DK2802660T3 - Nye C5A-bindende nucleinsyrer - Google Patents
Nye C5A-bindende nucleinsyrer Download PDFInfo
- Publication number
- DK2802660T3 DK2802660T3 DK13700617.7T DK13700617T DK2802660T3 DK 2802660 T3 DK2802660 T3 DK 2802660T3 DK 13700617 T DK13700617 T DK 13700617T DK 2802660 T3 DK2802660 T3 DK 2802660T3
- Authority
- DK
- Denmark
- Prior art keywords
- novel
- nucleic acids
- binding nucleic
- binding
- acids
- Prior art date
Links
- NCMVOABPESMRCP-SHYZEUOFSA-N NC(C=CN1[C@@H](C2)O[C@H](COP(O)(O)=O)[C@H]2O)=NC1=O Chemical compound NC(C=CN1[C@@H](C2)O[C@H](COP(O)(O)=O)[C@H]2O)=NC1=O NCMVOABPESMRCP-SHYZEUOFSA-N 0.000 description 1
- LTFMZDNNPPEQNG-YSLANXFLSA-N NC(NC1=O)=Nc2c1nc[n]2[C@@H](C1)O[C@H](COP(O)(O)=O)C1O Chemical compound NC(NC1=O)=Nc2c1nc[n]2[C@@H](C1)O[C@H](COP(O)(O)=O)C1O LTFMZDNNPPEQNG-YSLANXFLSA-N 0.000 description 1
- WCNLOVDQFDDWLB-LKYYUADZSA-N NC1[C@H]([n]2c3ncnc(N)c3nc2)O[C@H](COP(O)(O)=O)C1O Chemical compound NC1[C@H]([n]2c3ncnc(N)c3nc2)O[C@H](COP(O)(O)=O)C1O WCNLOVDQFDDWLB-LKYYUADZSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2012/000089 WO2012095303A1 (en) | 2011-01-10 | 2012-01-10 | Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same |
| EP12000106 | 2012-01-10 | ||
| EP12006960 | 2012-10-08 | ||
| PCT/EP2013/000056 WO2013104540A1 (en) | 2012-01-10 | 2013-01-10 | New c5a binding nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2802660T3 true DK2802660T3 (da) | 2020-05-18 |
Family
ID=48781063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13700617.7T DK2802660T3 (da) | 2012-01-10 | 2013-01-10 | Nye C5A-bindende nucleinsyrer |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US9518265B2 (enExample) |
| EP (1) | EP2802660B1 (enExample) |
| JP (1) | JP6415327B2 (enExample) |
| KR (1) | KR102034203B1 (enExample) |
| CN (1) | CN104145018B (enExample) |
| AU (2) | AU2013209131A1 (enExample) |
| BR (1) | BR112014016877B1 (enExample) |
| CA (1) | CA2860806C (enExample) |
| DK (1) | DK2802660T3 (enExample) |
| ES (1) | ES2786007T3 (enExample) |
| IL (1) | IL233516B (enExample) |
| IN (1) | IN2014DN05665A (enExample) |
| MX (1) | MX362061B (enExample) |
| PL (1) | PL2802660T3 (enExample) |
| PT (1) | PT2802660T (enExample) |
| RU (1) | RU2645261C2 (enExample) |
| SG (2) | SG10201605594UA (enExample) |
| WO (1) | WO2013104540A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111443069A (zh) | 2013-10-28 | 2020-07-24 | 多茨技术公司 | 过敏原检测 |
| WO2015103438A2 (en) | 2014-01-02 | 2015-07-09 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| EP3793427B1 (en) | 2018-05-17 | 2026-04-01 | The Procter & Gamble Company | Systems and methods for hair coverage analysis |
| US11172873B2 (en) | 2018-05-17 | 2021-11-16 | The Procter & Gamble Company | Systems and methods for hair analysis |
| EP3586865A1 (en) * | 2018-06-21 | 2020-01-01 | Charité - Universitätsmedizin Berlin | Complement anaphylatoxin binders and their use in treatment of a subject having an ocular wound and/or fibrosis |
| US11384357B2 (en) | 2018-06-29 | 2022-07-12 | The Procter And Gamble Company | Aptamers for personal care applications |
| CN113383079B (zh) * | 2018-11-12 | 2024-11-19 | 阿普塔里恩生物技术股份公司 | Cxcl8结合性核酸 |
| WO2020214784A1 (en) | 2019-04-16 | 2020-10-22 | The Procter & Gamble Company | Aptamers for odor control applications |
| US12039732B2 (en) | 2021-04-14 | 2024-07-16 | The Procter & Gamble Company | Digital imaging and learning systems and methods for analyzing pixel data of a scalp region of a users scalp to generate one or more user-specific scalp classifications |
| CN113150106B (zh) * | 2021-04-26 | 2022-08-16 | 华中农业大学 | 来源于补体成分C5a的抗菌肽及其应用 |
| TW202602466A (zh) | 2024-03-20 | 2026-01-16 | 德商艾普塔里昂生技公司 | 以Ｃ５ａ抑制劑治療疾病之方法 |
| EP4620474A1 (en) | 2024-03-20 | 2025-09-24 | APTARION biotech AG | Method of treating a disorder with a c5a inhibitor |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| US6395888B1 (en) | 1996-02-01 | 2002-05-28 | Gilead Sciences, Inc. | High affinity nucleic acid ligands of complement system proteins |
| US6140490A (en) | 1996-02-01 | 2000-10-31 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands of complement system proteins |
| US6395029B1 (en) | 1999-01-19 | 2002-05-28 | The Children's Hospital Of Philadelphia | Sustained delivery of polyionic bioactive agents |
