DK2790712T3 - Human monocyt-subpopulation til behandling af skade på centralnervesystemet - Google Patents
Human monocyt-subpopulation til behandling af skade på centralnervesystemet Download PDFInfo
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- DK2790712T3 DK2790712T3 DK12858248.3T DK12858248T DK2790712T3 DK 2790712 T3 DK2790712 T3 DK 2790712T3 DK 12858248 T DK12858248 T DK 12858248T DK 2790712 T3 DK2790712 T3 DK 2790712T3
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4614—Monocytes; Macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46432—Nervous system antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (10)
- HUMAN MONOCYT-SUBPOPULATION TIL BEHANDLING AF SKADE PÅ CENTRALNERVESYSTEMET1. Subpopulation af mononukleære celler fra perifert blod (PBMC'er), der i det væsentlige er uden CD3+-celier, CD19+-cei!er og CD56+-cel!er, til anvendelse ved behandling af skade på centralnervesystemet (CNS).
- 2. Subpopulation af PBMC'er til anvendelse ifølge krav 1, hvilken subpopulation endvidere i det væsentlige er uden CD16+-ce!ler.
- 3. Subpopulation af mononukleære celler fra perifert blod (PBMC'er), der i det væsentlige er uden CD3+-celler, CD19+-celler, CD56+-celler og CD16+-celler, til anvendelse ved behandling af CNS-skade.
- 4. Subpopulation af PBMC'er til anvendelse ifølge krav 1 eller 3, hvilken subpopulation i det væsentlige er beriget med CD14+-celler.
- 5. Subpopulation af PBMC'er til anvendelse ifølge et hvilket som helst af kravene 1 til 4 til anvendelse ved behandling af neurondegenerering forårsaget af CNS-skaden.
- 6. Subpopulation af PBMC'er til anvendelse ifølge et hvilket som helst af kravene 1 til 4 til anvendelse ved behandling af rygmarvslæsion.
- 7. Subpopulation af PBMC'er til anvendelse ifølge krav 5 eller 6, hvor behandlingen omfatter fremme af rygmarvsvævsgenoprettelse, funktionel restitution eller begge dele.
- 8. Subpopulation af PBMC'er ti! anvendelse ifølge et hvilket som helst af kravene 1 til 5, hvor CNS-skaden er traume, såsom stumpt traume, penetrerende traume, coup-læsion eller contrecoup-læsion, traume pådraget under en neurokirurgisk operation eller en anden procedure eller slagtilfælde, såsom hæmoragisk slagtilfælde eller iskæmisk slagtilfælde.
- 9. Subpopulation af PBMC'er ti! anvendelse ifølge et hvilket som helst af kravene 1 ti! 8, hvilken subpopulation er formuleret til injektion.
- 10. Subpopulation af PBMC'er ti! anvendelse iføige krav 9, hvilken subpopulation er formuleret til injektion i cerebrospinalvæsken (CSF).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161570593P | 2011-12-14 | 2011-12-14 | |
| PCT/IL2012/050522 WO2013088441A1 (en) | 2011-12-14 | 2012-12-13 | Human monocyte sub-population for treatment of central nervous system injury |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2790712T3 true DK2790712T3 (da) | 2016-12-19 |
Family
ID=48611950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12858248.3T DK2790712T3 (da) | 2011-12-14 | 2012-12-13 | Human monocyt-subpopulation til behandling af skade på centralnervesystemet |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9314483B2 (da) |
| EP (1) | EP2790712B1 (da) |
| JP (1) | JP6148679B2 (da) |
| KR (1) | KR20140107439A (da) |
| CN (1) | CN104159590A (da) |
| AU (2) | AU2012354057B2 (da) |
| BR (1) | BR112014014560A8 (da) |
| DK (1) | DK2790712T3 (da) |
| ES (1) | ES2604356T3 (da) |
| HU (1) | HUE032096T2 (da) |
| IN (1) | IN2014MN01420A (da) |
| MX (1) | MX358589B (da) |
| PL (1) | PL2790712T3 (da) |
| PT (1) | PT2790712T (da) |
| WO (1) | WO2013088441A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2786253T3 (es) | 2013-03-14 | 2020-10-09 | Immusoft Corp | Métodos para la diferenciación y transducción in vitro de células b de memoria con vectores virales pseudotipados vsv-g |
| BR112015029299A2 (pt) * | 2013-05-22 | 2017-07-25 | Yeda Res & Dev | subpopulação de monócitos humanos para tratamento de doenças e distúrbios oculares |
| PL3234107T3 (pl) * | 2014-12-19 | 2023-01-16 | Immusoft Corporation | Limfocyty b do dostarczania in vivo środków terapeutycznych |
| US10722529B2 (en) | 2015-12-03 | 2020-07-28 | Temple University—Of the Commonwealth System of Higher Education | Modulation of NAD+ metabolic pathways for treatment of disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5800812A (en) | 1995-09-15 | 1998-09-01 | Yeda Research And Development Co. Ltd. | Methods of use of mononuclear phagocytes to promote axonal regeneration |
| WO1998005795A1 (en) * | 1996-08-02 | 1998-02-12 | The Center For Blood Research, Inc. | Enrichment of dendritic cells from blood |
| US6267995B1 (en) | 1999-03-03 | 2001-07-31 | Pure World Botanicals, Inc. | Extract of Lepidium meyenii roots for pharmaceutical applications |
| KR101001119B1 (ko) * | 2001-11-21 | 2010-12-14 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | 인간 단핵 식세포성 백혈구의 제조 방법 |
| CN102036671A (zh) * | 2008-03-28 | 2011-04-27 | 永生细胞生技股份有限公司 | 使用脐带血细胞治疗脑损伤 |
| BR112015029299A2 (pt) * | 2013-05-22 | 2017-07-25 | Yeda Res & Dev | subpopulação de monócitos humanos para tratamento de doenças e distúrbios oculares |
-
2012
- 2012-12-13 ES ES12858248.3T patent/ES2604356T3/es active Active
- 2012-12-13 CN CN201280069645.XA patent/CN104159590A/zh active Pending
- 2012-12-13 WO PCT/IL2012/050522 patent/WO2013088441A1/en active Application Filing
- 2012-12-13 PL PL12858248T patent/PL2790712T3/pl unknown
- 2012-12-13 EP EP12858248.3A patent/EP2790712B1/en active Active
- 2012-12-13 KR KR1020147019424A patent/KR20140107439A/ko active IP Right Grant
- 2012-12-13 PT PT128582483T patent/PT2790712T/pt unknown
- 2012-12-13 DK DK12858248.3T patent/DK2790712T3/da active
- 2012-12-13 BR BR112014014560A patent/BR112014014560A8/pt not_active IP Right Cessation
- 2012-12-13 JP JP2014546730A patent/JP6148679B2/ja active Active
- 2012-12-13 HU HUE12858248A patent/HUE032096T2/en unknown
- 2012-12-13 AU AU2012354057A patent/AU2012354057B2/en active Active
- 2012-12-13 IN IN1420MUN2014 patent/IN2014MN01420A/en unknown
- 2012-12-13 MX MX2014007188A patent/MX358589B/es active IP Right Grant
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2014
- 2014-06-12 US US14/303,212 patent/US9314483B2/en not_active Expired - Fee Related
-
2017
- 2017-10-31 AU AU2017254830A patent/AU2017254830A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP6148679B2 (ja) | 2017-06-14 |
| MX2014007188A (es) | 2015-09-22 |
| AU2012354057A1 (en) | 2014-07-31 |
| EP2790712A4 (en) | 2015-06-24 |
| PL2790712T3 (pl) | 2017-04-28 |
| AU2017254830A1 (en) | 2017-11-16 |
| BR112014014560A2 (pt) | 2017-06-13 |
| CN104159590A (zh) | 2014-11-19 |
| AU2012354057B2 (en) | 2017-08-03 |
| BR112014014560A8 (pt) | 2017-07-04 |
| MX358589B (es) | 2018-08-27 |
| HUE032096T2 (en) | 2017-09-28 |
| KR20140107439A (ko) | 2014-09-04 |
| PT2790712T (pt) | 2016-12-02 |
| US20140363411A1 (en) | 2014-12-11 |
| JP2015501835A (ja) | 2015-01-19 |
| IN2014MN01420A (da) | 2015-04-03 |
| ES2604356T3 (es) | 2017-03-06 |
| EP2790712B1 (en) | 2016-08-31 |
| WO2013088441A1 (en) | 2013-06-20 |
| US9314483B2 (en) | 2016-04-19 |
| EP2790712A1 (en) | 2014-10-22 |
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