DK3434671T3 - Sultam forbindelse og fremgangsmåde til anvendelse deraf - Google Patents

Sultam forbindelse og fremgangsmåde til anvendelse deraf Download PDF

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Publication number
DK3434671T3
DK3434671T3 DK17769434.6T DK17769434T DK3434671T3 DK 3434671 T3 DK3434671 T3 DK 3434671T3 DK 17769434 T DK17769434 T DK 17769434T DK 3434671 T3 DK3434671 T3 DK 3434671T3
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DK
Denmark
Prior art keywords
sultam
connection
sultam connection
Prior art date
Application number
DK17769434.6T
Other languages
English (en)
Other versions
DK3434671T5 (da
Inventor
Liguang Dai
Zhao Yang
Yanqing Yang
Hui Zhang
Yuandong Hu
Yong Peng
Yongxin Han
Rui Zhao
Xin Tian
Shanchun Wang
Li Zhu
Xiaowei Duan
Original Assignee
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Lianyungang Runzhong Pharmaceutical Co Ltd
Centaurus Biopharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chia Tai Tianqing Pharmaceutical Group Co Ltd, Lianyungang Runzhong Pharmaceutical Co Ltd, Centaurus Biopharma Co Ltd filed Critical Chia Tai Tianqing Pharmaceutical Group Co Ltd
Application granted granted Critical
Publication of DK3434671T3 publication Critical patent/DK3434671T3/da
Publication of DK3434671T5 publication Critical patent/DK3434671T5/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D275/00Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D275/00Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433Thidiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/101,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DK17769434.6T 2016-03-22 2017-03-22 Sultam forbindelse og fremgangsmåde til anvendelse deraf DK3434671T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610165138 2016-03-22
PCT/CN2017/077612 WO2017162157A1 (zh) 2016-03-22 2017-03-22 内磺酰胺化合物及其使用方法

Publications (2)

Publication Number Publication Date
DK3434671T3 true DK3434671T3 (da) 2021-01-25
DK3434671T5 DK3434671T5 (da) 2021-03-29

Family

ID=59899279

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17769434.6T DK3434671T5 (da) 2016-03-22 2017-03-22 Sultam forbindelse og fremgangsmåde til anvendelse deraf

Country Status (15)

Country Link
US (1) US11111240B2 (da)
EP (1) EP3434671B1 (da)
JP (1) JP6880166B2 (da)
KR (1) KR102389985B1 (da)
CN (2) CN109071471B (da)
AU (1) AU2017239318B2 (da)
BR (1) BR112018069504B1 (da)
CA (1) CA3018649A1 (da)
DK (1) DK3434671T5 (da)
ES (1) ES2842448T3 (da)
PT (1) PT3434671T (da)
RU (1) RU2741915C9 (da)
TW (1) TWI729094B (da)
WO (1) WO2017162157A1 (da)
ZA (1) ZA201806379B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111065630B (zh) * 2017-09-22 2022-12-30 正大天晴药业集团股份有限公司 一种内磺酰胺化合物结晶
WO2021028791A1 (en) * 2019-08-09 2021-02-18 Alembic Pharmaceuticals Limited An improved process of preparation of ivosidenib
WO2023226964A1 (en) * 2022-05-26 2023-11-30 Danatlas Pharmaceuticals Co., Ltd. Heterocyclic derivatives, compositions and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100455899B1 (ko) * 2000-10-20 2004-11-08 주식회사 티지 바이오텍 이소시트릭산 탈수소화 효소 및 그의 유전자 그리고 이효소의 활성 및 그 유전자의 발현을 저해하는 비만,고지혈증, 지방간 등을 포함하는 대사성 질환 치료제의 선별 방법
JP6081354B2 (ja) * 2010-07-16 2017-02-15 アジオス ファーマシューティカルズ, インコーポレイテッド 治療活性組成物およびそれらの使用方法
US9474779B2 (en) * 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
MX350432B (es) * 2012-01-19 2017-09-06 Agios Pharmaceuticals Inc Compuestos terapeuticamente activos y sus metodos de empleo.
WO2015010297A1 (en) * 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use

Also Published As

Publication number Publication date
TW201736354A (zh) 2017-10-16
WO2017162157A1 (zh) 2017-09-28
BR112018069504A2 (pt) 2019-01-29
DK3434671T5 (da) 2021-03-29
RU2741915C9 (ru) 2021-03-31
AU2017239318A1 (en) 2018-10-18
PT3434671T (pt) 2020-12-24
KR20180128935A (ko) 2018-12-04
RU2018136487A (ru) 2020-04-22
JP6880166B2 (ja) 2021-06-02
KR102389985B1 (ko) 2022-04-22
CN113666922A (zh) 2021-11-19
RU2018136487A3 (da) 2020-04-24
CN109071471A (zh) 2018-12-21
EP3434671A1 (en) 2019-01-30
US11111240B2 (en) 2021-09-07
ZA201806379B (en) 2021-03-31
CN109071471B (zh) 2021-05-07
ES2842448T3 (es) 2021-07-14
JP2019513819A (ja) 2019-05-30
US20210047314A1 (en) 2021-02-18
RU2741915C2 (ru) 2021-01-29
AU2017239318B2 (en) 2020-08-20
EP3434671A4 (en) 2019-08-14
TWI729094B (zh) 2021-06-01
BR112018069504B1 (pt) 2023-12-26
EP3434671B1 (en) 2020-10-21
CA3018649A1 (en) 2017-09-28

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