537T4 (tr) | 2004-09-23 | 2018-07-23 | Genentech Inc | Sistein değiştirilmiş antikorlar ve konjugatlar. |
| KR101281501B1 (ko) | 2004-12-09 | 2013-07-15 | 얀센 바이오테크 인코포레이티드 | 항인테그린 면역 컨쥬게이트, 방법 및 용도 |
| US7301019B2 (en) * | 2005-01-21 | 2007-11-27 | Immunogen, Inc. | Method for the preparation of maytansinoid esters |
| WO2007011721A1 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
| ATE535529T1 (de) * | 2005-08-09 | 2011-12-15 | Millennium Pharm Inc | Verfahren zur acylierung von maytansinol mit chiralen aminosäuren |
| CA2668134A1 (en) * | 2006-11-06 | 2008-05-15 | Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag | Ascomycin and pimecrolimus having reduced levels of des-methylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof |
| JP2008288289A (ja) | 2007-05-16 | 2008-11-27 | Oki Electric Ind Co Ltd | 電界効果トランジスタとその製造方法 |
| JP5784592B2 (ja) | 2009-06-03 | 2015-09-24 | イミュノジェン・インコーポレーテッド | 抱合方法 |
| US8754207B2 (en) * | 2009-09-25 | 2014-06-17 | Cadila Healthcare Limited | Process for the preparation of rapamycin derivatives |
| EP2640727B1 (en) * | 2010-11-17 | 2015-05-13 | Genentech, Inc. | Alaninyl maytansinol antibody conjugates |
| SMT201900170T1 (it) | 2012-09-26 | 2019-05-10 | Immunogen Inc | Metodo migliorato per l'acilazione di maytansinolo |
-
2013
- 2013-09-26 SM SM20190170T patent/SMT201900170T1/it unknown
- 2013-09-26 SI SI201331899T patent/SI3486248T1/sl unknown
- 2013-09-26 CN CN201380049853.8A patent/CN104768955B/zh active Active
- 2013-09-26 SI SI201331374T patent/SI2900676T1/sl unknown
- 2013-09-26 EP EP21166484.2A patent/EP3904358A1/en active Pending
- 2013-09-26 DK DK18213678.8T patent/DK3486248T3/da active
- 2013-09-26 CA CA2884873A patent/CA2884873C/en active Active
- 2013-09-26 WO PCT/US2013/061839 patent/WO2014052537A1/en not_active Ceased
- 2013-09-26 RU RU2015111635A patent/RU2648992C2/ru active
- 2013-09-26 MX MX2019008652A patent/MX390615B/es unknown
- 2013-09-26 MY MYPI2015000663A patent/MY169250A/en unknown
- 2013-09-26 DK DK13774881.0T patent/DK2900676T3/en active
- 2013-09-26 NZ NZ73957313A patent/NZ739573A/en unknown
- 2013-09-26 CN CN201810251853.0A patent/CN108586487B/zh active Active
- 2013-09-26 ES ES18213678T patent/ES2880754T3/es active Active
- 2013-09-26 CA CA3133906A patent/CA3133906C/en active Active
- 2013-09-26 PL PL13774881T patent/PL2900676T3/pl unknown
- 2013-09-26 HU HUE18213678A patent/HUE055443T2/hu unknown
- 2013-09-26 SG SG11201501918UA patent/SG11201501918UA/en unknown
- 2013-09-26 HR HRP20190473TT patent/HRP20190473T1/hr unknown
- 2013-09-26 ES ES13774881T patent/ES2716561T3/es active Active
- 2013-09-26 RS RS20210825A patent/RS62075B1/sr unknown
- 2013-09-26 BR BR112015006505-8A patent/BR112015006505B1/pt active IP Right Grant
- 2013-09-26 PT PT182136788T patent/PT3486248T/pt unknown
- 2013-09-26 EP EP18213678.8A patent/EP3486248B1/en active Active
- 2013-09-26 PL PL18213678T patent/PL3486248T3/pl unknown
- 2013-09-26 US US14/037,657 patent/US9012629B2/en active Active
- 2013-09-26 TR TR2019/03625T patent/TR201903625T4/tr unknown
- 2013-09-26 AU AU2013323572A patent/AU2013323572B2/en active Active
- 2013-09-26 LT LTEP18213678.8T patent/LT3486248T/lt unknown
- 2013-09-26 SM SM20210390T patent/SMT202100390T1/it unknown
- 2013-09-26 RS RS20190314A patent/RS58493B1/sr unknown
- 2013-09-26 HU HUE13774881A patent/HUE043285T2/hu unknown
- 2013-09-26 LT LTEP13774881.0T patent/LT2900676T/lt unknown
- 2013-09-26 RU RU2018109295A patent/RU2765072C2/ru active
- 2013-09-26 MX MX2015003745A patent/MX366701B/es active IP Right Grant
- 2013-09-26 EP EP13774881.0A patent/EP2900676B1/en active Active
- 2013-09-26 NZ NZ706019A patent/NZ706019A/en unknown
- 2013-09-26 JP JP2015534641A patent/JP6517693B2/ja active Active
- 2013-09-26 BR BR122021022582-6A patent/BR122021022582B1/pt active IP Right Grant
- 2013-09-26 PT PT13774881T patent/PT2900676T/pt unknown
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2015
- 2015-03-17 US US14/660,050 patent/US9469655B2/en active Active
- 2015-03-19 ZA ZA2015/01898A patent/ZA201501898B/en unknown
- 2015-03-23 IL IL237899A patent/IL237899A/en active IP Right Grant
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2016
- 2016-09-19 US US15/269,163 patent/US9796731B2/en active Active
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2017
- 2017-08-14 IL IL253988A patent/IL253988B/en active IP Right Grant
- 2017-09-19 US US15/708,346 patent/US10100062B2/en active Active
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2018
- 2018-02-27 AU AU2018201392A patent/AU2018201392B2/en active Active
- 2018-02-27 JP JP2018032684A patent/JP2018109044A/ja not_active Ceased
- 2018-09-12 US US16/129,268 patent/US10461449B2/en active Active
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2019
- 2019-03-13 CY CY20191100302T patent/CY1121415T1/el unknown
- 2019-09-18 US US16/574,718 patent/US10944190B2/en active Active
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2020
- 2020-04-06 JP JP2020068137A patent/JP6735000B1/ja active Active
- 2020-06-10 AU AU2020203823A patent/AU2020203823B2/en active Active
- 2020-07-10 JP JP2020118929A patent/JP2020180150A/ja active Pending
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2021
- 2021-06-29 HR HRP20211030TT patent/HRP20211030T1/hr unknown
- 2021-07-02 CY CY20211100594T patent/CY1124337T1/el unknown
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2022
- 2022-02-28 JP JP2022029253A patent/JP2022068367A/ja active Pending
- 2022-03-07 AU AU2022201557A patent/AU2022201557A1/en not_active Abandoned
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2023
- 2023-09-05 US US18/242,321 patent/US20240145953A1/en not_active Abandoned
- 2023-10-23 JP JP2023181529A patent/JP2024010055A/ja active Pending
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2024
- 2024-01-19 US US18/417,406 patent/US20240313444A1/en not_active Abandoned
- 2024-05-31 US US18/679,863 patent/US20250007192A1/en active Pending
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2025
- 2025-03-31 JP JP2025058629A patent/JP2025098242A/ja active Pending
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