HRP20190341T1 - Dijagnosticiranje srčane insuficijencije - Google Patents
Dijagnosticiranje srčane insuficijencije Download PDFInfo
- Publication number
- HRP20190341T1 HRP20190341T1 HRP20190341TT HRP20190341T HRP20190341T1 HR P20190341 T1 HRP20190341 T1 HR P20190341T1 HR P20190341T T HRP20190341T T HR P20190341TT HR P20190341 T HRP20190341 T HR P20190341T HR P20190341 T1 HRP20190341 T1 HR P20190341T1
- Authority
- HR
- Croatia
- Prior art keywords
- heart failure
- igfbp2
- concentration
- patient
- quantification
- Prior art date
Links
- 206010019280 Heart failures Diseases 0.000 title claims 7
- 102000004372 Insulin-like growth factor binding protein 2 Human genes 0.000 claims 10
- 108090000964 Insulin-like growth factor binding protein 2 Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 238000011002 quantification Methods 0.000 claims 3
- 210000002700 urine Anatomy 0.000 claims 2
- 206010007556 Cardiac failure acute Diseases 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 238000005251 capillar electrophoresis Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4745—Insulin-like growth factor binding protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/4473—Arrangements for investigating the separated zones, e.g. localising zones by electric means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- External Artificial Organs (AREA)
- Paper (AREA)
Claims (7)
1. Postupak klasificiranja srčane insuficijencije kod pacijenta klasificiranjem srčane insuficijencije prema Njujorškom kardiološkom društvu (NYHA), naznačen time što se navedeni postupak sastoji u koracima mjerenja koncentracije proteina 2 koji veže inzulinu sličan čimbenik rasta (IGFBP2) u uzorku plazme ili mokraće dobivenom iz navedenog pacijenta, gdje se koncentraciju IGFBP2 uspoređuje s klasificiranjem srčane insuficijencije prema NYHA.
2. Postupak dijagnosticiranja srčane insuficijencije kod pacijenta, naznačen time što se sastoji u:
i. određivanju koncentracije IGFBP2 u uzorku plazme ili mokraće dobivenom iz navedenog pacijenta; i
ii. uspoređivanju navedene koncentracije s kontrolnom vrijednošću.
3. Postupak u skladu s patentnim zahtjevima 1 ili 2, naznačen time što je srčana insuficijencija asimptomatska srčana insuficijencija, kronična srčana insuficijencija ili akutna srčana insuficijencija.
4. Postupak u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačen time što se koncentraciju IGFBP2 mjeri kvantificiranjem razine proteina IGFBP2 u uzorku.
5. Postupak u skladu s patentnim zahtjevom 4, naznačen time što se kvantificiranje razine proteina IGFBP2 provodi upotrebom kompleta protutijela usmjerenih protiv IGFBP2.
6. Postupak u skladu s patentnim zahtjevom 4, naznačen time što se kvantificiranje razine proteina IGFBP2 provodi ELISA-om.
7. Postupak u skladu s patentnim zahtjevom 4, naznačen time što se kvantificiranje razine proteina IGFBP2 provodi tehnikom kapilarne elektroforeze s masenom spektroskopijom.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305988 | 2012-08-09 | ||
| EP13747847.5A EP2883057B1 (en) | 2012-08-09 | 2013-08-09 | Diagnostic of heart failure |
| PCT/EP2013/066697 WO2014023820A1 (en) | 2012-08-09 | 2013-08-09 | Diagnostic of heart failure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20190341T1 true HRP20190341T1 (hr) | 2019-05-31 |
Family
ID=48953397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20190341TT HRP20190341T1 (hr) | 2012-08-09 | 2019-02-21 | Dijagnosticiranje srčane insuficijencije |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20150219669A1 (hr) |
| EP (1) | EP2883057B1 (hr) |
| JP (2) | JP6298054B2 (hr) |
| CY (1) | CY1121406T1 (hr) |
| DK (1) | DK2883057T3 (hr) |
| ES (1) | ES2713098T3 (hr) |
| HR (1) | HRP20190341T1 (hr) |
| HU (1) | HUE042708T2 (hr) |
