DK2909315T3 - Identifikation og analyse af føtale trofoblastceller i cervixslim til prænatal diagnose - Google Patents
Identifikation og analyse af føtale trofoblastceller i cervixslim til prænatal diagnose Download PDFInfo
- Publication number
- DK2909315T3 DK2909315T3 DK13847056.2T DK13847056T DK2909315T3 DK 2909315 T3 DK2909315 T3 DK 2909315T3 DK 13847056 T DK13847056 T DK 13847056T DK 2909315 T3 DK2909315 T3 DK 2909315T3
- Authority
- DK
- Denmark
- Prior art keywords
- prinatic
- trophy
- cervix
- slim
- diagnosis
- Prior art date
Links
- 210000003679 cervix uteri Anatomy 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- NMNIAXSDJGZKKT-UHFFFAOYSA-N methyl 3-hydroxy-4-[4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenoxy]pentanoate Chemical compound C1=CC(OC(C)C(O)CC(=O)OC)=CC=C1OC1=CC=C(C(F)(F)F)C=N1 NMNIAXSDJGZKKT-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/24—Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70539—MHC-molecules, e.g. HLA-molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Virology (AREA)
- Pregnancy & Childbirth (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261715854P | 2012-10-19 | 2012-10-19 | |
| PCT/US2013/065570 WO2014062995A1 (en) | 2012-10-19 | 2013-10-18 | Identification and analysis of fetal trophoblast cells in cervical mucus for prenatal diagnosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2909315T3 true DK2909315T3 (da) | 2019-06-03 |
Family
ID=50488767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13847056.2T DK2909315T3 (da) | 2012-10-19 | 2013-10-18 | Identifikation og analyse af føtale trofoblastceller i cervixslim til prænatal diagnose |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10344315B2 (https=) |
| EP (1) | EP2909315B1 (https=) |
| JP (1) | JP6421123B2 (https=) |
| AU (1) | AU2013331171B2 (https=) |
| CA (1) | CA2888746C (https=) |
| DK (1) | DK2909315T3 (https=) |
| ES (1) | ES2729182T3 (https=) |
| IN (1) | IN2015DN03186A (https=) |
| TR (1) | TR201908019T4 (https=) |
| WO (1) | WO2014062995A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2888746C (en) | 2012-10-19 | 2022-07-26 | Wayne State University | Identification and analysis of fetal trophoblast cells in cervical mucus for prenatal diagnosis |
| WO2016057993A1 (en) | 2014-10-10 | 2016-04-14 | Wayne State University | Methods and compositions relating to assays of fetal extravillous trophoblast cells |
| US10808239B2 (en) | 2016-04-06 | 2020-10-20 | Wayne State University | Isolation and analysis of fetal DNA from extravillous trophoblast cells retrieved from the endocervical canal |
| WO2017180909A1 (en) | 2016-04-13 | 2017-10-19 | Nextgen Jane, Inc. | Sample collection and preservation devices, systems and methods |
| WO2019021065A2 (en) * | 2017-02-13 | 2019-01-31 | Trophodiagnostics, Llc | NEW SYSTEM AND METHOD FOR COLLECTING, ENRICHING AND ISOLATING TROPHOBLASTIC CELLS FROM A ENDOCERVICAL CHANNEL |
| US11230729B2 (en) | 2018-04-20 | 2022-01-25 | Inanna Diagnostics, Inc | Methods and devices for obtaining cellular and DNA material from human female reproductive system |
| TWI668423B (zh) * | 2018-10-02 | 2019-08-11 | 吳宏偉 | 細胞分選方法及系統 |
| CN111122857A (zh) * | 2018-10-31 | 2020-05-08 | 苏州浚惠生物科技有限公司 | 胎儿滋养层细胞的标志物、鉴定方法、检测试剂盒和应用 |
| CN111304153A (zh) * | 2019-12-17 | 2020-06-19 | 广东凯普生物科技股份有限公司 | 一种分离滋养层细胞的方法 |
| JP7824649B2 (ja) * | 2020-02-21 | 2026-03-05 | 国立大学法人東海国立大学機構 | 胎児発育不全に対する定量的評価指標 |
| CN112980779B (zh) * | 2021-05-20 | 2021-08-24 | 广州凯普医药科技有限公司 | 一种从孕妇宫颈脱落细胞中分离胎盘滋养层细胞的方法 |
| AU2023406050A1 (en) * | 2022-11-29 | 2025-06-12 | Akna Health Inc. | Identification of cervical biomarkers |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5629147A (en) | 1992-07-17 | 1997-05-13 | Aprogenex, Inc. | Enriching and identifying fetal cells in maternal blood for in situ hybridization |
| DE69223617T2 (de) | 1992-09-18 | 1998-04-09 | Amersham Int Plc | Verfahren zum Auffangen von Zellkernen und dafür verwendete Vorrichtung |
