DK3265075T3 - Kombinationsbehandling af multipelt myelom med roneparstat - Google Patents
Kombinationsbehandling af multipelt myelom med roneparstat Download PDFInfo
- Publication number
- DK3265075T3 DK3265075T3 DK16709148.7T DK16709148T DK3265075T3 DK 3265075 T3 DK3265075 T3 DK 3265075T3 DK 16709148 T DK16709148 T DK 16709148T DK 3265075 T3 DK3265075 T3 DK 3265075T3
- Authority
- DK
- Denmark
- Prior art keywords
- melphalan
- use according
- roneparstat
- treatment
- multiple myeloma
- Prior art date
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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Landscapes
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Claims (18)
1. Roneparstat til anvendelse til forebyggelse eller behandling af multipelt myelom i kombinationsbehandling med melphalan eller et farmaceutisk acceptabelt salt, hydrat eller solvat deraf, eller i en indgiftsplan omfattende melphalan.
2. Roneparstat til anvendelse ifølge krav 1, hvor det multiple myelom er på et hvilket som helst stadium.
3. Roneparstat til anvendelse ifølge et hvilket som helst foregående krav, hvor det multiple myelom er et tilbagevendende, refraktært eller recidiverende myelom.
4. Roneparstat til anvendelse ifølge et hvilket som helst foregående krav, hvor det indgives i en subkutan dosis på fra 100 til 600 mg dagligt.
5. Roneparstat til anvendelse ifølge et hvilket som helst foregående krav, hvor melphalan til kombinationsbehandling indgives intravenøst i en dosis på 16 mg/m2 som en enkelt infusion i løbet af 15 til 20 minutter.
6. Roneparstat til anvendelse ifølge et hvilket som helst foregående krav, hvor melphalan til kombinationsbehandling indgives i en oral dosis på 6 mg en gang om dagen i 2 til 3 uger.
7. Kit af dele omfattende følgende bestanddele: a) Roneparstat; b) melphalan eller et farmaceutisk acceptabelt salt deraf, til anvendelse til forebyggelse eller behandling af multipelt myelom.
8. Kit af dele til anvendelse ifølge krav 7, hvor behandlingen omfatter en kombinationsbehandling eller en mephalan-omfattende indgiftsplan.
9. Kit af dele til anvendelse ifølge et hvilket som helst af kravene 7-8, hvor bestanddelen a) og bestanddelen b) indgives samtidigt.
10. Kit af dele til anvendelse ifølge et hvilket som helst af kravene 7-8, hvor bestanddelen a) og bestanddelen b) indgives sekventielt.
11. Kit af dele til anvendelse ifølge et hvilket som helst af kravene 7-10, hvor bestanddelen a) og bestanddelen b) er pakket separat.
12. Kit af dele til anvendelse ifølge et hvilket som helst af kravene 7-11, hvor det multiple myelom er på et hvilket som helst stadium.
13. Kit af dele til anvendelse ifølge et hvilket som helst af kravene 7-12, hvor det multiple myelom tilbagevendende, refraktært eller recidiverende myelom.
14. Kit af dele til anvendelse ifølge et hvilket som helst af kravene 7-13, hvor bestanddelen a) indgives i en subkutan dosis på fra 100 til 600 mg dagligt.
15. Kit af dele til anvendelse ifølge et hvilket som helst af kravene 7-14, hvor bestanddelen b) til kombinationsbehandlingen er melphalan og det indgives intravenøst i en dosis på 16 mg/m2 som en enkelt infusion i løbet af 15 til 20 minutter.
16. Kit af dele til anvendelse ifølge et hvilket som helst af kravene 7-15, hvor bestanddelen b) til kombinationsbehandling er melphalan og indgives i en oral dosis på 6 mg en gang om dagen i 2 til 3 uger.
17. Farmaceutisk sammensætning omfattende Roneparstat og melphalan eller et farmaceutisk acceptabelt salt, hydrat eller solvat deraf, og et eller flere farmaceutisk acceptable bærestof, excipienser eller diluenter.
18. Farmaceutisk sammensætning ifølge krav 17 til anvendelse til behandling af multipelt myelom.
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| US201562129221P | 2015-03-06 | 2015-03-06 | |
| US201562153899P | 2015-04-28 | 2015-04-28 | |
| PCT/IB2016/051196 WO2016142814A1 (en) | 2015-03-06 | 2016-03-03 | Roneparstat combined therapy of multiple myeloma |
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| US7781416B2 (en) | 2000-01-25 | 2010-08-24 | Sigma-Tau Research Switzerland S.A. | Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect |
| IT1316986B1 (it) | 2000-01-25 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica. |
| EP2343077B1 (en) | 2001-09-12 | 2013-07-17 | SIGMA-TAU Research Switzerland S.A. | Derivatives of totally N-desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect |
| US20100009934A1 (en) | 2008-06-09 | 2010-01-14 | Combinatorx, Incorporated | Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders |
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| CA2978040A1 (en) | 2016-09-15 |
| ES2715556T3 (es) | 2019-06-04 |
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| HK1245107A1 (zh) | 2018-08-24 |
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| US10576101B2 (en) | 2020-03-03 |
| AU2016230859A1 (en) | 2017-08-17 |
| CN107645954A (zh) | 2018-01-30 |
| KR20170138405A (ko) | 2017-12-15 |
| EP3265075A1 (en) | 2018-01-10 |
| US20180050061A1 (en) | 2018-02-22 |
| PT3265075T (pt) | 2019-03-25 |
| MX2017011093A (es) | 2018-02-19 |
| EP3265075B1 (en) | 2018-12-12 |
| PL3265075T3 (pl) | 2020-10-05 |
| WO2016142814A1 (en) | 2016-09-15 |
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