DK3368658T3 - Ekspansion af ikke-hæmatopoetiske vævsresidente gamma-delta-T-celler og anvendelser af disse celler - Google Patents
Ekspansion af ikke-hæmatopoetiske vævsresidente gamma-delta-T-celler og anvendelser af disse celler Download PDFInfo
- Publication number
- DK3368658T3 DK3368658T3 DK16788539.1T DK16788539T DK3368658T3 DK 3368658 T3 DK3368658 T3 DK 3368658T3 DK 16788539 T DK16788539 T DK 16788539T DK 3368658 T3 DK3368658 T3 DK 3368658T3
- Authority
- DK
- Denmark
- Prior art keywords
- cells
- delta
- expansion
- applications
- hematopoietic tissue
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title 1
- 210000004475 gamma-delta t lymphocyte Anatomy 0.000 title 1
- 230000003394 haemopoietic effect Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- AIDS & HIV (AREA)
- Toxicology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1519198.4A GB201519198D0 (en) | 2015-10-30 | 2015-10-30 | Expansion of gamma delta t cells resident in non-haematopoietic tissue and uses of these cells |
| GBGB1612731.8A GB201612731D0 (en) | 2016-07-22 | 2016-07-22 | Expansion of non-haematopoietic tissue-resident gamma delta t cells and uses of these cells |
| PCT/EP2016/076264 WO2017072367A1 (en) | 2015-10-30 | 2016-10-31 | EXPANSION OF NON-HAEMATOPOIETIC TISSUE-RESIDENT γδ T CELLS AND USES OF THESE CELLS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3368658T3 true DK3368658T3 (da) | 2022-08-01 |
Family
ID=57211532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16788539.1T DK3368658T3 (da) | 2015-10-30 | 2016-10-31 | Ekspansion af ikke-hæmatopoetiske vævsresidente gamma-delta-T-celler og anvendelser af disse celler |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11618885B2 (da) |
| EP (2) | EP3368658B1 (da) |
| JP (3) | JP2018533373A (da) |
| KR (1) | KR20180098235A (da) |
| CN (1) | CN108473958A (da) |
| AU (2) | AU2016344779B2 (da) |
| BR (1) | BR112018008293A2 (da) |
| CA (1) | CA3003077A1 (da) |
| DK (1) | DK3368658T3 (da) |
| ES (1) | ES2925261T3 (da) |
| HK (1) | HK1253954A1 (da) |
| IL (2) | IL295838A (da) |
| MX (2) | MX2018005207A (da) |
| MY (1) | MY198084A (da) |
| PH (1) | PH12018500926A1 (da) |
| PL (1) | PL3368658T3 (da) |
| PT (1) | PT3368658T (da) |
| WO (1) | WO2017072367A1 (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201707048D0 (en) | 2017-05-03 | 2017-06-14 | King S College London | Expansion of gamma delta cells, compositions, and methods of use thereof |
| WO2018229163A1 (en) | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
| WO2019053272A1 (en) | 2017-09-15 | 2019-03-21 | King's College London | COMPOSITIONS AND METHODS FOR IMPROVING T GAMMA DELTA LYMPHOCYTES IN INTESTINE |
| CN109777778B (zh) * | 2017-11-14 | 2023-07-18 | 中国科学院广州生物医药与健康研究院 | 一种基因改造的γδT细胞 |
| GB201804701D0 (en) | 2018-03-23 | 2018-05-09 | Gammadelta Therapeutics Ltd | Lymphocytes expressing heterologous targeting constructs |
| EP3831937A4 (en) * | 2018-07-31 | 2022-05-04 | Mie University | METHODS OF GENE TRANSFER INTO A ??-TYPE T-CELL |
| WO2020095058A1 (en) * | 2018-11-08 | 2020-05-14 | GammaDelta Therapeutics Limited | Methods for isolating and expanding cells |
