DK2785719T3 - Langtidsvirkende injicerbare moxidectin-formuleringer og hidtil ukendte moxidectin-krystalformer - Google Patents

Langtidsvirkende injicerbare moxidectin-formuleringer og hidtil ukendte moxidectin-krystalformer Download PDF

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Publication number
DK2785719T3
DK2785719T3 DK12798570.3T DK12798570T DK2785719T3 DK 2785719 T3 DK2785719 T3 DK 2785719T3 DK 12798570 T DK12798570 T DK 12798570T DK 2785719 T3 DK2785719 T3 DK 2785719T3
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DK
Denmark
Prior art keywords
moxidectin
amorphous
crystals
dried
dsc
Prior art date
Application number
DK12798570.3T
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English (en)
Inventor
Susan Mancini Cady
Baoqing Ma
Robert Clark Chapman
Uday Jain
Chunhua Yang
Original Assignee
Merial Inc
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Publication date
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Publication of DK2785719T3 publication Critical patent/DK2785719T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)

Claims (3)

1. Fremgangsmåde til fremstilling krystallinsk moxidectin Form A, kendetegnet ved et smeltepunkt på ca. 210°C, hvilken fremgangsmåde omfatter trinnene at opvarme amorf moxidectin i et oliebad holdt ved en temperatur på ca. 190°C i en periode på fra ca. 2 til ca. 10 minutter, efterfulgt af afkøling.
2. Fremgangsmåde til fremstilling krystallinsk moxidectin Form A, kendetegnet ved et smeltepunkt på ca. 210°C, hvilken fremgangsmåde omfatter trinnet til hurtig desolvatisering af [moxidectin·!.5 BuOH] solvat.
3. Fremgangsmåde ifølge krav 2, hvor [moxidectin»1.5 BuOH] solvatet fremstilles ved trinnene at tilsætte amorf moxidectin n-butanol gradvis til mætning mens temperaturen opretholdes ved 50°C til 60°C, efterfulgt af overførsel til -10°C natten over.
DK12798570.3T 2011-12-02 2012-11-30 Langtidsvirkende injicerbare moxidectin-formuleringer og hidtil ukendte moxidectin-krystalformer DK2785719T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161566336P 2011-12-02 2011-12-02
PCT/US2012/067215 WO2013082373A1 (en) 2011-12-02 2012-11-30 Long-acting injectable moxidectin formulations and novel moxidectin crystal forms

Publications (1)

Publication Number Publication Date
DK2785719T3 true DK2785719T3 (da) 2017-12-04

Family

ID=47324470

Family Applications (2)

Application Number Title Priority Date Filing Date
DK17190708.2T DK3351546T5 (da) 2011-12-02 2012-11-30 Langtidsvirkende injicerbare moxidectinformuleringer
DK12798570.3T DK2785719T3 (da) 2011-12-02 2012-11-30 Langtidsvirkende injicerbare moxidectin-formuleringer og hidtil ukendte moxidectin-krystalformer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK17190708.2T DK3351546T5 (da) 2011-12-02 2012-11-30 Langtidsvirkende injicerbare moxidectinformuleringer

Country Status (15)

Country Link
US (2) US8715711B2 (da)
EP (2) EP3351546B9 (da)
CN (2) CN104053660B (da)
AU (4) AU2012345813B2 (da)
BR (2) BR112014013371B1 (da)
CA (2) CA3082432C (da)
DK (2) DK3351546T5 (da)
ES (2) ES2978407T3 (da)
HK (2) HK1201264A1 (da)
HU (1) HUE036441T2 (da)
MX (1) MX358476B (da)
PL (2) PL2785719T3 (da)
PT (2) PT2785719T (da)
WO (1) WO2013082373A1 (da)
ZA (1) ZA201404122B (da)

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CN103405388B (zh) * 2013-08-21 2015-04-08 成都乾坤动物药业有限公司 一种可湿性莫西菌素固体分散粉及其制备方法和用途
FR3028314B1 (fr) * 2014-11-07 2016-12-23 Aircelle Sa Procede de caracterisation du vieillissement thermique de materiaux composites, en particulier de materiaux composites a matrice organique
JP6824900B2 (ja) * 2015-04-08 2021-02-03 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド イソオキサゾリン活性薬剤を含む延長放出注射製剤、方法及びその使用
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US11318156B2 (en) * 2017-04-13 2022-05-03 Ceva Sante Animale Solid injectable veterinary implants comprising monocyclic lactone
KR102101969B1 (ko) * 2017-09-06 2020-04-22 (주)인벤티지랩 목시덱틴을 포함하는 마이크로 입자 및 이의 제조 방법
CN111386112A (zh) * 2017-11-23 2020-07-07 法国诗华大药厂 用于治疗寄生虫感染的含有莫昔克丁的组合物
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Also Published As

Publication number Publication date
CN104053660B (zh) 2016-12-28
WO2013082373A1 (en) 2013-06-06
EP3351546B9 (en) 2024-07-10
PL3351546T3 (pl) 2024-09-09
HUE036441T2 (hu) 2018-07-30
DK3351546T3 (da) 2024-04-29
PT2785719T (pt) 2018-02-08
CA3082432C (en) 2023-01-03
AU2017268548A1 (en) 2018-01-04
AU2012345813B2 (en) 2017-02-02
CN105232529A (zh) 2016-01-13
PT3351546T (pt) 2024-03-07
EP2785719B1 (en) 2017-11-08
US20140323559A1 (en) 2014-10-30
BR112014013371A2 (pt) 2017-06-13
AU2019229407A1 (en) 2019-10-03
HK1201264A1 (en) 2015-08-28
AU2017268548B2 (en) 2019-09-19
US8715711B2 (en) 2014-05-06
PL2785719T3 (pl) 2018-03-30
CN105232529B (zh) 2018-11-23
CA2857958A1 (en) 2013-06-06
ZA201404122B (en) 2015-09-30
CA2857958C (en) 2020-08-25
EP3351546B1 (en) 2024-02-14
NZ626149A (en) 2016-06-24
AU2012345813A1 (en) 2014-07-03
EP3351546A1 (en) 2018-07-25
MX358476B (es) 2018-08-22
ES2978407T3 (es) 2024-09-12
MX2014006601A (es) 2015-03-05
ES2659159T3 (es) 2018-03-14
BR122020002199B1 (pt) 2021-01-19
DK3351546T5 (da) 2024-08-12
AU2017200177A1 (en) 2017-02-02
AU2017200177B2 (en) 2017-11-23
US9044453B2 (en) 2015-06-02
CA3082432A1 (en) 2013-06-06
US20130143956A1 (en) 2013-06-06
BR112014013371B1 (pt) 2020-04-07
HK1256641A1 (zh) 2019-09-27
CN104053660A (zh) 2014-09-17
EP2785719A1 (en) 2014-10-08

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