DK3294856T3 - Proceskontrolsystem til regulering og styring af et modulært opbygget anlæg til produktion af biofarmaceutiske og biologiske makromolekylære produkter - Google Patents

Proceskontrolsystem til regulering og styring af et modulært opbygget anlæg til produktion af biofarmaceutiske og biologiske makromolekylære produkter Download PDF

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Publication number
DK3294856T3
DK3294856T3 DK16722163T DK16722163T DK3294856T3 DK 3294856 T3 DK3294856 T3 DK 3294856T3 DK 16722163 T DK16722163 T DK 16722163T DK 16722163 T DK16722163 T DK 16722163T DK 3294856 T3 DK3294856 T3 DK 3294856T3
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DK
Denmark
Prior art keywords
regulation
plant
control system
biological macromolecular
process control
Prior art date
Application number
DK16722163T
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Danish (da)
English (en)
Inventor
Peter Schwan
Martin Lobedann
Jens Bernshausen
Original Assignee
Bayer Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53177195&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3294856(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
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Publication of DK3294856T3 publication Critical patent/DK3294856T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D7/00—Control of flow
    • G05D7/06—Control of flow characterised by the use of electric means
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B11/00—Automatic controllers
    • G05B11/01—Automatic controllers electric
    • G05B11/36—Automatic controllers electric with provision for obtaining particular characteristics, e.g. proportional, integral, differential
    • G05B11/42—Automatic controllers electric with provision for obtaining particular characteristics, e.g. proportional, integral, differential for obtaining a characteristic which is both proportional and time-dependent, e.g. P. I., P. I. D.
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B13/00—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion
    • G05B13/02—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
    • G05B13/0265—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric the criterion being a learning criterion
    • G05B13/0275—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric the criterion being a learning criterion using fuzzy logic only

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Computer Hardware Design (AREA)
  • General Physics & Mathematics (AREA)
  • Automation & Control Theory (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Medical Informatics (AREA)
  • Mathematical Physics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Computation (AREA)
  • Fuzzy Systems (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Feedback Control In General (AREA)
  • Testing And Monitoring For Control Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Flow Control (AREA)
DK16722163T 2015-05-13 2016-05-10 Proceskontrolsystem til regulering og styring af et modulært opbygget anlæg til produktion af biofarmaceutiske og biologiske makromolekylære produkter DK3294856T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15167538.6A EP3093335A1 (de) 2015-05-13 2015-05-13 Prozessleitsystem zur regelung und steuerung einer modular aufgebauten anlage zur produktion von biopharmazeutischen und biologischen makromolekularen produkten
PCT/EP2016/060369 WO2016180798A1 (de) 2015-05-13 2016-05-10 Prozessleitsystem zur regelung und steuerung einer modular aufgebauten anlage zur produktion von biopharmazeutischen und biologischen makromolekularen produkten

Publications (1)

Publication Number Publication Date
DK3294856T3 true DK3294856T3 (da) 2019-12-09

Family

ID=53177195

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16722163T DK3294856T3 (da) 2015-05-13 2016-05-10 Proceskontrolsystem til regulering og styring af et modulært opbygget anlæg til produktion af biofarmaceutiske og biologiske makromolekylære produkter

Country Status (21)

Country Link
US (2) US20180127461A1 (cg-RX-API-DMAC7.html)
EP (2) EP3093335A1 (cg-RX-API-DMAC7.html)
JP (1) JP6833721B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180005225A (cg-RX-API-DMAC7.html)
CN (1) CN107849506B (cg-RX-API-DMAC7.html)
AR (1) AR104554A1 (cg-RX-API-DMAC7.html)
AU (1) AU2016259746B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017024373B1 (cg-RX-API-DMAC7.html)
CA (1) CA2985678A1 (cg-RX-API-DMAC7.html)
DK (1) DK3294856T3 (cg-RX-API-DMAC7.html)
ES (1) ES2760468T3 (cg-RX-API-DMAC7.html)
IL (1) IL255556B (cg-RX-API-DMAC7.html)
MX (1) MX380681B (cg-RX-API-DMAC7.html)
PL (1) PL3294856T3 (cg-RX-API-DMAC7.html)
PT (1) PT3294856T (cg-RX-API-DMAC7.html)
RU (1) RU2724495C2 (cg-RX-API-DMAC7.html)
SA (1) SA517390330B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201709329YA (cg-RX-API-DMAC7.html)
TW (1) TWI689303B (cg-RX-API-DMAC7.html)
WO (1) WO2016180798A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201708418B (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3431173A1 (en) 2017-07-19 2019-01-23 Bayer Pharma Aktiengesellschaft Continuous manufacture of guidance molecule drug conjugates
US20210365019A1 (en) * 2018-09-05 2021-11-25 Commonwealth Scientific And Industrial Research Organisation A monitor for a multi-parameter manufacturing process
EP3699697A1 (en) 2019-02-25 2020-08-26 Bayer Aktiengesellschaft Automated simultaneous process control
CN115698881A (zh) * 2020-05-29 2023-02-03 株式会社大赛璐 异常调制原因确定装置、异常调制原因确定方法以及异常调制原因确定程序
WO2023247798A1 (de) 2022-06-24 2023-12-28 Bilfinger Life Science Gmbh Modulare vorrichtung und verfahren zur kontinuierlichen herstellung von biotechnologischen produkten
DE102022208467A1 (de) 2022-06-24 2024-01-04 Bilfinger Life Science Gmbh Modulare Vorrichtung und Verfahren zur kontinuierlichen Herstellung von biotechnologischen Produkten

