ES2757508T3 - Método para expandir células madre hematopoyéticas - Google Patents
Método para expandir células madre hematopoyéticas Download PDFInfo
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- ES2757508T3 ES2757508T3 ES14172624T ES14172624T ES2757508T3 ES 2757508 T3 ES2757508 T3 ES 2757508T3 ES 14172624 T ES14172624 T ES 14172624T ES 14172624 T ES14172624 T ES 14172624T ES 2757508 T3 ES2757508 T3 ES 2757508T3
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Classifications
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- C12N5/0634—Cells from the blood or the immune system
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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| WO2017136322A1 (en) * | 2016-02-04 | 2017-08-10 | Zhenglun Zhu | Treatment and diagnosis of inflammatory disorders |
| GB201608944D0 (en) * | 2016-05-20 | 2016-07-06 | Ospedale San Raffaele And Fond Telethon | Gene Tharapy |
| US20230279440A1 (en) | 2020-05-06 | 2023-09-07 | Cellectis S.A. | Methods to genetically modify cells for delivery of therapeutic proteins |
| WO2021224395A1 (en) | 2020-05-06 | 2021-11-11 | Cellectis S.A. | Methods for targeted insertion of exogenous sequences in cellular genomes |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| WO1987002671A1 (en) | 1985-11-01 | 1987-05-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| US5908779A (en) | 1993-12-01 | 1999-06-01 | University Of Connecticut | Targeted RNA degradation using nuclear antisense RNA |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US5837533A (en) | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| CA2386192A1 (en) * | 1999-10-07 | 2001-04-12 | Avi Biopharma, Inc. | C-myc antisense-treated hematopoietic stem cell composition and method |
| KR20050115231A (ko) * | 2003-02-10 | 2005-12-07 | 내셔날 인스티튜트 오브 어드밴스드 인더스트리얼 사이언스 앤드 테크놀로지 | 포유동물 세포의 조절 |
| CA2517959A1 (en) * | 2003-03-07 | 2004-09-16 | Gamida-Cell Ltd. | Expansion of renewable stem cell populations using modulators of pi 3-kinase |
| EP1991246B1 (en) | 2006-02-22 | 2013-09-11 | Zhenglun Zhu | Treatment of development-related disorders |
| CN101495623B (zh) * | 2006-03-24 | 2013-09-11 | 儿童医疗中心有限公司 | 调节造血干细胞生长的方法 |
| WO2011008947A2 (en) * | 2009-07-15 | 2011-01-20 | Zhenglun Zhu | Treatment and diagnosis of immune disorders |
| WO2011028819A1 (en) * | 2009-09-01 | 2011-03-10 | The Trustees Of Columbia University In The City Of New York | Synergistic transcription modules and uses thereof |
| US8741640B2 (en) * | 2010-11-24 | 2014-06-03 | Hong Gao | Expanding hematopoietic stem cells |
| WO2012170979A1 (en) | 2011-06-10 | 2012-12-13 | Zhenglun Zhu | Human homeobox gene ventx and macrophage terminal differentiation and activation, compositions and methods thereof |
| CA2848359A1 (en) * | 2011-09-11 | 2013-03-14 | Aurasense, Llc | Cellular uptake control systems |
| EP2984165B1 (en) * | 2013-04-10 | 2020-12-23 | Zhenglun Zhu | Homeobox transcription factor ventx regulates differentiation and maturation of human dendritic cells |
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| JP2015000064A (ja) | 2015-01-05 |
| HUE046356T2 (hu) | 2020-03-30 |
| DK2816107T3 (da) | 2019-11-11 |
| US20140369967A1 (en) | 2014-12-18 |
| JP6532653B2 (ja) | 2019-06-19 |
| EP2816107B1 (en) | 2019-08-07 |
| EP2816107A1 (en) | 2014-12-24 |
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