DK29789A - 5-substituerede 1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidoner og beslaegtede forbindelser, deres fremstilling og anvendelse som laegemidler - Google Patents

5-substituerede 1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidoner og beslaegtede forbindelser, deres fremstilling og anvendelse som laegemidler

Info

Publication number
DK29789A
DK29789A DK029789A DK29789A DK29789A DK 29789 A DK29789 A DK 29789A DK 029789 A DK029789 A DK 029789A DK 29789 A DK29789 A DK 29789A DK 29789 A DK29789 A DK 29789A
Authority
DK
Denmark
Prior art keywords
pyrrolidones
butynyl
pyrrolidinyl
medicines
substituted
Prior art date
Application number
DK029789A
Other languages
English (en)
Other versions
DK29789D0 (da
Inventor
Lawrence Leo Martin
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of DK29789D0 publication Critical patent/DK29789D0/da
Publication of DK29789A publication Critical patent/DK29789A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
DK029789A 1988-01-25 1989-01-24 5-substituerede 1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidoner og beslaegtede forbindelser, deres fremstilling og anvendelse som laegemidler DK29789A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/148,268 US4772601A (en) 1988-01-25 1988-01-25 5-Substituted 1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidinones, pharmaceutical compositions and use

Publications (2)

Publication Number Publication Date
DK29789D0 DK29789D0 (da) 1989-01-24
DK29789A true DK29789A (da) 1989-07-26

Family

ID=22525034

Family Applications (1)

Application Number Title Priority Date Filing Date
DK029789A DK29789A (da) 1988-01-25 1989-01-24 5-substituerede 1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidoner og beslaegtede forbindelser, deres fremstilling og anvendelse som laegemidler

Country Status (6)

Country Link
US (1) US4772601A (da)
EP (1) EP0325984A3 (da)
JP (1) JPH02138252A (da)
DK (1) DK29789A (da)
IE (1) IE890201L (da)
PT (1) PT89522A (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5236946A (en) * 1986-09-16 1993-08-17 Panmedica S.A. Amino acid esters of cycloaliphatic alcohols and their use in treating lipemic disorders
FR2603888B1 (fr) * 1986-09-16 1990-12-21 Panmedica Sa Esters d'amino acides du trimethyl cyclohexanol, procede de preparation et utilisation comme medicaments
IT1215587B (it) * 1987-06-26 1990-02-14 Roussel Maestretti Spa Derivati della 1-benzoil2-oxo 5-alcossi pirrolidina, loro procedimento di preparazione e loro impiego come sostanza medicinale.
GB8811410D0 (en) * 1988-05-13 1988-06-15 Unilever Plc Treatment of skin disorders
US5021439A (en) * 1988-10-31 1991-06-04 Takeda Chemical Industries, Ltd. Cerebral function ameliorating agents related to Tan-950 A
IT1244507B (it) * 1991-04-11 1994-07-15 Sigma Tau Ind Farmaceuti Derivati dell'acido piroglutammico quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
PL2049478T3 (pl) * 2006-07-06 2012-09-28 Glaxo Group Ltd Podstawione N-fenylometylo 5-okso-prolino-2-amidy jako antagoniści receptora P2X7 oraz sposoby ich zastosowania

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB833820A (en) * 1957-10-17 1960-04-27 Beecham Res Lab Improvements in or relating to the preparation of pyrrolidyl esters and quaternary compounds thereof
FR1405319A (fr) * 1964-05-26 1965-07-09 Ile Auguil Soc Civ Procédé de préparation de l'(oxo-2 pyrrolidino-1)-1 (pyrrolidino-1)-4 butyne-2, et nouveaux sels de ce composé
FR1517697A (fr) * 1966-03-15 1968-03-22 Leanord Nouveaux composés esters et amides de l'acide pyroglutamique, procédé pour leur fabrication, solvants à base de tels composés, et procédé d'extraction avec de tels solvants
FR2273533A1 (fr) * 1974-06-04 1976-01-02 Ferlux Sa Nouveaux derives n-substitues d'acides pyrrolidones-2 carboxyliques-5
DE2528664A1 (de) * 1975-06-27 1977-01-13 Hoechst Ag Pyrrolidone und verfahren zu ihrer herstellung
DE2556326A1 (de) * 1975-12-13 1977-06-23 Hoechst Ag Neue pyrrolidone und verfahren zu ihrer herstellung
JPS5283367A (en) * 1975-12-27 1977-07-12 Tanabe Seiyaku Co Ltd Synthesis of 2-pyrrolidone derivatives
JPS5283368A (en) * 1975-12-27 1977-07-12 Tanabe Seiyaku Co Ltd Synthesis of 2-pyprolidone derivatives
DE3336024A1 (de) * 1983-10-04 1985-04-18 Boehringer Ingelheim KG, 6507 Ingelheim 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
JPS6330466A (ja) * 1986-07-24 1988-02-09 Hisamitsu Pharmaceut Co Inc アザシクロアルカン化合物