| LT (1) | LT2883057T (hr) |
| PL (1) | PL2883057T3 (hr) |
| PT (1) | PT2883057T (hr) |
| RS (1) | RS58553B1 (hr) |
| SI (1) | SI2883057T1 (hr) |
| TR (1) | TR201902555T4 (hr) |
| WO (1) | WO2014023820A1 (hr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3004891T3 (pl) | 2013-06-06 | 2019-09-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Biomarker ponownej hospitalizacji po niewydolności serca |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060183681A1 (en) * | 2005-02-14 | 2006-08-17 | Bio-Rad Laboratories, Inc. | Stabilized compositions containing natriuretic peptides |
| JP4465469B2 (ja) * | 2005-02-21 | 2010-05-19 | 国立大学法人佐賀大学 | 循環器病マーカーとしてのインターロイキン１３ |
| EP1722232A1 (en) * | 2005-05-09 | 2006-11-15 | F.Hoffmann-La Roche Ag | Devices and methods for diagnosing or predicting early stage cardiac dysfunctions |
| US20080166734A1 (en) * | 2005-12-21 | 2008-07-10 | David Xing-Fei Deng | Genes and methods of using the same for diagnosis and for targeting the therapy of cardiovascular disease |
| ES2427924T3 (es) | 2006-06-30 | 2013-11-04 | Merck Sharp & Dohme Corp. | Biomarcador IGFBP2 |
| CN106908603B (zh) | 2007-01-25 | 2019-04-02 | 霍夫曼-拉罗奇有限公司 | Igfbp-7在心力衰竭评估中的用途 |
| EP2310860A1 (en) * | 2008-07-30 | 2011-04-20 | INSERM - Institut National de la Santé et de la Recherche Médicale | Blood glutathione as a biomarker for screening asymptomatic patients at risk for heart failure |
| CN105755112B (zh) * | 2010-07-14 | 2019-06-07 | 视觉科技生物私人有限公司 | 结肠直肠癌的诊断 |
| CN105044349B (zh) * | 2010-08-26 | 2018-04-06 | 弗·哈夫曼-拉罗切有限公司 | 生物标志物在评估从动脉高血压向心力衰竭的早期转变中的用途 |
| US9733261B2 (en) | 2012-04-24 | 2017-08-15 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of stroke or other cerebral injury |
| WO2014116708A1 (en) * | 2013-01-22 | 2014-07-31 | Singulex, Inc. | Endothelin in the diagnosis of cardiac disease |
-
2013
- 2013-08-09 RS RS20190247A patent/RS58553B1/sr unknown
- 2013-08-09 JP JP2015525897A patent/JP6298054B2/ja not_active Expired - Fee Related
- 2013-08-09 SI SI201331364T patent/SI2883057T1/sl unknown
- 2013-08-09 LT LTEP13747847.5T patent/LT2883057T/lt unknown
- 2013-08-09 EP EP13747847.5A patent/EP2883057B1/en active Active
- 2013-08-09 DK DK13747847.5T patent/DK2883057T3/en active
- 2013-08-09 US US14/419,566 patent/US20150219669A1/en not_active Abandoned
- 2013-08-09 HU HUE13747847A patent/HUE042708T2/hu unknown
- 2013-08-09 PL PL13747847T patent/PL2883057T3/pl unknown
- 2013-08-09 ES ES13747847T patent/ES2713098T3/es active Active
- 2013-08-09 TR TR2019/02555T patent/TR201902555T4/tr unknown
- 2013-08-09 WO PCT/EP2013/066697 patent/WO2014023820A1/en active Application Filing
- 2013-08-09 PT PT13747847T patent/PT2883057T/pt unknown
-
2018
- 2018-01-12 US US15/869,438 patent/US11061037B2/en active Active
- 2018-02-22 JP JP2018029702A patent/JP6595641B2/ja active Active
-
2019
- 2019-02-21 HR HRP20190341TT patent/HRP20190341T1/hr unknown
- 2019-02-25 CY CY20191100229T patent/CY1121406T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6298054B2 (ja) | 2018-03-20 |
| PT2883057T (pt) | 2019-03-06 |
| JP6595641B2 (ja) | 2019-10-23 |
| RS58553B1 (sr) | 2019-05-31 |
| EP2883057B1 (en) | 2018-12-05 |
| JP2015528562A (ja) | 2015-09-28 |
| DK2883057T3 (en) | 2019-03-18 |
| EP2883057A1 (en) | 2015-06-17 |
| SI2883057T1 (sl) | 2019-07-31 |
| US11061037B2 (en) | 2021-07-13 |
| PL2883057T3 (pl) | 2019-07-31 |
| TR201902555T4 (tr) | 2019-03-21 |
| US20150219669A1 (en) | 2015-08-06 |
| US20180143208A1 (en) | 2018-05-24 |
| ES2713098T3 (es) | 2019-05-17 |
| CY1121406T1 (el) | 2020-05-29 |
| JP2018109640A (ja) | 2018-07-12 |
| LT2883057T (lt) | 2019-04-25 |
| HUE042708T2 (hu) | 2019-07-29 |
| WO2014023820A1 (en) | 2014-02-13 |
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