DK3277807T3 - Eukaryotiske ekspressionsvektorer, der omfatter regulatoriske elementer af globin-genklynger - Google Patents
Eukaryotiske ekspressionsvektorer, der omfatter regulatoriske elementer af globin-genklynger Download PDFInfo
- Publication number
- DK3277807T3 DK3277807T3 DK16715272.7T DK16715272T DK3277807T3 DK 3277807 T3 DK3277807 T3 DK 3277807T3 DK 16715272 T DK16715272 T DK 16715272T DK 3277807 T3 DK3277807 T3 DK 3277807T3
- Authority
- DK
- Denmark
- Prior art keywords
- expression vectors
- regulatory elements
- eukaryotic expression
- vectors including
- including regulatory
- Prior art date
Links
- 239000013604 expression vector Substances 0.000 title 1
- 102000018146 globin Human genes 0.000 title 1
- 108060003196 globin Proteins 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/473—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used alpha-Glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15161922 | 2015-03-31 | ||
| LU92686 | 2015-03-31 | ||
| PCT/EP2016/056926 WO2016156404A1 (en) | 2015-03-31 | 2016-03-30 | Eukaryotic expression vectors comprising regulatory elements of the globin gene clusters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3277807T3 true DK3277807T3 (da) | 2020-01-20 |
Family
ID=55699621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16715272.7T DK3277807T3 (da) | 2015-03-31 | 2016-03-30 | Eukaryotiske ekspressionsvektorer, der omfatter regulatoriske elementer af globin-genklynger |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10184135B2 (da) |
| EP (1) | EP3277807B1 (da) |
| JP (1) | JP6861637B2 (da) |
| KR (1) | KR102598130B1 (da) |
| CN (1) | CN108012545B (da) |
| AU (1) | AU2016239324B2 (da) |
| CA (1) | CA2978659C (da) |
| DK (1) | DK3277807T3 (da) |
| ES (1) | ES2764457T3 (da) |
| LT (1) | LT3277807T (da) |
| RU (1) | RU2716974C2 (da) |
| WO (1) | WO2016156404A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201839136A (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 |
| CA3057862A1 (en) * | 2017-03-29 | 2018-10-04 | Bluebird Bio, Inc. | Vectors and compositions for treating hemoglobinopathies |
| WO2019113321A1 (en) * | 2017-12-06 | 2019-06-13 | Memorial Sloan-Kettering Cancer Center | Globin gene therapy for treating hemoglobinopathies |
| CN115125270A (zh) * | 2021-03-22 | 2022-09-30 | 华东师范大学 | 一种α-珠蛋白过表达载体及其应用 |
| CN117210457A (zh) * | 2022-06-10 | 2023-12-12 | 拜奥卡德联合股份公司 | 具有启动子活性的核酸及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8718779D0 (en) * | 1987-08-07 | 1987-09-16 | Grosveld F G | Dna sequence & expression vector |
| AU6505690A (en) * | 1989-09-26 | 1991-04-28 | Richard R Behringer | Erythroid-specific gene expression system |
| US20040133934A1 (en) | 1996-03-06 | 2004-07-08 | Townes Tim M. | Transgenic animals that produce human hemoglobin |
| CA2246005A1 (en) | 1998-10-01 | 2000-04-01 | Hsc Research And Development Limited Partnership | Hybrid genes for gene therapy in erythroid cells |
| US7541179B2 (en) * | 2001-06-29 | 2009-06-02 | Memorial Sloan-Kettering Cancer Center | Vector encoding human globin gene and use thereof in treatment of hemoglobinopathies |
| WO2008028686A2 (en) | 2006-09-10 | 2008-03-13 | Glycotope Gmbh | Use of human cells of myeloid leukaemia origin for expression of antibodies |
| US20110294873A1 (en) * | 2008-10-23 | 2011-12-01 | Université de Lausanne | Gene Transfer Vectors Comprising At Least One Isolated DNA Molecule Having Insulator Or Boundary Properties And Methods To Identify The Same |
-
2016
- 2016-03-30 CN CN201680016315.2A patent/CN108012545B/zh active Active
- 2016-03-30 AU AU2016239324A patent/AU2016239324B2/en active Active
- 2016-03-30 CA CA2978659A patent/CA2978659C/en active Active
- 2016-03-30 RU RU2017134578A patent/RU2716974C2/ru active
- 2016-03-30 LT LTEP16715272.7T patent/LT3277807T/lt unknown
- 2016-03-30 WO PCT/EP2016/056926 patent/WO2016156404A1/en active Application Filing
- 2016-03-30 KR KR1020177029139A patent/KR102598130B1/ko active IP Right Grant
- 2016-03-30 ES ES16715272T patent/ES2764457T3/es active Active
- 2016-03-30 EP EP16715272.7A patent/EP3277807B1/en active Active
- 2016-03-30 JP JP2017548439A patent/JP6861637B2/ja active Active
- 2016-03-30 DK DK16715272.7T patent/DK3277807T3/da active
- 2016-03-30 US US15/559,272 patent/US10184135B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2764457T3 (es) | 2020-06-03 |
| AU2016239324A1 (en) | 2017-09-21 |
| CN108012545A (zh) | 2018-05-08 |
| KR20170132784A (ko) | 2017-12-04 |
| RU2017134578A3 (da) | 2019-08-29 |
| JP2018510633A (ja) | 2018-04-19 |
| AU2016239324B2 (en) | 2022-04-21 |
| CA2978659A1 (en) | 2016-10-06 |
| CN108012545B (zh) | 2022-08-30 |
| LT3277807T (lt) | 2020-01-10 |
| RU2716974C2 (ru) | 2020-03-17 |
| KR102598130B1 (ko) | 2023-11-02 |
| CA2978659C (en) | 2023-05-16 |
| WO2016156404A1 (en) | 2016-10-06 |
| EP3277807A1 (en) | 2018-02-07 |
| JP6861637B2 (ja) | 2021-04-21 |
| BR112017018538A2 (pt) | 2018-04-17 |
| US20180094279A1 (en) | 2018-04-05 |
| US10184135B2 (en) | 2019-01-22 |
| EP3277807B1 (en) | 2019-12-11 |
| RU2017134578A (ru) | 2019-04-04 |
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