DK2948140T3 - Doseringsformer og terapeutiske anvendelser af l-4-chlorkynurenin - Google Patents
Doseringsformer og terapeutiske anvendelser af l-4-chlorkynurenin Download PDFInfo
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- DK2948140T3 DK2948140T3 DK14743570.5T DK14743570T DK2948140T3 DK 2948140 T3 DK2948140 T3 DK 2948140T3 DK 14743570 T DK14743570 T DK 14743570T DK 2948140 T3 DK2948140 T3 DK 2948140T3
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- chlorokynurenine
- pain
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Epidemiology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Organic Chemistry (AREA)
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- Physiology (AREA)
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- Psychology (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Lubricants (AREA)
- Quinoline Compounds (AREA)
Claims (6)
1. L-4-chlorkynurenin til anvendelse i en fremgangsmåde til behandling af depression ved indgivelse af en terapeutisk virksom mængde af L-4-chlorkynurenin til en patient.
2. Farmaceutisk sammensætning, som pr. enhedsdosis i det væsentlige består af L-4-chlorkynurenin i en mængde på 50 til 1800 mg sammen med farmaceutisk acceptable bestanddele såsom bærere og hjælpestoffer, til anvendelse i en fremgangsmåde til behandling af depression ved indgivelse af sammensætningen til en patient.
3. Farmaceutisk sammensætning til anvendelse i en fremgangsmåde til behandling af depression ifølge krav 2, hvor sammensætningen indgives fra 1 til 30 dage.
4. Farmaceutisk sammensætning til anvendelse i en fremgangsmåde til behandling af depression ifølge krav 2, hvor indgivelse af sammensætningen inducerer eller øger følelser af velvære hos patienten.
5. Farmaceutisk kombinationsprodukt, der omfatter L-DOPA og en farmaceutisk sammensætning, som pr. enhedssdosis i det væsentlige består af L-4-chlorkynurenin i en mængde på 50 til 1800 mg sammen med farmaceutisk acceptable bestanddele såsom bærere og hjælpestoffer.
6. Farmaceutisk formulering, som pr. enhedsdosis i det væsentlige består af L-4-chlorkynurenin i en mængde på 50 til 1800 mg sammen med farmaceutisk acceptable bestanddele såsom bærere og hjælpestoffer, til anvendelse i en fremgangsmåde til reduktion af L-DOPA-associerede dyskinesier, omfattende indgivelse af en terapeutisk virksom mængde af 7-chlorkynurenin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361849191P | 2013-01-22 | 2013-01-22 | |
| PCT/US2014/012598 WO2014116739A1 (en) | 2013-01-22 | 2014-01-22 | Dosage forms and therapeutic uses l-4-chlorokynurenine |
Publications (1)
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|---|---|
| DK2948140T3 true DK2948140T3 (da) | 2017-08-21 |
Family
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| DK19196366.9T DK3598971T3 (da) | 2013-01-22 | 2014-01-22 | Doseringsformer og terapeutiske anvendelser af L-4-chlorkynurenin |
| DK14743570.5T DK2948140T3 (da) | 2013-01-22 | 2014-01-22 | Doseringsformer og terapeutiske anvendelser af l-4-chlorkynurenin |
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| DK17170079T DK3228313T3 (da) | 2013-01-22 | 2014-01-22 | Doseringsformer og terapeutiske anvendelser af L-4-chlorkynurenin |
| DK19196366.9T DK3598971T3 (da) | 2013-01-22 | 2014-01-22 | Doseringsformer og terapeutiske anvendelser af L-4-chlorkynurenin |
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| EP (4) | EP4385563A3 (da) |
| JP (5) | JP6436913B2 (da) |
| KR (5) | KR102257284B1 (da) |
| CN (4) | CN113116877A (da) |
| AU (4) | AU2014209466B2 (da) |
| BR (1) | BR112015017535A2 (da) |
| CA (3) | CA3216579A1 (da) |
| CY (1) | CY1122403T1 (da) |
| DK (3) | DK3228313T3 (da) |
| ES (3) | ES2980120T3 (da) |
| HK (1) | HK1217170A1 (da) |
| HR (2) | HRP20240812T1 (da) |
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| MX (2) | MX2015009277A (da) |
| PL (2) | PL3228313T3 (da) |
| PT (3) | PT2948140T (da) |
| RS (1) | RS59687B1 (da) |
| SI (1) | SI3228313T1 (da) |
