DK2777398T3 - Fremgangsmåde til isolering af en cancercelle med stamcelleegenskaber, der er resistent over for kemoterapeutisk middel - Google Patents
Fremgangsmåde til isolering af en cancercelle med stamcelleegenskaber, der er resistent over for kemoterapeutisk middel Download PDFInfo
- Publication number
- DK2777398T3 DK2777398T3 DK14171733.0T DK14171733T DK2777398T3 DK 2777398 T3 DK2777398 T3 DK 2777398T3 DK 14171733 T DK14171733 T DK 14171733T DK 2777398 T3 DK2777398 T3 DK 2777398T3
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- Prior art keywords
- cells
- cancer
- agarose
- beads
- chemotherapeutic agent
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
- C12N5/0695—Stem cells; Progenitor cells; Precursor cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/76—Agarose, agar-agar
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4703—Regulators; Modulating activity
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Developmental Biology & Embryology (AREA)
- Inorganic Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (1)
1. Fremgangsmåde til fastlæggelse af en prognose for et individ, der lider af cancer, omfattende: (i) at indkapsle en prøve af cancerceller, der er taget fra individet, i en kugle, der er overtrukket med agarose og indeholder agarose; ii) at dyrke kuglen, der er overtrukket med agarose og indeholder agarose, for at dyrke cancercellerne; iii) at bringe kuglen, der er overtrukket med agarose og indeholder agarose, med et kemoterapeutisk middel; og iv) at fastlægge, hvilke af de cancerceller, der er tilbage efter kontakt med det kemoterapeutiske middel, der udtrykker OCT4; og v) hvor en høj procentdel af de cancerceller, der udtrykker OCT4, er angivende for en ringere prognose for individet sammenlignet med et individ, som udtrykker få eller ingen celler, der udtrykker OCT4 i den tilsvarende indkapslede prøve.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45839110P | 2010-11-23 | 2010-11-23 | |
US45839010P | 2010-11-23 | 2010-11-23 | |
EP11842977.8A EP2597952B1 (en) | 2010-11-23 | 2011-11-22 | Method for isolating a chemotherapeutic agent resistant cancer cell with stem cell properties |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2777398T3 true DK2777398T3 (da) | 2017-06-26 |
Family
ID=46146185
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK11842977T DK2597952T3 (da) | 2010-11-23 | 2011-11-22 | Fremgangsmåde til isolering af en cancercelle med stamcelleegenskaber, hvilken cancercelle er resistent over for kemoterapeutisk middel |
DK14171733.0T DK2777398T3 (da) | 2010-11-23 | 2011-11-22 | Fremgangsmåde til isolering af en cancercelle med stamcelleegenskaber, der er resistent over for kemoterapeutisk middel |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK11842977T DK2597952T3 (da) | 2010-11-23 | 2011-11-22 | Fremgangsmåde til isolering af en cancercelle med stamcelleegenskaber, hvilken cancercelle er resistent over for kemoterapeutisk middel |
Country Status (20)
Country | Link |
---|---|
US (2) | US8741637B2 (da) |
EP (2) | EP2597952B1 (da) |
JP (1) | JP5899230B2 (da) |
KR (1) | KR101874654B1 (da) |
CN (1) | CN103108547B (da) |
AP (1) | AP3446A (da) |
AU (1) | AU2011332020B2 (da) |
BR (1) | BR112013012710B1 (da) |
CA (1) | CA2801370C (da) |
DK (2) | DK2597952T3 (da) |
ES (2) | ES2534374T3 (da) |
HK (1) | HK1179827A1 (da) |
HU (1) | HUE035164T2 (da) |
IL (2) | IL223362A (da) |
MX (1) | MX2013005836A (da) |
NZ (1) | NZ603949A (da) |
PL (2) | PL2777398T3 (da) |
PT (2) | PT2777398T (da) |
RU (1) | RU2583296C2 (da) |
WO (1) | WO2012071394A1 (da) |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19511572C2 (de) * | 1995-03-29 | 1998-02-26 | Henkel Kgaa | Niedrigviskose Trübungsmittelkonzentrate |
US5888497A (en) * | 1996-04-03 | 1999-03-30 | The Rogosin Institute | Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation |
US6224912B1 (en) | 1996-04-03 | 2001-05-01 | The Rogo Institute | Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment |
