DK3303297T3 - Ny fremgangsmåde til fremstilling af ivabradinbase med høj renhed og salte deraf - Google Patents
Ny fremgangsmåde til fremstilling af ivabradinbase med høj renhed og salte deraf Download PDFInfo
- Publication number
- DK3303297T3 DK3303297T3 DK16728882.8T DK16728882T DK3303297T3 DK 3303297 T3 DK3303297 T3 DK 3303297T3 DK 16728882 T DK16728882 T DK 16728882T DK 3303297 T3 DK3303297 T3 DK 3303297T3
- Authority
- DK
- Denmark
- Prior art keywords
- salts
- preparation
- high purity
- new process
- ivabradine base
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/25—Sulfonic acids having sulfo groups bound to carbon atoms of rings other than six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15382293.7A EP3101010A1 (en) | 2015-06-03 | 2015-06-03 | New method for the preparation of highly pure ivabradine base and salts thereof |
| PCT/EP2016/062533 WO2016193386A2 (en) | 2015-06-03 | 2016-06-02 | New method for the preparation of highly pure ivabradine base and salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3303297T3 true DK3303297T3 (da) | 2021-02-01 |
Family
ID=53398017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16728882.8T DK3303297T3 (da) | 2015-06-03 | 2016-06-02 | Ny fremgangsmåde til fremstilling af ivabradinbase med høj renhed og salte deraf |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10221141B2 (da) |
| EP (2) | EP3101010A1 (da) |
| DK (1) | DK3303297T3 (da) |
| ES (2) | ES2854284T3 (da) |
| LT (1) | LT3303297T (da) |
| PL (1) | PL3303297T3 (da) |
| PT (1) | PT3303297T (da) |
| WO (1) | WO2016193386A2 (da) |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2681862B1 (fr) | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
| FR2868777B1 (fr) | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2870537A1 (fr) | 2004-05-19 | 2005-11-25 | Servier Lab | Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| EP2097383B1 (en) * | 2006-11-30 | 2012-02-08 | Cadila Healthcare Limited | Process for preparation of ivabradine hydrochloride |
| CN101434552B (zh) | 2007-11-16 | 2012-05-23 | 江苏恒瑞医药股份有限公司 | 4,5-二甲氧基-1-(甲基氨基甲基)-苯并环丁烷的拆分 |
| FR2932800B1 (fr) | 2008-06-20 | 2015-02-20 | Servier Lab | Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2933975B1 (fr) | 2008-07-17 | 2011-02-18 | Servier Lab | Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. |
| FR2935381B1 (fr) | 2008-08-29 | 2010-12-17 | Servier Lab | Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine |
| CN101671265B (zh) | 2008-09-12 | 2012-08-15 | 中国科学院上海药物研究所 | 一种苯并环丁烷类化合物及其制备方法与用途 |
| CN102264689B (zh) * | 2008-12-22 | 2014-12-31 | 新梅斯托克尔卡公司 | 制备伊伐布雷定的方法 |
| FR2940287B1 (fr) | 2008-12-24 | 2010-12-24 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. |
| FR2941695B1 (fr) | 2009-02-04 | 2011-02-18 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2943667B1 (fr) | 2009-03-31 | 2011-05-06 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. |
| ME00986B (me) | 2009-03-31 | 2012-06-20 | Servier Lab | Novi postupak sinteze ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom |
| HUP1000245A2 (en) | 2010-05-07 | 2011-11-28 | Richter Gedeon Nyrt | Industrial process for the production ivabradin salts |
| CN102249937A (zh) | 2010-05-18 | 2011-11-23 | 上海京新生物医药有限公司 | 1-(s)-4,5-二甲氧基-1-甲胺基甲基-苯并环丁烷的制备方法 |
| CN101857549B (zh) | 2010-06-22 | 2013-04-10 | 浙江美诺华药物化学有限公司 | (1s)-4,5-二甲氧基-1-(甲基氨基甲基)-苯并环丁烷的合成方法 |
