DK3485883T3 - Metoder til behandling af øjensygdomme forbundet med betændelse og vaskulær spredning - Google Patents

Metoder til behandling af øjensygdomme forbundet med betændelse og vaskulær spredning Download PDF

Info

Publication number
DK3485883T3
DK3485883T3 DK18207689.3T DK18207689T DK3485883T3 DK 3485883 T3 DK3485883 T3 DK 3485883T3 DK 18207689 T DK18207689 T DK 18207689T DK 3485883 T3 DK3485883 T3 DK 3485883T3
Authority
DK
Denmark
Prior art keywords
inflammation
treatment
methods
diseases related
eye diseases
Prior art date
Application number
DK18207689.3T
Other languages
English (en)
Inventor
Darren James Kelly
David Stapleton
Original Assignee
Occurx Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2010905197A external-priority patent/AU2010905197A0/en
Application filed by Occurx Pty Ltd filed Critical Occurx Pty Ltd
Application granted granted Critical
Publication of DK3485883T3 publication Critical patent/DK3485883T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41921,2,3-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04Amoebicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
DK18207689.3T 2010-11-24 2011-11-10 Metoder til behandling af øjensygdomme forbundet med betændelse og vaskulær spredning DK3485883T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2010905197A AU2010905197A0 (en) 2010-11-24 Methods of treating eye diseases associated with inflammation and vascular proliferation
EP11843788.8A EP2642989B1 (en) 2010-11-24 2011-11-10 Methods of treating eye diseases associated with inflammation and vascular proliferation

Publications (1)

Publication Number Publication Date
DK3485883T3 true DK3485883T3 (da) 2020-10-12

Family

ID=46145280

Family Applications (2)

Application Number Title Priority Date Filing Date
DK11843788.8T DK2642989T3 (da) 2010-11-24 2011-11-10 Frengangsmåder til behandling af øjensygdomme associeret med inflammation og vaskulær proliferation
DK18207689.3T DK3485883T3 (da) 2010-11-24 2011-11-10 Metoder til behandling af øjensygdomme forbundet med betændelse og vaskulær spredning

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK11843788.8T DK2642989T3 (da) 2010-11-24 2011-11-10 Frengangsmåder til behandling af øjensygdomme associeret med inflammation og vaskulær proliferation

Country Status (21)

Country Link
US (5) US9839640B2 (da)
EP (2) EP2642989B1 (da)
JP (1) JP5942131B2 (da)
KR (1) KR101899613B1 (da)
CN (1) CN103228275B (da)
AU (1) AU2011334592C1 (da)
CA (1) CA2815390C (da)
DK (2) DK2642989T3 (da)
ES (2) ES2829620T3 (da)
HR (1) HRP20190561T1 (da)
HU (1) HUE042676T2 (da)
MX (1) MX352517B (da)
NZ (1) NZ609144A (da)
PL (1) PL2642989T3 (da)
PT (1) PT2642989T (da)
RS (1) RS58603B1 (da)
SG (1) SG189326A1 (da)
SI (1) SI2642989T1 (da)
TR (1) TR201904760T4 (da)
WO (1) WO2012068612A1 (da)
ZA (1) ZA201302638B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2642989T (pt) 2010-11-24 2019-04-23 Occurx Pty Ltd Métodos de tratamento de doenças oculares associadas a inflamação e proliferação vascular
JP7185631B2 (ja) 2017-02-03 2022-12-07 サータ セラピューティクス プロプライエタリー リミテッド 抗線維化化合物
CN110357789B (zh) * 2018-04-11 2022-09-30 华东理工大学 作为dhodh抑制剂的n-取代丙烯酰胺衍生物及其制备和用途
WO2021247900A1 (en) * 2020-06-05 2021-12-09 Occurx Pty. Ltd. Compounds and methods for the treatment of eye disorders
WO2022197681A1 (en) * 2021-03-17 2022-09-22 Occurx Pty Ltd Compounds for the treatment of disorders and salts and polymorphs thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09176003A (ja) 1995-12-28 1997-07-08 Tsumura & Co 角膜治療剤
WO1997029744A1 (fr) 1996-02-15 1997-08-21 Kissei Pharmaceutical Co., Ltd. Inhibiteur de la neoformation de vaisseaux sanguins
JPH09278653A (ja) 1996-04-05 1997-10-28 Santen Pharmaceut Co Ltd 網膜疾患治療剤
JPH10259129A (ja) * 1997-01-16 1998-09-29 Kissei Pharmaceut Co Ltd 血管新生阻害剤
IL131216A (en) 1997-02-14 2003-10-31 Kissei Pharmaceutical Drugs inhibiting progress of pterygium and postoperative recurrence of the same
JPH10330254A (ja) * 1997-04-01 1998-12-15 Kissei Pharmaceut Co Ltd 翼状片の進行および術後の再発抑制剤
US20070254055A1 (en) 2003-11-21 2007-11-01 Trustees Of Tufts College Therapeutic Avenanthramide Compounds
WO2006073126A1 (ja) 2005-01-06 2006-07-13 Kissei Pharmaceutical Co., Ltd. 慢性移植片対宿主症におけるドライアイの予防および治療剤
EP2035369B1 (en) 2006-07-05 2014-06-25 Fibrotech Therapeutics PTY LTD Therapeutic compounds
WO2008131481A1 (en) * 2007-04-26 2008-11-06 Fibrotech Therapeutics Pty Ltd Treatment of mesangioproliferative diseases
KR20100047860A (ko) 2007-07-06 2010-05-10 누온 테라피우틱스, 아이엔씨. 신경병증 통증의 치료
AU2008341010B2 (en) * 2007-12-21 2013-04-18 Certa Therapeutics Pty. Ltd. Halogenated analogues of anti-fibrotic agents
US20100158905A1 (en) 2008-12-19 2010-06-24 Nuon Therapeutics, Inc. Combination therapy of arthritis with tranilast
WO2010144959A1 (en) 2009-06-18 2010-12-23 Fibrotech Therapeutics Pty Ltd Analogues of anti-fibrotic agents
IN2012DN03312A (da) 2009-10-22 2015-10-23 Fibrotech Therapeutics Pty Ltd
PT2642989T (pt) 2010-11-24 2019-04-23 Occurx Pty Ltd Métodos de tratamento de doenças oculares associadas a inflamação e proliferação vascular