US7297331B2 (en) | 1996-04-03 | 2007-11-20 | The Rogosin Institute | Beads containing restricted cancer cells producing material suppressing cancer cell proliferation |
US6303151B1 (en) | 1996-04-03 | 2001-10-16 | The Rogosin Institute | Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment |
US20050053586A1 (en) * | 2003-09-04 | 2005-03-10 | Bryan Conn | Entrapped stem cells and uses thereof |
NZ566621A (en) | 2005-09-26 | 2010-07-30 | Rogosin Inst Inc | Agarose coated pancreas islets cells used for the treatment of insulin dependent diabetes |
US7704967B2 (en) * | 2006-03-14 | 2010-04-27 | University Of Maryland, Baltimore | TFIIS and GDOWN1 as targets for cancer therapy |
WO2007118242A2 (en) * | 2006-04-07 | 2007-10-18 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Identification of a constitutively resistant cancer stem cell |
KR100783199B1 (ko) * | 2006-05-18 | 2007-12-06 | 부산대학교 산학협력단 | 인간의 뇌 암 조직으로부터 확립된 신규 암 줄기 세포주gbm 2 |
EP2783700A1 (en) * | 2006-09-07 | 2014-10-01 | Stemline Therapeutics, Inc. | Cancer stem cell-targeted cancer therapy |
WO2009012357A2 (en) * | 2007-07-17 | 2009-01-22 | The General Hospital Corporation | Methods to identify and enrich for populations of ovarian cancer stem cells and somatic ovarian stem cells and uses thereof |
WO2009098698A2 (en) * | 2008-02-07 | 2009-08-13 | Shahar Cohen | Compartmental extract compositions for tissue engineering |
WO2010119001A1 (en) * | 2009-04-14 | 2010-10-21 | Institut Gustave Roussy | Prostate cancer cell lines and their use in screening method |
WO2010124498A1 (en) * | 2009-04-30 | 2010-11-04 | Beijing Cellonis Biotechnology Co., Ltd | A resistance-screened tumor stem cell, its antigen composition, an anti-tumor dendritic cell loading with said antigens, their preparation methods, uses and kits thereof as well as a dendritic cell vaccine |
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2011
- 2011-11-22 WO PCT/US2011/061812 patent/WO2012071394A1/en active Application Filing
- 2011-11-22 PL PL14171733T patent/PL2777398T3/pl unknown
- 2011-11-22 HU HUE14171733A patent/HUE035164T2/en unknown
- 2011-11-22 AP AP2013006904A patent/AP3446A/xx active
- 2011-11-22 MX MX2013005836A patent/MX2013005836A/es active IP Right Grant
- 2011-11-22 BR BR112013012710-4A patent/BR112013012710B1/pt active IP Right Grant
- 2011-11-22 AU AU2011332020A patent/AU2011332020B2/en not_active Ceased
- 2011-11-22 PL PL11842977T patent/PL2597952T3/pl unknown
- 2011-11-22 ES ES11842977.8T patent/ES2534374T3/es active Active
- 2011-11-22 EP EP11842977.8A patent/EP2597952B1/en active Active
- 2011-11-22 RU RU2012151922/10A patent/RU2583296C2/ru active
- 2011-11-22 CN CN201180031067.6A patent/CN103108547B/zh active Active
- 2011-11-22 NZ NZ603949A patent/NZ603949A/en unknown
- 2011-11-22 PT PT141717330T patent/PT2777398T/pt unknown
- 2011-11-22 US US13/701,705 patent/US8741637B2/en active Active
- 2011-11-22 DK DK11842977T patent/DK2597952T3/da active
- 2011-11-22 CA CA2801370A patent/CA2801370C/en active Active
- 2011-11-22 PT PT118429778T patent/PT2597952E/pt unknown
- 2011-11-22 ES ES14171733.0T patent/ES2632066T3/es active Active
- 2011-11-22 JP JP2013540108A patent/JP5899230B2/ja not_active Expired - Fee Related
- 2011-11-22 EP EP14171733.0A patent/EP2777398B1/en active Active
- 2011-11-22 KR KR1020137002954A patent/KR101874654B1/ko active IP Right Grant
- 2011-11-22 DK DK14171733.0T patent/DK2777398T3/da active
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2012
- 2012-11-29 IL IL223362A patent/IL223362A/en active IP Right Grant
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2013
- 2013-06-21 HK HK13107275.6A patent/HK1179827A1/zh not_active IP Right Cessation
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2014
- 2014-04-25 US US14/262,232 patent/US9375448B2/en active Active
- 2014-06-18 IL IL233227A patent/IL233227A/en active IP Right Grant
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