DK2856152T3 - Nye biomarkører til at skønne risikoen for allotransplantationssvigt og patientdødelighed efter organtransplantation - Google Patents

Nye biomarkører til at skønne risikoen for allotransplantationssvigt og patientdødelighed efter organtransplantation Download PDF

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Publication number
DK2856152T3
DK2856152T3 DK13729629.9T DK13729629T DK2856152T3 DK 2856152 T3 DK2856152 T3 DK 2856152T3 DK 13729629 T DK13729629 T DK 13729629T DK 2856152 T3 DK2856152 T3 DK 2856152T3
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DK
Denmark
Prior art keywords
assess
risk
organ transplantation
new biomarkers
patient mortality
Prior art date
Application number
DK13729629.9T
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English (en)
Inventor
Cornelis Vermeer
Borst Martin De
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Nattopharma Asa
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Publication of DK2856152T3 publication Critical patent/DK2856152T3/da

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/10Post-translational modifications [PTMs] in chemical analysis of biological material acylation, e.g. acetylation, formylation, lipoylation, myristoylation, palmitoylation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
DK13729629.9T 2012-06-04 2013-06-04 Nye biomarkører til at skønne risikoen for allotransplantationssvigt og patientdødelighed efter organtransplantation DK2856152T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12170756.6A EP2671574A1 (en) 2012-06-04 2012-06-04 Use of vitamin K to decrease allograft failure and patient mortality after organ transplantation
PCT/EP2013/061519 WO2013182579A1 (en) 2012-06-04 2013-06-04 New biomarkers to estimate the risk of allograft failure and patient mortality after organ transplantation

Publications (1)

Publication Number Publication Date
DK2856152T3 true DK2856152T3 (da) 2021-11-01

Family

ID=48651994

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13729629.9T DK2856152T3 (da) 2012-06-04 2013-06-04 Nye biomarkører til at skønne risikoen for allotransplantationssvigt og patientdødelighed efter organtransplantation

Country Status (11)

Country Link
US (2) US20150153352A1 (da)
EP (3) EP2671574A1 (da)
DK (1) DK2856152T3 (da)
ES (1) ES2891249T3 (da)
HR (1) HRP20211676T1 (da)
HU (1) HUE056601T2 (da)
LT (1) LT2856152T (da)
PL (1) PL2856152T3 (da)
PT (1) PT2856152T (da)
SI (1) SI2856152T1 (da)
WO (2) WO2013182579A1 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180199610A1 (en) * 2015-02-20 2018-07-19 Vitak B.V. Vitamin k and capillary function

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635478A (en) * 1989-09-18 1997-06-03 Yale University Use of calcitonin gene-related peptide to regulate immune response
WO2000008495A2 (en) * 1998-08-06 2000-02-17 University Of Pittsburgh Of The Commonwealth System Of Higher Education Antiproliferative naphthoquinones, derivatives, compositions, and uses thereof
US7700296B2 (en) 1999-07-04 2010-04-20 Mgp Diagnostics As Diagnostic assay for human Matrix Gla-protein and its use as a biomarker
ES2296634T3 (es) 1999-07-04 2008-05-01 Cardiovascular Research Institute Of Maastricht (Carim) Ensayo de diagnostico para proteina gla de matriz humana y su utilizacion como biomarcador.
PT1153548E (pt) 2000-05-12 2007-08-08 Nattopharma Asa Produto alimentar contendo vitamina k
AU2003304180A1 (en) * 2002-09-24 2005-01-04 Dow, Kenneth, Centocor, Inc. Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses
US20070111210A1 (en) * 2003-12-03 2007-05-17 Marc Bigaud Biomarkers for graft rejection
WO2005107731A1 (ja) * 2004-05-12 2005-11-17 Eisai R & D Management Co., Ltd. ビタミンk2を有効成分として含む治療剤
RU2318500C2 (ru) * 2005-10-18 2008-03-10 Общество С Ограниченной Ответственностью "Митотехнология" Способ воздействия на организм путем адресной доставки биологически активных веществ в митохондрии, фармацевтическая композиция для его осуществления и соединение, применяемое для этой цели
WO2008147283A1 (en) * 2007-05-25 2008-12-04 Leif Salford The use of zeburaline for the treatment of autoimmune diseases or immune rejection of transplants
CA2805745C (en) * 2010-07-19 2019-01-15 Summa Health System Vitamin c and chromium-free vitamin k, and compositions thereof for treating an nfkb-mediated condition or disease

Also Published As

Publication number Publication date
PT2856152T (pt) 2021-09-29
SI2856152T1 (sl) 2022-01-31
WO2013182578A1 (en) 2013-12-12
US20150153352A1 (en) 2015-06-04
US20150141386A1 (en) 2015-05-21
WO2013182579A1 (en) 2013-12-12
LT2856152T (lt) 2021-12-10
EP2856152B1 (en) 2021-08-04
PL2856152T3 (pl) 2022-02-07
ES2891249T3 (es) 2022-01-26
EP2854788A1 (en) 2015-04-08
HRP20211676T1 (hr) 2022-02-18
EP2856152A1 (en) 2015-04-08
EP2671574A1 (en) 2013-12-11
HUE056601T2 (hu) 2022-02-28

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