DK3164380T3 - Hæmmere af lysinspecifik demethylase-1 - Google Patents

Hæmmere af lysinspecifik demethylase-1 Download PDF

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Publication number
DK3164380T3
DK3164380T3 DK15814038.4T DK15814038T DK3164380T3 DK 3164380 T3 DK3164380 T3 DK 3164380T3 DK 15814038 T DK15814038 T DK 15814038T DK 3164380 T3 DK3164380 T3 DK 3164380T3
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DK
Denmark
Prior art keywords
inhibitors
light
specific demethylase
demethylase
specific
Prior art date
Application number
DK15814038.4T
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Danish (da)
English (en)
Inventor
Young K Chen
Zhe Nie
Jeffrey Alan Stafford
James Marvin Veal
Toufike Kanouni
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Celgene Quanticel Res Inc
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Publication of DK3164380T3 publication Critical patent/DK3164380T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyamides (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK15814038.4T 2014-07-03 2015-06-29 Hæmmere af lysinspecifik demethylase-1 DK3164380T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462020886P 2014-07-03 2014-07-03
PCT/US2015/038345 WO2016003917A1 (en) 2014-07-03 2015-06-29 Inhibitors of lysine specific demethylase-1

Publications (1)

Publication Number Publication Date
DK3164380T3 true DK3164380T3 (da) 2022-03-28

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DK15814038.4T DK3164380T3 (da) 2014-07-03 2015-06-29 Hæmmere af lysinspecifik demethylase-1
DK19156976.3T DK3511319T3 (da) 2014-07-03 2015-06-29 Hæmmere af lysinspecifik demethylase-1

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DK19156976.3T DK3511319T3 (da) 2014-07-03 2015-06-29 Hæmmere af lysinspecifik demethylase-1

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US (3) US9902719B2 (enExample)
EP (2) EP3511319B1 (enExample)
JP (2) JP6663866B2 (enExample)
KR (1) KR102475498B1 (enExample)
CN (2) CN106795103B (enExample)
AU (1) AU2015284383B2 (enExample)
BR (1) BR112017000043A2 (enExample)
CA (1) CA2954049A1 (enExample)
CL (1) CL2016003422A1 (enExample)
CO (1) CO2017000549A2 (enExample)
CY (1) CY1125127T1 (enExample)
DK (2) DK3164380T3 (enExample)
EA (2) EA033698B1 (enExample)
EC (1) ECSP17006821A (enExample)
ES (2) ES2907676T3 (enExample)
FI (1) FI3511319T3 (enExample)
HR (2) HRP20220414T1 (enExample)
HU (2) HUE062558T2 (enExample)
IL (2) IL249881B (enExample)
LT (2) LT3511319T (enExample)
MX (2) MX395534B (enExample)
PL (2) PL3511319T3 (enExample)
PT (2) PT3164380T (enExample)
RS (2) RS64423B1 (enExample)
SA (1) SA517380651B1 (enExample)
SG (2) SG11201610975RA (enExample)
SI (2) SI3164380T1 (enExample)
SM (2) SMT202200136T1 (enExample)
WO (1) WO2016003917A1 (enExample)

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CN116102533A (zh) * 2021-11-11 2023-05-12 中国科学院上海药物研究所 一种芳杂环类化合物及其应用
JP2025516647A (ja) 2022-05-09 2025-05-30 オリゾン・ゲノミクス・ソシエダッド・アノニマ Ｌｓｄ１阻害薬を用いる悪性末梢神経鞘腫（ｍｐｎｓｔ）の治療法
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CN120529900A (zh) 2022-11-24 2025-08-22 奥莱松基因组股份有限公司 用于治疗癌症的LSD1抑制剂和Menin抑制剂的组合

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RS63074B1 (sr) 2022-04-29
IL272130A (en) 2020-03-31
SI3164380T1 (sl) 2022-06-30
EA033698B1 (ru) 2019-11-18
CN108530424B (zh) 2021-10-01
EA201790085A1 (ru) 2017-08-31
US20170129882A1 (en) 2017-05-11
CY1125127T1 (el) 2024-02-16
AU2015284383B2 (en) 2019-04-18
PL3164380T3 (pl) 2022-04-04
EA201891526A2 (ru) 2018-12-28
CO2017000549A2 (es) 2017-04-20
PT3511319T (pt) 2023-06-29
ES2948782T3 (es) 2023-09-19
EP3164380A4 (en) 2018-07-18
US9902719B2 (en) 2018-02-27
JP6663866B2 (ja) 2020-03-13
PL3511319T3 (pl) 2023-09-11
MX376207B (es) 2025-03-07
SA517380651B1 (ar) 2020-09-30
HUE062558T2 (hu) 2023-11-28
JP2017525668A (ja) 2017-09-07
CL2016003422A1 (es) 2017-11-10
PT3164380T (pt) 2022-03-02
HRP20220414T1 (hr) 2022-05-27
LT3511319T (lt) 2023-08-25
SI3511319T1 (sl) 2023-10-30
US10100046B2 (en) 2018-10-16
BR112017000043A2 (pt) 2018-07-17
HRP20230595T1 (hr) 2023-09-15
EP3511319A1 (en) 2019-07-17
CN106795103B (zh) 2019-07-12
CA2954049A1 (en) 2016-01-07
MX2017000168A (es) 2017-05-01
IL272130B (en) 2021-03-25
SMT202200136T1 (it) 2022-05-12
ECSP17006821A (es) 2017-03-31
US20180127408A1 (en) 2018-05-10
EP3164380A1 (en) 2017-05-10
IL249881B (en) 2020-01-30
EA201891526A3 (ru) 2019-05-31
KR102475498B1 (ko) 2022-12-07
US20190002456A1 (en) 2019-01-03
HUE058852T2 (hu) 2022-09-28
EP3164380B1 (en) 2022-02-09
AU2015284383A1 (en) 2017-02-02
DK3511319T3 (da) 2023-07-31
ES2907676T3 (es) 2022-04-26
SG10201802501RA (en) 2018-05-30
SMT202300205T1 (it) 2023-09-06
WO2016003917A1 (en) 2016-01-07
IL249881A0 (en) 2017-03-30
LT3164380T (lt) 2022-06-27
KR20170018100A (ko) 2017-02-15
MX2020010900A (es) 2022-09-13
SG11201610975RA (en) 2017-01-27
CN106795103A (zh) 2017-05-31
JP2019108346A (ja) 2019-07-04
EP3511319B1 (en) 2023-05-03
RS64423B1 (sr) 2023-09-29
FI3511319T3 (fi) 2023-07-20
JP6768857B2 (ja) 2020-10-14
MX395534B (es) 2025-03-25
CN108530424A (zh) 2018-09-14

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