DK321887A - Mevalonolactonanaloge - Google Patents

Mevalonolactonanaloge

Info

Publication number
DK321887A
DK321887A DK321887A DK321887A DK321887A DK 321887 A DK321887 A DK 321887A DK 321887 A DK321887 A DK 321887A DK 321887 A DK321887 A DK 321887A DK 321887 A DK321887 A DK 321887A
Authority
DK
Denmark
Prior art keywords
mevalonolactonanaloge
Prior art date
Application number
DK321887A
Other languages
Danish (da)
English (en)
Other versions
DK321887D0 (da
Inventor
James Richard Wareing
Robert Edson Damon
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of DK321887D0 publication Critical patent/DK321887D0/da
Publication of DK321887A publication Critical patent/DK321887A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK321887A 1985-10-25 1987-06-24 Mevalonolactonanaloge DK321887A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79119885A 1985-10-25 1985-10-25
US81666486A 1986-01-07 1986-01-07
PCT/EP1986/000598 WO1987002662A2 (en) 1985-10-25 1986-10-21 Heterocyclic analogs of mevalonolactone and derivatives thereof, processes for their production and their use as pharmaceuticals

Publications (2)

Publication Number Publication Date
DK321887D0 DK321887D0 (da) 1987-06-24
DK321887A true DK321887A (da) 1987-06-24

Family

ID=27121116

Family Applications (1)

Application Number Title Priority Date Filing Date
DK321887A DK321887A (da) 1985-10-25 1987-06-24 Mevalonolactonanaloge

Country Status (12)

Country Link
EP (1) EP0221025A1 (pl)
KR (1) KR900001212B1 (pl)
AU (1) AU598775B2 (pl)
CA (1) CA1278794C (pl)
DK (1) DK321887A (pl)
FI (1) FI872299A0 (pl)
HU (1) HUT48208A (pl)
IL (1) IL80403A (pl)
NZ (1) NZ218045A (pl)
PL (1) PL154130B1 (pl)
PT (1) PT83610B (pl)
WO (1) WO1987002662A2 (pl)

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US5091378A (en) * 1987-05-22 1992-02-25 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method
DE3722806A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
DE3817808A1 (de) * 1987-07-21 1989-02-02 Bayer Ag Verfahren zur herstellung von 2-substituierten pyrrolen
US4822799A (en) * 1988-01-27 1989-04-18 Sandoz Pharm. Corp. Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals
NO890988L (no) * 1988-03-24 1989-09-25 Bayer Ag Disubstituerte pyrroler.
EP0339342A1 (de) * 1988-04-23 1989-11-02 Bayer Ag N-Substituierte N-Amino-pyrrole
EP0352575A3 (de) * 1988-07-28 1991-08-21 Bayer Ag Substituierte anellierte Pyrrole
DE3826814A1 (de) * 1988-08-06 1990-02-08 Hoechst Ag Neue 6-fluor-3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
US5506219A (en) * 1988-08-29 1996-04-09 E. R. Squibb & Sons, Inc. Pyridine anchors for HMG-CoA reductase inhibitors
DE3832570A1 (de) * 1988-09-24 1990-03-29 Hoechst Ag 7-substituierte derivate der 3,5-dihydroxyhept-6-insaeure, verfahren zur ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte
DK483689A (da) * 1988-10-03 1990-04-04 Glaxo Group Ltd Imidazolderivater
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
IE903606A1 (en) * 1989-10-10 1991-04-24 Glaxo Group Ltd Chemical compounds
IT1237792B (it) * 1989-12-21 1993-06-17 Zambon Spa Composti attivi come inibitori dell'enzima hmg-coa reduttasi
US5049577A (en) * 1990-01-29 1991-09-17 E. R. Squibb & Sons, Inc. 2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkynoic acids, compositions and HMG-CoA reductase inhibition therewith
US5049578A (en) * 1990-03-09 1991-09-17 E. R. Squibb & Sons, Inc. 1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones
US5128366A (en) * 1990-07-05 1992-07-07 Shinogi & Co., Ltd. Pyrrole derivatives
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WO1992019239A1 (en) * 1991-05-01 1992-11-12 University Of New Mexico Treatment of aberrant cellular states with biomodulators
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Also Published As

Publication number Publication date
DK321887D0 (da) 1987-06-24
EP0221025A1 (en) 1987-05-06
PL262032A1 (en) 1988-07-21
PT83610A (en) 1986-11-01
PT83610B (pt) 1989-05-31
PL154130B1 (en) 1991-07-31
HUT48208A (en) 1989-05-29
AU598775B2 (en) 1990-07-05
CA1278794C (en) 1991-01-08
WO1987002662A3 (en) 1987-12-17
IL80403A (en) 1990-09-17
FI872299A (fi) 1987-05-25
IL80403A0 (en) 1987-01-30
KR870700602A (ko) 1987-12-30
AU6599486A (en) 1987-05-19
WO1987002662A2 (en) 1987-05-07
NZ218045A (en) 1990-03-27
KR900001212B1 (ko) 1990-02-28
FI872299A0 (fi) 1987-05-25

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