DK279790D0 - Aromatiske steroid-5-alfa-reduktaseinhibitorer - Google Patents

Aromatiske steroid-5-alfa-reduktaseinhibitorer

Info

Publication number
DK279790D0
DK279790D0 DK279790A DK279790A DK279790D0 DK 279790 D0 DK279790 D0 DK 279790D0 DK 279790 A DK279790 A DK 279790A DK 279790 A DK279790 A DK 279790A DK 279790 D0 DK279790 D0 DK 279790D0
Authority
DK
Denmark
Prior art keywords
beta
alpha
alfa
reductase inhibitors
steroid
Prior art date
Application number
DK279790A
Other languages
English (en)
Other versions
DK279790A (da
DK168295B1 (da
Inventor
Dennis Alan Holt
Mark Alan Levy
Brian Walter Metcalf
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of DK279790A publication Critical patent/DK279790A/da
Publication of DK279790D0 publication Critical patent/DK279790D0/da
Application granted granted Critical
Publication of DK168295B1 publication Critical patent/DK168295B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J13/00Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051Estrane derivatives
    • C07J1/0059Estrane derivatives substituted in position 17 by a keto group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J13/00Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J21/00Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J3/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J3/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0095Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 carbon in position 21 is part of carboxylic group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK279790A 1988-05-25 1990-11-23 Østrananalog forbindelse, farmaceutisk middel indeholdende forbindelsen samt anvendelse af forbindelsen ved fremstilling af et lægemiddel til inhibering af steroid-5-alfa-reduktaseaktivitet DK168295B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19853488A 1988-05-25 1988-05-25
US19853488 1988-05-25
PCT/US1989/002269 WO1989011282A1 (en) 1988-05-25 1989-05-23 AROMATIC STEROID 5-alpha-REDUCTASE INHIBITORS
US8902269 1989-05-23

Publications (3)

Publication Number Publication Date
DK279790A DK279790A (da) 1990-11-23
DK279790D0 true DK279790D0 (da) 1990-11-23
DK168295B1 DK168295B1 (da) 1994-03-07

Family

ID=22733779

Family Applications (2)

Application Number Title Priority Date Filing Date
DK279790A DK168295B1 (da) 1988-05-25 1990-11-23 Østrananalog forbindelse, farmaceutisk middel indeholdende forbindelsen samt anvendelse af forbindelsen ved fremstilling af et lægemiddel til inhibering af steroid-5-alfa-reduktaseaktivitet
DK130393A DK169787B1 (da) 1988-05-25 1993-11-19 3-trifluormethylsulfonatsteroidderivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK130393A DK169787B1 (da) 1988-05-25 1993-11-19 3-trifluormethylsulfonatsteroidderivater

Country Status (16)