| BR9907852A (pt) * | 1998-02-12 | 2000-10-24 | Immunivest Corp | Processos para detectar e enumerar células raras e cancerosas em uma população celular mista, para diagnosticar câncer de estágio precoce em um paciente de teste, para determinar a probabilidade de recorrência de câncer em um paciente humano anteriormente tratado de câncer, para distinguir um carcinoma confinado ao órgão de um carcinoma com propriedades metastáticas, para acompanhar a situação de remissão em um paciente humano com câncer que passa pelo tratamento de terapia contra o câncer e para aumentar quantidades de células epiteliais circulantes em uma amostra de sangue, partìcula magnética revestida, composição, conjuntos de teste para avaliar uma amostra de paciente quanto a presença de células raras circulantes, quanto a presença de células de tumor circulantes, quanto a presença de células de câncer de mama circulantes, quanto a presença de células de câncer de próstata circulantes, quanto a presença de células de câncer de cólon circulantes, quanto a presença de células de câncer de bexiga circulantes e para monitorar um paciente quanto a recorrência de câncer, e, fração de sangue periférico enriquecido quanto a células neoplásticas circulantes |
| AUPR749901A0 (en) * | 2001-09-06 | 2001-09-27 | Monash University | Method of identifying chromosomal abnormalities and prenatal diagnosis |
| US20040197832A1 (en) * | 2003-04-03 | 2004-10-07 | Mor Research Applications Ltd. | Non-invasive prenatal genetic diagnosis using transcervical cells |
| US20050181429A1 (en) | 2003-04-03 | 2005-08-18 | Monaliza Medical Ltd. | Non-invasive prenatal genetic diagnosis using transcervical cells |
| JP2008514900A (ja) | 2004-07-30 | 2008-05-08 | アデザ・バイオメデイカル・コーポレイシヨン | 疾病および他の状態のマーカーとしての癌胎児性フィブロネクチンならびに癌胎児性フィブロネクチンの検出のための方法 |
| US20070224597A1 (en) | 2006-03-23 | 2007-09-27 | Biocept, Inc. | Isolating fetal trophoblasts |
| US20090286271A1 (en) | 2006-05-31 | 2009-11-19 | Karumanchi Ananth S | Methods of Diagnosing and Treating Complications of Pregnancy |
| US20110183338A1 (en) | 2008-01-30 | 2011-07-28 | Novartis Vaccines And Diagnostics, Inc. | Two stage enrichment of cell-free fetal dna in maternal plasma |
| CA2752838A1 (en) * | 2008-02-18 | 2009-08-27 | Genetic Technologies Limited | Cell processing and/or enrichment methods |
| WO2010121294A1 (en) * | 2009-04-21 | 2010-10-28 | Genetic Technologies Limited | Methods for obtaining fetal genetic material |
| CA2888746C (en) | 2012-10-19 | 2022-07-26 | Wayne State University | Identification and analysis of fetal trophoblast cells in cervical mucus for prenatal diagnosis |
-
2013
- 2013-10-18 CA CA2888746A patent/CA2888746C/en active Active
- 2013-10-18 DK DK13847056.2T patent/DK2909315T3/da active
- 2013-10-18 WO PCT/US2013/065570 patent/WO2014062995A1/en not_active Ceased
- 2013-10-18 TR TR2019/08019T patent/TR201908019T4/tr unknown
- 2013-10-18 JP JP2015538043A patent/JP6421123B2/ja active Active
- 2013-10-18 EP EP13847056.2A patent/EP2909315B1/en active Active
- 2013-10-18 ES ES13847056T patent/ES2729182T3/es active Active
- 2013-10-18 US US14/436,270 patent/US10344315B2/en active Active
- 2013-10-18 IN IN3186DEN2015 patent/IN2015DN03186A/en unknown
- 2013-10-18 AU AU2013331171A patent/AU2013331171B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TR201908019T4 (tr) | 2019-06-21 |
| EP2909315B1 (en) | 2019-05-01 |
| ES2729182T3 (es) | 2019-10-30 |
| HK1214294A1 (en) | 2016-07-22 |
| US10344315B2 (en) | 2019-07-09 |
| CA2888746C (en) | 2022-07-26 |
| EP2909315A4 (en) | 2016-04-20 |
| IN2015DN03186A (https=) | 2015-10-02 |
| US20150267240A1 (en) | 2015-09-24 |
| WO2014062995A1 (en) | 2014-04-24 |
| AU2013331171A1 (en) | 2015-05-28 |
| JP6421123B2 (ja) | 2018-11-07 |
| JP2015533504A (ja) | 2015-11-26 |
| AU2013331171B2 (en) | 2019-05-30 |
| EP2909315A1 (en) | 2015-08-26 |
| CA2888746A1 (en) | 2014-04-24 |
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