| US6652886B2 (en) | 2001-02-16 | 2003-11-25 | Expression Genetics | Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents |
| DK2431377T3 (en) | 2001-10-26 | 2017-08-14 | Noxxon Pharma Ag | Modified L-nucleic acids |
| EP1306382A1 (de) | 2001-10-26 | 2003-05-02 | Noxxon Pharma AG | Modifizierte L-Nukleinsäure |
| ATE441706T1 (de) | 2002-02-20 | 2009-09-15 | Gen Hospital Corp | Konjugate mit biologisch abbaubarem polymer und verwendung dafür |
| MXPA05011022A (es) | 2003-04-13 | 2006-04-27 | Enzon Pharmaceuticals Inc | Profarmacos oligonucleotidos polimericos. |
| GB0314472D0 (en) | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
| US20070116710A1 (en) | 2004-02-03 | 2007-05-24 | Leonard Bell | Methods of treating hemolytic anemia |
| US20090281296A1 (en) | 2004-02-09 | 2009-11-12 | Supramol Parenteral Colloid Gmbh | Process for the production of conjugates from polysaccharides and polynucelotides |
| US7803931B2 (en) | 2004-02-12 | 2010-09-28 | Archemix Corp. | Aptamer therapeutics useful in the treatment of complement-related disorders |
| DK1727567T3 (da) * | 2004-02-12 | 2013-10-14 | Archemix Llc | Aptamer-terapeutiske midler nyttige i behandling af komplementrelaterede forstyrrelser |
| WO2005099768A2 (en) | 2004-03-23 | 2005-10-27 | Complex Biosystems Gmbh | Polymeric prodrug with a self-immolative linker |
| CA2585664C (en) | 2004-11-05 | 2014-05-20 | The Children's Hospital Of Philadelphia | Biodegradable linkers for molecular therapies |
| AU2006205830A1 (en) * | 2005-01-17 | 2006-07-20 | Jerini Ag | C5a receptor antagonists |
| EP2596807B1 (en) | 2006-03-08 | 2015-12-16 | Archemix LLC | Complement binding aptamers and anti-C5 agents useful in the treatment of ocular disorders |
| MX2009002859A (es) | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos. |
| EP2061901A2 (en) | 2006-10-31 | 2009-05-27 | Noxxon Pharma AG | Methods for detection of a single- or double-stranded nucleic acid molecule |
| CA2700441A1 (en) * | 2007-09-24 | 2009-04-02 | Noxxon Pharma Ag | C5a binding nucleic acids |
| WO2010103868A1 (ja) | 2009-03-11 | 2010-09-16 | オリンパスメディカルシステムズ株式会社 | 画像処理システム、その外部装置およびその画像処理方法 |
| WO2010108657A2 (en) | 2009-03-23 | 2010-09-30 | Noxxon Pharma Ag | C5a binding nucleic acids and the use thereof |
| EP2561079A1 (en) | 2010-04-21 | 2013-02-27 | Noxxon Pharma AG | Lipid binding nucleic acids |
| EP2663640B1 (en) * | 2011-01-10 | 2020-11-04 | APTARION biotech AG | Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same |
| KR20140083039A (ko) | 2011-10-21 | 2014-07-03 | 녹손 파르마 아게 | 글루카곤 결합형 핵산 |
| BR112014016939A2 (pt) | 2012-01-10 | 2019-09-24 | Noxxon Pharma Ag | ácidos nucleicos que se ligam especificamente a cgrp |
-
2013
- 2013-01-10 US US14/371,006 patent/US9518265B2/en active Active
- 2013-01-10 CN CN201380009020.9A patent/CN104145018B/zh active Active
- 2013-01-10 JP JP2014551570A patent/JP6415327B2/ja active Active
- 2013-01-10 DK DK13700617.7T patent/DK2802660T3/da active
- 2013-01-10 MX MX2014008454A patent/MX362061B/es active IP Right Grant
- 2013-01-10 CA CA2860806A patent/CA2860806C/en active Active
- 2013-01-10 BR BR112014016877-6A patent/BR112014016877B1/pt active IP Right Grant
- 2013-01-10 EP EP13700617.7A patent/EP2802660B1/en active Active
- 2013-01-10 WO PCT/EP2013/000056 patent/WO2013104540A1/en not_active Ceased
- 2013-01-10 RU RU2014132708A patent/RU2645261C2/ru active
- 2013-01-10 PT PT137006177T patent/PT2802660T/pt unknown
- 2013-01-10 IN IN5665DEN2014 patent/IN2014DN05665A/en unknown
- 2013-01-10 SG SG10201605594UA patent/SG10201605594UA/en unknown
- 2013-01-10 KR KR1020147022321A patent/KR102034203B1/ko active Active
- 2013-01-10 AU AU2013209131A patent/AU2013209131A1/en not_active Abandoned
- 2013-01-10 PL PL13700617T patent/PL2802660T3/pl unknown
- 2013-01-10 ES ES13700617T patent/ES2786007T3/es active Active
- 2013-01-10 SG SG11201403771SA patent/SG11201403771SA/en unknown
-
2014
- 2014-07-03 IL IL233516A patent/IL233516B/en active IP Right Grant
-
2016
- 2016-12-12 US US15/376,338 patent/US10590424B2/en active Active
-
2018
- 2018-11-30 AU AU2018271388A patent/AU2018271388B2/en active Active
-
2020
- 2020-03-15 US US16/819,102 patent/US11492625B2/en active Active
-
2022
- 2022-11-07 US US17/982,469 patent/US12188021B2/en active Active
-
2025
- 2025-01-05 US US19/010,141 patent/US20250327082A1/en active Pending
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