Country Link
EP (1) EP0343954B1 (da)
JP (1) JP2675418B2 (da)
AT (1) ATE114665T1 (da)
AU (1) AU627466B2 (da)
CA (1) CA1331457C (da)
DE (1) DE68919537T2 (da)
DK (2) DK168295B1 (da)
ES (1) ES2065378T3 (da)
GR (1) GR3015135T3 (da)
HK (1) HK1006461A1 (da)
IE (1) IE68858B1 (da)
IL (1) IL91968A (da)
NO (1) NO174964C (da)
PT (1) PT90656B (da)
WO (1) WO1989011282A1 (da)
ZA (1) ZA893971B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571817A (en) * 1984-02-27 1996-11-05 Merck & Co., Inc. Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones]
US5138063A (en) * 1984-02-27 1992-08-11 Merck & Co., Inc. 17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones
US5151430A (en) * 1990-06-20 1992-09-29 Merck & Co., Inc. Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents
US5061802A (en) * 1990-06-20 1991-10-29 Merck & Co. Inc. 17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents
US5162332A (en) * 1990-06-20 1992-11-10 Merck & Co., Inc. Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors
US5098908A (en) * 1990-06-20 1992-03-24 Merck & Co., Inc. 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
US5091380A (en) * 1990-06-28 1992-02-25 Merck & Co., Inc. N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
IL101243A (en) * 1991-03-20 1999-12-22 Merck & Co Inc Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history
EP0638090A4 (en) * 1992-04-30 1995-10-04 Smithkline Beecham Corp SUBSTITUTED ESTRA-1,3,5 (10) -TRIENE-3-CARBOXYLIC ACID 17-g (a) AND 17-g (b).
US5237064A (en) * 1992-05-20 1993-08-17 Merck & Co., Inc. Process for producing 7β-substituted-aza-5αandrostan-3-ones
JPH07508034A (ja) * 1992-05-20 1995-09-07 メルク エンド カンパニー インコーポレーテッド 17−アミノ置換4−アザステロイド5α−レダクターゼ阻害剤
HUT71484A (en) * 1992-05-20 1995-11-28 Merck & Co Inc Process for producing of 7beta-substituted-4-aza-5alpha-cholestan-ones as 5-alpha-reductase inhibitors and pharmaceuticals compositions containing them
DE69329856D1 (de) * 1992-05-20 2001-02-15 Merck & Co Inc Ester derivate von 4-aza-steroiden
US5620986A (en) * 1992-05-20 1997-04-15 Merck & Co., Inc. 17 urea, thiourea, thiocarbamyl and carbamyl4-azasteroid 5-reductase inhibitors useful in the prevention and treatment of hyperandrogenic disorders
JPH07508038A (ja) * 1992-05-20 1995-09-07 メルク エンド カンパニー インコーポレーテッド 4−アザステロイドの17−エーテル及びチオエーテル
US5324734A (en) * 1992-09-15 1994-06-28 Merck & Co., Inc. Oxidization metabolites of 5-α-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione
US5278159A (en) * 1992-10-06 1994-01-11 Merck & Co., Inc. Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors
US5641765A (en) * 1992-11-18 1997-06-24 Smithkline Beecham Corporation 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
US5683995A (en) * 1992-11-18 1997-11-04 Smithkline Beecham Corporation 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
US5359071A (en) * 1993-03-12 1994-10-25 Merck & Co., Inc. 15-substituted 4-azasteroids
AU6413594A (en) * 1993-03-24 1994-10-11 Merck & Co., Inc. Substituted 3-phenanthridinone derivatives as 5alpha-reductase inhibitors
JP3325026B2 (ja) * 1993-06-28 2002-09-17 メルク エンド カンパニー インコーポレーテッド 4−アザ−プレグナン5α−レダクターゼアイソザイム1阻害剤
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5430157A (en) * 1993-12-13 1995-07-04 Eli Lilly And Company Reduced phenanthrenes
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5595996A (en) * 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1107664B (de) * 1959-11-05 1961-05-31 Schering Ag Verfahren zur Herstellung neuer in 3-Stellung substituierter OEstratriene
US3622670A (en) * 1969-08-22 1971-11-23 American Home Prod Method of inducing ovulation
US4185101A (en) * 1977-08-11 1980-01-22 Schering Corporation 1,3,5(10),6,8-19-Nor-pregnapentaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
US4191759A (en) * 1978-04-13 1980-03-04 Merck & Co., Inc. N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors
US4340602A (en) * 1978-10-18 1982-07-20 Wayne State University Compositions inhibiting estrogen sulfotransferase activity
US4910226A (en) * 1987-04-29 1990-03-20 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors

Also Published As

Publication number Publication date
NO894065L (no) 1991-04-12
GR3015135T3 (en) 1995-05-31
CA1331457C (en) 1994-08-16
DK130393D0 (da) 1993-11-19
EP0343954B1 (en) 1994-11-30
ATE114665T1 (de) 1994-12-15
IL91968A (en) 1994-10-21
NO894065D0 (no) 1989-10-11
DK279790A (da) 1990-11-23
DE68919537T2 (de) 1995-05-11
PT90656A (pt) 1989-11-30
HK1006461A1 (en) 1999-02-26
DK169787B1 (da) 1995-02-27
WO1989011282A1 (en) 1989-11-30
EP0343954A3 (en) 1990-05-16
IE891732L (en) 1989-11-25
DK130393A (da) 1993-11-19
ZA893971B (en) 1990-05-30
AU627466B2 (en) 1992-08-27
NO174964C (no) 1994-08-10
PT90656B (pt) 1994-10-31
JPH03504498A (ja) 1991-10-03
IE68858B1 (en) 1996-07-24
DK168295B1 (da) 1994-03-07
JP2675418B2 (ja) 1997-11-12
DE68919537D1 (de) 1995-01-12
AU3748789A (en) 1989-12-12
EP0343954A2 (en) 1989-11-29
ES2065378T3 (es) 1995-02-16
NO174964B (no) 1994-05-02

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed