HRP20190341T1 - Dijagnosticiranje srčane insuficijencije - Google Patents
Dijagnosticiranje srčane insuficijencije Download PDFInfo
- Publication number
- HRP20190341T1 HRP20190341T1 HRP20190341TT HRP20190341T HRP20190341T1 HR P20190341 T1 HRP20190341 T1 HR P20190341T1 HR P20190341T T HRP20190341T T HR P20190341TT HR P20190341 T HRP20190341 T HR P20190341T HR P20190341 T1 HRP20190341 T1 HR P20190341T1
- Authority
- HR
- Croatia
- Prior art keywords
- heart failure
- igfbp2
- concentration
- patient
- quantification
- Prior art date
Links
- 206010019280 Heart failures Diseases 0.000 title claims 7
- 102000004372 Insulin-like growth factor binding protein 2 Human genes 0.000 claims 10
- 108090000964 Insulin-like growth factor binding protein 2 Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 238000011002 quantification Methods 0.000 claims 3
- 210000002700 urine Anatomy 0.000 claims 2
- 206010007556 Cardiac failure acute Diseases 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 238000005251 capillar electrophoresis Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4745—Insulin-like growth factor binding protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/4473—Arrangements for investigating the separated zones, e.g. localising zones by electric means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- External Artificial Organs (AREA)
- Paper (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Claims (7)
1. Postupak klasificiranja srčane insuficijencije kod pacijenta klasificiranjem srčane insuficijencije prema Njujorškom kardiološkom društvu (NYHA), naznačen time što se navedeni postupak sastoji u koracima mjerenja koncentracije proteina 2 koji veže inzulinu sličan čimbenik rasta (IGFBP2) u uzorku plazme ili mokraće dobivenom iz navedenog pacijenta, gdje se koncentraciju IGFBP2 uspoređuje s klasificiranjem srčane insuficijencije prema NYHA.
2. Postupak dijagnosticiranja srčane insuficijencije kod pacijenta, naznačen time što se sastoji u:
i. određivanju koncentracije IGFBP2 u uzorku plazme ili mokraće dobivenom iz navedenog pacijenta; i
ii. uspoređivanju navedene koncentracije s kontrolnom vrijednošću.
3. Postupak u skladu s patentnim zahtjevima 1 ili 2, naznačen time što je srčana insuficijencija asimptomatska srčana insuficijencija, kronična srčana insuficijencija ili akutna srčana insuficijencija.
4. Postupak u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačen time što se koncentraciju IGFBP2 mjeri kvantificiranjem razine proteina IGFBP2 u uzorku.
5. Postupak u skladu s patentnim zahtjevom 4, naznačen time što se kvantificiranje razine proteina IGFBP2 provodi upotrebom kompleta protutijela usmjerenih protiv IGFBP2.
6. Postupak u skladu s patentnim zahtjevom 4, naznačen time što se kvantificiranje razine proteina IGFBP2 provodi ELISA-om.
7. Postupak u skladu s patentnim zahtjevom 4, naznačen time što se kvantificiranje razine proteina IGFBP2 provodi tehnikom kapilarne elektroforeze s masenom spektroskopijom.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305988 | 2012-08-09 | ||
| EP13747847.5A EP2883057B1 (en) | 2012-08-09 | 2013-08-09 | Diagnostic of heart failure |
| PCT/EP2013/066697 WO2014023820A1 (en) | 2012-08-09 | 2013-08-09 | Diagnostic of heart failure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20190341T1 true HRP20190341T1 (hr) | 2019-05-31 |
Family
ID=48953397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20190341TT HRP20190341T1 (hr) | 2012-08-09 | 2019-02-21 | Dijagnosticiranje srčane insuficijencije |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20150219669A1 (hr) |
| EP (1) | EP2883057B1 (hr) |
| JP (2) | JP6298054B2 (hr) |
| CY (1) | CY1121406T1 (hr) |
| DK (1) | DK2883057T3 (hr) |
| ES (1) | ES2713098T3 (hr) |
| HR (1) | HRP20190341T1 (hr) |
| HU (1) | HUE042708T2 (hr) |
| LT (1) | LT2883057T (hr) |
| PL (1) | PL2883057T3 (hr) |
