DK2766014T3 - Fremgangsmåder til behandling af pædiatriske patienter under anvendelse af dexmedetomidin - Google Patents
Fremgangsmåder til behandling af pædiatriske patienter under anvendelse af dexmedetomidin Download PDFInfo
- Publication number
- DK2766014T3 DK2766014T3 DK12840033.0T DK12840033T DK2766014T3 DK 2766014 T3 DK2766014 T3 DK 2766014T3 DK 12840033 T DK12840033 T DK 12840033T DK 2766014 T3 DK2766014 T3 DK 2766014T3
- Authority
- DK
- Denmark
- Prior art keywords
- dexmedetomidine
- dose
- hours
- administered
- weeks
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (11)
1
1. Dexmedetomidin til anvendelse til sedation eller analgesi hos en pædiatrisk patient med behov herfor, 5 hvor den pædriatiske patient har en gestationsalder på fra 20 uger til 44 uger, hvor indgivelsen af dexmedetomidin omfatter en første initialdosis indgivet i løbet af et tidsrum på fra 10 til 20 minutter før en anden vedligeholdelsesdosis, hvor initialdosen er 0,4 pg/kg eller mindre, hvor dexmedetomidin i den anden vedligeholdelsesdosis indgives som en kon-10 tinuerlig intravenøs dosis til den pædiatriske patient i en koncentration på mel lem 0,005 pg/kg/t til 0,25 pg/kg/t, og hvor dexmedetomidin indgives som en kontinuerlig infusion i løbet af et tidsrum på mindre end 36 timer.
2. Dexmedetomidin til anvendelse ifølge krav 1, hvor dexmedetomidin indgives som en kontinuerlig dosis i løbet af et tidsrum på mellem 6 og 24 timer.
3. Dexmedetomidin til anvendelse ifølge krav 1, hvor den pædiatriske patient intuberes før, under eller efter indgivelse af dexmedetomidin. 20
4. Dexmedetomidin til anvendelse ifølge krav 1, hvor den pædiatriske patient er kritisk syg.
5. Dexmedetomidin til anvendelse ifølge krav 1, hvor dexmedetomidin indgives 25 før kirurgi.
6. Dexmedetomidin til anvendelse ifølge krav 1, hvor dexmedetomidin indgives efter kirurgi.
7. Dexmedetomidin til anvendelse ifølge krav 6, hvor dexmedetomidin indgives efter kardiopulmonal bypass.
8. Dexmedetomidin til anvendelse ifølge krav 1, hvor indgivelsen af dexmedetomidin reducerer et behov for redningsmedicin. 35 2
9. Dexmedetomidin til anvendelse ifølge krav 8, hvor redningsmedicinen er et sedativ; eller hvor redningsmedicinen er et analgetikum.
10. Dexmedetomidin til anvendelse ifølge krav 1, hvor dexmedetomidin indgi- 5 ves i en mængde, der er virksom til at reducere en forekomst af neurologisk skade.
11. Dexmedetomidin til anvendelse ifølge krav 1, hvor den pædiatriske patient har en gestationsalder på mellem 28 uger og 44 uger.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161547626P | 2011-10-14 | 2011-10-14 | |
| US13/343,693 US20130096170A1 (en) | 2011-10-14 | 2012-01-04 | Methods of treating pediatric patients using dexmedetomidine |
| US13/471,403 US8324260B1 (en) | 2011-10-14 | 2012-05-14 | Methods of treating pediatric patients using dexmedetomidine |
| PCT/US2012/057652 WO2013055528A1 (en) | 2011-10-14 | 2012-09-27 | Methods of treating pediatric patients using dexmedetomidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2766014T3 true DK2766014T3 (da) | 2018-09-24 |
Family
ID=47226666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12840033.0T DK2766014T3 (da) | 2011-10-14 | 2012-09-27 | Fremgangsmåder til behandling af pædiatriske patienter under anvendelse af dexmedetomidin |
Country Status (23)
| Country | Link |
|---|---|
| US (8) | US20130096170A1 (da) |
| EP (2) | EP2766014B1 (da) |
| JP (5) | JP6270727B2 (da) |
| KR (3) | KR20200019791A (da) |
| CN (2) | CN103957906A (da) |
| AU (3) | AU2012321246C1 (da) |
| BR (1) | BR112014008983A2 (da) |
| CA (2) | CA2851780C (da) |
| CY (1) | CY1121041T1 (da) |
