DK3354665T3 - Modificerede alginater til celleindkapsling og celleterapi - Google Patents
Modificerede alginater til celleindkapsling og celleterapi Download PDFInfo
- Publication number
- DK3354665T3 DK3354665T3 DK18162427.1T DK18162427T DK3354665T3 DK 3354665 T3 DK3354665 T3 DK 3354665T3 DK 18162427 T DK18162427 T DK 18162427T DK 3354665 T3 DK3354665 T3 DK 3354665T3
- Authority
- DK
- Denmark
- Prior art keywords
- cell
- enclosure
- modified alginates
- therapy
- cell therapy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161492705P | 2011-06-02 | 2011-06-02 | |
EP12728887.6A EP2714747B1 (en) | 2011-06-02 | 2012-06-04 | Modified alginates for cell encapsulation and cell therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
DK3354665T3 true DK3354665T3 (da) | 2022-04-25 |
DK3354665T5 DK3354665T5 (da) | 2022-09-19 |
Family
ID=46321466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18162427.1T DK3354665T5 (da) | 2011-06-02 | 2012-06-04 | Modificerede alginater til celleindkapsling og celleterapi |
Country Status (7)
Country | Link |
---|---|
US (6) | US9422373B2 (da) |
EP (3) | EP2714747B1 (da) |
CA (1) | CA2837558C (da) |
DK (1) | DK3354665T5 (da) |
ES (1) | ES2912545T3 (da) |
HK (1) | HK1259279A1 (da) |
WO (1) | WO2012167223A1 (da) |
Families Citing this family (34)
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CN112999429B (zh) * | 2014-08-01 | 2022-07-22 | 麻省理工学院 | 用于抗纤维化材料的修饰的藻酸盐以及应用 |
EP3267965A4 (en) * | 2015-03-11 | 2018-11-14 | Atta Behfar | Exosome delivery technology |
MX2018005420A (es) | 2015-11-01 | 2018-06-06 | Massachusetts Inst Technology | Alginatos modificados para materiales anti-fibroticos y aplicaciones. |
KR102558416B1 (ko) * | 2015-11-01 | 2023-07-24 | 메사추세츠 인스티튜트 오브 테크놀로지 | 개선된 특성을 가진 물질 |
US10697972B2 (en) | 2016-01-12 | 2020-06-30 | Bioatla, Llc | Diagnostics using conditionally active antibodies |
EP3403098B1 (en) | 2016-01-12 | 2021-09-22 | BioAtla, Inc. | Diagnostics using conditionally active antibodies |
US9999640B2 (en) | 2016-02-02 | 2018-06-19 | University Of Dammam | Microencapsulated probiotic bacteria |
US10046985B2 (en) | 2016-02-11 | 2018-08-14 | King Fahd University Of Petroleum And Minerals | Method for removing cationic dyes from an aqueous solution using an adsorbent |
EP4151661A1 (en) * | 2016-03-24 | 2023-03-22 | Takeda Pharmaceutical Company Limited | Alginate hydrogel compositions |
CA3027856A1 (en) | 2016-06-13 | 2017-12-21 | Massachusetts Institute Of Technology | Surface-coated continuous glucose monitors |
EP3512500A1 (en) * | 2016-09-14 | 2019-07-24 | Ecole Polytechnique Federale de Lausanne (EPFL) | Hydrogels based on functionalized polysaccharides |
EP3295933A1 (en) | 2016-09-14 | 2018-03-21 | Ecole Polytechnique Federale De Lausanne (Epfl) | Hydrogels based on functionalized polysaccharides |
WO2018140834A1 (en) * | 2017-01-27 | 2018-08-02 | Cornell University | Zwitterionically modified polymers and hydrogels |
WO2018232027A1 (en) | 2017-06-13 | 2018-12-20 | Massachusetts Institute Of Technology | Biocompatible microfabricated devices for transplanting cells |
MX2020003351A (es) | 2017-09-27 | 2020-10-12 | Sigilon Therapeutics Inc | Metodos, composiciones y elementos implantables que comprenden celulas activas. |
US11318231B2 (en) | 2017-11-06 | 2022-05-03 | Massachusetts Institute Of Technology | Anti-inflammatory coatings to improve biocompatibility of neurological implants |
EP3759154A1 (en) | 2018-03-02 | 2021-01-06 | Sigilon Therapeutics, Inc. | Biocompatible hydrogel capsules and process for preparing same |
CN112105612A (zh) | 2018-03-02 | 2020-12-18 | 西吉隆医疗股份有限公司 | 抗纤维化化合物、装置及其用途 |
CA3096742A1 (en) * | 2018-03-16 | 2019-09-19 | Nutech Ventures | Cell expansion system |