| PT (1) | PT2883057T (hr) |
| RS (1) | RS58553B1 (hr) |
| SI (1) | SI2883057T1 (hr) |
| TR (1) | TR201902555T4 (hr) |
| WO (1) | WO2014023820A1 (hr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014195456A1 (en) | 2013-06-06 | 2014-12-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Biomarker of rehospitalization after heart failure |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060183681A1 (en) * | 2005-02-14 | 2006-08-17 | Bio-Rad Laboratories, Inc. | Stabilized compositions containing natriuretic peptides |
| JP4465469B2 (ja) * | 2005-02-21 | 2010-05-19 | 国立大学法人佐賀大学 | 循環器病マーカーとしてのインターロイキン１３ |
| EP1722232A1 (en) | 2005-05-09 | 2006-11-15 | F.Hoffmann-La Roche Ag | Devices and methods for diagnosing or predicting early stage cardiac dysfunctions |
| US20080166734A1 (en) * | 2005-12-21 | 2008-07-10 | David Xing-Fei Deng | Genes and methods of using the same for diagnosis and for targeting the therapy of cardiovascular disease |
| CA2655997A1 (en) * | 2006-06-30 | 2008-01-10 | Schering Corporation | Igfbp2 biomarker |
| CA2671298C (en) * | 2007-01-25 | 2020-07-28 | F. Hoffmann-La Roche Ag | Use of igfbp-7 in the assessment of heart failure |
| EP2310860A1 (en) * | 2008-07-30 | 2011-04-20 | INSERM - Institut National de la Santé et de la Recherche Médicale | Blood glutathione as a biomarker for screening asymptomatic patients at risk for heart failure |
| RU2013103995A (ru) * | 2010-07-14 | 2014-08-20 | Коммонуэл Сайентифик энд Индастриз Рисерч Организейшн | Диагностика колоректального рака |
| ES2627337T3 (es) * | 2010-08-26 | 2017-07-27 | F. Hoffmann-La Roche Ag | Uso de biomarcadores para controlar una medicación en un sujeto que padece insuficiencia cardíaca |
| EP2841945A4 (en) | 2012-04-24 | 2016-04-27 | Astute Medical Inc | METHOD AND COMPOSITIONS FOR DIAGNOSIS AND FORECASTING OF STROKE OR OTHER BRAINS |
| US20140206632A1 (en) * | 2013-01-22 | 2014-07-24 | Singulex, Inc. | Endothelin in the Diagnosis of Cardiac Disease |
-
2013
- 2013-08-09 PT PT13747847T patent/PT2883057T/pt unknown
- 2013-08-09 US US14/419,566 patent/US20150219669A1/en not_active Abandoned
- 2013-08-09 EP EP13747847.5A patent/EP2883057B1/en active Active
- 2013-08-09 ES ES13747847T patent/ES2713098T3/es active Active
- 2013-08-09 JP JP2015525897A patent/JP6298054B2/ja not_active Expired - Fee Related
- 2013-08-09 DK DK13747847.5T patent/DK2883057T3/en active
- 2013-08-09 TR TR2019/02555T patent/TR201902555T4/tr unknown
- 2013-08-09 SI SI201331364T patent/SI2883057T1/sl unknown
- 2013-08-09 PL PL13747847T patent/PL2883057T3/pl unknown
- 2013-08-09 WO PCT/EP2013/066697 patent/WO2014023820A1/en active Application Filing
- 2013-08-09 HU HUE13747847A patent/HUE042708T2/hu unknown
- 2013-08-09 LT LTEP13747847.5T patent/LT2883057T/lt unknown
- 2013-08-09 RS RS20190247A patent/RS58553B1/sr unknown
-
2018
- 2018-01-12 US US15/869,438 patent/US11061037B2/en active Active
- 2018-02-22 JP JP2018029702A patent/JP6595641B2/ja active Active
-
2019
- 2019-02-21 HR HRP20190341TT patent/HRP20190341T1/hr unknown
- 2019-02-25 CY CY20191100229T patent/CY1121406T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6595641B2 (ja) | 2019-10-23 |
| US11061037B2 (en) | 2021-07-13 |
| JP6298054B2 (ja) | 2018-03-20 |
| EP2883057A1 (en) | 2015-06-17 |
| EP2883057B1 (en) | 2018-12-05 |
| US20180143208A1 (en) | 2018-05-24 |
| CY1121406T1 (el) | 2020-05-29 |
| JP2015528562A (ja) | 2015-09-28 |
| SI2883057T1 (sl) | 2019-07-31 |
| LT2883057T (lt) | 2019-04-25 |
| ES2713098T3 (es) | 2019-05-17 |
| PT2883057T (pt) | 2019-03-06 |
| PL2883057T3 (pl) | 2019-07-31 |
| WO2014023820A1 (en) | 2014-02-13 |
| HUE042708T2 (hu) | 2019-07-29 |
| RS58553B1 (sr) | 2019-05-31 |
| DK2883057T3 (en) | 2019-03-18 |
| TR201902555T4 (tr) | 2019-03-21 |
| JP2018109640A (ja) | 2018-07-12 |
| US20150219669A1 (en) | 2015-08-06 |
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