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011838A1 (en) * 1992-11-06 1994-05-26 Abbott Laboratories Process control system for biological fluid testing
JP2004198123A (ja) * 2002-12-16 2004-07-15 Shimadzu Corp 分取液体クロマトグラフ質量分析装置
JP3823092B2 (ja) * 2003-03-11 2006-09-20 株式会社日立ハイテクノロジーズ 分離分析装置
JP2006018711A (ja) * 2004-07-05 2006-01-19 Earekkusu:Kk 液体除染剤供給システム
HUE032538T2 (en) 2004-09-30 2017-10-30 Bayer Healthcare Llc Tools and procedures for the integrated, continuous production of biological molecules
CN101321856A (zh) * 2005-05-09 2008-12-10 萨克松尼亚生物科技有限责任公司 用于细胞培养模块的供应系统
CN101400418B (zh) * 2006-03-17 2012-11-14 沃特世科技公司 保持流体完整性和预先形成梯度的适于液相色谱的溶剂输送系统
JP4831480B2 (ja) * 2006-06-21 2011-12-07 三浦工業株式会社 膜濾過システム
US9891157B2 (en) * 2010-12-03 2018-02-13 Cellply S.R.L. Microanalysis of cellular function
JP2013544524A (ja) * 2010-12-06 2013-12-19 ターポン バイオシステムズ，インコーポレイテッド 生物学的生成物の連続プロセス法
CN103243026B (zh) * 2012-02-14 2014-09-03 常州医凌生命科技有限公司 多功能全自动细胞及溶液处理仪
EP2682168A1 (en) * 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
CN104903722B (zh) * 2013-01-18 2017-07-14 株式会社岛津制作所 样品浓缩装置
EP2964663A2 (en) 2013-03-08 2016-01-13 Genzyme Corporation Continuous purification of therapeutic proteins
DE102013212540A1 (de) * 2013-06-27 2014-12-31 Agilent Technologies Inc. Konditionieren eines nachfolgenden Probenpakets in einer Probentrennstufe während Prozessierens eines vorangehenden Probenpakets in einer Probenweiterverarbeitungsstufe
BR112017002083B1 (pt) * 2014-07-31 2022-04-05 Govind Rao Sistema de bioprocessamento para a fabricação de proteína de sangue

Also Published As

Publication number Publication date
EP3294856A1 (de) 2018-03-21
EP3093335A1 (de) 2016-11-16
AU2016259746A1 (en) 2017-12-07
RU2017143437A (ru) 2019-06-13
EP3294856B1 (de) 2019-09-18
MX380681B (es) 2025-03-12
US20180127461A1 (en) 2018-05-10
RU2017143437A3 (cg-RX-API-DMAC7.html) 2019-08-29
IL255556A (en) 2018-01-31
SA517390330B1 (ar) 2021-09-22
AU2016259746B2 (en) 2020-12-24
RU2724495C2 (ru) 2020-06-23
SG11201709329YA (en) 2017-12-28
WO2016180798A1 (de) 2016-11-17
TWI689303B (zh) 2020-04-01
BR112017024373B1 (pt) 2022-08-09
PT3294856T (pt) 2019-12-16
US20210221842A1 (en) 2021-07-22
JP6833721B2 (ja) 2021-02-24
CA2985678A1 (en) 2016-11-17
TW201717886A (zh) 2017-06-01
AR104554A1 (es) 2017-07-26
ZA201708418B (en) 2022-08-31
HK1252939A1 (zh) 2019-06-06
IL255556B (en) 2022-04-01
ES2760468T3 (es) 2020-05-14
MX2017014527A (es) 2018-03-12
AU2016259746A8 (en) 2018-04-05
BR112017024373A2 (pt) 2018-07-31
CN107849506A (zh) 2018-03-27
CN107849506B (zh) 2020-11-03
KR20180005225A (ko) 2018-01-15
PL3294856T3 (pl) 2020-04-30
JP2018524668A (ja) 2018-08-30

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