Also Published As

Publication number Publication date
ES2722723T3 (es) 2019-08-16
PT2642989T (pt) 2019-04-23
CA2815390C (en) 2021-07-13
MX2013005561A (es) 2014-11-10
US20180117049A1 (en) 2018-05-03
US20180117050A1 (en) 2018-05-03
EP2642989B1 (en) 2019-01-02
PL2642989T3 (pl) 2019-07-31
US9839640B2 (en) 2017-12-12
WO2012068612A1 (en) 2012-05-31
EP3485883B1 (en) 2020-08-26
KR20140012032A (ko) 2014-01-29
EP2642989A4 (en) 2014-09-24
HRP20190561T1 (hr) 2019-06-14
SI2642989T1 (sl) 2019-07-31
JP5942131B2 (ja) 2016-06-29
KR101899613B1 (ko) 2018-09-17
EP3485883A1 (en) 2019-05-22
JP2014502267A (ja) 2014-01-30
US10695353B2 (en) 2020-06-30
US20180117051A1 (en) 2018-05-03
TR201904760T4 (tr) 2019-04-22
US10786510B2 (en) 2020-09-29
US20130310386A1 (en) 2013-11-21
US20210244741A1 (en) 2021-08-12
HUE042676T2 (hu) 2019-07-29
ZA201302638B (en) 2023-07-26
AU2011334592C1 (en) 2015-04-02
ES2829620T3 (es) 2021-06-01
SG189326A1 (en) 2013-05-31
MX352517B (es) 2017-04-06
RS58603B1 (sr) 2019-05-31
AU2011334592B2 (en) 2014-10-23
US11583535B2 (en) 2023-02-21
CN103228275A (zh) 2013-07-31
DK2642989T3 (da) 2019-04-15
CN103228275B (zh) 2016-08-10
AU2011334592A1 (en) 2013-05-02
NZ609144A (en) 2014-08-29
CA2815390A1 (en) 2012-05-31
EP2642989A1 (en) 2013-10-02

Similar Documents

Publication Publication Date Title
DK3444342T3 (da) Fremgangsmåder og sammensætninger til behandlingen af lysosomale aflejringssygdomme
DK2882441T3 (da) Behandling af immunrelaterede og inflammatoriske sygdomme
DK3495387T3 (da) Bispecifikke anti-VEGF-/anti-ANG-2-antistoffer og deres anvendelse ved behandling af okulære vaskulære sygdomme
DK2774616T3 (da) Anvendelse af roseburia i behandling og forebyggelse af fedmerelaterede sygdomme
DK2688557T3 (da) Fremgangsmåder og sammensætninger til behandling af forstyrelse af opmærksomhed
EP3071193A4 (en) Compositions and methods for treatment of ocular inflammation and pain
EP2621499A4 (en) METHODS OF TREATING ALLERGIC DISEASES
DK2877184T3 (da) Sammensætninger og behandling for øjensygdomme og -lidelser
DK2747763T3 (da) (bacterio-)chlorofyllfotosensibilisatorer til behandling af øjensygdomme og -lidelser
EP2890440A4 (en) DEVICES AND METHOD FOR THE TREATMENT OF VASCULAR DISEASES
DK2726511T3 (da) Sammensætninger, anvendelser og fremgangsmåder til behandling af stofskiftesygdomme og -lidelser
DK2663864T3 (da) Fremgangsmåde til at vurdere immundiversitet og anvendelse af denne
EP2819687A4 (en) COMPOSITIONS AND METHODS FOR TREATING PERIPHERAL VASCULAR DISEASE
DK2723347T3 (da) Forebyggelse og behandling af inflammationstilstande
FI20135146L (fi) Farmaseuttiset koostumukset ja hoitomenetelmät
DK2793895T3 (da) Fremgangsmåder og sammensætninger til reducering af kropsfedt og adipocytter
DK2538986T3 (da) Intraartikulært supplement til anvendelse til behandling af ledsygdomme og -skader
DK2717914T3 (da) Depotformuleringer til administration af proteiner til øjet og fremgangsmåder til fremstilling deraf
DK2917231T3 (da) Lipopeptider til anvendelse ved behandling af leversygdomme og hjerte-kar-sygdomme
DK2800575T3 (da) Behandling af subarachnoidalblødning og iskæmi
DK2549995T3 (da) Brug af anatabin til behandling af inflammation og metoder til syntetisering af anatabin
DK2892556T3 (da) Sammensætninger og fremgangsmåder til behandling af sygdomme
DK3121198T3 (da) Rekombinant human g-csf-dimer og anvendelse deraf til behandlingen af neurologiske sygdomme
DK2780059T3 (da) Medicinsk anordning og fremgangsmåde til begrænsning af anvendelsen af den medicinske anordning
IL235874A0 (en) Treatment of ocular inflammatory diseases by laquinimod