DK3150203T3 - Forbindelser med (1e,6e)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstitueret-hepa-1,6-dien-3,5-di-on strukturel scaffold, deres biologiske aktivitet og anvendelser deraf - Google Patents
Forbindelser med (1e,6e)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstitueret-hepa-1,6-dien-3,5-di-on strukturel scaffold, deres biologiske aktivitet og anvendelser deraf Download PDFInfo
- Publication number
- DK3150203T3 DK3150203T3 DK16187672.7T DK16187672T DK3150203T3 DK 3150203 T3 DK3150203 T3 DK 3150203T3 DK 16187672 T DK16187672 T DK 16187672T DK 3150203 T3 DK3150203 T3 DK 3150203T3
- Authority
- DK
- Denmark
- Prior art keywords
- hepa
- dimethoxyphenyl
- disubstituted
- diene
- bis
- Prior art date
Links
- -1 3,4-DIMETHOXYPHENYL Chemical class 0.000 title 1
- 230000004071 biological effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/121—Ketones acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/525,941 US8710272B2 (en) | 2007-01-08 | 2012-06-18 | Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof |
| EP13806162.7A EP2861222A4 (en) | 2012-06-18 | 2013-06-17 | COMPOUNDS OF (1E, 6E) -1,7-BIS- (3,4-DIMETHOXYPHENYL) -4,4-DISUBSTITUTED HEPA-1,6-DIENE-3,5-DION STRUCTURE, THEIR BIOLOGICAL ACTIVITY, AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3150203T3 true DK3150203T3 (da) | 2020-04-14 |
Family
ID=49769258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16187672.7T DK3150203T3 (da) | 2012-06-18 | 2013-06-17 | Forbindelser med (1e,6e)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstitueret-hepa-1,6-dien-3,5-di-on strukturel scaffold, deres biologiske aktivitet og anvendelser deraf |
Country Status (14)
| Country | Link |
|---|---|
| EP (3) | EP3150203B1 (OSRAM) |
| JP (2) | JP6392752B2 (OSRAM) |
| KR (1) | KR102171469B1 (OSRAM) |
| CN (3) | CN104755076A (OSRAM) |
| AU (1) | AU2013277423B2 (OSRAM) |
| CA (1) | CA2876957C (OSRAM) |
| DK (1) | DK3150203T3 (OSRAM) |
| ES (1) | ES2775173T3 (OSRAM) |
| HK (1) | HK1211211A1 (OSRAM) |
| IN (1) | IN2015MN00131A (OSRAM) |
| MX (1) | MX2014015936A (OSRAM) |
| NZ (1) | NZ703167A (OSRAM) |
| SG (1) | SG11201408387YA (OSRAM) |
| WO (1) | WO2013192091A1 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3064829C (en) | 2017-05-26 | 2023-08-22 | Bruin Biosciences, Inc. | Chemoembolization agents |
| CN107226783B (zh) * | 2017-06-20 | 2019-07-23 | 武汉工程大学 | 一种溶酶体靶向荧光探针及其制备方法 |
| EP3508855A1 (en) * | 2018-01-05 | 2019-07-10 | Allianz Pharmascience Ltd | Method for the selection of patients and kit |
| GB2572259B (en) * | 2018-03-23 | 2022-03-30 | Merry Life Biomedical Company Ltd | Uses of curcumin derivative |
| JP2020125285A (ja) * | 2019-01-04 | 2020-08-20 | アリアンツ ファーマサイエンス リミテッド | 神経変性性障害の治療方法 |
| JP2020117489A (ja) * | 2019-01-04 | 2020-08-06 | アリアンツ ファーマサイエンス リミテッド | 脳癌の治療方法 |
| CN110183320B (zh) * | 2019-04-15 | 2021-06-11 | 四川大学 | 一类多烯二酮类抗肿瘤化合物 |
| WO2023208187A1 (zh) * | 2022-04-29 | 2023-11-02 | 南京迈诺威医药科技有限公司 | 一种具备抗雄激素受体活性的化合物及其用途 |
| CN116120182A (zh) * | 2023-02-16 | 2023-05-16 | 常州大学 | 姜黄素衍生物及其合成方法和在抗雄激素受体中的应用 |
