DK2883057T3 - DIAGNOSTICATION OF HEART FAILURE - Google Patents
DIAGNOSTICATION OF HEART FAILURE Download PDFInfo
- Publication number
- DK2883057T3 DK2883057T3 DK13747847.5T DK13747847T DK2883057T3 DK 2883057 T3 DK2883057 T3 DK 2883057T3 DK 13747847 T DK13747847 T DK 13747847T DK 2883057 T3 DK2883057 T3 DK 2883057T3
- Authority
- DK
- Denmark
- Prior art keywords
- igfbp2
- heart failure
- patients
- concentration
- patient
- Prior art date
Links
- 206010019280 Heart failures Diseases 0.000 title claims description 130
- 102000004372 Insulin-like growth factor binding protein 2 Human genes 0.000 claims description 170
- 108090000964 Insulin-like growth factor binding protein 2 Proteins 0.000 claims description 170
- 238000000034 method Methods 0.000 claims description 57
- 206010007556 Cardiac failure acute Diseases 0.000 claims description 45
- 206010007558 Cardiac failure chronic Diseases 0.000 claims description 38
- 238000000738 capillary electrophoresis-mass spectrometry Methods 0.000 claims description 23
- 210000002700 urine Anatomy 0.000 claims description 23
- 238000002965 ELISA Methods 0.000 claims description 12
- 230000002596 correlated effect Effects 0.000 claims description 9
- 238000011002 quantification Methods 0.000 claims 3
- 102400000667 Brain natriuretic peptide 32 Human genes 0.000 description 53
- 101800000407 Brain natriuretic peptide 32 Proteins 0.000 description 53
- 101800002247 Brain natriuretic peptide 45 Proteins 0.000 description 53
- 239000000090 biomarker Substances 0.000 description 31
- 108090000765 processed proteins & peptides Proteins 0.000 description 24
- 238000010200 validation analysis Methods 0.000 description 24
- 239000000523 sample Substances 0.000 description 22
- 238000004458 analytical method Methods 0.000 description 21
- 102000004196 processed proteins & peptides Human genes 0.000 description 19
- 238000003745 diagnosis Methods 0.000 description 18
- 238000012360 testing method Methods 0.000 description 17
- 229920001184 polypeptide Polymers 0.000 description 16
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 description 12
- 102100037852 Insulin-like growth factor I Human genes 0.000 description 12
- 206010013975 Dyspnoeas Diseases 0.000 description 11
- 238000010967 transthoracic echocardiography Methods 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 10
- 230000000747 cardiac effect Effects 0.000 description 9
- 239000012634 fragment Substances 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 230000002526 effect on cardiovascular system Effects 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 230000002861 ventricular Effects 0.000 description 8
- 108010074051 C-Reactive Protein Proteins 0.000 description 7
- 102100032752 C-reactive protein Human genes 0.000 description 7
- 208000000059 Dyspnea Diseases 0.000 description 7
- 230000037081 physical activity Effects 0.000 description 7
- 230000036470 plasma concentration Effects 0.000 description 7
- 230000002485 urinary effect Effects 0.000 description 7
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 6
- 208000019622 heart disease Diseases 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 108020004999 messenger RNA Proteins 0.000 description 6
- 238000013508 migration Methods 0.000 description 6
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 5
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 5
- 102000013275 Somatomedins Human genes 0.000 description 5
- 230000001154 acute effect Effects 0.000 description 5
- 239000012472 biological sample Substances 0.000 description 5
- 238000013211 curve analysis Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 206010012601 diabetes mellitus Diseases 0.000 description 5
- 210000002837 heart atrium Anatomy 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- 230000000302 ischemic effect Effects 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 4
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 4
- 206010002383 Angina Pectoris Diseases 0.000 description 4
- 208000020446 Cardiac disease Diseases 0.000 description 4
- 206010020772 Hypertension Diseases 0.000 description 4
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 4
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 4
- 108010026552 Proteome Proteins 0.000 description 4
- 208000012871 acute dyspnea Diseases 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000005251 capillar electrophoresis Methods 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 239000002934 diuretic Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000002592 echocardiography Methods 0.000 description 4