JP2021520374A (ja) | 2018-04-04 | 2021-08-19 | シギロン セラピューティクス, インコーポレイテッドSigilon Therapeutics, Inc. | 移植可能な粒子及び関連方法 |
US20210145889A1 (en) | 2018-04-04 | 2021-05-20 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising stem cells |
KR20210019441A (ko) * | 2018-06-14 | 2021-02-22 | 모찌다 세이야쿠 가부시끼가이샤 | 신규 가교 알긴산 |
US20210353781A1 (en) * | 2018-09-21 | 2021-11-18 | Massachusetts Institute Of Technology | Surface-modified cells, methods of making and using |
UY38389A (es) | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | Dispositivos implantables para terapia celular y métodos relacionados |
US20220143270A1 (en) | 2019-02-15 | 2022-05-12 | William Marsh Rice University | Vascularizing devices and methods for implanted diagnostics and therapeutics |
JP7236533B2 (ja) | 2019-04-09 | 2023-03-09 | 富士フイルム株式会社 | マイクロカプセルの製造方法およびコート液 |
JP7431247B2 (ja) | 2019-08-23 | 2024-02-14 | 富士フイルム株式会社 | ミクロカプセルと細胞構造体とを含む組成物 |
EP4126001A1 (en) * | 2020-04-02 | 2023-02-08 | Cornell University | Nanofiber-enabled encapsulation devices and uses thereof |
EP3940072A1 (en) * | 2020-07-13 | 2022-01-19 | Biomillenia SAS | Alginate beads and production thereof |
US20220089537A1 (en) | 2020-09-18 | 2022-03-24 | Massachusetts Institute Of Technology | High-throughput method to rapidly add chemical moieties to a small molecule library |
WO2023230524A1 (en) | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vi, Llc | Compositions of secretory and/or catalytic cells and methods using the same |
WO2023235884A1 (en) | 2022-06-03 | 2023-12-07 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods |
WO2024006528A1 (en) | 2022-07-01 | 2024-01-04 | Sigilon Therapeutics, Inc. | Covalently photocrosslinked polysaccharides and methods of use thereof |
WO2024081309A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
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GB676618A (en) * | 1947-09-12 | 1952-07-30 | Kelco Co | Alkylene glycol esters of alginic acid |
GB768309A (en) * | 1954-03-27 | 1957-02-13 | Henkel & Cie Gmbh | Process for the production of amides of alginic acid |
US2860130A (en) * | 1954-11-01 | 1958-11-11 | Kelco Co | Methyl alginate |
US2881161A (en) * | 1955-03-25 | 1959-04-07 | Henkel & Cie Gmbh | Amides of alginic acid |
US4352883A (en) | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
NO845059L (no) | 1984-12-17 | 1986-06-18 | Sintef Inst For Marin Biokjemi | Fremgangsmaate for fremstilling av alginater med endrede fysikalske egenskaper samt anvendelse av disse alginater. |
IT1203814B (it) | 1986-06-30 | 1989-02-23 | Fidia Farmaceutici | Esteri dell'acido alginico |
JP2643669B2 (ja) | 1990-12-28 | 1997-08-20 | 共成製薬株式会社 | アルギン含有食品 |
US5876452A (en) | 1992-02-14 | 1999-03-02 | Board Of Regents, University Of Texas System | Biodegradable implant |
GB2270920B (en) * | 1992-09-25 | 1997-04-02 | Univ Keele | Alginate-bioactive agent conjugates |
FR2699545B1 (fr) * | 1992-12-18 | 1995-01-27 | Oreal | Agent gélifiant résultant de l'association d'un chitosane et d'un alginate d'alkyle ou d'hydroxyalkyle et son utilisation dans la préparation de compositions cosmétiques et pharmaceutiques. |
EP2025353A2 (en) | 1993-04-30 | 2009-02-18 | Massachusetts Institute of Technology | Injectable polysaccharide-cell compositions |
US5709854A (en) | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
US6129761A (en) | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
US6171232B1 (en) | 1997-06-26 | 2001-01-09 | Cordis Corporation | Method for targeting in vivo nitric oxide release |
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US6159531A (en) | 1999-08-30 | 2000-12-12 | Cardiovasc, Inc. | Coating having biological activity and medical implant having surface carrying the same and method |