| WO (1) | WO2014116739A1 (da) |
| ZA (2) | ZA201505569B (da) |
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| BR112015017535A2 (pt) | 2013-01-22 | 2020-02-04 | Vistagen Therapeutics Inc | formas de dosagem e utilizações terapêuticas de l-4-cloroquinurenina |
| KR20240068766A (ko) * | 2015-05-22 | 2024-05-17 | 비스타젠 쎄라퓨틱스, 인크. | L-４-클로로키누레닌의 치료적 용도 |
| US20180327351A1 (en) * | 2015-09-08 | 2018-11-15 | Cephalon, Inc. | Prodrugs of chlorokynurenines |
| JP7431163B2 (ja) | 2018-02-09 | 2024-02-14 | ヴィスタゲン セラピューティクス、インコーポレイテッド | ４－クロロキヌレニンおよび中間体の合成 |
| CN109223785A (zh) * | 2018-10-29 | 2019-01-18 | 中国药科大学 | 犬尿喹啉酸或其衍生物在制备改善慢性精神应激相关病理损伤药物中的应用 |
| WO2022082100A1 (en) * | 2020-10-16 | 2022-04-21 | Vistagen Therapeutics, Inc. | Cocrystals of l-4-chlorokynurenine, compositions and therapeutic uses thereof |
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| US5086072A (en) | 1990-06-18 | 1992-02-04 | The United States Of America As Represented By The Department Of Health And Human Services | Treatment of mood disorders with functional antagonists of the glycine/nmda receptor complex |
| US5360814A (en) | 1991-02-28 | 1994-11-01 | Merrell Dow Pharmaceuticals Inc. | NMDA antagonists |
| US5484814A (en) * | 1991-02-28 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | NMDA antagonists |
| US5763393A (en) | 1996-05-17 | 1998-06-09 | Neurotherapeutics L.P. | Neuroactive peptides |
| TW518218B (en) | 1999-05-27 | 2003-01-21 | Merck Patent Gmbh | Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders |
| EP1427404A4 (en) | 2001-08-20 | 2005-10-26 | Maiken Nedergaard | TREATMENT OF GLIAL TUMORS WITH GLUTAMATE ANTAGONISTS |
| CA2497867A1 (en) | 2002-09-06 | 2004-03-18 | Durect Corporation | Delivery of modulators of glutamate-mediated neurotransmission to the inner ear |
| US20060063802A1 (en) | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| MX2008013130A (es) | 2006-04-12 | 2008-11-19 | Probiodrug Ag | Inhibidores de enzima. |
| EP1903028A1 (en) * | 2006-09-22 | 2008-03-26 | Werner Tschollar | Conjugates of glutamate and NMDA receptor channel blockers without excito-toxic effects |
| CA2606658A1 (en) | 2006-10-13 | 2008-04-13 | Mike Tyers | Compositions and methods for treating neurological disorders or damage |
| EP2865670B1 (en) | 2007-04-18 | 2017-01-11 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| WO2009135091A1 (en) * | 2008-04-30 | 2009-11-05 | Medivation Technologies, Inc. | Use of asenapine and related compounds for the treatment of neuronal or non-neuronal diseases or conditions |
| WO2010022300A1 (en) | 2008-08-21 | 2010-02-25 | Forest Laboratories Holdings Limited | Methods for treating neuropathic pain |
| PT2421519T (pt) | 2009-04-23 | 2017-01-26 | Univ Zuerich | Bloqueadores do recetor nmda para o tratamento de anemia falciforme |
| KR20120061047A (ko) * | 2009-06-17 | 2012-06-12 | 타가셉트 인코포레이티드 | 신경원성 니코틴 수용체 리간드에 의한 ｌ?도파?유도 운동 장애의 역전 |
| EP2466312B1 (en) | 2009-08-12 | 2019-10-16 | Human Metabolome Technologies, Inc. | Phosphoethanolamine as biomarker of depression |
| US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
| EP2338873A1 (en) * | 2009-12-22 | 2011-06-29 | Gmeiner, Peter | New aminotetraline derivatives |
| KR101831616B1 (ko) * | 2010-06-15 | 2018-04-04 | 그뤼넨탈 게엠베하 | 통증 치료용 약제학적 병용물 |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| BR112015017535A2 (pt) | 2013-01-22 | 2020-02-04 | Vistagen Therapeutics Inc | formas de dosagem e utilizações terapêuticas de l-4-cloroquinurenina |
| JP2016513718A (ja) | 2013-03-14 | 2016-05-16 | ヴィスタゲン セラピューティクス、インコーポレイテッド | キラルキヌレニン化合物及び中間体の合成 |
| JP6603668B2 (ja) | 2013-10-28 | 2019-11-06 | ノーレックス インコーポレイテッド | Ｎｍｄａ受容体モジュレーター及びプロドラッグ、塩、並びにこれらの使用 |
| KR20240068766A (ko) | 2015-05-22 | 2024-05-17 | 비스타젠 쎄라퓨틱스, 인크. | L-４-클로로키누레닌의 치료적 용도 |
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2015
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2016
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