| EP2495237A1 (en) | 2011-03-04 | 2012-09-05 | Alembic Pharmaceuticals Limited | An improved process for the preparation of highly pure ivabradine hydrochloride |
| CN102372642B (zh) | 2011-07-04 | 2014-01-08 | 江苏宇田生物医药科技有限公司 | (1s)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷的制备方法 |
| ITMI20111467A1 (it) | 2011-08-01 | 2013-02-02 | Laboratorio Chimico Int Spa | Procedimento per la preparazione di ivabradina e di suoi intermedi di sintesi |
| CN102408346B (zh) | 2011-10-31 | 2014-07-02 | 江苏阿尔法药业有限公司 | 一种4,5-二甲氧基-1-（甲基氨基甲基）-苯并环丁烷的制备方法 |
| FR2986804A1 (fr) | 2012-02-09 | 2013-08-16 | Servier Lab | Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels |
| FR2993561B1 (fr) | 2012-07-17 | 2014-10-31 | Servier Lab | Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels |
| FR2996845A1 (fr) | 2012-10-12 | 2014-04-18 | Servier Lab | Nouveau procede de synthese du 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2997696B1 (fr) | 2012-11-08 | 2014-12-05 | Servier Lab | Nouveau procede de synthese du (2e)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2999178B1 (fr) * | 2012-12-06 | 2014-11-28 | Servier Lab | Nouveau procede de synthese du 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR3002542B1 (fr) | 2013-02-28 | 2016-01-22 | Servier Lab | Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique et application a la synthese de l'ivabradine et de ses sels |
| FR3005658B1 (fr) | 2013-05-17 | 2015-04-24 | Servier Lab | "procede de synthese du 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable" |
| WO2015022702A2 (en) * | 2013-08-10 | 2015-02-19 | Ind-Swift Laboratories Limited | Process for preparation of 4,5-dimethoxybenzene derivatives and use in the synthesis of ivabradine and salts thereof |
| CN103524360B (zh) | 2013-10-17 | 2015-09-30 | 安徽安腾药业有限责任公司 | 一种伊伐布雷定关键中间体的合成方法 |
| CN104557573B (zh) | 2013-10-24 | 2018-02-27 | 上海天慈生物谷生物工程有限公司 | (1s)‑4,5‑二甲氧基‑1‑[(甲基氨基)甲基]苯并环丁烷盐酸盐的制备方法 |
| CN104262179A (zh) | 2014-09-10 | 2015-01-07 | 王晓伟 | 一种伊伐布雷定的关键中间体制备方法 |
| HU230826B1 (hu) | 2014-11-19 | 2018-07-30 | Richter Gedeon Nyrt. | Eljárás benzazepin származékok előállítására |
| CN104829470B (zh) | 2015-04-20 | 2017-08-25 | 江苏宇田医药有限公司 | 一组合成伊伐布雷定的中间体化合物及其应用 |
-
2015
- 2015-06-03 EP EP15382293.7A patent/EP3101010A1/en not_active Withdrawn
-
2016
- 2016-06-02 PT PT167288828T patent/PT3303297T/pt unknown
- 2016-06-02 DK DK16728882.8T patent/DK3303297T3/da active
- 2016-06-02 LT LTEP16728882.8T patent/LT3303297T/lt unknown
- 2016-06-02 PL PL16728882T patent/PL3303297T3/pl unknown
- 2016-06-02 ES ES16728882T patent/ES2854284T3/es active Active
- 2016-06-02 EP EP16728882.8A patent/EP3303297B1/en active Active
- 2016-06-02 US US15/735,172 patent/US10221141B2/en active Active
- 2016-06-02 WO PCT/EP2016/062533 patent/WO2016193386A2/en active Application Filing
- 2016-06-02 ES ES201700315A patent/ES2653709B1/es not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP3303297B1 (en) | 2020-12-02 |
| LT3303297T (lt) | 2021-03-10 |
| ES2653709A2 (es) | 2018-02-08 |
| PL3303297T3 (pl) | 2021-06-28 |
| EP3303297A2 (en) | 2018-04-11 |
| ES2653709B1 (es) | 2018-11-21 |
| EP3101010A1 (en) | 2016-12-07 |
| ES2653709R1 (es) | 2018-02-13 |
| WO2016193386A3 (en) | 2017-01-12 |
| PT3303297T (pt) | 2021-03-01 |
| ES2854284T3 (es) | 2021-09-21 |
| US10221141B2 (en) | 2019-03-05 |
| US20180162820A1 (en) | 2018-06-14 |
| WO2016193386A2 (en) | 2016-12-08 |
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