| GB201818243D0 (en) * | 2018-11-08 | 2018-12-26 | Gammadelta Therapeutics Ltd | Methods for isolating and expanding cells |
| CA3125474A1 (en) | 2019-01-07 | 2020-07-16 | Shattuck Labs, Inc. | Heterodimeric proteins for modulating gamma delta t cells |
| US11098093B2 (en) | 2019-01-07 | 2021-08-24 | Shattuck Labs, Inc. | Heterodimeric proteins for modulating gamma delta T cells |
| WO2021016652A1 (en) * | 2019-07-29 | 2021-02-04 | The University Of Melbourne | METHODS AND COMPOSITIONS FOR MONITORING, TREATING AND PREVENTING CMV INFECTION OR GRAFT REJECTION USING γδ T-CELLS |
| CA3145523A1 (en) | 2019-08-16 | 2021-02-25 | GammaDelta Therapeutics Limited | Therapeutic uses of anti-tcr delta variable 1 antibodies |
| KR20220045980A (ko) | 2019-08-16 | 2022-04-13 | 감마델타 테라퓨틱스 리미티드 | 체외 감마 델타 t 세포 집단 |
| AU2020372646A1 (en) | 2019-10-31 | 2022-05-12 | Incyte Corporation | Anti-tumor combination therapy comprising anti-CD19 antibody and gamma delta T-cells |
| WO2021178890A1 (en) | 2020-03-06 | 2021-09-10 | Sorrento Therapeutics, Inc. | Innate immunity killer cells targeting psma positive tumor cells |
| KR20230013022A (ko) | 2020-03-20 | 2023-01-26 | 감마델타 테라퓨틱스 엘티디 | 골수성 악성종양의 치료를 위한 v 델타1+ t 세포 |
| GB202006989D0 (en) | 2020-05-12 | 2020-06-24 | Gammadelta Therapeutics Ltd | Methods for isolating gamma delta t cells |
| MX2023001728A (es) | 2020-08-14 | 2023-04-20 | Gammadelta Therapeutics Ltd | Anticuerpos multiespecíficos anti-tcr delta variable 1. |
| GB202013962D0 (en) | 2020-09-04 | 2020-10-21 | Gammadelta Therapeutics Ltd | Immunotherapy composition |
| TW202246338A (zh) | 2021-02-17 | 2022-12-01 | 英商適應生物治療有限公司 | 抗ＴＣＲδ可變1抗體 |
| GB202105113D0 (en) | 2021-04-09 | 2021-05-26 | Gammadelta Therapeutics Ltd | Novel method |
| KR20240040799A (ko) | 2021-08-03 | 2024-03-28 | 감마델타 테라퓨틱스 엘티디 | 감마 델타 t 세포 및 이의 조성물의 조작 |
| WO2023053994A1 (ja) * | 2021-09-29 | 2023-04-06 | アイ ピース， インコーポレイテッド | 幹細胞の製造方法 |
| CA3208653A1 (en) | 2022-02-17 | 2022-08-25 | Mihriban Tuna | Multispecific anti-tcr delta variable 1 antibodies |
| WO2023176896A1 (ja) * | 2022-03-18 | 2023-09-21 | 国立大学法人長崎大学 | 糸状菌感染症の治療薬及び糸状菌感染症の治療方法 |
| WO2023194915A1 (en) | 2022-04-04 | 2023-10-12 | Gammadelta Therapeutics Ltd | Novel gene armoring |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1127107B1 (en) | 1998-11-04 | 2009-01-21 | Therapure Biopharma Inc. | Methods for the production of tcr gamma delta t cells |
| EP1777294A1 (en) | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
| WO2009131730A2 (en) * | 2008-01-31 | 2009-10-29 | University Of Iowa Research Foundation | IMMUNOGENIC COMPOSITIONS FOR ACTIVATING γδ T CELLS |
| WO2012088446A1 (en) | 2010-12-22 | 2012-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| ES2643387T3 (es) | 2011-05-19 | 2017-11-22 | Instituto De Medicina Molecular | Estirpe celular de linfocitos que comprende células gama-delta, composición y método de producción de la misma |
| CA2926859A1 (en) | 2013-10-25 | 2015-04-30 | Board Of Regents, The University Of Texas System | Polyclonal gamma delta t cells for immunotherapy |
| JP7413639B2 (ja) * | 2014-06-11 | 2024-01-16 | ポリバイオセプト ゲーエムベーハー | 能動的細胞免疫療法のためのサイトカイン組成物を用いたリンパ球の増殖 |