- 235000019253 formic acid Nutrition 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 102000028416 insulin-like growth factor binding Human genes 0.000 description 4
- 108091022911 insulin-like growth factor binding Proteins 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 238000007619 statistical method Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 238000004885 tandem mass spectrometry Methods 0.000 description 4
- 206010020880 Hypertrophy Diseases 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 108020001621 Natriuretic Peptide Proteins 0.000 description 3
- 102000004571 Natriuretic peptide Human genes 0.000 description 3
- 206010033557 Palpitations Diseases 0.000 description 3
- 238000011529 RT qPCR Methods 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 238000000692 Student's t-test Methods 0.000 description 3
- 229940127218 antiplatelet drug Drugs 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 208000029078 coronary artery disease Diseases 0.000 description 3
- 229940109239 creatinine Drugs 0.000 description 3
- 230000003205 diastolic effect Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 229940030606 diuretics Drugs 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 206010016256 fatigue Diseases 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 230000003908 liver function Effects 0.000 description 3
- 230000005012 migration Effects 0.000 description 3
- 239000000692 natriuretic peptide Substances 0.000 description 3
- 239000000106 platelet aggregation inhibitor Substances 0.000 description 3
- 108010008064 pro-brain natriuretic peptide (1-76) Proteins 0.000 description 3
- 238000011552 rat model Methods 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 2
- 238000010152 Bonferroni least significant difference Methods 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- 208000023445 Congenital pulmonary airway malformation Diseases 0.000 description 2
- 206010056370 Congestive cardiomyopathy Diseases 0.000 description 2
- 206010052337 Diastolic dysfunction Diseases 0.000 description 2
- 201000010046 Dilated cardiomyopathy Diseases 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102100037738 Fatty acid-binding protein, heart Human genes 0.000 description 2
- 101710136552 Fatty acid-binding protein, heart Proteins 0.000 description 2
- 240000008168 Ficus benjamina Species 0.000 description 2
- 206010018092 Generalised oedema Diseases 0.000 description 2
- 102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 description 2
- 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 description 2
- 102000010789 Interleukin-2 Receptors Human genes 0.000 description 2
- 108010038453 Interleukin-2 Receptors Proteins 0.000 description 2
- 102400000569 Myeloperoxidase Human genes 0.000 description 2
- 108090000235 Myeloperoxidases Proteins 0.000 description 2
- 101710193418 Myosin light chain 1 Proteins 0.000 description 2
- 102100030740 Myosin light chain 1/3, skeletal muscle isoform Human genes 0.000 description 2
- 108010035766 P-Selectin Proteins 0.000 description 2
- 102100023472 P-selectin Human genes 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 101710142969 Somatoliberin Proteins 0.000 description 2
- 206010071436 Systolic dysfunction Diseases 0.000 description 2
- 108010000499 Thromboplastin Proteins 0.000 description 2
- 102000002262 Thromboplastin Human genes 0.000 description 2
- 102000004903 Troponin Human genes 0.000 description 2
- 108090001027 Troponin Proteins 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 description 2
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 description 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 2
- 102000005630 Urocortins Human genes 0.000 description 2
- 108010059705 Urocortins Proteins 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 206010007625 cardiogenic shock Diseases 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000008828 contractile function Effects 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 230000004217 heart function Effects 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 210000005240 left ventricle Anatomy 0.000 description 2
- 238000010841 mRNA extraction Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000003098 myoblast Anatomy 0.000 description 2
- 230000002107 myocardial effect Effects 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- HPNRHPKXQZSDFX-OAQDCNSJSA-N nesiritide Chemical compound C([C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1N=CNC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 HPNRHPKXQZSDFX-OAQDCNSJSA-N 0.000 description 2
- 229960002748 norepinephrine Drugs 0.000 description 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 230000004224 protection Effects 0.000 description 2
