DK3389727T3 - Radioaktivt mærkede mglur2/3-pet-ligander - Google Patents

Radioaktivt mærkede mglur2/3-pet-ligander Download PDF

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Publication number
DK3389727T3
DK3389727T3 DK16812961.7T DK16812961T DK3389727T3 DK 3389727 T3 DK3389727 T3 DK 3389727T3 DK 16812961 T DK16812961 T DK 16812961T DK 3389727 T3 DK3389727 T3 DK 3389727T3
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DK
Denmark
Prior art keywords
ligander
mglur2
pet
radioactively labeled
radioactively
Prior art date
Application number
DK16812961.7T
Other languages
English (en)
Inventor
Joost Verbeek
Guy Maurits R Bormans
José Ignacio Andrés-Gil
Gool Michiel Luc Maria Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK3389727T3 publication Critical patent/DK3389727T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK16812961.7T 2015-12-18 2016-12-16 Radioaktivt mærkede mglur2/3-pet-ligander DK3389727T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15201240 2015-12-18
PCT/EP2016/081542 WO2017103182A1 (en) 2015-12-18 2016-12-16 Radiolabelled mglur2/3 pet ligands

Publications (1)

Publication Number Publication Date
DK3389727T3 true DK3389727T3 (da) 2020-11-02

Family

ID=55023944

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16812961.7T DK3389727T3 (da) 2015-12-18 2016-12-16 Radioaktivt mærkede mglur2/3-pet-ligander

Country Status (16)

Country Link
US (1) US11033641B2 (da)
EP (1) EP3389727B1 (da)
JP (1) JP6927974B2 (da)
AU (1) AU2016374571B2 (da)
CA (1) CA3003998A1 (da)
CY (1) CY1124935T1 (da)
DK (1) DK3389727T3 (da)
ES (1) ES2828976T3 (da)
HR (1) HRP20201372T1 (da)
HU (1) HUE050665T2 (da)
LT (1) LT3389727T (da)
PL (1) PL3389727T3 (da)
PT (1) PT3389727T (da)
RS (1) RS60981B1 (da)
SI (1) SI3389727T1 (da)
WO (1) WO2017103182A1 (da)

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JOP20150179B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
US10072014B2 (en) 2014-12-03 2018-09-11 Janssen Pharmaceutica Nv 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of MGLUR2 receptors
WO2016087489A1 (en) 2014-12-03 2016-06-09 Janssen Pharmaceutica Nv Radiolabelled mglur2 pet ligands
ES2820823T3 (es) * 2015-12-18 2021-04-22 Janssen Pharmaceutica Nv Ligandos PET mGluR2/3 radiomarcados
DK3389727T3 (da) 2015-12-18 2020-11-02 Janssen Pharmaceutica Nv Radioaktivt mærkede mglur2/3-pet-ligander
AU2018373464B2 (en) 2017-11-24 2022-12-08 Sumitomo Pharma Co., Ltd. 6,7-dihydropyrazolo[1,5-a] pyrazinone derivative and medical use thereof

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Also Published As

Publication number Publication date
CY1124935T1 (el) 2022-07-22
PL3389727T3 (pl) 2021-02-08
SI3389727T1 (sl) 2020-10-30
RS60981B1 (sr) 2020-11-30
JP6927974B2 (ja) 2021-09-01
JP2019502700A (ja) 2019-01-31
PT3389727T (pt) 2020-10-30
WO2017103182A1 (en) 2017-06-22
US20200306389A1 (en) 2020-10-01
HUE050665T2 (hu) 2020-12-28
CA3003998A1 (en) 2017-06-22
EP3389727B1 (en) 2020-08-12
LT3389727T (lt) 2020-10-12
AU2016374571A1 (en) 2018-05-17
HRP20201372T1 (hr) 2020-11-27
ES2828976T3 (es) 2021-05-28
US11033641B2 (en) 2021-06-15
AU2016374571B2 (en) 2021-05-06
EP3389727A1 (en) 2018-10-24

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