| DK (1) | DK2766014T3 (da) |
| ES (1) | ES2685814T3 (da) |
| HK (1) | HK1200333A1 (da) |
| HR (1) | HRP20181378T1 (da) |
| HU (1) | HUE039671T2 (da) |
| IL (2) | IL232070A0 (da) |
| IN (1) | IN2014KN00996A (da) |
| LT (1) | LT2766014T (da) |
| MX (1) | MX362626B (da) |
| PL (1) | PL2766014T3 (da) |
| PT (1) | PT2766014T (da) |
| RS (1) | RS57660B1 (da) |
| SI (1) | SI2766014T1 (da) |
| WO (1) | WO2013055528A1 (da) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130096170A1 (en) | 2011-10-14 | 2013-04-18 | Hospira, Inc. | Methods of treating pediatric patients using dexmedetomidine |
| US8242158B1 (en) | 2012-01-04 | 2012-08-14 | Hospira, Inc. | Dexmedetomidine premix formulation |
| KR101891186B1 (ko) * | 2013-10-07 | 2018-08-24 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 덱스메데토미딘 경피 조성물을 포함하는 통증을 관리하기 위한 방법 및 조성물 |
| US20150098997A1 (en) | 2013-10-07 | 2015-04-09 | Teikoku Pharma Usa, Inc. | Methods and Compositions for Treating Attention Deficit Hyperactivity Disorder, Anxiety and Insomnia Using Dexmedetomidine Transdermal Compositions |
| RU2648449C2 (ru) * | 2013-10-07 | 2018-03-26 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Способы и композиции для трансдермальной доставки неседативного количества дексмедетомидина |
| TWI645866B (zh) | 2013-10-07 | 2019-01-01 | 美商帝國製藥美國股份有限公司 | 右美托咪啶經皮輸送裝置及使用其之方法 |
| US11017330B2 (en) * | 2014-05-20 | 2021-05-25 | Elasticsearch B.V. | Method and system for analysing data |
| EP3182893B1 (en) | 2014-08-18 | 2024-02-07 | Electronic Pain Assessment Technologies (EPAT) Pty Ltd | A pain assessment system |
| CN104784174A (zh) * | 2015-03-06 | 2015-07-22 | 北京大学第一医院 | 右美托咪定的药物新用途 |
| US9717796B1 (en) * | 2016-04-20 | 2017-08-01 | Slypharma, Llc | Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container |
| JP2019534288A (ja) * | 2016-10-31 | 2019-11-28 | テイコク ファーマ ユーエスエー インコーポレーテッド | デクスメデトミジン経皮送達デバイスを用いた疼痛管理の方法 |
| CN106539778A (zh) * | 2016-12-08 | 2017-03-29 | 武汉大学 | 一种小儿麻醉术前含服口腔泡腾片及其制备方法 |
| MX2019007923A (es) | 2016-12-31 | 2019-09-10 | Bioxcel Therapeutics Inc | Uso de dexmedetomidina sublingual para el tratamiento de la agitacion. |
| US11783046B2 (en) | 2017-04-26 | 2023-10-10 | Elasticsearch B.V. | Anomaly and causation detection in computing environments |
| US11621969B2 (en) | 2017-04-26 | 2023-04-04 | Elasticsearch B.V. | Clustering and outlier detection in anomaly and causation detection for computing environments |
| CN108042533B (zh) * | 2017-12-25 | 2020-11-13 | 苏州格兰科医药科技有限公司 | 右美托米定在制备用于预防和/或抑制创伤性脑损伤后的神经元死亡的药物组合物中的用途 |
| EP3813828A4 (en) * | 2018-06-27 | 2022-03-30 | Bioxcel Therapeutics, Inc. | METHOD OF TREATMENT OF AGITATION WITH DEXMEDETOMIDIN HYDROCHLORIDE |
| US10792246B2 (en) | 2018-06-27 | 2020-10-06 | Bioxcel Therapeutics, Inc. | Film formulations containing dexmedetomidine and methods of producing them |
| JP2022500407A (ja) * | 2018-09-12 | 2022-01-04 | ハフ イアー インスティテュート | 人工内耳手術に伴う難聴の治療方法 |
| US20220054455A1 (en) * | 2018-09-13 | 2022-02-24 | Taiwan Liposome Co., Ltd. | Sustained-release pharmaceutical compositions comprising of a sedative drug and uses thereof |
| WO2020123680A1 (en) * | 2018-12-13 | 2020-06-18 | Dignity Health | System and method for detection and monitoring of over sedation to prevent harm to patients |
| US10817669B2 (en) | 2019-01-14 | 2020-10-27 | International Business Machines Corporation | Automatic classification of adverse event text fragments |
| CN109793709A (zh) * | 2019-02-22 | 2019-05-24 | 青岛农业大学 | 一种斑海豹用复方注射剂及其制备方法 |
| US11000488B2 (en) * | 2019-03-22 | 2021-05-11 | Syntrix Biosystems Inc. | Treating pain using desmetramadol |