- 238000007634 remodeling Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000010839 reverse transcription Methods 0.000 description 2
- 210000005241 right ventricle Anatomy 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000009897 systematic effect Effects 0.000 description 2
- 229940116269 uric acid Drugs 0.000 description 2
- 239000000777 urocortin Substances 0.000 description 2
- 108010047303 von Willebrand Factor Proteins 0.000 description 2
- 102100036537 von Willebrand factor Human genes 0.000 description 2
- 229960001134 von willebrand factor Drugs 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000001262 western blot Methods 0.000 description 2
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 102000004379 Adrenomedullin Human genes 0.000 description 1
- 101800004616 Adrenomedullin Proteins 0.000 description 1
- 206010002388 Angina unstable Diseases 0.000 description 1
- 201000003126 Anuria Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010003671 Atrioventricular Block Diseases 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 208000009079 Bronchial Spasm Diseases 0.000 description 1
- 208000014181 Bronchial disease Diseases 0.000 description 1
- 206010006482 Bronchospasm Diseases 0.000 description 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 description 1
- 208000031229 Cardiomyopathies Diseases 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 206010009866 Cold sweat Diseases 0.000 description 1
- 208000032781 Diabetic cardiomyopathy Diseases 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 238000004252 FT/ICR mass spectrometry Methods 0.000 description 1
- 102100031513 Fc receptor-like protein 4 Human genes 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 108010001517 Galectin 3 Proteins 0.000 description 1
- 102100039558 Galectin-3 Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 208000010271 Heart Block Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 101000897480 Homo sapiens C-C motif chemokine 2 Proteins 0.000 description 1
- 101000846909 Homo sapiens Fc receptor-like protein 4 Proteins 0.000 description 1
- 101001076292 Homo sapiens Insulin-like growth factor II Proteins 0.000 description 1
- 101001044940 Homo sapiens Insulin-like growth factor-binding protein 2 Proteins 0.000 description 1
- 101000900767 Homo sapiens Protein cornichon homolog 1 Proteins 0.000 description 1
- 208000019025 Hypokalemia Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 102000015611 Hypothalamic Hormones Human genes 0.000 description 1
- 108010024118 Hypothalamic Hormones Proteins 0.000 description 1
- 102000038455 IGF Type 1 Receptor Human genes 0.000 description 1
- 108010031794 IGF Type 1 Receptor Proteins 0.000 description 1
- 101150088952 IGF1 gene Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 description 1
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 description 1
- 102100025947 Insulin-like growth factor II Human genes 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 208000009378 Low Cardiac Output Diseases 0.000 description 1
- 102000043136 MAP kinase family Human genes 0.000 description 1
- 108091054455 MAP kinase family Proteins 0.000 description 1
- 238000000585 Mann–Whitney U test Methods 0.000 description 1
- 102400001263 NT-proBNP Human genes 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010030124 Oedema peripheral Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 description 1
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 102100022049 Protein cornichon homolog 1 Human genes 0.000 description 1
- 206010037368 Pulmonary congestion Diseases 0.000 description 1
- 230000010799 Receptor Interactions Effects 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 102100038803 Somatotropin Human genes 0.000 description 1
- 238000003646 Spearman's rank correlation coefficient Methods 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 description 1
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 description 1
- 208000007814 Unstable Angina Diseases 0.000 description 1
- 230000011759 adipose tissue development Effects 0.000 description 1
- ULCUCJFASIJEOE-NPECTJMMSA-N adrenomedullin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H]1C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)[C@@H](C)O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 ULCUCJFASIJEOE-NPECTJMMSA-N 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000013103 analytical ultracentrifugation Methods 0.000 description 1
- 208000024783 anasarca Diseases 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 208000006218 bradycardia Diseases 0.000 description 1
