DK338789A - 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf - Google Patents

2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf Download PDF

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Publication number
DK338789A
DK338789A DK338789A DK338789A DK338789A DK 338789 A DK338789 A DK 338789A DK 338789 A DK338789 A DK 338789A DK 338789 A DK338789 A DK 338789A DK 338789 A DK338789 A DK 338789A
Authority
DK
Denmark
Prior art keywords
alkyl
production
substituted
ergolinylurine
medicines
Prior art date
Application number
DK338789A
Other languages
Danish (da)
English (en)
Other versions
DK338789D0 (da
Inventor
Thomas Brumby
Gehard Sauer
Josef Heindl
Jonathan Turner
Gerhard Kuehne
Helmut Wachtel
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19883824661 external-priority patent/DE3824661A1/de
Priority claimed from DE19893917268 external-priority patent/DE3917268A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK338789D0 publication Critical patent/DK338789D0/da
Publication of DK338789A publication Critical patent/DK338789A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK338789A 1988-07-15 1989-07-07 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf DK338789A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19883824661 DE3824661A1 (de) 1988-07-15 1988-07-15 2'-substituierte 3-(8'(alpha)-ergolinyl)-1,1-diethylharnstoffe bzw. -thioharnstoffe, ihre herstellung und verwendung als zwischenprodukte sowie in arzneimitteln
DE19893917268 DE3917268A1 (de) 1989-05-23 1989-05-23 2-substituierte ergoline, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
DK338789D0 DK338789D0 (da) 1989-07-07
DK338789A true DK338789A (da) 1990-01-16

Family

ID=25870307

Family Applications (1)

Application Number Title Priority Date Filing Date
DK338789A DK338789A (da) 1988-07-15 1989-07-07 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf

Country Status (10)

Country Link
US (2) US5037832A (fr)
EP (1) EP0351352B1 (fr)
JP (1) JPH02142790A (fr)
AT (1) ATE119529T1 (fr)
CA (1) CA1339584C (fr)
DE (1) DE58909077D1 (fr)
DK (1) DK338789A (fr)
ES (1) ES2072917T3 (fr)
HU (1) HU211486A9 (fr)
PT (1) PT91154B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242678A (en) * 1986-07-10 1993-09-07 Schering Aktiengesellschaft BR*-diagnostics for monoamine receptors
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
PT99864B (pt) * 1990-12-21 1999-06-30 Schering Ag Processo para a preparacao de novas composicoes farmaceuticas contendo antagonistas de receptor de quisqualato
US5371000A (en) * 1991-02-08 1994-12-06 Schering Aktiengesellschaft Process for the production of ergoline derivatives
DE4123587A1 (de) * 1991-07-12 1993-01-14 Schering Ag 2,14-disubstituierte ergoline, deren herstellung und verwendung in arzneimitteln
DE4343920A1 (de) * 1993-12-22 1995-06-29 Hoechst Ag Filter zur Entfernung von Stickoxiden aus Tabakrauch
WO2011079313A1 (fr) * 2009-12-23 2011-06-30 Map Pharmaceuticals, Inc. Analogues d'ergoline
US8604035B2 (en) 2011-06-23 2013-12-10 Map Pharmaceuticals, Inc. Fluoroergoline analogs
WO2013095707A1 (fr) * 2011-12-19 2013-06-27 Map Pharmaceuticals, Inc. Nouveaux dérivés d'iso-ergoline
EP2793583A4 (fr) 2011-12-21 2015-08-12 Map Pharmaceuticals Inc Nouveaux composés neuromodulateurs
JP2015525239A (ja) * 2012-06-22 2015-09-03 マップ・ファーマシューティカルズ・インコーポレイテッド 新規カベルゴリン誘導体
US9012640B2 (en) 2012-06-22 2015-04-21 Map Pharmaceuticals, Inc. Cabergoline derivatives
EP2934529A1 (fr) * 2012-12-21 2015-10-28 MAP Pharmaceuticals, Inc. Nouveaux dérivés d'ergoline et leurs utilisations

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0021206B1 (fr) * 1979-06-13 1983-06-22 Schering Aktiengesellschaft Dérivés de l'(ergoline-yl)-N', N'-diéthylurée, leur préparation et médicaments les contenant
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3309493A1 (de) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
PH21123A (en) * 1983-04-28 1987-07-27 Erba Farmitalia Ergoline derivatives
NL193541C (nl) * 1984-01-12 2000-01-04 Novartis Ag 8 Alfa-acylaminoergolinen, werkwijzen voor de bereiding daarvan en preparaten die ze bevatten.
DE3411981A1 (de) * 1984-03-28 1985-10-10 Schering AG, Berlin und Bergkamen, 1000 Berlin Verfahren zur herstellung von 2.3-dihydroergolinen
DE3413659A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 2-substituierte ergolin-derivate
DE3587860D1 (de) * 1984-04-09 1994-07-28 Schering Ag 2-substituierte Ergolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
CH666035A5 (de) * 1984-12-24 1988-06-30 Sandoz Ag 8-alpha-acylaminoergolene.
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate
DE3533672A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-substituierte ergolinderivate
DE3535929A1 (de) * 1985-10-04 1987-04-09 Schering Ag 1,2-disubstituierte ergolinderivate
DE3535930A1 (de) * 1985-10-04 1987-04-09 Schering Ag Neue 2-substituierte ergolinderivate
HUT45248A (en) * 1986-01-24 1988-06-28 Sandoz Ag Process for producing 8alpha-(acylamino)-ergoline derivatives and pharmaceuticals comprising such compounds
DE3620293A1 (de) * 1986-06-16 1987-12-17 Schering Ag 1-und/oder 2-substituierte ergolinderivate
DE3623438C2 (de) * 1986-07-10 1998-04-09 Schering Ag In 2-Stellung mit radioaktivem Iod markierte Ergolinylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Diagnostika
DE3623437C2 (de) * 1986-07-10 1998-04-09 Schering Ag In 2-Stellung mit radioaktivem Brom markierte Ergolinylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Diagnostika
DE3708028A1 (de) * 1987-03-10 1988-09-22 Schering Ag Verfahren zur herstellung von 2,3ss-dihydroergolinen, 2-substituierte 2,3ss-dihydroergoline und ihre verwendung als arzneimittel
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf

Also Published As

Publication number Publication date
CA1339584C (fr) 1997-12-16
DE58909077D1 (de) 1995-04-13
PT91154B (pt) 1995-01-31
DK338789D0 (da) 1989-07-07
EP0351352A3 (fr) 1991-07-03
ES2072917T3 (es) 1995-08-01
PT91154A (pt) 1990-02-08
JPH02142790A (ja) 1990-05-31
EP0351352A2 (fr) 1990-01-17
ATE119529T1 (de) 1995-03-15
HU211486A9 (en) 1995-11-28
US5037832A (en) 1991-08-06
EP0351352B1 (fr) 1995-03-08
US5158957A (en) 1992-10-27

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Legal Events

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AHB Application shelved due to non-payment