| AU2016274633B2 (en) * | 2015-06-09 | 2022-04-21 | Gammadelta Therapeutics Ltd | Methods for the production of TCR gamma delta+ T cells |
| WO2016198906A1 (fr) * | 2015-06-10 | 2016-12-15 | Arcelormittal | Acier a haute résistance et procédé de fabrication |
-
2016
- 2016-10-31 EP EP16788539.1A patent/EP3368658B1/en active Active
- 2016-10-31 CN CN201680074800.5A patent/CN108473958A/zh active Pending
- 2016-10-31 WO PCT/EP2016/076264 patent/WO2017072367A1/en active Application Filing
- 2016-10-31 IL IL295838A patent/IL295838A/en unknown
- 2016-10-31 US US15/771,875 patent/US11618885B2/en active Active
- 2016-10-31 ES ES16788539T patent/ES2925261T3/es active Active
- 2016-10-31 PT PT167885391T patent/PT3368658T/pt unknown
- 2016-10-31 CA CA3003077A patent/CA3003077A1/en active Pending
- 2016-10-31 AU AU2016344779A patent/AU2016344779B2/en active Active
- 2016-10-31 MX MX2018005207A patent/MX2018005207A/es unknown
- 2016-10-31 JP JP2018541524A patent/JP2018533373A/ja active Pending
- 2016-10-31 BR BR112018008293A patent/BR112018008293A2/pt active Search and Examination
- 2016-10-31 EP EP22182997.1A patent/EP4148124A1/en active Pending
- 2016-10-31 DK DK16788539.1T patent/DK3368658T3/da active
- 2016-10-31 MY MYPI2018000604A patent/MY198084A/en unknown
- 2016-10-31 KR KR1020187015244A patent/KR20180098235A/ko unknown
- 2016-10-31 PL PL16788539.1T patent/PL3368658T3/pl unknown
-
2018
- 2018-04-26 IL IL258985A patent/IL258985B2/en unknown
- 2018-04-26 MX MX2022011003A patent/MX2022011003A/es unknown
- 2018-04-30 PH PH12018500926A patent/PH12018500926A1/en unknown
- 2018-10-12 HK HK18113105.5A patent/HK1253954A1/zh unknown
-
2021
- 2021-09-10 JP JP2021147372A patent/JP7451468B2/ja active Active
-
2022
- 2022-09-29 US US17/936,811 patent/US20230099491A1/en active Pending
- 2022-12-09 AU AU2022283768A patent/AU2022283768A1/en active Pending
-
2024
- 2024-03-06 JP JP2024033438A patent/JP2024069306A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024069306A (ja) | 2024-05-21 |
| AU2016344779B2 (en) | 2023-01-05 |
| RU2018119684A3 (da) | 2020-03-17 |
| CA3003077A1 (en) | 2017-05-04 |
| EP3368658A1 (en) | 2018-09-05 |
| PT3368658T (pt) | 2022-08-17 |
| JP2018533373A (ja) | 2018-11-15 |
| WO2017072367A1 (en) | 2017-05-04 |
| PH12018500926A1 (en) | 2018-11-05 |
| US20180312808A1 (en) | 2018-11-01 |
| IL258985B2 (en) | 2023-02-01 |
| MX2018005207A (es) | 2018-09-19 |
| JP2022002517A (ja) | 2022-01-11 |
| EP4148124A1 (en) | 2023-03-15 |
| EP3368658B1 (en) | 2022-07-06 |
| IL258985B (en) | 2022-10-01 |
| MX2022011003A (es) | 2022-10-07 |
| US20230099491A1 (en) | 2023-03-30 |
| IL258985A (en) | 2018-06-28 |
| KR20180098235A (ko) | 2018-09-03 |
| AU2022283768A1 (en) | 2023-02-02 |
| AU2016344779A1 (en) | 2018-06-14 |
| ES2925261T3 (es) | 2022-10-14 |
| MY198084A (en) | 2023-07-31 |
| HK1253954A1 (zh) | 2019-07-05 |
| BR112018008293A2 (pt) | 2018-10-30 |
| CN108473958A (zh) | 2018-08-31 |
| JP7451468B2 (ja) | 2024-03-18 |
| US11618885B2 (en) | 2023-04-04 |
| RU2018119684A (ru) | 2019-12-02 |
| IL295838A (en) | 2022-10-01 |
| PL3368658T3 (pl) | 2022-11-28 |
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