- 230000036471 bradycardia Effects 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- 230000001269 cardiogenic effect Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000000546 chi-square test Methods 0.000 description 1
- 210000003040 circulating cell Anatomy 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000000132 electrospray ionisation Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 208000014471 histiocytoid cardiomyopathy Diseases 0.000 description 1
- 102000050770 human IGFBP2 Human genes 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000001969 hypertrophic effect Effects 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 230000002267 hypothalamic effect Effects 0.000 description 1
- 239000000601 hypothalamic hormone Substances 0.000 description 1
- 229940043650 hypothalamic hormone Drugs 0.000 description 1
- 238000000760 immunoelectrophoresis Methods 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 229940068935 insulin-like growth factor 2 Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000007477 logistic regression Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 206010029446 nocturia Diseases 0.000 description 1
- 238000001422 normality test Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000010837 poor prognosis Methods 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 208000024896 potassium deficiency disease Diseases 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000009979 protective mechanism Effects 0.000 description 1
- 238000000575 proteomic method Methods 0.000 description 1
- 238000003762 quantitative reverse transcription PCR Methods 0.000 description 1
- 238000013139 quantization Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 238000004725 rapid separation liquid chromatography Methods 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000001764 somatotrope Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012706 support-vector machine Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 238000007473 univariate analysis Methods 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4745—Insulin-like growth factor binding protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/4473—Arrangements for investigating the separated zones, e.g. localising zones by electric means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Peptides Or Proteins (AREA)
- Paper (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305988 | 2012-08-09 | ||
| PCT/EP2013/066697 WO2014023820A1 (en) | 2012-08-09 | 2013-08-09 | Diagnostic of heart failure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2883057T3 true DK2883057T3 (en) | 2019-03-18 |
Family
ID=48953397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13747847.5T DK2883057T3 (en) | 2012-08-09 | 2013-08-09 | DIAGNOSTICATION OF HEART FAILURE |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20150219669A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2883057B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6298054B2 (cg-RX-API-DMAC7.html) |
| CY (1) | CY1121406T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2883057T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2713098T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20190341T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE042708T2 (cg-RX-API-DMAC7.html) |
| LT (1) | LT2883057T (cg-RX-API-DMAC7.html) |
| PL (1) | PL2883057T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2883057T (cg-RX-API-DMAC7.html) |
| RS (1) | RS58553B1 (cg-RX-API-DMAC7.html) |
| SI (1) | SI2883057T1 (cg-RX-API-DMAC7.html) |
| SM (1) | SMT201900108T1 (cg-RX-API-DMAC7.html) |
| TR (1) | TR201902555T4 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014023820A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3004891T3 (pl) * | 2013-06-06 | 2019-09-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Biomarker ponownej hospitalizacji po niewydolności serca |
| JP7401442B2 (ja) * | 2018-01-31 | 2023-12-19 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 新規使用 |
| US20220390468A1 (en) * | 2019-11-06 | 2022-12-08 | National University Corporation Kagawa University | Heart failure marker |
| CN120053474B (zh) * | 2025-02-26 | 2025-12-12 | 浙江大学 | 辅酶a在制备心肌细胞铁死亡抑制剂中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060183681A1 (en) * | 2005-02-14 | 2006-08-17 | Bio-Rad Laboratories, Inc. | Stabilized compositions containing natriuretic peptides |
| JP4465469B2 (ja) * | 2005-02-21 | 2010-05-19 | 国立大学法人佐賀大学 | 循環器病マーカーとしてのインターロイキン１３ |
| EP1722232A1 (en) | 2005-05-09 | 2006-11-15 | F.Hoffmann-La Roche Ag | Devices and methods for diagnosing or predicting early stage cardiac dysfunctions |
| US20080166734A1 (en) * | 2005-12-21 | 2008-07-10 | David Xing-Fei Deng | Genes and methods of using the same for diagnosis and for targeting the therapy of cardiovascular disease |
| US20080112888A1 (en) * | 2006-06-30 | 2008-05-15 | Schering Corporation | Igfbp2 biomarker |
| EP2498095A3 (en) | 2007-01-25 | 2012-11-28 | Roche Diagniostics GmbH | Use of IGFBP-7 in the assessment of heart failure |
| EP2310860A1 (en) * | 2008-07-30 | 2011-04-20 | INSERM - Institut National de la Santé et de la Recherche Médicale | Blood glutathione as a biomarker for screening asymptomatic patients at risk for heart failure |
| US20130345322A1 (en) * | 2010-07-14 | 2013-12-26 | Commonwealth Scientific And Industrial Research Organisation | Diagnostic for colorectal cancer |
| JP5676763B2 (ja) * | 2010-08-26 | 2015-02-25 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 動脈性高血圧症から心不全への初期移行の評価におけるバイオマーカーの使用 |
| WO2013163345A1 (en) | 2012-04-24 | 2013-10-31 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of stroke or other cerebral injury |
| WO2014116708A1 (en) * | 2013-01-22 | 2014-07-31 | Singulex, Inc. | Endothelin in the diagnosis of cardiac disease |
-
2013
- 2013-08-09 LT LTEP13747847.5T patent/LT2883057T/lt unknown
- 2013-08-09 HR HRP20190341TT patent/HRP20190341T1/hr unknown
- 2013-08-09 SM SM20190108T patent/SMT201900108T1/it unknown
- 2013-08-09 JP JP2015525897A patent/JP6298054B2/ja not_active Expired - Fee Related
- 2013-08-09 RS RS20190247A patent/RS58553B1/sr unknown
- 2013-08-09 SI SI201331364T patent/SI2883057T1/sl unknown
- 2013-08-09 EP EP13747847.5A patent/EP2883057B1/en active Active
- 2013-08-09 US US14/419,566 patent/US20150219669A1/en not_active Abandoned
- 2013-08-09 PL PL13747847T patent/PL2883057T3/pl unknown
- 2013-08-09 ES ES13747847T patent/ES2713098T3/es active Active
- 2013-08-09 PT PT13747847T patent/PT2883057T/pt unknown
- 2013-08-09 DK DK13747847.5T patent/DK2883057T3/en active
- 2013-08-09 HU HUE13747847A patent/HUE042708T2/hu unknown
- 2013-08-09 TR TR2019/02555T patent/TR201902555T4/tr unknown
- 2013-08-09 WO PCT/EP2013/066697 patent/WO2014023820A1/en not_active Ceased
-
2018
- 2018-01-12 US US15/869,438 patent/US11061037B2/en active Active
- 2018-02-22 JP JP2018029702A patent/JP6595641B2/ja active Active
-
2019
- 2019-02-25 CY CY20191100229T patent/CY1121406T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6298054B2 (ja) | 2018-03-20 |
| TR201902555T4 (tr) | 2019-03-21 |
| US11061037B2 (en) | 2021-07-13 |
| RS58553B1 (sr) | 2019-05-31 |
| LT2883057T (lt) | 2019-04-25 |
| US20150219669A1 (en) | 2015-08-06 |
| SI2883057T1 (sl) | 2019-07-31 |
| PT2883057T (pt) | 2019-03-06 |
| JP6595641B2 (ja) | 2019-10-23 |
| CY1121406T1 (el) | 2020-05-29 |
| HUE042708T2 (hu) | 2019-07-29 |
| EP2883057A1 (en) | 2015-06-17 |
| EP2883057B1 (en) | 2018-12-05 |
| JP2018109640A (ja) | 2018-07-12 |
| JP2015528562A (ja) | 2015-09-28 |
| ES2713098T3 (es) | 2019-05-17 |
| HRP20190341T1 (hr) | 2019-05-31 |
| WO2014023820A1 (en) | 2014-02-13 |
| PL2883057T3 (pl) | 2019-07-31 |
| SMT201900108T1 (it) | 2019-05-10 |
| US20180143208A1 (en) | 2018-05-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4944185B2 (ja) | 症状のある患者における急性および慢性の心筋壊死の区別のための手段と方法 | |
| JP2011523051A (ja) | １型糖尿病におけるバイオマーカーとしてのｇｄｆ−１５ | |
| US20110104813A1 (en) | Diagnosis of early stage cardiac dysfunction | |
| Berry et al. | Proteomics analysis reveals IGFBP2 as a candidate diagnostic biomarker for heart failure | |
| JP2013527453A (ja) | 急性炎症における生存および回復を推定するためのｇｄｆ−１５に基づく手段および方法 | |
| CN105683758A (zh) | 改善心力衰竭风险的预测的生物标志物 | |
| US11061037B2 (en) | Diagnostic of heart failure | |
| CN105102984B (zh) | sCD14或它的片段或衍生物用于风险分级、诊断和预后的用途 | |
| US10274502B2 (en) | Biomarkers and methods for progression prediction for chronic kidney disease | |
| US10557860B2 (en) | Circulating pulmonary hypertension biomarker | |
| JP2010537212A (ja) | 息切れの原因の鑑別におけるサーファクタントプロテインｂ及びｄ | |
| EP2597466A1 (en) | Means and methods for proSP-B based diagnosis of alveolar damage in pulmonary hypertension patients | |
| JP2010528306A (ja) | 心筋梗塞の早期予測因子としてのｈ−ｆａｂｐ | |
| JP5307141B2 (ja) | 心筋梗塞の早期予測因子としてのミオグロビン | |
| JP2011523072A (ja) | １型糖尿病を有する患者の合併症の評価 | |
| Koukoui et al. | IJC Metabolic & Endocrine | |
| HK1119771B (en) | Devices and methods for diagnosing or predicting early stage cardiac dysfunctions | |
| HK1118334A (en) | Means and methods for the differentiation of cardiac and pulmonary causes of acute shortness of breath | |
| WO2016113719A1 (en) | Use of 1,25-dihydroxyvitamin d values in ratio with pth as a prognostic biomarker | |
| HK1113819A (en) | Means and methods for the differentiation of cardiac and pulmonary causes of shortness of breath | |
| EP2508890A1 (en) | CAIX based diagnosis of heart failure | |
| HK1124391A (en) | The use of bnp-type peptides for predicting the need for dialysis |