| US20240024288A1 (en) | 2019-07-19 | 2024-01-25 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
| WO2021211507A1 (en) * | 2020-04-17 | 2021-10-21 | Bioventures, Llc | Methods and systems for predicting the effect of inhaled and infused anesthetics |
| KR20230094816A (ko) | 2021-12-21 | 2023-06-28 | 충남대학교산학협력단 | 감염 환자에서 반코마이신 최적 용량을 결정하는 방법 |
| US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
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| US8242158B1 (en) | 2012-01-04 | 2012-08-14 | Hospira, Inc. | Dexmedetomidine premix formulation |
-
2012
- 2012-01-04 US US13/343,693 patent/US20130096170A1/en not_active Abandoned
- 2012-05-14 US US13/471,403 patent/US8324260B1/en active Active
- 2012-09-27 CN CN201280058634.1A patent/CN103957906A/zh active Pending
- 2012-09-27 EP EP12840033.0A patent/EP2766014B1/en not_active Revoked
- 2012-09-27 EP EP18181747.9A patent/EP3446691A1/en not_active Withdrawn
- 2012-09-27 CA CA2851780A patent/CA2851780C/en not_active Expired - Fee Related
- 2012-09-27 DK DK12840033.0T patent/DK2766014T3/da active
- 2012-09-27 HU HUE12840033A patent/HUE039671T2/hu unknown
- 2012-09-27 BR BR112014008983A patent/BR112014008983A2/pt not_active Application Discontinuation
- 2012-09-27 IN IN996KON2014 patent/IN2014KN00996A/en unknown
- 2012-09-27 CA CA2978258A patent/CA2978258A1/en not_active Abandoned
- 2012-09-27 WO PCT/US2012/057652 patent/WO2013055528A1/en active Application Filing
- 2012-09-27 RS RS20181048A patent/RS57660B1/sr unknown
- 2012-09-27 JP JP2014535738A patent/JP6270727B2/ja active Active
- 2012-09-27 AU AU2012321246A patent/AU2012321246C1/en not_active Ceased
- 2012-09-27 LT LTEP12840033.0T patent/LT2766014T/lt unknown
- 2012-09-27 ES ES12840033.0T patent/ES2685814T3/es active Active
- 2012-09-27 PL PL12840033T patent/PL2766014T3/pl unknown
- 2012-09-27 MX MX2014004548A patent/MX362626B/es active IP Right Grant
- 2012-09-27 CN CN201811538616.9A patent/CN109700806A/zh active Pending
- 2012-09-27 SI SI201231349T patent/SI2766014T1/sl unknown
- 2012-09-27 KR KR1020207004550A patent/KR20200019791A/ko not_active Application Discontinuation
- 2012-09-27 KR KR1020197007143A patent/KR20190029775A/ko active Application Filing
- 2012-09-27 PT PT12840033T patent/PT2766014T/pt unknown
- 2012-09-27 KR KR1020147012837A patent/KR20140094539A/ko active Application Filing
- 2012-12-24 US US13/726,479 patent/US8507542B2/en active Active
- 2012-12-24 US US13/726,496 patent/US9314449B2/en active Active
-
2013
- 2013-08-09 US US13/963,885 patent/US20140005243A1/en not_active Abandoned
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2014
- 2014-04-10 IL IL232070A patent/IL232070A0/en unknown
-
2015
- 2015-01-23 HK HK15100803.0A patent/HK1200333A1/xx unknown
- 2015-11-16 US US14/942,880 patent/US20160067220A1/en not_active Abandoned
-
2017
- 2017-01-09 IL IL249991A patent/IL249991A0/en unknown
- 2017-07-20 AU AU2017206211A patent/AU2017206211B2/en not_active Ceased
- 2017-09-29 JP JP2017189989A patent/JP6640164B2/ja active Active
-
2018
- 2018-08-28 HR HRP20181378TT patent/HRP20181378T1/hr unknown
- 2018-09-04 CY CY181100916T patent/CY1121041T1/el unknown
-
2019
- 2019-05-21 AU AU2019203564A patent/AU2019203564A1/en not_active Abandoned
- 2019-05-21 US US16/418,754 patent/US20190269657A1/en not_active Abandoned
- 2019-12-25 JP JP2019234042A patent/JP2020073529A/ja active Pending
-
2020
- 2020-11-11 US US17/095,391 patent/US20210137891A1/en not_active Abandoned
-
2021
- 2021-10-04 JP JP2021163378A patent/JP2022008828A/ja not_active Withdrawn
-
2023
- 2023-10-23 JP JP2023181585A patent/JP2023179764A/ja active Pending
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