Also Published As

Publication number Publication date
PT89522A (pt) 1989-10-04
EP0325984A2 (en) 1989-08-02
EP0325984A3 (en) 1991-01-02
DK29789D0 (da) 1989-01-24
US4772601A (en) 1988-09-20
JPH02138252A (ja) 1990-05-28
IE890201L (en) 1989-07-25

Similar Documents

Publication Publication Date Title
NO922940D0 (no) Fem-leddete heterocykliske forbindelser, fremgangsmaate for deres fremstilling og legemidler inneholdende dem
DK430485D0 (da) Trans-6-(2-(substitueretpyrrol-1-yl)alkyl)-pyran-2-oner, deres fremstilling og farmaceutiske anvendelse
NO924027D0 (no) Heterobiarylderivater, legemidler inneholdende disse forbindelser, og fremgangsmaate for deres fremstilling
DK641589A (da) N-aryl-azetidinoner, fremgangsmaade til deres fremstilling og deres anvendelse som elastaseinhibitorer
NO881164L (no) Substituerte 9-amino-tetrahydroakridiner og relaterte forbindelser, en fremgangsmaate for deres fremstilling og deres bruk som medikamenter.
DK381985D0 (da) 3-pyridylforbindelser, deres fremstilling og anvendelse som laegemiddel
NO932120D0 (no) Bifenylderivater, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling
DK394489D0 (da) Benzamid- og sulfonbenzamid-forbindelser, deres anvendelse til fremstilling af antiarytmiske laegemidler, farmaceutiske praeparater indeholdende forbindelserne og mellemprodukter ved fremstilling af forbindelserne
DK45786D0 (da) N-(2-(4-fluorphenyl)-1-methyl)-ethyl-n-methyl-n-propynylamin, isomere og salte deraf, deres fremstilling og anvendelse som farmaceutika
DK347986A (da) N-substituerede arylalkyl- og -arylalkylenaminoheterocycliske forbindelser og deres anvendelse som cardiovaskulaere, antihistamin- og antisekretoriske midler
DK451588D0 (da) Heterocycliske forbindelser, deres fremstilling og laegemidler indeholdende forbindelserne
DK219685D0 (da) Heterocycliske forbindelser, deres fremstilling og anvendelse som laegemidler
DK29789D0 (da) 5-substituerede 1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidoner og beslaegtede forbindelser, deres fremstilling og anvendelse som laegemidler
DK581586A (da) N-(pyrrol-l-yl)-pyridinaminer, deres fremstilling og anvendelse som laegemidler
DK392785A (da) 1-(2-oxyaminocarbonylphenylsulfonyl)-3-heteroaryl-urinstoffer, deres fremstilling og anvendelse som herbicider
DK133587D0 (da) 2-heterocyclylthio-penemer, deres anvendelse og farmaceutisk komposition indeholdende forbindelserne
DK686888D0 (da) Aminoketaler, deres fremstilling og deres anvendelse som fungicider
NO921908D0 (no) Aminosyreazetidinylsubstituerte pyridonderivater, deres fremstilling og anvendelse som medikamenter
NO911465D0 (no) Fremgangsmaate for fremstilling av 4-(3-(4-oksotiazoldinyl))-butynylaminer og deres anvendelse som medikamenter.
DK278290D0 (da) Substituerede 6h-pyridooe4,3-baacarbazoler og deres anvendelse som laegemidler
NO950560D0 (no) Piperazinderivater, deres fremstilling og terapautiske anvendelse
DK37787A (da) 2,3-dioxabicyclooe3,3,0aaoctan-derivater og deres anvendelse som laegemidler
DK415785D0 (da) Salicylamid-derivater, deres fremstilling og anvendelse som fungicider
NO880206L (no) 1-((4-morfolinyl)alkyl)-1h-indoler med analgetisk aktivitet og fremgangsmaate for deres fremstilling.
DK625886D0 (da) Aminoethere og deres anvendelse som fungicider

Legal Events

Date Code Title Description
ATS Application withdrawn