DK2880181T3 - Prognosebiomarkører ved brusklidelser - Google Patents

Prognosebiomarkører ved brusklidelser Download PDF

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Publication number
DK2880181T3
DK2880181T3 DK13745418.7T DK13745418T DK2880181T3 DK 2880181 T3 DK2880181 T3 DK 2880181T3 DK 13745418 T DK13745418 T DK 13745418T DK 2880181 T3 DK2880181 T3 DK 2880181T3
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DK
Denmark
Prior art keywords
genotype
cartilage
seq
drug
complement
Prior art date
Application number
DK13745418.7T
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English (en)
Inventor
Christoph Hubertus Ladel
Pierre Jacques Farmer
Alix Anne Simone Berton
Armand Valsesia
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Merck Patent Gmbh
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Publication date
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Publication of DK2880181T3 publication Critical patent/DK2880181T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (2)

1. Fremgangsmåde til at forudsige alvorligheden af en lidelse hos et individ, der har osteoarthritis, hvor fremgangsmåden omfatter de følgende trin: a. at bestemme, ud fra en nukleinsyreprøve, forekomsten af genotypen G/G ved IL-1 RN rs9005 og T/T ved IL-1 RN rs315952; og b. at forudsige ud fra resultatet fra trin a. en mindre alvorlig form af ostheoar-thritis.
2. Fremgangsmåde til at forudsige alvorligheden af en lidelse hos et individ, der har osteoarthritis, hvor fremgangsmåden omfatter de følgende trin: a. at bestemme, ud fra en nukleinsyreprøve, fraværet af genotypen G/G ved IL-1 RN rs9005 og T/T ved IL-1 RN rs315952; og b. at forudsige ud fra resultatet fra trin a. en mere alvorlig form af ostheoarthri-tis.
DK13745418.7T 2012-08-06 2013-08-05 Prognosebiomarkører ved brusklidelser DK2880181T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12179393 2012-08-06
US201261680493P 2012-08-07 2012-08-07
US201361778950P 2013-03-13 2013-03-13
PCT/EP2013/066422 WO2014023704A1 (en) 2012-08-06 2013-08-05 Prognosis biomarkers in cartilage disorders

Publications (1)

Publication Number Publication Date
DK2880181T3 true DK2880181T3 (da) 2019-01-14

Family

ID=50067441

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13745418.7T DK2880181T3 (da) 2012-08-06 2013-08-05 Prognosebiomarkører ved brusklidelser

Country Status (14)

Country Link
US (1) US20150203917A1 (da)
EP (1) EP2880181B1 (da)
JP (1) JP6272860B2 (da)
CN (1) CN104755629A (da)
AU (1) AU2013301607B2 (da)
CA (1) CA2881027C (da)
DK (1) DK2880181T3 (da)
HK (1) HK1207400A1 (da)
HR (1) HRP20182052T1 (da)
LT (1) LT2880181T (da)
PL (1) PL2880181T3 (da)
RS (1) RS58131B1 (da)
SI (1) SI2880181T1 (da)
WO (1) WO2014023704A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2660818T3 (es) * 2012-08-06 2018-03-26 Merck Patent Gmbh Marcadores genéticos para predecir la capacidad de respuesta a un compuesto de FGF-18
CN105567847A (zh) * 2016-02-22 2016-05-11 郑州大学 一种用MspI检测人胃癌易感基因IL-1RN多态性rs9005的方法
JP6935079B2 (ja) * 2017-05-09 2021-09-15 国立大学法人千葉大学 機能的ｓｎｐの組合せ解析
EP3886809A4 (en) 2018-11-28 2022-03-30 Genascence Corporation METHODS AND COMPOSITIONS FOR THE TREATMENT OF OSTEOARTHRITIS
CN112410413A (zh) * 2020-09-24 2021-02-26 吉林大学 Onfh易感相关vdr、mmp2、mmp3、mmp9基因snp的检测物质及应用
CN113244413B (zh) * 2021-06-28 2021-10-26 深圳市瑞吉生物科技有限公司 一种mRNA剂型的骨关节炎药物制剂及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001241583A1 (en) * 2000-02-17 2001-08-27 Millennium Pharmaceuticals, Inc. A human pyridoxal-phosphate dependent enzyme family member and uses therefor
MX2009002063A (es) * 2006-08-25 2009-03-06 Ares Trading Sa Tratamiento de desordenes en cartilagos con factor de crecimiento de fibroblastos-18.
WO2009135218A2 (en) * 2008-05-02 2009-11-05 Interleukin Genetics, Inc. Detecting genetic predisposition to osteoarthritis associated conditions
US20120115137A1 (en) * 2010-08-31 2012-05-10 Kornman Kenneth S Methods of Predicting Osteoarthritis
FR2994587B1 (fr) * 2012-08-20 2017-07-07 Snecma Allumeur bimodal et procede d'injection bimodale pour allumeur de moteur-fusee

Also Published As

Publication number Publication date
LT2880181T (lt) 2018-12-27
PL2880181T3 (pl) 2019-03-29
AU2013301607A1 (en) 2015-03-12
US20150203917A1 (en) 2015-07-23
EP2880181A1 (en) 2015-06-10
WO2014023704A1 (en) 2014-02-13
AU2013301607B2 (en) 2018-10-18
HK1207400A1 (en) 2016-01-29
RS58131B1 (sr) 2019-02-28
WO2014023704A8 (en) 2014-04-03
JP6272860B2 (ja) 2018-01-31
CA2881027C (en) 2022-06-28
SI2880181T1 (sl) 2019-02-28
JP2015535172A (ja) 2015-12-10
CN104755629A (zh) 2015-07-01
CA2881027A1 (en) 2014-02-13
EP2880181B1 (en) 2018-09-19
HRP20182052T1 (hr) 2019-02-08

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