| CN116283676B (zh) * | 2023-03-24 | 2025-03-28 | 常州大学 | 一种姜黄素衍生物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US812408A (en) | 1905-08-19 | 1906-02-13 | Roy Ernest Dickerson | Educational device for teaching spherics. |
| US6790979B2 (en) * | 2002-04-17 | 2004-09-14 | University Of North Carolina At Chapel Hill | Curcumin analogues and uses thereof |
| US7355081B2 (en) * | 2002-04-17 | 2008-04-08 | The University Of North Carolina At Chapel Hill | Curcumin analogues and uses thereof |
| AU2008205312B2 (en) * | 2007-01-08 | 2013-11-21 | Annji Pharmaceutical Co., Ltd. | Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof |
| JP2010535213A (ja) * | 2007-07-31 | 2010-11-18 | アンドロサイエンス コーポレーション | アンドロゲン受容体分解（ａｒｄ）エンハンサーを含む組成物ならびに皮膚疾患および脱毛の予防的または治療的処理方法 |
| US20090282496A1 (en) * | 2008-04-04 | 2009-11-12 | University Of Rochester Medical Center | Androgen Receptor Related Methods for Treating Bladder Cancer |
-
2013
- 2013-06-17 WO PCT/US2013/046138 patent/WO2013192091A1/en not_active Ceased
- 2013-06-17 AU AU2013277423A patent/AU2013277423B2/en active Active
- 2013-06-17 NZ NZ703167A patent/NZ703167A/en unknown
- 2013-06-17 CN CN201380040213.0A patent/CN104755076A/zh active Pending
- 2013-06-17 EP EP16187672.7A patent/EP3150203B1/en active Active
- 2013-06-17 IN IN131MUN2015 patent/IN2015MN00131A/en unknown
- 2013-06-17 JP JP2015518483A patent/JP6392752B2/ja active Active
- 2013-06-17 HK HK15112031.9A patent/HK1211211A1/xx unknown
- 2013-06-17 MX MX2014015936A patent/MX2014015936A/es active IP Right Grant
- 2013-06-17 DK DK16187672.7T patent/DK3150203T3/da active
- 2013-06-17 CA CA2876957A patent/CA2876957C/en active Active
- 2013-06-17 ES ES16187672T patent/ES2775173T3/es active Active
- 2013-06-17 SG SG11201408387YA patent/SG11201408387YA/en unknown
- 2013-06-17 EP EP19176039.6A patent/EP3549581A3/en not_active Withdrawn
- 2013-06-17 EP EP13806162.7A patent/EP2861222A4/en not_active Ceased
- 2013-06-17 KR KR1020157000948A patent/KR102171469B1/ko active Active
- 2013-06-17 CN CN201910150761.8A patent/CN110279680A/zh active Pending
- 2013-06-17 CN CN201610580850.2A patent/CN106220507A/zh active Pending
-
2018
- 2018-05-09 JP JP2018090272A patent/JP2018135386A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013277423B2 (en) | 2018-08-09 |
| JP2015520233A (ja) | 2015-07-16 |
| CA2876957C (en) | 2021-02-16 |
| EP3150203B1 (en) | 2020-02-19 |
| MX2014015936A (es) | 2016-06-24 |
| CN110279680A (zh) | 2019-09-27 |
| KR102171469B1 (ko) | 2020-10-30 |
| JP2018135386A (ja) | 2018-08-30 |
| CN104755076A (zh) | 2015-07-01 |
| EP3549581A2 (en) | 2019-10-09 |
| ES2775173T3 (es) | 2020-07-24 |
| EP3549581A3 (en) | 2020-02-19 |
| SG11201408387YA (en) | 2015-01-29 |
| KR20150023012A (ko) | 2015-03-04 |
| NZ703167A (en) | 2016-09-30 |
| CA2876957A1 (en) | 2013-12-27 |
| AU2013277423A1 (en) | 2015-01-22 |
| EP3150203A1 (en) | 2017-04-05 |
| JP6392752B2 (ja) | 2018-09-19 |
| CN106220507A (zh) | 2016-12-14 |
| EP2861222A4 (en) | 2015-08-05 |
| IN2015MN00131A (OSRAM) | 2015-10-16 |
| HK1211211A1 (en) | 2016-05-20 |
| EP2861222A1 (en) | 2015-04-22 |
| WO2013192091A1 (en) | 2013-12-27 |
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