DK2816107T3 - Fremgangsmåde til at ekspandere hæmapoietiske stamceller - Google Patents

Fremgangsmåde til at ekspandere hæmapoietiske stamceller Download PDF

Info

Publication number
DK2816107T3
DK2816107T3 DK14172624T DK14172624T DK2816107T3 DK 2816107 T3 DK2816107 T3 DK 2816107T3 DK 14172624 T DK14172624 T DK 14172624T DK 14172624 T DK14172624 T DK 14172624T DK 2816107 T3 DK2816107 T3 DK 2816107T3
Authority
DK
Denmark
Prior art keywords
expanding
stem cells
hemapoietic stem
hemapoietic
cells
Prior art date
Application number
DK14172624T
Other languages
Danish (da)
English (en)
Inventor
Hong Gao
Zhenglun Zhu
Original Assignee
Hong Gao
Zhenglun Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hong Gao, Zhenglun Zhu filed Critical Hong Gao
Application granted granted Critical
Publication of DK2816107T3 publication Critical patent/DK2816107T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3233—Morpholino-type ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/65—MicroRNA

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK14172624T 2013-06-17 2014-06-16 Fremgangsmåde til at ekspandere hæmapoietiske stamceller DK2816107T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13/919,241 US9428748B2 (en) 2013-06-17 2013-06-17 Method of expanding hematopoietic stem cells

Publications (1)

Publication Number Publication Date
DK2816107T3 true DK2816107T3 (da) 2019-11-11

Family

ID=50942591

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14172624T DK2816107T3 (da) 2013-06-17 2014-06-16 Fremgangsmåde til at ekspandere hæmapoietiske stamceller

Country Status (6)

Country Link
US (1) US9428748B2 (enExample)
EP (1) EP2816107B1 (enExample)
JP (1) JP6532653B2 (enExample)
DK (1) DK2816107T3 (enExample)
ES (1) ES2757508T3 (enExample)
HU (1) HUE046356T2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017136322A1 (en) * 2016-02-04 2017-08-10 Zhenglun Zhu Treatment and diagnosis of inflammatory disorders
GB201608944D0 (en) * 2016-05-20 2016-07-06 Ospedale San Raffaele And Fond Telethon Gene Tharapy
US20230279440A1 (en) 2020-05-06 2023-09-07 Cellectis S.A. Methods to genetically modify cells for delivery of therapeutic proteins
WO2021224395A1 (en) 2020-05-06 2021-11-11 Cellectis S.A. Methods for targeted insertion of exogenous sequences in cellular genomes

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
WO1987002671A1 (en) 1985-11-01 1987-05-07 International Genetic Engineering, Inc. Modular assembly of antibody genes, antibodies prepared thereby and use
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5679647A (en) 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
US5908779A (en) 1993-12-01 1999-06-01 University Of Connecticut Targeted RNA degradation using nuclear antisense RNA
US5739118A (en) 1994-04-01 1998-04-14 Apollon, Inc. Compositions and methods for delivery of genetic material
US5837533A (en) 1994-09-28 1998-11-17 American Home Products Corporation Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent
CA2386192A1 (en) * 1999-10-07 2001-04-12 Avi Biopharma, Inc. C-myc antisense-treated hematopoietic stem cell composition and method
KR20050115231A (ko) * 2003-02-10 2005-12-07 내셔날 인스티튜트 오브 어드밴스드 인더스트리얼 사이언스 앤드 테크놀로지 포유동물 세포의 조절
CA2517959A1 (en) * 2003-03-07 2004-09-16 Gamida-Cell Ltd. Expansion of renewable stem cell populations using modulators of pi 3-kinase
EP1991246B1 (en) 2006-02-22 2013-09-11 Zhenglun Zhu Treatment of development-related disorders
CN101495623B (zh) * 2006-03-24 2013-09-11 儿童医疗中心有限公司 调节造血干细胞生长的方法
WO2011008947A2 (en) * 2009-07-15 2011-01-20 Zhenglun Zhu Treatment and diagnosis of immune disorders
WO2011028819A1 (en) * 2009-09-01 2011-03-10 The Trustees Of Columbia University In The City Of New York Synergistic transcription modules and uses thereof
US8741640B2 (en) * 2010-11-24 2014-06-03 Hong Gao Expanding hematopoietic stem cells
WO2012170979A1 (en) 2011-06-10 2012-12-13 Zhenglun Zhu Human homeobox gene ventx and macrophage terminal differentiation and activation, compositions and methods thereof
CA2848359A1 (en) * 2011-09-11 2013-03-14 Aurasense, Llc Cellular uptake control systems
EP2984165B1 (en) * 2013-04-10 2020-12-23 Zhenglun Zhu Homeobox transcription factor ventx regulates differentiation and maturation of human dendritic cells

Also Published As

Publication number Publication date
JP2015000064A (ja) 2015-01-05
HUE046356T2 (hu) 2020-03-30
US20140369967A1 (en) 2014-12-18
JP6532653B2 (ja) 2019-06-19
EP2816107B1 (en) 2019-08-07
ES2757508T3 (es) 2020-04-29
EP2816107A1 (en) 2014-12-24
US9428748B2 (en) 2016-08-30

Similar Documents

Publication Publication Date Title
DK3044817T3 (da) Inverteret solcelle og fremgangsmåde til fremstilling deraf
PL2953634T3 (pl) Sposoby namnażania lub zubożania limfocytów t-regulatorowych
DK3527563T3 (da) Dna-pk-inhibitorer
DK3702443T3 (da) Sammensætninger og fremgangsmåder til opformering og dyrkning af epiteliale stamceller
DK3054782T3 (da) Fremgangsmåde til tørring af biomasse
BR112015020875A2 (pt) usina solar móvel
DK2992104T3 (da) Fremgangsmåde til ekspression
DK3010352T3 (da) Fremgangsmåde til fremstilling af fodertilsætning
DK3227435T3 (da) Gammadelta-t-celleekspansionsprocedure
DK3049059T3 (da) Intranasal dhe formulering til behandlingen af hovedpine
PT2953948T (pt) Antagonistas de integrina fluorada
DK3000526T3 (da) Fremgangsmåde til overførsel af præcise små volumen væsker
EP3066193C0 (en) CELL CULTURE PROCESS
LT3064575T (lt) Pliuripotentinių kamieninių ląstelių, indikuotų iš mezenchiminių kamieninių ląstelių, diferenciacijos į hepatocitus būdas
BR112015021083A2 (pt) método
EP2945942A4 (en) Voriconazole IMMUNOASSAY
FR3001759B1 (fr) Rouge aubagee de turbomachine
DK3050961T5 (da) Fremgangsmåde til forbedring af effektiviteten ved inducering af pluripotente stamceller
DK3514157T3 (da) Fremgangsmåde til fremstilling af glucosylceramidsynthase-hæmmere
DK3083493T3 (da) Fremgangsmåde til fremstilling af syntesegas
BR112015029076A2 (pt) método
FI20135361L (fi) Analyyttinen menetelmä
DK2816107T3 (da) Fremgangsmåde til at ekspandere hæmapoietiske stamceller
PL2982171T3 (pl) Weryfikacja w tle małych komórek
DK2978839T3 (da) Fremgangsmåde til celledyrkning