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US7008476B2 (en) * | 2003-06-11 | 2006-03-07 | Az Electronic Materials Usa Corp. | Modified alginic acid of alginic acid derivatives and thermosetting anti-reflective compositions thereof |
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BRPI0517800A (pt) | 2004-11-12 | 2008-10-21 | Fmc Biopolymer As | processo para preparar um polìmero de alginato modificado, polìmero de alginato modificado, e, gel ou fibra de alginato |
ES2377479T3 (es) * | 2005-09-27 | 2012-03-28 | Universite Joseph Fourier - Grenoble 1 | Hidrogel funcionalizado con una porción polimerizable y sus utilizaciones como biosensores o biorreactores. |
DE102005049833A1 (de) | 2005-10-14 | 2007-04-19 | Beiersdorf Ag | Hydrophob modifizierte Alginate |
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KR20100063744A (ko) | 2007-08-28 | 2010-06-11 | 에프엠씨 코포레이션 | 지연된 자가-겔화 알기네이트 시스템 및 이의 용도 |
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EP2127689A1 (en) | 2008-05-27 | 2009-12-02 | RevisiOs B.V. i.o. | Novel homogenous osteoinductive nanocomposites |
CN101565469B (zh) * | 2008-10-28 | 2011-05-11 | 中国海洋大学 | 酰胺接枝的海藻酸钠纳米材料及其制备方法与应用 |
EP2356167A4 (en) | 2008-12-12 | 2012-07-11 | Univ Massachusetts | POLYESTER WITH POTTED TWITTERS |
JP2012517284A (ja) | 2009-02-09 | 2012-08-02 | セント ジュード メディカル インコーポレイテッド | 医療デバイスの生体適合性の向上 |
US9555154B2 (en) | 2009-02-21 | 2017-01-31 | Covidien Lp | Medical devices having activated surfaces |
WO2011045443A1 (en) | 2009-10-16 | 2011-04-21 | Dsm Ip Assets B.V. | Coatings comprising bis-(alpha-amino-diol-diester) containing polyesteramide |
JP5876045B2 (ja) | 2010-07-12 | 2016-03-02 | ユニバーシティー オブ サザン カリフォルニア | 幹細胞と標的組織の相互接続を促進する生体適合性基材およびそれを埋め込む方法 |
US20120083767A1 (en) | 2010-10-01 | 2012-04-05 | The Johns Hopkins University | Implantable bioreactor for delivery of paracrine factors |
JP5963130B2 (ja) | 2012-02-16 | 2016-08-03 | 学校法人同志社 | 生体組織補強材料キット及び生体組織補強材料 |
-
2012
- 2012-06-04 DK DK18162427.1T patent/DK3354665T5/da active
- 2012-06-04 EP EP12728887.6A patent/EP2714747B1/en active Active
- 2012-06-04 EP EP22165043.5A patent/EP4083074A1/en active Pending
- 2012-06-04 WO PCT/US2012/040665 patent/WO2012167223A1/en unknown
- 2012-06-04 CA CA2837558A patent/CA2837558C/en active Active
- 2012-06-04 ES ES18162427T patent/ES2912545T3/es active Active
- 2012-06-04 EP EP18162427.1A patent/EP3354665B9/en active Active
- 2012-06-04 US US13/487,524 patent/US9422373B2/en active Active
-
2016
- 2016-07-12 US US15/208,192 patent/US10285949B2/en active Active
-
2017
- 2017-05-05 US US15/588,481 patent/US10292936B2/en active Active
-
2019
- 2019-01-30 HK HK19101640.1A patent/HK1259279A1/zh unknown
- 2019-05-10 US US16/408,899 patent/US10842753B2/en active Active
-
2020
- 2020-10-26 US US17/080,355 patent/US11337930B2/en active Active
-
2022
- 2022-05-20 US US17/749,795 patent/US20230130084A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2012167223A1 (en) | 2012-12-06 |
EP3354665B9 (en) | 2022-08-03 |
CA2837558C (en) | 2018-11-20 |
US20190262272A1 (en) | 2019-08-29 |
US20210186886A1 (en) | 2021-06-24 |
EP2714747B1 (en) | 2020-08-05 |
EP3354665B1 (en) | 2022-03-30 |
US20230130084A1 (en) | 2023-04-27 |
EP4083074A1 (en) | 2022-11-02 |
US20160324793A1 (en) | 2016-11-10 |
DK3354665T5 (da) | 2022-09-19 |
HK1259279A1 (zh) | 2019-11-29 |
US10842753B2 (en) | 2020-11-24 |
EP2714747A1 (en) | 2014-04-09 |
US20120308650A1 (en) | 2012-12-06 |
US20170239190A1 (en) | 2017-08-24 |
US10292936B2 (en) | 2019-05-21 |
ES2912545T3 (es) | 2022-05-26 |
US10285949B2 (en) | 2019-05-14 |
US11337930B2 (en) | 2022-05-24 |
EP3354665A1 (en) | 2018-08-01 |
CA2837558A1 (en) | 2012-12-06 |
US9422373B2 (en) | 2016-08-23 |
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