DK3351558T3 - Materiale og fremgangsmåder til behandling eller forebyggelse af her-3-relaterede sygdomme - Google Patents

Materiale og fremgangsmåder til behandling eller forebyggelse af her-3-relaterede sygdomme Download PDF

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Publication number
DK3351558T3
DK3351558T3 DK17197711.9T DK17197711T DK3351558T3 DK 3351558 T3 DK3351558 T3 DK 3351558T3 DK 17197711 T DK17197711 T DK 17197711T DK 3351558 T3 DK3351558 T3 DK 3351558T3
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Prior art keywords
procedures
prevention
here
treatment
materials
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DK17197711.9T
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Danish (da)
English (en)
Inventor
Thore Hettmann
Daniel J Freeman
Robert Radinsky
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Daiichi Sankyo Europe Gmbh
Amgen Inc
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Application filed by Daiichi Sankyo Europe Gmbh, Amgen Inc filed Critical Daiichi Sankyo Europe Gmbh
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Publication of DK3351558T3 publication Critical patent/DK3351558T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
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  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK17197711.9T 2009-11-13 2010-11-12 Materiale og fremgangsmåder til behandling eller forebyggelse af her-3-relaterede sygdomme DK3351558T3 (da)

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US26114909P 2009-11-13 2009-11-13
EP15154165.3A EP2896632B1 (en) 2009-11-13 2010-11-12 Material and methods for treating or preventing HER-3 associated diseases

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DK3351558T3 true DK3351558T3 (da) 2020-06-02

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DK17197711.9T DK3351558T3 (da) 2009-11-13 2010-11-12 Materiale og fremgangsmåder til behandling eller forebyggelse af her-3-relaterede sygdomme
DK13189092.3T DK2719708T3 (da) 2009-11-13 2010-11-12 Materiale og fremgangsmåder til behandling eller forebyggelse af her-3-relaterede sygdomme

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US (4) US9101760B2 (enExample)
EP (5) EP2719708B1 (enExample)
JP (5) JP5931736B2 (enExample)
KR (1) KR101806323B1 (enExample)
CN (2) CN105999263B (enExample)
AR (1) AR080564A1 (enExample)
AU (1) AU2010319483B2 (enExample)
BR (1) BR112012012160B1 (enExample)
CA (1) CA2780935C (enExample)
CY (2) CY1119751T1 (enExample)
DK (2) DK3351558T3 (enExample)
ES (3) ES2655737T3 (enExample)
HK (1) HK1207651A1 (enExample)
HR (2) HRP20180104T1 (enExample)
HU (2) HUE035605T2 (enExample)
LT (2) LT2719708T (enExample)
MX (3) MX358013B (enExample)
NO (1) NO2719708T3 (enExample)
PL (2) PL3351558T3 (enExample)
PT (2) PT3351558T (enExample)
RS (2) RS60390B1 (enExample)
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HUE035605T2 (en) 2018-05-28
JP2013510868A (ja) 2013-03-28
LT2719708T (lt) 2018-02-12
EP2896632A3 (en) 2015-08-19
US20160222126A1 (en) 2016-08-04
JP2018076300A (ja) 2018-05-17
US20140017166A1 (en) 2014-01-16
CY1119751T1 (el) 2018-06-27
JP5931736B2 (ja) 2016-06-08
CA2780935A1 (en) 2011-05-19
WO2011060206A3 (en) 2011-09-09
WO2011060206A2 (en) 2011-05-19
JP2016128430A (ja) 2016-07-14
MX358013B (es) 2018-08-01
NO2719708T3 (enExample) 2018-03-24
LT3351558T (lt) 2020-06-10
MX357972B (es) 2018-08-01
UY33034A (es) 2011-05-31
SI2719708T1 (en) 2018-03-30
AR080564A1 (es) 2012-04-18
BR112012012160A2 (pt) 2017-01-10
ES2655737T3 (es) 2018-02-21
US12139549B2 (en) 2024-11-12
US9101760B2 (en) 2015-08-11
HK1207651A1 (en) 2016-02-05
CN105999263B (zh) 2021-06-29
JP6235620B2 (ja) 2017-11-22
PL3351558T3 (pl) 2020-08-24
RS56741B1 (sr) 2018-03-30
CY1123030T1 (el) 2021-10-29
PT3351558T (pt) 2020-04-09
AU2010319483A1 (en) 2012-05-31
HUE049880T2 (hu) 2020-10-28
JP2020011980A (ja) 2020-01-23
EP2719708A3 (en) 2014-09-03
ES2781299T3 (es) 2020-09-01
US9988462B2 (en) 2018-06-05
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EP2896632B1 (en) 2017-10-25
HRP20200921T1 (hr) 2020-09-18
MX349513B (es) 2017-08-02
SMT201800167T1 (it) 2018-05-02
MX2012005589A (es) 2012-11-30
US9803025B2 (en) 2017-10-31
KR101806323B1 (ko) 2017-12-07
CA2780935C (en) 2022-05-24
DK2719708T3 (da) 2018-01-29
HRP20180104T1 (hr) 2018-03-09
TWI630916B (zh) 2018-08-01
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ES2647466T3 (es) 2017-12-21

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